Brain derived neurotrophic factor. Medical search. Frequent questions

Brain-derived neurotrophic factor (BDNF), or abrineurin, is a protein that, in humans, is encoded by the BDNF gene. (wikipedia.org)
BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4/NT-5. (wikipedia.org)
BDNF was first isolated from a pig brain in 1982 by Yves-Alain Barde and Hans Thoenen. (wikipedia.org)
Mice born without the ability to make BDNF have developmental defects in the brain and sensory nervous system, and usually die soon after birth, suggesting that BDNF plays an important role in normal neural development. (wikipedia.org)
Certain types of physical exercise have been shown to markedly (threefold) increase BDNF synthesis in the human brain, a phenomenon which is partly responsible for exercise-induced neurogenesis and improvements in cognitive function. (wikipedia.org)
BDNF binds at least two receptors on the surface of cells that are capable of responding to this growth factor, TrkB (pronounced "Track B") and the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). (wikipedia.org)
TrkB autophosphorylation is dependent upon its ligand-specific association with BDNF, a widely expressed activity-dependent neurotrophic factor that regulates plasticity and is dysregulated following hypoxic injury. (wikipedia.org)
The role of brain-derived neurotrophic factor (BDNF) in emotional processes suggests an interaction with the endocannabinoid system. (jneurosci.org)
Here, we addressed the functional interplay between BDNF and cannabinoid CB 1 receptors (CB 1 Rs) in the striatum, a brain area in which both BDNF and CB 1 s play a role in the emotional consequences of stress and of rewarding experiences. (jneurosci.org)
Brain-derived neurotrophic factor (BDNF) is a widely expressed, activity-regulated secretory protein with pleiotropic actions within the CNS. (jneurosci.org)
raising the possibility that BDNF and CB 1 Rs interact to regulate multiple functions in the brain. (jneurosci.org)
Postnatal deficits in brain-derived neurotrophic factor (BDNF) are thought to contribute to pathogenesis of Rett syndrome (RTT), a progressive neurodevelopmental disorder caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2). (jneurosci.org)
One of the chemicals that gets released yields the production of a very important protein called brain-derived neurotrophic factor (BDNF) which gets released in the brain and muscles. (ubc.ca)
When produced in the body, BDNF maintains existing brain cells, promotes the growth of new blood vessels in the brain and encourages growth of the hippocampus, a region of the brain that is associated with memory. (ubc.ca)
There were conflicting results on the comparison of brain-derived neurotrophic factor (BDNF) levels between poststroke depression (PSD) patients and stroke patients without PSD among previous studies. (frontiersin.org)
Brain-derived neurotrophic factor (BDNF) promotes the survival of neurons by regulating nerve function, promoting nerve growth, increasing synaptic plasticity, and delivering efficiency ( 18 ). (frontiersin.org)
BDNF is a secretory growth factor that mainly contributes to the regeneration of nerve and the development and plasticity of the nervous system via tyrosine kinase receptor B (TrkB) ( 19 ). (frontiersin.org)
BDNF, which is mainly secreted by the central nervous system, and its mRNA and TrkB are expressed in the hypothalamus, limbic system, and other areas of the brain ( 20 ). (frontiersin.org)
This study aimed to investigate whether there are differences in serum brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and neurotrophin-3 (NTF3) levels between children with ADHD and healthy controls. (springer.com)
Meng WD, Sun SJ, Yang J, Chu RX, Tu W, Liu Q (2016) Elevated serum brain-derived neurotrophic factor (BDNF) but not BDNF gene Val66Met polymorphism is associated with autism spectrum disorders. (springer.com)
Wysokinski A (2016) Serum levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in depressed patients with schizophrenia. (springer.com)
This amino acid is BDNF, or brain-derived neurotrophic factor . (soma-analytics.com)
High stress levels can also damage your overall brain health, including BDNF levels, and your mental wellbeing. (soma-analytics.com)
Cortisol, the hormone our bodies create to deal with stress, can impair BDNF production, which in turn will lead to a reduction in new brain cell formation. (soma-analytics.com)
BDNF levels also decline naturally as we age, explaining in part older populations' increased risk factor for cognitive decline and neurodegenerative disorders like Parkinson's and dementia. (soma-analytics.com)
Happily, just as dietary and lifestyle factors can negatively effect your BDNF levels, so too can they positively impact them. (soma-analytics.com)
There are plenty of ways you can help to raise your BDNF levels and allow it to more ably enter your brain. (soma-analytics.com)
Brain-derived neurotrophic factor (BDNF) plays an essential role in regulating the neuronal growth, differentiation and survival in the central nervous system (CNS). (edu.au)
Blood Brain-Derived Neurotrophic Factor (BDNF) and Major Depression: Do We Have a Translational Perspective? (unimi.it)
Brain-derived neurotrophic factor (BDNF) is an important neurotrophin, and it has been extensively investigated in both experimental models and clinical studies of MDD. (unimi.it)
Although evidence has pointed to increased levels of BDNF after antidepressant therapy, several factors, such as heterogeneous results, low sample size, publication bias, and different BDNF measurements (serum or plasma), pose a challenge in the interpretation of the relation between peripheral blood BDNF and MDD. (unimi.it)
