Caenorhabditis elegans. Medical search. Frequent questions

In 1965 Sydney Brenner chose the free-living nematode Caenorhabditis elegans as a promising model system for a concerted genetic, ultrastructural, and behavioral attack on the development and function of a simple nervous system. (cshlpress.com)

The free-living nematode Caenorhabditis elegans is widely recognized as a model organism for investigating the biology of parasitic nematodes due to its easy laboratory culture, short generation time and fully sequenced genome. (unifesp.br)
Background: The free-living nematode Caenorhabditis elegans is the predominant model organism in biological research, being used by a huge number of laboratories worldwide. (uni-bielefeld.de)

C. elegans neurons contain dendrites which extend from the cell to receive neurotransmitters, and a process that extends to the nerve ring (the "brain") for a synaptic connection between neurons. (wikipedia.org)
C. elegans has motor excitatory and inhibitory neurons, known as cholinergic and gabaergic neurons, which simply act as further regulation for the tiny creature. (wikipedia.org)
In this thesis, I study mechanosensation in the C. elegans touch receptor neurons (TRNs) to understand how sensory systems are modulated and adapt to the environment. (columbia.edu)
Here, we demonstrate that in Caenorhabditis elegans specific sensory neurons influence onset of oogenesis through insulin signaling in response to food-derived cues. (elifesciences.org)
In contrast, other sensory neurons, the olfactory neurons AWA, regulate food type-dependent differences in C. elegans fertilization rates, but not onset of oogenesis. (elifesciences.org)
As this Caenorhabditis elegans worm undulates, 113 neurons throughout its brain and body (green/yellow spots) get brighter and darker as each neuron activates and deactivates. (nih.gov)
The nematode Caenorhabditis elegans possesses a simple embryonic nervous system with few enough neurons that the growth of each cell could be followed to provide a systems-level view of development. (nih.gov)
For example, in 2019, WormGUIDES research teams expanded knowledge on morphogenesis of the nervous system by visualizing neurons in a C. elegans sensory organ (called the amphid) as it underwent a collective dendrite extension to form the amphid's sensory system. (nih.gov)
Cilia are present only on sensory neurons in C. elegans,and as in other organisms, are essential for the unique functions of theseneuron types. (nih.gov)
In particular, many sensory neurons in C. elegans exhibitremarkably complex cilia structures, providing an excellent system in which toexplore the conserved pathways that couple the generation of specialized ciliamorphology to unique cellular and signaling functions. (nih.gov)
Cilia are present only on sensory neurons in C. elegans, and as in other organisms, are essential for the unique functions of these neuron types. (nih.gov)

Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans. (nih.gov)
We are in the process of screening genes involved in ionizing radiation-induced DNA repair using a C. elegans germ line tumor model. (mskcc.org)
Using system wide analysis, we showed that C. elegans and P. pacificus respond to B. thuringiensis DB27 or any other given pathogen in strikingly different ways, regulating a very different set of effector genes. (uni-tuebingen.de)
C. elegans have an invariant cell lineage, a fully sequenced genome, and provide an opportunity to study these genes in a more controlled, simple way. (kennesaw.edu)
Today, C. elegans remains a widely used model for neuroscience research because of its short life cycle, transparent body, and homology to human genes expressed in neurodevelopment. (nih.gov)
An RNAi screen for genes that affect nuclear morphology in Caenorhabditis elegans reveals the involvement of unexpected processes. (nih.gov)
Down-regulation of tricarboxylic acid (TCA) cycle genes blocks progression through the first mitotic division in Caenorhabditis elegans embryos. (nih.gov)

