• Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene. (wikipedia.org)
  • This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. (wikipedia.org)
  • Characterization by cDNA cloning of two new human protein kinases. (wikipedia.org)
  • This antibody detects endogenous level of total CDC2 protein. (prosci-inc.com)
  • CDK4 is a member of the Ser/Thr protein kinase family. (thermofisher.com)
  • This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. (thermofisher.com)
  • It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
  • To examine the involvement of interchromatin granule clusters (IGCs) in transcription and pre-mRNA splicing in mammalian cell nuclei, the serine-arginine (SR) protein kinase cdc2-like kinase (Clk)/STY was used as a tool to manipulate IGC integrity in vivo. (rupress.org)
  • A family of cell cycle-dependent kinases that are related in structure to CDC28 PROTEIN KINASE, S CEREVISIAE and the CDC2 PROTEIN KINASE found in mammalian species. (bvsalud.org)
  • The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. (wikidata.org)
  • The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. (wikidata.org)
  • The protein encoded by this gene is a member of the Ser/Thr protein kinase family. (ayassbioscience.com)
  • Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. (ayassbioscience.com)
  • Differential expression of genes for cyclin-dependent protein kinases in rice plants , 1999, Plant Physiol. (github.io)
  • A rice homolog of Cdk7/MO15 phosphorylates both cyclin-dependent protein kinases and the carboxy-terminal domain of RNA polymerase II , 1998, The Plant Journal. (github.io)
  • Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. (jefferson.edu)
  • Protein kinases are critical to cellular signalling and post-translational gene regulation, but their biological substrates are difficult to identify. (biomedcentral.com)
  • Protein kinases are ubiquitous components of cellular signalling networks [ 1 ]. (biomedcentral.com)
  • Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. (ox.ac.uk)
  • It is widely assumed that degradation of mitotic cyclins causes a decrease in mitotic cdc2/CDC28 kinase activity and thereby triggers the metaphase to anaphase transition. (ox.ac.uk)
  • Two observations made on the budding yeast Saccharomyces cerevisiae are inconsistent with this scenario: (i) anaphase occurs in the presence of high levels of kinase in cdc15 mutants and (ii) overproduction of a B-type mitotic cyclin causes arrest not in metaphase as previously reported but in telophase. (ox.ac.uk)
  • Although we did not identify any highly Clb2-specific substrates, we found that Clb2-Cdk1 possessed higher intrinsic kinase activity than Clb5-Cdk1, enabling efficient phosphorylation of a broad range of mitotic Cdk1 targets. (nature.com)
  • Fisher, D. L. & Nurse, P. A single fission yeast mitotic cyclin B p34 cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. (nature.com)
  • Cyclin-Dependent Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events. (jefferson.edu)
  • This graph shows the total number of publications written about "Cyclin-Dependent Kinases" by people in this website by year, and whether "Cyclin-Dependent Kinases" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "Cyclin-Dependent Kinases" by people in Profiles. (jefferson.edu)
  • Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. (jefferson.edu)
  • We show that cyclin-dependent kinase (CDK) consensus motifs are frequently clustered in CDK substrate proteins. (biomedcentral.com)
  • A relatively well understood example is the network that controls progression of the cell cycle, where cyclin-dependent kinases (CDKs) couple with various cyclins over the cell cycle to regulate critical processes [ 2 - 4 ]. (biomedcentral.com)
  • Cell-cycle events are controlled by cyclin-dependent kinases (CDKs), whose periodic activation is driven by cyclins. (nature.com)
  • Here we compare the specificity of two budding yeast cyclins, the S-phase cyclin Clb5 and the M-phase cyclin Clb2, in the phosphorylation of 150 Cdk1 (Cdc28) substrates. (nature.com)
  • Targets of the cyclin-dependent kinase Cdk1. (nature.com)
  • Brown, N. R., Noble, M. E., Endicott, J. A. & Johnson, L. N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. (nature.com)
  • Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. (nature.com)
  • Schulman, B. A., Lindstrom, D. L. & Harlow, E. Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. (nature.com)
  • Direct modulation of the non-kinase functions of cyclin and CDK-cyclin complexes poses challenges. (bvsalud.org)
  • We utilize hydrophobic tag (HyT) based small-molecule degraders induced degradation of cyclin T1 and its corresponding kinase partner CDK9. (bvsalud.org)
  • Familia de cinasas dependientes del ciclo celular que se relacionan estructuralmente con la PROTEÍNA CINASA CDC28 DE SACCHAROMYCES CEREVISIAE y con la PROTEÍNA CINASA CDC2 que se encuentra en mamíferos. (bvsalud.org)
  • CDC2 (Ab-161) antibody was raised against a peptide sequence around aa.159~163 (T-Y-T-H-E) derived from Human CDC2. (prosci-inc.com)
  • p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. (prosci-inc.com)
  • Kinase destruction is therefore implicated in the exit from mitosis rather than the entry into anaphase. (ox.ac.uk)
  • Isolation and characterization of cDNA clones encoding cdc2 homologues from Oryza sativa: a functional homologue and cognate variants , 1992, Mol Gen Genet. (github.io)
  • The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). (thermofisher.com)
  • Schindler K, Benjamin KR, Martin A, Boglioli A, Herskowitz I, Winter E. The Cdk-activating kinase Cak1p promotes meiotic S phase through Ime2p. (jefferson.edu)
  • The execution of anaphase and the destruction of CDC28 kinase activity therefore appear to take place independently of one another. (ox.ac.uk)
