Ccaat enhancer binding proteins. Medical search. Frequent questions

We used unbiased genome-wide mapping to identify 115 C/EBPbeta target genes in PC12 cells that include transcription factors, neurotransmitter receptors, ion channels, protein kinases and synaptic vesicle proteins. (nih.gov)
Target genes in rat brain were subsequently found to preferentially bind C/EBPalpha, beta and delta. (nih.gov)
This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity (expression) of certain genes. (medlineplus.gov)
However the effect of HDAC is not restricted to epigenetic changes and in fact there are several other proteins regulated by acetylation including transcription factors (c-myc YY1 E2F) and tumor suppressor genes (pRb p53).2 In recent years there has been an increasing interest in the use of HDAC inhibitors in cancer treatment protocols given these inhibitors' apparent ability to preferentially target tumor cells in comparison to nonmalignant cells. (tech-strategy.org)
The program begins with the induction of genes involved in transcriptional regulation and signal transduction and is followed, sequentially, by the regulation of genes involved in protein biosynthesis, cell proliferation, and epithelial cell differentiation. (nih.gov)
2. Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: a possible prognostic marker. (nih.gov)
Evolutionary studies have demonstrated that the increase in organisms complexity corresponds to a decrease in the abundance of protein-coding genes and a concomitant rise in the number of ncRNAs, indicating that regulatory RNA diversification has been critical to increase vertebrate complexity ( 15 , 16 ). (frontiersin.org)
The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. (nih.gov)
VME and VMA also reversed the HFD-induced mRNA expression of lipogenic genes such as CCAAT/enhancer binding protein (C/EBP)α, C/EBPβ, sterol regulatory element-binding protein 1c, and leptin in adipose tissue, whereas they increased mRNA expression of uncoupling protein 2 and adenosine monophosphate-activated protein kinase (AMPK). (biomedcentral.com)
Hematoxylin and eosin staining of various fat depots showed that increased adipocyte size caused by HFD intake was markedly reduced and correlated with reduced mRNA levels of lipogenesis genes, including sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and CCAAT/enhancer binding protein alpha, and increased uncoupling protein 1 levels. (springer.com)
lncRNAs can be categorized into intergenic, intronic, bidirectional, sense, and antisense lncRNAs, depending on their genomic position relative to nearby protein-coding genes ( 10 , 11 ). (frontiersin.org)

CCAAT enhancer-binding protein-α (CEBPA) is a transcription factor in which gene mutations result in a differentiation block in myeloid precursors. (medscape.com)
C/EPBα proteins encoded with the CCAAT-enhancer-binding protein α gene play an essential role in granulocytic advancement and defects within this transcription factor have already been reported in severe myeloid leukemia. (tech-strategy.org)
The myeloid-specific transcription factor, CCAAT/enhancer-binding protein ε (C/EBPε) is a critical mediator of myelopoiesis. (medicalnewstoday.com)
From NCBI Gene: The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. (nih.gov)
CCAAT-enhancer binding protein alpha (C/EBP alpha) is a widely expressed 42 kDa basic-leucine zipper transcription factor that forms functional homodimers and heterodimers with C/EBP beta and gamma. (rndsystems.com)

CCAAT/enhancer-binding proteins (C/EBPs) are a family of basic leucine zipper (bZIP) DNA binding proteins that play important roles in normal cellular differentiation and function in a variety of tissues. (novusbio.com)

A Kinase Interacting Protein 1 (AKIP1) is a signalling adaptor that promotes physiological hypertrophy in vitro. (nature.com)
Mechanistically, AKIP1 promoted exercise-induced activation of protein kinase B (Akt), downregulation of CCAAT Enhancer Binding Protein Beta (C/EBPβ) and de-repression of Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 (CITED4). (nature.com)
B3 Ku binds to the C-terminal region of DNA-PK (amino acids 3002-3850) near the protein kinase domain (Jin et al. (nih.gov)
B10 HMG1 or 2 compete with Ku for binding to DNA-PK and stimulate DNA-dependent kinase activity in vitro in the absence of Ku (Yumoto et al. (nih.gov)
death associated protein kinase 2 [So. (gsea-msigdb.org)

CCAAT-enhancer-binding proteins (or C/EBPs) is a family of transcription factors composed of six members, named from C/EBPα to C/EBPζ. (wikipedia.org)
Once bound to DNA, C/EBPs can recruit so-called co-activators (such as CBP) that in turn can open up chromatin structure or recruit basal transcription factors. (wikipedia.org)
The dimerization is necessary to enable C/EBPs to bind specifically to DNA through a palindromic sequence in the major groove of the DNA. (wikipedia.org)
CCAAT/Enhancer Binding Proteins (C/EBPs) play pivotal roles in the development and plasticity of the nervous system. (nih.gov)

