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  • sensitivity
  • In the mid 1990s, immunoassays for C-reactive protein (CRP), with greater sensitivity than those previously in routine use, revealed that increased CRP values, even within the range previously considered normal, strongly predict future coronary events. (jci.org)
  • acute-phase re
  • This article provides information about CRP as a protein and an acute-phase reactant, and a knowledge-based framework for interpretation and analysis of clinical observations of CRP in relation to cardiovascular and other diseases. (jci.org)
  • 2001
  • In addition to her contributions to the study of protein folding, Carol has conducted important work on ribosomes, molecular chaperones and most recently membrane proteins.In 2001, she returned to Cambridge to take up a professorship in the Department of Chemistry, becoming this department's first female professor. (wikipedia.org)
  • nuclear
  • In wild-type cells, macromolecules in the nucleus with the leucine-rich nuclear export signal (NES) can be transported to the cytoplasm by binding to a karyopherin protein called chromosome region maintenance 1 (CRM1)/exportin 1. (wikipedia.org)
  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. (wikipedia.org)
  • snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. (wikipedia.org)
  • synthesis
  • In particular, the synthesis of a number of proteins is rapidly upregulated, principally in hepatocytes, under the control of cytokines originating at the site of pathology. (jci.org)
  • The later discovery of hepatic synthesis demonstrated that it is a native protein. (wikipedia.org)
  • IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow. (wikipedia.org)
  • somatic
  • Tillett WS, Francis T. Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. (springer.com)
  • hepatic
  • Yue CC, Muller-Greven J, Dailey P, Lozanski G, Anderson V, Macintyre S. Identification of a C-reactive protein binding site in two hepatic carboxylesterases capable of retaining C-reactive protein within the endoplasmic reticulum. (springer.com)
  • It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. (wikipedia.org)
  • gene
  • Histone H1.1 is a protein that in humans is encoded by the HIST1H1A gene. (wikipedia.org)
  • Interferon-stimulated gene 15 (ISG15) is a 17 kDA secreted protein that in humans is encoded by the ISG15 gene. (wikipedia.org)
  • levels
  • We assessed whether higher C-reactive protein (CRP) levels were related to white matter lesion and lacunar infarcts. (ahajournals.org)
  • While there is an association between increased levels of C-reactive protein and risk of developing cancer, there is no association between genetic polymorphisms influencing circulating levels of CRP and cancer risk. (wikipedia.org)
  • molecular
  • After a postdoctoral training fellowship at the University of Bristol, she took up a junior position in the mass spectrometry unit at the University of Oxford, where she began analysing protein folding.Her research on the three-dimensional structure of proteins in particular has demonstrated the power of such techniques in studying large molecular compounds. (wikipedia.org)
  • blood
  • The occurrence during acute infections of a protein normally present in the blood: I. Distribution of the reactive protein in patients' sera and the effect of calcium on the flocculation reaction with C polysaccharide of pneumococcus. (springer.com)
  • It is not related to C-peptide (insulin) or protein C (blood coagulation). (wikipedia.org)
  • specific
  • The E2 protein subsequently transfers the ISG15 to specific E3 ligases (Herc5) and relevant intracellular substrates. (wikipedia.org)
  • Role
  • It is suggested that both proteins mediate the uptake of synaptic macromolecules and play a role in synaptic plasticity. (wikipedia.org)
  • Western Blot
  • Photo Leucine, as well as another photo-reactive amino acid derived from Methionine, Photo-Methionine, were first synthesized in 2005 by Monika Suchanek, Anna Radzikoska and Christoph Thiele from the Max Planck Institute of Molecular Cell Biology and Genetics with the objective of identifying protein to protein interaction throughout a simple western blot test that would provide high specificity. (wikipedia.org)
  • kinase
  • D. Li, B. Yang, and J. L. Mehta, "Tumor necrosis factor- α enhances hypoxia-reoxygenation-mediated apoptosis in cultured human coronary artery endothelial cells: critical role of protein kinase C," Cardiovascular Research , vol. 42, no. 3, pp. 805-813, 1999. (hindawi.com)
  • Hyperglycemia-induced ROS productions can induce oxidative stress through four major molecular mechanisms including, the polyol pathway, advanced glycation end-products formation, activation of protein kinase C isoforms, and the hexosamine pathways. (ijmcmed.org)
  • cells
  • Metabolism is usually divided into two categories: catabolism, the breaking down of organic matter for example, the breaking down of glucose to pyruvate, by cellular respiration, and anabolism, the building up of components of cells such as proteins and nucleic acids. (wikipedia.org)
  • This helps eliminate autoreactive T cells that recognize a protein from a specific body part. (wikipedia.org)
  • expression
  • We have created transgenic (Tg) rats expressing an antisense GHS-R mRNA under the control of the promoter for tyrosine hydroxylase (TH), thus selectively attenuating GHS-R protein expression in the Arc. (jci.org)
  • The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. (wikipedia.org)
  • makes
  • The symmetrical substitution pattern with reactive bromine atoms makes 1,2,4,5-tetrabromobenzene an interesting starting compound for nematic liquid crystals with crossed mesogens and for columnar (diskotic) liquid crystals with an extensive planar, "board-like" tetrabenzoanthracene ring system. (wikipedia.org)
  • L-Photo-Leucine is a synthetic derivative of the L-Leucine amino acid that is used as its natural analog and is characterized for having photo-reactivity, which makes it suitable for observing and characterizing protein-protein interactions (PPI). (wikipedia.org)
  • energy
  • The three main purposes of metabolism are the conversion of food/fuel to energy to run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination of nitrogenous wastes. (wikipedia.org)
  • likely
  • The bacterioruberin radical produced is less reactive than the initial radical, and will likely react with another radical, resulting in termination of the radical chain reaction. (wikipedia.org)
  • changes
  • Upon absorption of a photon, retinal changes conformation, causing a conformational change in the bacterioopsin protein which drives proton transport. (wikipedia.org)
  • Predictive medicine changes the paradigm of medicine from being reactive to being proactive and has the potential to significantly extend the duration of health and to decrease the incidence, prevalence and cost of diseases. (wikipedia.org)