Nucleotide correlations that suggest tertiary interactions in the TV-replacement loop-containing mitochondrial tRNAs of the nematodes, Caenorhabditis elegans and Ascaris suum. (nih.gov)
The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum. (nih.gov)
In the growth assay, C. elegans in the first larval stage, L1, were exposed to varying concentrations of each of the 12 spil ed chemicals for 48 hours, which is the time required for untreated nematodes to mature to the L4 stage. (nih.gov)
After exposure to the chemicals, the size of the nematodes in each treatment group was measured and compared with the size of untreated nematodes to determine if treatment with any of the spil ed chemicals affected C. elegans development. (nih.gov)
compared with untreated nematodes to determine if treatment with any of the spil ed chemicals affected C. elegans feeding. (nih.gov)
The number of adults and their offspring in each treatment group was measured and compared to untreated nematodes to determine if treatment decreased C. elegans reproduction. (nih.gov)
C. elegans muscle age is a data set of fluorescence 20X microscopy images of C. elegans nematodes stained with phalloidin to visualize actin in muscles at different ages (1,2,4, and 8). (cellimagelibrary.org)
While the C. elegans model provided invaluable insights into innate defense pathways against infections, it remains to be discovered what the role of these pathways is in other nematodes and how they shape the evolution of bacterial pathogenicity. (uni-tuebingen.de)

In our previous studies we identified C. elegans ABL-1, the homolog for human c-Abl and demonstrate that ABL-1 plays an anti-apoptotic role in the C. elegans germ line by acting as a negative regulator of the p53 homolog CEP-1 (Nature Genetics, 2004). (mskcc.org)
Since then, with the help of a growing number of investigators, knowledge about the biology of "the worm" has accumulated at a steadily accelerating pace to the extent that C. elegans is now probably the most completely understood metazoan in terms of anatomy, genetics, development, and behavior. (cshlpress.com)
Effectively isolating and categorizing large quantities of Caenorhabditis elegans (C. elegans) based on different phenotypes is important for most worm research, especially genetics. (nih.gov)
The nematode Pristionchus pacificus has been extensively used for comparative studies with C. elegans, linking developmental biology, ecology and population genetics. (uni-tuebingen.de)

Spindle assembly checkpoint strength is linked to cell fate in the Caenorhabditis elegans embryo. (iric.ca)
By integrating light-sheet microscopy, imaging, and computational approaches, consortium investigators developed the WormGUIDES Atlas, an interactive resource that provides dynamic information in four dimensions (4D) on the behaviors of individual cells as they coordinately assemble into a functional nervous system in the C. elegans embryo (Figure 1). (nih.gov)

This "Book of the Worm" serves as a reference source for C. elegans investigators as well as an introductory monograph for other biologists. (cshlpress.com)
The characteristics of these effects, their relevance for C. elegans fitness, the presence of specific co-adaptations between microbiome members and the worm, and the molecular underpinnings of microbiome-host interactions represent promising areas of future research, for which the advantages of C. elegans as an experimental system should prove of particular value. (frontiersin.org)
iii) discovered that C. elegans commensal bacterium B. subtilis protects the worm from infection via bacteriocin-mediated pathogen inhibition. (uni-tuebingen.de)

sequenced.The Caenorhabditis elegans nuclear genome is approximately 100 Mb, distributed among six chromosomes. (nih.gov)
Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856. (nih.gov)
Illumina Synthetic Long Read Sequencing Allows Recovery of Missing Sequences even in the "Finished" C. elegans Genome. (nih.gov)
Genome sequence of the nematode C. elegans: a platform for investigating biology. (nih.gov)
Found in the Caenorhabditis elegans reference genome. (rnacentral.org)

The National Toxicology Program (NTP)1 evaluated the toxicity of six chemicals that were spil ed into the West Virginia Elk River, four structural y related chemicals, and two chemical mixtures to the nematode roundworm Caenorhabditis elegans ( C. elegans ). (nih.gov)
Caenorhabditis elegans ( C. elegans ) is a roundworm about 1mm in length that lives freely in soil and feeds on bacteria. (nih.gov)
The roundworm Caenorhabditis elegans exhibits robust escape behavior in response to rapidly rising temperature. (nih.gov)
More than 30 years after the adult nervous system and cell lineage of the roundworm Caenorhabditis elegans were first mapped, 1 that map of neuron connectivity (i.e., the connectome) still enables scientists to better understand diverse neurobiological mechanisms. (nih.gov)