This domain is involved in dimerization and DNA binding, as are other transcription factors of the leucine zipper domain-containing family (c-Fos and c-jun). (wikipedia.org)
C/EBP alpha contains three TE transactivation domains (aa 1-69, aa 70-96, and aa 126-200) and one basic DNA binding motif and leucine zipper (aa 286-345). (rndsystems.com)
The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA -binding basic region, and a leucine-rich dimerization domain ( LEUCINE ZIPPERS ). (bvsalud.org)

The synthesis of fatty acids and cholesterol, the building blocks of membranes, is regulated by three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -1c, and -2. (nih.gov)
Several mediators are involved in lipid metabolism, including sterol regulatory element-binding protein-1c (SREBP-1c) and CCAAT/enhancer binding protein alpha (C/EBPα), which are important transcription factors involved in the regulation of lipogenic gene mRNA expression. (springer.com)

9. Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells. (nih.gov)
10. Transforming growth factor-beta inhibits CCAAT/enhancer-binding protein expression and PPARgamma activity in unloaded bone marrow stromal cells. (nih.gov)
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. (cancerindex.org)
This process is mediated by the major thermogenic factor uncoupling protein-1 and can be activated by certain stimuli, such as cold exposure, adrenergic compounds or genetic alterations. (degruyter.com)
HSF1 granule formation only requires the DNA binding competence and the trimerization of the factor. (rupress.org)
Functional genomics data indicate that 2 of the suggestive SNPs (rs2446823 and rs2446824) are located within putative binding sites for the CCAAT/Enhancer Binding Protein (CEBP) and Hepatocyte Nuclear Factor 4, Alpha transcription factors (TFs), respectively. (cdc.gov)
El FACTOR DE UNIÓN A CCAAT es estructuralmente un tipo distinto de proteína de unión aumentadora a CCAAT que consta de un trímero de tres subunidades diferentes. (bvsalud.org)
CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits. (bvsalud.org)

CCAAT-Enhancer-Binding Protein-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)

The CEBPA gene provides instructions for making a protein called CCAAT enhancer-binding protein alpha. (medlineplus.gov)
This shortened protein is produced from one copy of the CEBPA gene in each cell, and it is believed to interfere with the tumor suppressor function of the normal protein produced from the second copy of the gene. (medlineplus.gov)
The somatic CEBPA gene mutations that have been identified in leukemia cells generally decrease the DNA-binding ability of CCAAT enhancer-binding protein alpha. (medlineplus.gov)
This RNA binds to DNMT1 and prevents CEBPA gene locus methylation. (nih.gov)

B7 The SH3 domain of c-Abl binds to the C-terminal region of DNA-PK (amino acids 3414-3850) and may compete with Ku for binding to the same region (Jin et al. (nih.gov)
Domain organization of RNA polymerase alpha subunit: C-terminal 85 amino acids constitute a domain capable of dimerization and DNA binding. (nature.com)

Their function in liver has been characterized in transgenic mice that overexpress each SREBP isoform and in mice that lack all three nuclear SREBPs as a result of gene knockout of SREBP cleavage-activating protein (SCAP), a protein required for nuclear localization of SREBPs. (nih.gov)
11. CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma. (nih.gov)
Among these proteins, C/EBP beta is usually highly expressed in liver, intestine, lung and adipose. (novusbio.com)
These younger LINEs are enriched for binding sites of immune-associated transcription factors, whereas older LINEs are enriched for liver-specific transcription factors. (biomedcentral.com)

16. The expression of CCAAT/enhancer binding protein (C/EBP) in the human ovary in vivo: specific increase in C/EBPbeta during epithelial tumour progression. (nih.gov)
17. Differential regulation of elafin in normal and tumor-derived mammary epithelial cells is mediated by CCAAT/enhancer binding protein beta. (nih.gov)

Binding of c-Abl to p53 inhibits the Mdm2-mediated degradation of p53 (Sionov et al. (nih.gov)

18. CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis. (nih.gov)

In this latest study, the team showed mice bred to be deficient in C/EBPε were severely affected by infection with S. aureus , and it was deficiency of the C/EBPε protein in their neutrophils (a type of white blood cell that kills and devours harmful bacteria), that was responsible. (medicalnewstoday.com)
2014. Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice. . (oregonstate.edu)

flanking region of CYP3A2 revealed the presence of 5 NF-IL6 and 4 AP-1 putative DNA binding sites. (nih.gov)

C/EBP proteins also contain activation domains at the N-terminus and regulatory domains. (wikipedia.org)
C/EBPbeta binding sites were located primarily within introns, suggesting novel regulatory functions, and were associated with binding sites for other developmentally important transcription factors. (nih.gov)
They discovered that the circles contained as many as 20 to 50 enhancers and other regulatory elements. (drugdiscoverynews.com)

