Bryostatins are potent modulators of protein kinase C. They have been studied in clinical trials as anti-cancer agents, as anti-AIDS/HIV agents and in people with Alzheimer's disease. (wikipedia.org)
The bryostatins are protein kinase C modulators with unique structural features and potential anticancer and neurological activities. (scite.ai)
Lactones2
Bryostatins are a group of macrolide lactones from the marine organism Bugula neritina that were first collected and provided to JL Hartwell's anticancer drug discovery group at the National Cancer Institute (NCI) by Jack Rudloe. (wikipedia.org)
Bryostatins are a group of macrolide lactones first discovered in the late 1960s in a species of bryozoan , Bugula neritina . (med-chemist.com)
Bryostatin2
Total syntheses of natural bryostatins have impressively improved, and a noteworthy synthesis of bryostatin 1 has been reported, requiring 57 steps,' says Paul Wender at Stanford University, US, who led the study. (chemistryworld.com)
The resulting hypothetical compound bryostatin 0 is the common basis for the 20 known bryostatins. (scite.ai)
Chemical1
Chemical synthesis still seems the best option, but bryostatins are complex and structurally challenging so the synthetic routes to these molecules are long. (chemistryworld.com)
National Cancer In1
This is just as well as, when the US National Cancer Institute (NCI) went hunting for bryostatins in 1991, 12.7 tonnes of the bryozoan only yielded 18g of the compound. (chemistryworld.com)
Natural2
These post-β-Branching steps generate the vinyl methylester moieties which are found in all natural product bryostatins. (wikipedia.org)
Bryostatins are a family of natural products consisting of large macrocyclic lactone rings. (chemistryworld.com)
Large1
As "E. sertula" is to date uncultured, heterologous expression of this biosynthetic gene cluster has the potential of producing the bioactive bryostatins in large enough quantities for development into a pharmaceutical. (scite.ai)
Descriptor1
Bryostatins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
Lactones1
Bryostatins are a group of macrolide lactones from the marine organism Bugula neritina that were first collected and provided to JL Hartwell's anticancer drug discovery group at the National Cancer Institute (NCI) by Jack Rudloe. (wikipedia.org)
Total1
This graph shows the total number of publications written about "Bryostatins" by people in this website by year, and whether "Bryostatins" was a major or minor topic of these publications. (musc.edu)
Effects2
1. Effects of bryostatins 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells. (nih.gov)
4. Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells. (nih.gov)