Background: Brain-derived neurotrophic factor (BDNF) is a type of growth factor that promotes growth and survival of neurons. (uky.edu)
Preclinical and clinical studies have shown an association between opiates exposure and alteration in BDNF expression in the brain and serum levels in adult. (uky.edu)
Cortisol and brain-derived neurotrophic factor ( BDNF ), as markers of emotional distress , increase cardiometabolic risk . (bvsalud.org)
Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene expression as strongly as did stimulation of L-type calcium channels. (nih.gov)
To investigate whether manipulations that enhance neurotrophin levels will also restore neuronal structure and function in diabetes, we examined the effects of wheel running and dietary energy restriction on hippocampal neuron morphology and brain-derived neurotrophic factor (BDNF) levels in db/db mice, a model of insulin resistant diabetes. (nih.gov)
Among myriad of functions in central and peripheral tissues, brain-derived neurotrophic factor (BDNF) also regulates energy homeostasis, food intake and feeding behavior, and has a role in obesity and increased body mass index (BMI). (irb.hr)
Objective: to test the effect of a 16-week multimodal exercise program on neurocognitive and physical functioning and brain-derived neurotrophic factor (BDNF). (edu.au)
Brain-derived neurotrophic factor (BDNF) is secreted by immune cells in response to neuroimmune and inflammatory cascades as an act to prevent axonal and neuronal damage after various pathological insults. (springeropen.com)
After nerve growth factor, BDNF is the second recognized member in the neurotrophin family. (springeropen.com)
Attempts to correlate blood levels of brain-derived neurotrophic factor (BDNF) with post-traumatic stress disorder (PTSD) have provided conflicting results. (providence.org)
Consistent evidence has pointed to the role of serum brain-derived neurotrophic factor (BDNF) as a plausible illness biomarker in SCZ-spectrum disorders. (unica.it)
In adults, these benefits are associated with the actions of the brain-derived neurotrophic factor (BDNF), a protein critical in modulating neuroplasticity, glucose regulation, fat oxidation, and appetite regulation in adults. (haloresearch.ca)
This study examined the associations between changes in diabetes risk factors and changes in BDNF levels after 6 months of exercise training in adolescents with obesity. (haloresearch.ca)
Resting serum BDNF levels and diabetes risk factors, such as fasting glucose, insulin, homeostasis model assessment (HOMA-B-beta cell insulin secretory capacity) and (HOMA-IS-insulin sensitivity), and hemoglobin A1c (HbA1c), were measured after an overnight fast at baseline and 6 months. (haloresearch.ca)
There were no significant intergroup differences on changes in BDNF or diabetes risk factors. (haloresearch.ca)
No associations were found between changes in diabetes risk factors and BDNF in controls. (haloresearch.ca)
In conclusion, exercise-induced reductions in some diabetes risk factors were associated with increases in BDNF in adolescents with obesity, suggesting that exercise training may be an effective strategy to promote metabolic health and increases in BDNF, a protein favoring neuroplasticity. (haloresearch.ca)
To understand the role of neurotrophic factor in SD and emotional stress we measured regional distribution of brain derived neurotrophic facto (BDNF) in SD. (techconnect.org)
Regional brain BDNF levels in cerebral cortex, hippocampus, thalamus, hypothalamus, cerebellum and brain stem were measured using commercial ELISA kit. (techconnect.org)
Interestingly, cerebrolysin (2.5 ml/kg, i.v.) administration in rats 4 to 6 h after SD in normal rats significantly reduced brain pathology and enhanced regional BDNF levels at 48 h SD, a feature not seen in stressed rats after identical SD. (techconnect.org)
However, when TiO2 nanowired cerebrolysin (2.5 ml/kg, i.v.) was given in identical conditions in SD in stressed rats, markedly reduced BBB breakdown, brain pathology and enhanced the regional BDNF level at 48 h. (techconnect.org)
Introduction and aims: Brain-Derived Neurotrophic Factor (BDNF) as one of the factors associated with neuromuscular performance and cognitive function is reduced with increasing age. (ac.ir)
We found a significant increase, in both gene and protein expression, of the neurotrophin brain-derived neurotrophic factor (BDNF), in the prefrontal cortex (PFC) of adult TPH2-deficient (TPH2 −/− ) male and female rats in comparison to wild type (TPH2 +/+ ) counterparts. (frontiersin.org)
The brain-derived neurotrophic factor ( BDNF ) gene is also located in the region of chromosomal loss associated with WAGR syndrome. (medscape.com)
Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. (rndsystems.com)
These include brain-derived neurotrophic factor (BDNF), epidermal growth factor (EGF), Wingless (Wnt) and Sonic hedgehog (Shh). (news-medical.net)
RDD is also decreased in KCC2-deficient mice and in intact rats after intrathecal brain-derived neurotrophic factor (BDNF) injection, which downregulates KCC2. (nature.com)
In situ hybridization showed 30% reduction of basal NT-3 mRNA levels and lack of upregulation of TrkC mRNA expression at 2 h after a generalized seizure in dentate granule cells of the NT-3+/- mice, whereas the seizure-evoked increase in brain-derived neurotrophic factor (BDNF) and TrkB mRNA levels was enhanced. (lu.se)

