• collagen
  • Alport's Syndrome, a genetic disorder affecting the alpha(IV) collagen chains, can also lead to defects in the Bruch membrane such as 'dot and fleck' retinopathy. (wikipedia.org)
  • We fabricated novel ultrathin three-dimensional (3-D) nanofibrous membranes from collagen type I and poly(lactic-co-glycolic acid) (PLGA) by an advanced clinical-grade needle-free electrospinning process. (edu.au)
  • bound
  • While BrM of controls did not exhibit any visible changes, membrane bound translucent particles were seen in all BrM of knockout mice. (bmj.com)
  • functional
  • Such ultrathin membranes may provide a promising vehicle for a functional RPE cell monolayer implantation in the subretinal space in patients with AMD or SD. (edu.au)
  • human
  • Human RPE cells grown on our nanofibrous membranes bore a striking resemblance to native human RPE. (edu.au)
  • Our nanofibrous membranes may imitate the natural BM to such extent that they allow for the engineering of an in vivo-like human RPE monolayer that maintains the natural biofunctional characteristics. (edu.au)