In 1974, he began research into the molecular and developmental biology of C. elegans, which has since been extensively used as a model organism. (wikipedia.org)
Caenorhabditis elegans , a free-living soil nematode, is widely used as a model organism. (nih.gov)
In addition, we show how to decellularize the multicellular organism C. elegans in order to harvest its cuticle, one of the two major extracellular matrices, mainly composed of collagen. (nih.gov)
This study demonstrates that individual subunits of SET1-related complexes can show tissue specificity and developmental regulation and establishes C. elegans as a model to study SET1-related complexes in a multicellular organism. (ens-lyon.fr)
In this study the effects of catechin, epicatechin, 3'-O-methylepicatechin and 4'-O-methylepicatechin have been evaluated using C. elegans as a model organism. (edu.pe)
Caenorhabditis elegans, which has a CALR ortholog (CRT-1), has been used as a model organism for the characterization of CALR, and several conditions promoting the upregulation of crt-1 have been studied and established to understand the molecular control of crt-1 transcription and assess the function of the protein. (unav.edu)
New strategy for antihelmintic discovery using the model organism caenorhabditis elegans. (unifesp.br)
Prior to OHAT, she managed the NTP WormTox Screening Facility, which developed bioassays using the nematode Caenorhabditis elegans as an alternative model organism in high-throughput toxicological screening. (nih.gov)

Narbonne, P. & Roy, R. Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling. (nature.com)
Together our findings suggest that optimal reproduction requires the integration of diverse food-derived inputs through multiple neuronal signals acting on the C. elegans germline. (elifesciences.org)
Here we show that SAC strength is correlated with cell fate during development of Caenorhabditis elegans embryos, with germline-fated cells experiencing longer mitotic delays upon spindle perturbation than somatic cells. (iric.ca)
FBF, a PUF RNA-binding protein, is a key regulator of the mitosis/meiosis decision in the Caenorhabditis elegans germline. (umn.edu)

For the last decade, our laboratory has been evaluating conserved gene functions and their genetic interactions after ionizing radiation using the nematode C. elegans . (mskcc.org)
Subsequently we characterized 24 genetic mutants of the C. elegans sphingolipid metabolic pathway. (mskcc.org)
First, C. elegans is highly amenable to genetic manipulation. (frontiersin.org)
A global analysis of genetic interactions in Caenorhabditis elegans. (ca.gov)
Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the nematode Caenorhabditis elegans. (ca.gov)
Finally, we showed that the properties of genetic networks are conserved between C. elegans and Saccharomyces cerevisiae, but that the connectivity of interactions within the current networks is not. (ca.gov)
2007 . Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assay. (nih.gov)
Genetic Control of Fusion Pore Expansion in the Epidermis of Caenorhabditis elegans . (nih.gov)

A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay. (nih.gov)

In the reproduction assay, C. elegans in the fourth larval stage, L4, were exposed to each of the 12 spil ed chemicals for 48 hours, yielding a population of adults, embryos, and larvae in stages L1 and L2. (nih.gov)

This review brings together results from the first three studies on C. elegans microbiomes, all published in 2016. (frontiersin.org)
2016). Evaluation of Burkholderia cepacia Complex Bacteria Pathogenicity Using Caenorhabditis elegans. (cdc.gov)

Thenematode C. elegans provides an excellent model for the study of ciliogenesisand sensory signaling. (nih.gov)
In her presentation, Dr.Sengupta will describe recent and ongoing work in the lab on mechanisms thatgenerate and maintain cilia structural diversity in C. elegans, and discuss thecomplex interplay between cilia architecture and sensory neuron function. (nih.gov)

Caenorhabditis elegans piwi-interacting RNA 21ur-9855 sequence is a product of 21ur-9855 gene. (rnacentral.org)

2014 . A high-content assay for identifying small molecules that reprogram C. elegans germ cell fate. (nih.gov)