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
The rug was pulled out from beneath this theory in the 1980s, however, as researchers isolated an amino acid (a protein) that could inspire new brain cell growth. (soma-analytics.com)
The messenger RNA for brain-derived neurotrophic factor was found predominantly in the central nervous system, and the sequence of the protein indicates that it is structurally related to nerve growth factor. (unibas.ch)
Although the pattern of corticosterone release was similar between the genotypes, neuronal activation in response to stress, quantified by the expression of the immediate early genes activity regulated cytoskeleton associated protein ( Arc ) and Fos Proto-Oncogene ( cFos ), was blunted in both sexes of animals lacking brain serotonin. (frontiersin.org)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)

Although the vast majority of neurons in the mammalian brain are formed prenatally, parts of the adult brain retain the ability to grow new neurons from neural stem cells in a process known as neurogenesis. (wikipedia.org)
Whereas the dependency of many neurons on their target cells for normal development, and the restricted neuronal specificity of nerve growth factor have long suggested the existence of other such proteins, their low abundance has rendered their characterization difficult. (unibas.ch)
It involves the formation of highly specialized neurons within the brain, both in fetal and adult growth. (news-medical.net)
Neurodegeneration is a natural process which occurs in adult brains, particularly at older age, in which neurons are broken down. (news-medical.net)
The neurotrophins nerve growth factor and brain-derived neurotrophic factor are key regulatory elements of neuronal development and responsiveness of airway sensory neurons. (cdc.gov)
Based on these observations, the dopamine neu- from dopamine neurons implanted into the brain pa- rons used for transplantation in these experiments renchyma with the goal of reinnervating the dener- were neuroblasts obtained from mid-trimester rat vated striatum.8,9 Rats with unilateral, 6-hydroxydo- fetuses. (lu.se)
VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)