Hepatic nuclear protein was isolated and analyzed for binding activity to AP-1, NFkappaB, and NF-IL6 consensus sequences. (nih.gov)

Absence of the tumor suppressor function of CCAAT enhancer-binding protein alpha is believed to disrupt the regulation of blood cell production, leading to the uncontrolled production of abnormal cells that occurs in acute myeloid leukemia. (medlineplus.gov)
One type leads to production of an abnormally short protein that interferes with the tumor suppressor function of normal versions of CCAAT enhancer-binding protein alpha. (medlineplus.gov)
Impaired DNA binding interferes with the protein's ability to regulate gene expression and impairs its tumor suppressor function. (medlineplus.gov)

DNA affinity protein binding assay and chromatin immunoprecipitation assay showed the dissociation of HDAC1/2 and association of CBP, leading to the histone-H3 acetylation on the Sp1 sites of p21 promoter. (aacrjournals.org)

Upon stress, HSF1 undergoes trimerization, phosphorylation, and activation of DNA binding activity, and activates hsp gene transcription through binding to heat shock elements (HSEs) present in their promoter. (rupress.org)
NFTs contain a large number of metal ions that play an important role in regulating tau protein phosphorylation and AD progression. (bvsalud.org)
Treatment with DpdtpA also suppressed tau protein expression and phosphorylation. (bvsalud.org)

C/EBP proteins are involved in different cellular responses, such as in the control of cellular proliferation, growth and differentiation, in metabolism, and in immunity. (wikipedia.org)

Obesity element binding protein 1 and fatty acid synthase. (cdc.gov)
BAT, in contrast to WAT, dissipates energy through a process called uncoupled respiration mediated by uncoupling protein-1 (UCP1), resulting in increased fatty acid oxidation and heat production (thermogenesis) [7, 8]. (degruyter.com)

The NPM1 gene encodes for a shuttling protein that, when mutated, is aberrantly localized to the cytoplasm. (medscape.com)
Moreover, we found that (PR)50 induces mdm2 mistranslocation from the nucleus to the cytoplasm and competitively binds to p53, reducing mdm2-p53 interactions in the nucleus in two different (PR)50 transfected cells. (bvsalud.org)

The mutations result in a shorter version of CCAAT enhancer-binding protein alpha. (medlineplus.gov)
Mutations that alter the ability of the Escherichia coli cyclic AMP receptor protein to activate transcription. (nature.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Experiments with knock-out mice have demonstrated that CCAAT-enhancer binding protein-alpha is essential for the functioning and differentiation of HEPATOCYTES and ADIPOCYTES. (rush.edu)
This graph shows the total number of publications written about "CCAAT-Enhancer-Binding Protein-alpha" by people in this website by year, and whether "CCAAT-Enhancer-Binding Protein-alpha" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "CCAAT-Enhancer-Binding Protein-alpha" by people in Profiles. (rush.edu)
CCAAT enhancer-binding protein alpha is involved in the maturation (differentiation) of certain blood cells. (medlineplus.gov)
The other type of mutation blocks the DNA-binding ability of CCAAT enhancer-binding protein alpha. (medlineplus.gov)
Despite the clinical usage of these medicines and the large numbers of FAI ongoing medical tests the molecular systems of action stay far from becoming completely realized.3 4 Being among the most common abnormalities in AML are flaws in CCAAT/enhancer-binding protein alpha (C/EBPα). (tech-strategy.org)
PPAR-gamma) and CCAAT box enhancer binding protein alpha? (nih.gov)
1. Reciprocal expression of CCAAT/enhancer binding proteins alpha and beta in hepatoblastomas and its prognostic significance. (nih.gov)
4. Decreased expression of the CCAAT/enhancer binding protein alpha gene involved in hepatocyte proliferation in human hepatocellular carcinomas. (nih.gov)
6. Hypoxia down-regulates CCAAT/enhancer binding protein-alpha expression in breast cancer cells. (nih.gov)
It can also form heterodimers with the related protein CEBP-alpha. (nih.gov)
A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase. (nature.com)
CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. (cdc.gov)

7. Increased expression of CCAAT/enhancer binding protein beta correlates with prognosis in glioma patients. (nih.gov)

NFkB-IkB is a family of proteins involved in the control of a large number of normal cellular and organismal processes, such as immune and inflammatory responses, developmental processes and cellular growth. (nih.gov)

Overlap of 2 suggestive SNPs with likely TF binding sites suggests possible roles in disruption of gene regulation. (cdc.gov)

Heterochromatin is tightly coiled chromosomal material while CCAAT/enhancer binding proteins are a family of transcription factors. (nih.gov)