We show here that C. elegans larvae that lack LKB1/AMPK (AMP-activated protein kinase) signalling enter dauer normally, but then rapidly consume their stored energy and prematurely expire following vital organ failure. (nature.com)
McElwee, J., Bubb, K. & Thomas, J. H. Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. (nature.com)
We have recently demonstrated in C. elegans that the sole Musashi RNA-binding protein (RBP) plays an important regulatory role in forgetting by modulating cytoskeletal changes at the translational level [ 7 ]. (springer.com)
Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos. (nih.gov)

Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells. (ens-lyon.fr)
Home / Teams / Epigenetic regulation of cell identity and environmental stress responses - F. Palladino / Publications / Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells. (ens-lyon.fr)

In many instances where mammalian systems are too complicated to obtain clear information concerning signaling pathways, C. elegans has been instructive. (mskcc.org)

Here we report the production of C. elegans separase-securin complex and its characterisation using biochemical methods and by negative staining electron microscopy. (whiterose.ac.uk)
Assuming that its reproducibility is validated in further studies, the method will reduce the inter-laboratory variability of life-history estimates and may ultimately prove to be more convenient than the current standard methods used by C. elegans researchers. (uni-bielefeld.de)

The nematode Caenorhabditis elegans has been widely used as a genetically amenable invertebrate for studying host-pathogen interactions. (uni-tuebingen.de)

Terminal Bulb is a dataset of DIC (differential interference contrast) 20x microscopy images of the pharynx terminal bulb of C. elegans at different ages (0, 2, 4, 6, 8, 10, 12 days). (cellimagelibrary.org)
Britz S, Markert SM, Witvliet D, Steyer AM, Tröger S, Mulcahy B, Kollmannsberger P, Schwab Y, Zhen M and Stigloher C (2021) Structural Analysis of the Caenorhabditis elegans Dauer Larval Anterior Sensilla by Focused Ion Beam-Scanning Electron Microscopy. (zenodo.org)

When Caenorhabditis elegans larvae enter dauer they arrest feeding but remain active and motile, yet become stress-resistant, extremely long-lived and non-ageing 1 . (nature.com)
Here, we describe an improved protocol for dissociation and preparation of single cell suspensions from developmentally synchronized populations of C. elegans L1 larvae. (uu.nl)

Cell Biology of the Caenorhabditis elegans Nucleus. (nih.gov)

Caenorhabditis elegans polo-like kinase PLK-1 is required for merging parental genomes into a single nucleus. (nih.gov)

Caenorhabditis elegans and parasitic helminths are unable to synthesize heme de novo, but instead acquire heme from exogenous sources for growth and development. (nih.gov)

Movement in C. elegans is structured around different reorientation behaviours, and we measured how these contributed to changing search strategies as worms became familiar with their new environment. (gla.ac.uk)
Our results show how movement strategies arise from a balance between intrinsic and extrinsic mechanisms, that search behaviour in C. elegans is initially determined by expectations developed from previous environmental experiences, and which reorientation behaviours are modified as information is acquired from new environments. (gla.ac.uk)

Fortunately, many TFs are conserved across species, allowing the use of simple organisms such as the nematode Caenorhabditis elegans in understanding TF function. (kennesaw.edu)
A screening test was proposed for neurotoxins using a computer tracking system and Caenorhabditis-elegans, a species of nematode. (cdc.gov)

The worms, known as Caenorhabditis elegans, are commonly used in research because they are easy to genetically manipulate. (nih.gov)

Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope. (nih.gov)

Medium- and high-throughput screening of neurotoxicants using C. elegans. (nih.gov)

The untwisting and cell tracking capabilities of our method provide a foundation on which to catalog C. elegans neurodevelopment, allowing interrogation of developmental events in previously inaccessible periods of embryogenesis. (nih.gov)
C. elegans offers an ideal system for visualizing neurodevelopment and for modeling neurodegenerative diseases, such as Alzheimer's disease and autism spectrum disorder (ASD). (nih.gov)

1976 . The life cycle of the nematode Caenorhabditis elegans. (nih.gov)

Here, we show that the eIF4E isoform IFE-2 is increasingly sequestered in mRNA processing (P) bodies during aging and upon stress in Caenorhabditis elegans. (uni-koeln.de)