Serum brain-derived neurotrophic factor remains elevated after long te" by Gwyneth W Y Wu, Owen M Wolkowitz et al. (providence.org)
Serum brain-derived neurotrophic factor remains elevated after long term follow-up of combat veterans with chronic post-traumatic stress disorder. (providence.org)
The impact of depot and long acting injectable antipsychotics on serum levels of brain-derived neurotrophic factor in schizophrenic and schizoaffective patients: results of a 24-month longitudinal prospective study points to a moderate to large magnitude of effect that should be investigated in future prospective studies. (unica.it)
The pathogenicity of anti-GlyR autoantibodies and thereby the autoimmunologic etiology of the disease was confirmed by passive transfer of patient serum to zebrafish (Danio rerio) larvae, that yielded an abnormal escape response - a brain stem reflex that corresponds to the exaggerated startle of afflicted patients. (uni-wuerzburg.de)

Emerging studies shown that aerobic exercise can slow down aging of the brain and have positive implications on cognitive abilities such as memory retention. (ubc.ca)
2014). The effects of multimodal exercise on cognitive and physical functioning and brain-derived neurotrophic factor in older women: a randomised controlled trial. (edu.au)
Since neurotrophic factors are the primary architects of neurogenesis, synaptic plasticity, learning, and memory, the findings from preclinical and clinical studies that assess changes in neurogenesis and neurotrophic factors and their relationship to cognitive performance in schizophrenia, and how these mechanisms might be impacted by APD treatment, may provide valuable clues in developing therapies to combat cognitive deficit in schizophrenia. (benthamscience.com)
Since schizophrenia is considered a neurodevelopmental disorder, early intervention with neurotrophic factors may be more effective in ameliorating the cognitive deficits and psychopathological symptoms associated with this pathology. (benthamscience.com)
Discover how exercise and a balanced diet can boost your cognitive abilities and help you achieve optimum brain health. (bodykind.com)
it contributes to maintaining your cognitive health and enhancing brain function. (bodykind.com)
This growth is linked to better cognitive function and improved overall brain health. (bodykind.com)
Regular physical activity has anti-inflammatory effects and improves insulin sensitivity in the brain, protecting against cognitive decline and brain diseases. (bodykind.com)
Understanding these physiological changes and the connection between physical fitness and cognitive health is the first step in leveraging exercise to boost your brain health. (bodykind.com)
Nootropics have gained enormous popularity as more people become aware of their advantages for improving memory, focus, cognitive function, and other areas, as well as brain power. (naspcenter.org)
The most excellent brain supplements may aid in treating dementia, Alzheimer's disease, and attention deficit hyperactivity disorder (ADHD) due to their capacity to improve memory and cognitive performance. (naspcenter.org)
Nootropics aren't brain-boosting miracle medication, but they can enhance your cognitive function under the appropriate conditions. (naspcenter.org)

Pivac, Nela (2013) Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults . (irb.hr)

Kotyuk E, Keszler G, Nemeth N, Ronai Z, Sasvari-Szekely M, Szekely A (2013) Glial cell line-derived neurotrophic factor (GDNF) as a novel candidate gene of anxiety. (springer.com)
Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators, and gene therapy. (researchandmarkets.com)
Rare Syndromes and Common Variants of the Brain-Derived Neurotrophic Factor Gene in Human Obesity. (cdc.gov)
The ability to regulate transgene expression will be crucial for development of gene therapy to the brain. (lu.se)
This ®nding will lead to the development of lentiviral vectors with autoregulatory capacities that may be very useful for gene therapy to the brain. (lu.se)
An aspect of gene delivery to the brain that is currently being regulate the endogenous GFAP expression in a lesioned brain. (lu.se)

There are also epigenetic factors which are utilized in the control of neurogenesis, as well as cytokines, morphogens, neurotransmitters and growth factors. (news-medical.net)
L-Tyrosine (250 mg): Aids produce neurotransmitters that help the brain remain focused, even during stressful situations. (naspcenter.org)