The efficacy of macrophage-mediated inflammatory responses relies on the coordinated expression of key proteins involved in macrophage activation and polarization processes, whose expression is finely regulated at both transcriptional and post-transcriptional levels ( 4 - 9 ). (frontiersin.org)
In this study, we found that miR-155 expression was downregulated in a time-dependent manner in cells of the preosteoblast cell line MC3T3-E1 after osteogenic induction using bone morphogenetic protein 2 (BMP2). (hindawi.com)
miR-155 transfection significantly decreased the expression of SMAD5 protein and mRNA in MC3T3-E1 cells under control media and the p-SMAD5 protein level during osteogenesis. (hindawi.com)
Insulin obviously upregulated hepcidin expression in HepG2 cells and enhanced signal transducer and activator of transcription 3 protein synthesis and DNA binding activity. (diabetesjournals.org)
It is worth noting that ISL can strongly inhibit the mRNA and protein expression of Mincle (macrophage-induced c-type lectin) in BMDM and UUO. (scienceopen.com)
More interestingly, when dealing with TDB, a ligand of Mincle, it revealed significant reversal of protein expression levels as that observed with ISL. (scienceopen.com)
Treatment with DpdtpA attenuated the increase in the expression of NF-κB and production of inflammatory cytokines, IL-1ß, IL-6 and IL-10, in rat microglial cells induced by expression of human tau40 proteins. (bvsalud.org)

Increasing evidence has suggested that stress signals, which impair endoplasmic reticulum (ER) function, lead to an accumulation of unfolded proteins, which results in ER stress. (aspetjournals.org)

This protein is expressed in the mammalian nervous system and plays a significant role in the development and function of nerve cells. (wikipedia.org)
Only 1-2% of the mammalian genome is translated into proteins. (frontiersin.org)

Within this locus, HSF1 binds through direct DNA-protein interaction with a nucleosome-containing subclass of satellite III repeats. (rupress.org)
C9orf72-derived dipeptide repeats (DPRs) proteins have been regarded as the pathogenic cause of neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). (bvsalud.org)

12. Essential requirement of CCAAT/enhancer binding proteins in embryogenesis. (nih.gov)
Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. (cancerindex.org)

The isoprenoids are lipid moieties that are added to various proteins, including Ras, Rho, and Rac of small G proteins during posttranslational modification (prenylation), and anchor these proteins to the cell membrane ( 2 ). (aacrjournals.org)

Genome-wide sequencing approaches have lead to the discovery of non-coding RNAs (ncRNAs), which account for approximately 98% of the entire genome output, compared to the remaining 2% corresponding to protein-coding transcripts ( 14 ). (frontiersin.org)

ER stress-induced leptin resistance was mediated through protein tyrosine phosphatase 1B but not through suppressors of cytokine signaling 3. (aspetjournals.org)

Location, structure and function of the target of a transcription activator protein. (nature.com)
Chen, Y., Ebright, Y. W. & Ebright, R. H. Identification of the target of a transcription activator protein by protein-protein photocrosslinking. (nature.com)

It is noteworthy that a chemical chaperone, which could improve the protein-folding capacity, reversed ER stress-induced leptin resistance. (aspetjournals.org)

This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. (cancerindex.org)

This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. (cancerindex.org)

C/EBP proteins interact with the CCAAT (cytosine-cytosine-adenosine-adenosine-thymidine) box motif, which is present in several gene promoters. (wikipedia.org)

Li, M., Moyle, H. & Susskind, M. M. Target of the transcriptional activating function of phage lambda cl protein. (nature.com)

The luciferase assay confirmed that miR-155 can bind to the 3′ untranslated region of SMAD5 mRNA. (hindawi.com)

The strongest increase in AP-1 binding activity occurred between 6 and 24 hr, and the alteration in binding complexes to an NF-IL6 oligonucleotide occurred between 4 and 24 hr. (nih.gov)
1993) and has helicase activity, but ssb-bound Ku does not activate DNA-PK (Smider et al. (nih.gov)

C/EBPβ can interact with CREB, NF-κB, and other proteins, leading to a trans-activation potential. (wikipedia.org)

Anatomy30

Organisms7

Diseases6

Chemicals and Drugs90

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes62

Disciplines and Occupations1

Information Science3

Genes11

Transcription factor5

Basic leucine zipper1

Kinase5

EBPs4

Leucine3

Sterol2

Factor8

MeSH1

CEBPA4

Amino Acids2

LIVER4

Epithelial2

Inhibits1

Mediates1

Deficiency2

Putative1

Regulatory3

Nuclear1

Tumor3

Chromatin1

Phosphorylation3

Metabolism1

Fatty2

Cytoplasm2

Mutations3

Alpha13

Glioma1

Cellular1

Roles1

Tightly1

Expression7

Accumulation1

Mammalian2

Repeats2

Essential2

Lipid1

Genome1

Tyrosine1

Activator2

Stress1

Beta1

CD401

Promoters1

Transcriptional1

Region1

Activity2

Activation1