  • A multifunctional CDC2 kinase-related kinase that plays roles in transcriptional elongation, CELL DIFFERENTIATION , and APOPTOSIS . (nih.gov)
  • The behaviour of esp1 mutants shows in addition that kinase destruction can occur in the absence of anaphase completion. (ox.ac.uk)
  • Immunohistochemistry was used to analyze samples of 40 newly diagnosed childhood acute lymphoblastic leukemias (ALL) for their expression of cyclins (D1, E, A), cyclin-dependent kinases (cdk2, cdk4) and tumor-suppressor genes (pRb, p16INK4A), in order to discover whether or not the expression of these various proteins may be of prognostic relevance for the survival of children with ALL. (nih.gov)
  • Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. (elifesciences.org)
  • Theactivity of this kinase is restricted to the G1-S phase, which is controlled by the regulatorysubunits D-type cyclins and CDK inhibitor p16(INK4a). (biopaqc.com)
  • These proteins perform as mitotic cyclins, and bind with Cdc28 to form complexes that are necessary for nuclear division and chromosome segregation. (blogspot.com)
  • Here we show that Smad3 is a major physiological substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. (nih.gov)
  • In contrast, in TNFR1-/- mice, which exhibit exaggerated acetaminophen hepatotoxicity, hepatocyte proliferation, and expression of cyclin D1 and cyclin A, as well as the cyclin dependent kinases, Cdk4 and Cdk2, were reduced. (nih.gov)
  • Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. (nih.gov)
  • Analysis of p27kip1 derived from Burkitt's lymphoma cell lines expressing high levels of p27kip1, BL40 and BL41, in a cyclin E/cdk2 kinase inhibition assay demonstrated that p27kip1 is not permanently inactivated since heat treatment can restore the inhibitory activity of p27kip1. (ox.ac.uk)
  • Furthermore, cyclinD3/cdk4 complex could sequester p27kip1 in a cyclin E/cdk2 kinase assay in vitro. (ox.ac.uk)
  • 1997). Hyperphosphorylation of the N-terminal domain of Cdc25 regulates activity toward cyclin B1/cdc2 but not cyclin A/cdk2. (sdbonline.org)
  • Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity. (sdbonline.org)
  • The cyclin-dependent kinase inhibitor p21 was also induced in the liver following acetaminophen administration. (nih.gov)
  • Lack of detectable expression of p27kip1 cyclin dependent kinase inhibitor has previously been correlated with high degree of malignancy in human breast, colorectal, gastric and small cell lung carcinomas. (ox.ac.uk)
  • We have shown that the polo-box motif, which resides in the C-terminal noncata-lytic domain, is essential for the localization of both budding yeast polo kinase Cdc5 and mammalian Plk1 to specific subcellular structures. (nih.gov)
  • One of the critical events that budding yeast polo kinase Cdc5 mediates is mitotic entry, a process that requires activation of Cdc28 (homolog of mammalian Cdc2). (nih.gov)
  • The Cdk-activating kinase (CAK) from budding yeast. (sdbonline.org)
  • Our results provide evidence that during Plasmodium male gametogony, this divergent cyclin/CDK pair fills the functional space of other eukaryotic cell-cycle kinases controlling DNA replication. (elifesciences.org)
  • Studies have shown that Swe1 (ortholog of mammalian Wee1) inhibits mitotic entry by negatively regulating Cdc28. (nih.gov)
  • Plks also regulate pathways leading to the inactivation of Cdc2 at mitotic exit. (nih.gov)
  • 1999). Cyclin B-cdk1 kinase stimulates ORC- and Cdc6-independent steps of semiconservative plasmid replication in yeast nuclear extracts. (sdbonline.org)
  • 1999). Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. (sdbonline.org)
  • Anaphase-promoting-complex (APC) of yeast is considered as one of the significant substrates for Cdc28-Cln2 and Cdc28-Cln1 complexes. (blogspot.com)
  • Progression through the cell cycle critically relies upon post-translational mechanisms including changes in activity of cell cycle kinases and phosphatases, and ubiquitin-mediated degradation of specific components once their function is complete. (elifesciences.org)
  • Signals relating to DNA damage and completeness of replication impact on balance of Wee1 (a Cdc2 inhibitory kinase) and Cdc25 activities to delay entry into M phase. (comprehensivephysiology.com)
  • Dephosphorylation of Cdc2 by Cdc25 phosphatase(s) at positions T14 and Y15 leads to generation of active MPF heterodimers ( right ). (comprehensivephysiology.com)
  • Even when the cdc28 cells are arrested in G 1 phase, at non-permissive temperatures they continue to grow in size but do not initiate bud formation, DNA replication, or synthesize, and thereby cannot enter the S phase. (blogspot.com)
  • These changes activate the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft. (nih.gov)
  • This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. (nih.gov)
  • The phenotypic behavior of cdc28 mutants that are sensitive to temperature signifies the importance of the Cdc28 function in allowing the cell into S phase. (blogspot.com)
  • It has been identified from different experiments that Cdc28-Cln3 activity is controlled in response to cell size, even though there is no clear understanding of the regulating mechanism. (blogspot.com)
  • The cell gets inactivated at late G 1 when APC is phosphorylated by either Cdc28-Cln2 or Cdc28-Cln1. (blogspot.com)
  • Red No. 3, beta-estradiol, and DDT increase ER site-specific DNA binding to the estrogen response element in HTB 133 cells and increase cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells. (researchgate.net)
  • Wu X, An X, Zhang C, Huang M. Clb6-Cdc28 Promotes Ribonucleotide Reductase Subcellular Redistribution during S Phase. (ucdenver.edu)
  • thus cyclin - dependent kinase (CDK) must actively contribute to stationary phase establishment. (biologists.com)