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  • limb-girdle muscular d
  • When defective, the mammalian calpain 3 (also known as p94) is the gene product responsible for limb-girdle muscular dystrophy type 2A, calpain 10 has been identified as a susceptibility gene for type II diabetes mellitus, and calpain 9 has been identified as a tumour suppressor for gastric cancer. (wikipedia.org)
  • neurodegenerative
  • We also summarized data underscoring the participation of calpains in the neurodegenerative mechanisms associated with AD. (hindawi.com)
  • Calpain activation has been implicated in neuronal apoptosis in ischemic brain injury and neurodegenerative diseases such as Alzheimer's. (abcam.com)
  • Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. (acris-antibodies.com)
  • CAPNS1
  • Enhanced calpain activity, regulated by CAPNS1, significantly contributes to platelet hyperreactivity under hypoxic environment. (wikipedia.org)
  • substrate
  • Calpain activity can be easily detected in many cell types using a specific calpain substrate linked to a colorimetric or fluorogenic detection molecule that will be released upon cleavage of the substrate. (abcam.com)
  • Arguably, the best currently available fluorogenic calpain substrate is (EDANS)-Glu-Pro-Leu-Phe=Ala-Glu-Arg-Lys-(DABCYL), with cleavage occurring at the Phe=Ala bond. (wikipedia.org)
  • physiological
  • Although the physiological role of calpains is still poorly understood, they have been shown to be active participants in processes such as cell mobility and cell cycle progression, as well as cell-type specific functions such as long-term potentiation in neurons and cell fusion in myoblasts. (wikipedia.org)
  • activation
  • One of such mechanisms seems to be the dysregulation of calcium homeostasis that results in the abnormal activation of calpains. (hindawi.com)
  • Calpain is likely to be active at some level in the cell, so use the appropriate background controls (untreated cells) to provide a baseline for calpain activation. (abcam.com)