It does so through a variety of mechanisms, including increasing brain plasticity, suppressing cranial inflammation, acting as a natural antidepressant, warding against neurodegeneration, and mitigating the effects of stress and anxiety on the brain. (soma-analytics.com)
Former HALO postdoctoral fellow Dr. Jeremy Walsh is lead author on a paper, " Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomized Controlled Trial ," that was recently published in Neural Plasticity . (haloresearch.ca)
Changes in the Brain-Derived Neurotrophic Factor Are Associated with Improvements in Diabetes Risk Factors after Exercise Training in Adolescents with Obesity: The HEARTY Randomized Controlled Trial ," Neural Plasticity , vol. 2018, Article ID 7169583, 8 pages, 2018. (haloresearch.ca)
It is currently believed that miRNAs, as important regulatory factors of epigenetics, may be widely involved in the regulation of various cellular activities including neurobiological responses, such as neuronal growth, metabolism, apoptosis, and synaptic plasticity [ 6 , 7 ]. (hindawi.com)
We took advantage of tryptophan hydroxylase 2 (TPH2) deficient rats, lacking serotonin specifically in the brain, to investigate whether a vulnerable genotype can be associated with alterations of neuronal plasticity from the early stage of maturation of the brain until adulthood. (frontiersin.org)

Thus, neurotrophic signaling may trigger apoptosis rather than survival pathways in cells expressing the p75 receptor in the absence of Trk receptors. (wikipedia.org)
The inhibitory ionotropic GlyR is one of the major inhibitory neurotransmitter receptors and therefore involved in maintaining homeostasis of neuronal excitation levels at brain stem and spinal cord. (uni-wuerzburg.de)

By enhancing blood flow and stimulating neurogenesis, exercise improves brain function, including decision-making abilities. (bodykind.com)
This balance can be enhanced by many different factors, including increased neurogenesis due to more physical activity, engaging environments, and education. (news-medical.net)

2000). We of glial cell line-derived neurotrophic factor (GDNF) in models of have recently reported that this vector directs transgene expression to Parkinson's disease (Georgievska et al. (lu.se)

Receptor proteína tirosina cinasa, específico para el FACTOR NEUROTROFICO DERIVADO DEL CEREBRO, la NEUROTROFINA 3, neurotrofina 4 y neurotrofina 5. (bvsalud.org)

The interaction between diverse genetic and environmental factors contributes to development of obesity. (irb.hr)
Obesity in youth increases the risk of type 2 diabetes (T2D), and both are risk factors for neurocognitive deficits. (haloresearch.ca)
Despite a significant increase in research on pediatric obesity since the initial publication of these guidelines 8 years ago, further study is needed of the genetic and biological factors that increase the risk of weight gain and influence the response to therapeutic interventions. (medscape.com)
Furthermore, continued investigation into the most effective methods of preventing and treating obesity and into methods for changing environmental and economic factors that will lead to worldwide cultural changes in diet and activity should be priorities. (medscape.com)
Brain-derived neurotrophic factor and obesity in the WAGR syndrome. (cdc.gov)

ABSTRACT Postpartum blues is a major risk factor for the incidence of postpartum depression and disruption of breastfeeding. (who.int)

Cortisol:brain-derived neurotrophic factor ratio associated with silent ischaemia in a black male cohort: the SA BPA study. (bvsalud.org)

In these control or experimental rats BBB, brain water and neuronal damages were examined 48 h after SD. (techconnect.org)
Our results showed 1 to 2.5-fold exacerbation of BBB breakdown to Evans blue albumin (EBA) and radioiodine ([131]-I) in several brain regions as mentioned above in SD rats subjected to emotional stress as compared to normal rats. (techconnect.org)
The brain water content also showed greater increase in stressed rats after SD. (techconnect.org)

Scholars@Duke publication: Long-term regulation of excitatory and inhibitory synaptic transmission in hippocampal cultures by brain-derived neurotrophic factor. (duke.edu)
A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep. (ox.ac.uk)
Since in adulthood it cannot pass the blood-brain barrier, these two enzymes define two 5-HT systems with independent regulation and different function. (frontiersin.org)

Aloe L, Rocco ML, Bianchi P, Manni L (2012) Nerve growth factor: from the early discoveries to the potential clinical use. (springer.com)

Brain-derived neurotrophic factor may work as a potential biomarker to predict the risk of PSD among stroke survivors. (frontiersin.org)

Researchers have also described clear brain structural and functional effects from being physically active. (medscape.com)

Since emotional stress is always associated with SD in military, in this investigation we examined a combination of emotional stress and SD on brain pathology and behavioral dysfunction in a rat model. (techconnect.org)
In addition, we used exogenous supplement of Cerebrolysin that is a balanced composition of several neurotrophic factors and active peptide fragments to reduce SD induced brain pathology and behavioral dysfunction. (techconnect.org)