The simplicity of the C. elegans system coupled with the capacity to readily incorporate more than 1 mutated allele in a single animal make this model ideal for asking questions regarding the molecular ordering of signaling cascades. (mskcc.org)
The nematode Caenorhabditis elegans is used as a central model system across biological disciplines. (frontiersin.org)
2009 . Application of a mathematical model to describe the effects of chlorpyrifos on Caenorhabditis elegans development. (nih.gov)
The nematode Caenorhabditis elegans as a model of organophosphate-induced mammalian neurotoxicity. (nih.gov)
Most commercial anthelmintics are active against C. elegans, levamisole and benzimidazole derivatives, and this animal model has been useful in understanding the mechanism of action of the same, making it a useful system for selection and investigation of compounds with potential anthelmintic activity. (unifesp.br)
It is also worth noting that two of the compounds selected in the collaborator screening reduced the parasitemia in the in vivo model of Ascarissum infection by 61.96% and 59.78%, confirming the translational value of the C. elegans biological model. (unifesp.br)

Salvador, L. C. M. , Bartumeus, F. , Levin, S. A. and Ryu, W. S. (2014) Mechanistic analysis of the search behaviour of Caenorhabditis elegans. (gla.ac.uk)

In 1963, Sydney Brenner proposed research into C. elegans, primarily in the area of neuronal development. (wikipedia.org)
The past few years have seen the completion of two major long-term projects that provide new insights into C. elegans development and lay important groundwork for future investigation: completion of the cell lineages of both sexes, from zygote to adult, and description of the complete anatomy at the level of electron microscope resolution, providing a complete "wiring diagram" of cell contacts in the animal. (cshlpress.com)
These assays evaluated effects on growth and development, feeding, and reproduction at different developmental stages in C. elegans' lifecycle. (nih.gov)
NTP found that none of the chemicals affected growth and development, feeding, or reproduction of C. elegans . (nih.gov)
During development, C. elegans mature through the embryonic stage, four larval stages (L1- L4), and adulthood. (nih.gov)
In the present study the development and standardization of a new methodology of in vivo high content screening using the C. elegans is described. (unifesp.br)

The current paucity of microbiome studies in C. elegans is unexpected, because several characteristics make this nematode ideally suited for the experimental analysis of host-microbe interactions. (frontiersin.org)
Taken together, these results not only tackle both sides of C. elegans - B. thuringiensis DB27 host-pathogen interactions, but also reveal previously unrecognized mechanism of nematode protection by commensal-mediated inhibition of the pathogen. (uni-tuebingen.de)

In relation to lipid metabolism, C. elegans does not have any specialized adipose tissues, a pancreas, a liver, or even blood to deliver nutrients compared to mammals. (wikipedia.org)

The purpose of the dataset C. elegans terminal bulb aging is to deduce the age of the nemathode based on images of the pharynx terminal bulb (part of the eating apparatus). (cellimagelibrary.org)

In this work the authors perform a rigorous and detailed analysis of the cellular and molecular basis for food type influences on reproduction in C. elegans . (elifesciences.org)

In 1900, Maupas initially named it Rhabditides elegans. (wikipedia.org)

Current studies largely ignore the natural ecology of C. elegans . (frontiersin.org)

Anatomy24

Organisms11

Diseases1

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology3

Phenomena and Processes60

Information Science4

Health Care1

Nematode Caenorhabditis elegans as a promi1

Free-living nematode Caenorhabditis2

Neurons11

Genes7

Nematodes8

Genetics4

Embryo2

Worm3

Genome5

Roundworm4

Organism8

Germline4

Genetic8

Toxicity1

Reproduction assay1

20162

Sensory2

Gene1

Assay1

Protein4

Embryos2

Pathways1

Methods2

Widely1

Microscopy2

Larvae2

Biology1

Genomes1

Helminths1

Reorientation2

Species2

Genetically1

Homolog1

High-throughput1

Neurodevelopment2

19761

MRNA1

Model6

Search1

Development6

Interactions2

Lipid1

Aging1

Molecular1

Initially1

Ecology1