Progress in Brain Research 128 (January 2000): 203-18. (duke.edu)

Introduction: Schizophrenia (SCZ) and schizoaffective disorder (SAD) are severe and complex psychiatric disorders whose liability threshold is likely modulated by the interplay of biological, mainly genetic, and environmental factors. (unica.it)
Numerous evidence produced over the years suggests a deficit in a wide spectrum of neurotrophic factors in schizophrenia. (benthamscience.com)
In this context, results from initial clinical trials with neurotrophic factors and their future potential to improve cognition and psychosocial functioning in schizophrenia are discussed. (benthamscience.com)

Domingos da Silveira da Luz AC, Pereira Dias G, do Nascimento Bevilaqua MC, Cocks G, Gardino PF, Thuret S, Nardi AE (2013) Translational findings on brain-derived neurotrophic factor and anxiety: contributions from basic research to clinical practice. (springer.com)
See Wilms Tumor: A Pediatric Oncology Success Story , a Critical Images slideshow, to help identify the clinical features, staging evaluation, prognostic factors, and therapeutic options for this tumor. (medscape.com)

In the brain it is active in the hippocampus, cortex, and basal forebrain-areas vital to learning, memory, and higher thinking. (wikipedia.org)
The hippocampus, a part of the brain vital for learning and memory, is particularly responsive to physical exercise. (bodykind.com)

Previous studies from our laboratory show that 12 to 48 h of SD results in widespread breakdown of the blood-brain barrier (BBB) associated with brain edema and cellular injuries. (techconnect.org)

These stem cells are usually maintained in a quiescent state within their niche, and are only activated upon the interaction with intrinsic or niche-derived stimuli. (news-medical.net)
Both intrinsic and niche-derived factors are involved in this process, including Sox2, NeuroD1, Pax6, and many other factors. (news-medical.net)

Neural stem cells are located within the ventricular zone, where they divide to form the ventricular system of the brain. (news-medical.net)
Our investigation indicates that most of these studies examined endothelial progenitor cells, hematopoietic stem cells, mesenchymal stem cells, adipose-derived stem cells, and a few others were about less-discussed types of stem cells such as cardiac stem cells, myeloblasts, and induced pluripotent stem cells. (magiran.com)

However, the effects of nanoparticle exposure on neurotrophin-driven airway responses and their potential role as a predisposing factor for developing asthma have not been clearly elucidated. (cdc.gov)
Critical role of brain-derived neurotrophic factor in mood disorders. (bvsalud.org)

En conclusion, on peut dire que la formation reposant sur le modèle BASNEF a eu une influence positive sur les connaissances, les attitudes, et par conséquent l'intensité du baby blues des mères. (who.int)

Recent research has identified the gut-brain axis as a key mechanistic pathway and potential therapeutic target in depression. (mdpi.com)

We model central nervous system development using organoids, and select three histone modifications as proxies for dynamic epigenetic change and validate our findings in a primary developing human brain. (researchgate.net)

It is the most efficient thing you can do to boost your brain health. (soma-analytics.com)

Here, we present whole-genome chromatin immunoprecipitation followed by high-throughput DNA sequencing (ChIP-seq) analyses of a wide variety of histone markers in the brain, heart, and liver of early human embryos shortly after their formation. (researchgate.net)

There were significant differences between the groups regarding mean scores of knowledge, mothers' evaluation of behaviour outcomes, attitude, and enabling factors. (who.int)

Anatomy65

Organisms10

Diseases24

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Psychiatry and Psychology10

Phenomena and Processes39

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care1

BDNF59

Protein5

Neurons7

Serum4

Cognitive12

Val66Met1

Gene6

Neurotransmitters2

Plasticity5

Receptors2

Neurogenesis2

Glial1

Receptor1

Obesity5

Abstract1

Cortisol1

Rats3

Regulation3

Nerve1

Potential biomarker1

Structural and functional1

Dysfunction2

20001

Schizophrenia3

Clinical2

Hippocampus2

Blood-brain b1

Intrinsic2

Stem cells2

Role2

Conclusion1

Depression1

Findings1

Boost your brain health1

Markers1

Differences1