Reperfusion injuryFocal cerebralMiddle cerebral arteryHippocampusStrokeSymptoms of brain ischemiaHypoxiaTransient focalInfarctionSubarachnoid hemorrhageOcclusionTissueNeuroprotectionNeuronalRatsCerebrovascularNeuroinflammationTraumatic BrainPathologicalVasospasmOxygenNeuronsCerebral blooSevereCarotidHypothermiaDysfunctionInjury inducedVivoNeurologicalExtracellularMCAODisruptionDiagnosisDamageMiceAbstractHypotensionSickleVascularOccursCongenitalOnsetInjuriesBlood flowMetabolic
Reperfusion injury13
- When cerebral ischemia-reperfusion injury happened in patients, multiple pathological processes occur, such as leukocyte infiltration, platelet, and complement activation, which would result in cognitive dysfunction and inflammation. (hindawi.com)
- The original phenolic hydroxyl in the puerarin molecules was substituted in order to change the blood-brain barrier permeability and thus enhance the efficacy for preventing cerebral ischemia/reperfusion injury. (hindawi.com)
- The mouse model of cerebral artery ischemia/reperfusion injury was established to test the anticerebral ischemia-reperfusion injury activity of the puerarin derivatives. (hindawi.com)
- The results showed that puerarin derivative P1-EA and P2-EA were resulting in an increased lipophilicity that enabled the derivatives to pass more efficiently through the blood-brain barrier, thus, improving the protective effects against cerebral ischemia/reperfusion injury. (hindawi.com)
- Studies have shown that VaD is frequently caused by ischemia-reperfusion injury. (hindawi.com)
- Studies have shown that puerarin reduced cerebral edema in rats with cerebral ischemia-reperfusion injury, removed lipid peroxidation products, enhanced antioxidant capacity, improved antioxidant activity of the brain tissue, and reduced the degree of focal cerebral ischemic injury [ 2 - 4 ]. (hindawi.com)
- In addition, we tested the anticerebral ischemia-reperfusion injury activity of these puerarin derivatives in order to determine their permeability through the blood-brain barrier and pharmacological activity. (hindawi.com)
- Cerebral ischemia - reperfusion injury was examined in mice with transient middle cerebral artery occlusion (tMCAO) for 90 minutes, followed by 24-hour reperfusion . (bvsalud.org)
- Ent2 plays a critical role in modulating cerebral collateral circulation and ameliorating pathological events of brain ischemia and reperfusion injury . (bvsalud.org)
- This suggests that hepatic ischemia-reperfusion injury may play a critical role in the pathogenesis of AKI after liver transplantation. (birmingham.ac.uk)
- The aim of this single-center study was to determine if hepatic ischemia-reperfusion injury, estimated by peak peri-operative serum amino-transferase (AST), is associated with AKI following donation after brain death (DBD) liver transplantation. (birmingham.ac.uk)
- In conclusion, hepatic ischemia-reperfusion injury demonstrates a strong relationship with peri-operative AKI in DBD liver transplant recipients. (birmingham.ac.uk)
- I focus my attention on ischemic/reperfusion injury to the brain. (benbest.com)
Focal cerebral7
- In the in vivo focal cerebral ischemia model, BAI3 expression decreased from 0.5 h after hypoxia until 8 h, but returned to control level after 24 h. (nih.gov)
- The effect of moderate whole body hypothermia (300 C) on transient focal cerebral ischemia induced inflammatory injury was investigated. (banglajol.info)
- Experimental stroke (transient focal cerebral ischemia) was induced by a 2-hour middle cerebral artery occlusion (MCAO) with the use of a suture inserting into the lumen of the internal carotid artery (ICA) in male Wistar rats. (banglajol.info)
- Our results indicate that moderate hypothermia has a significant protective effect on the inflammatory injury induced by transient focal cerebral ischemia. (banglajol.info)
- Focal cerebral ischemia can lead to blood-brain barrier (BBB) breakdown, which is implicated in neuroinflammation and elevation of matrix metalloproteinases (MMPs). (preprints.org)
- Pre-stroke surgery is not beneficial to normotensive rats undergoing sixty minutes of transient focal cerebral ischemia PLOS ONE. (nottingham.ac.uk)
- Ischemic Stroke Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). (msdmanuals.com)
Middle cerebral artery1
- The ischemic lesion was induced by transient middle cerebral artery occlusion for 60 min, followed by brain imaging and analysis at four time points until 28 days after ischemia. (ulaval.ca)
Hippocampus4
- In situ hybridization analyses of the brain showed the same localization of BAI3 as BAI1 and BAI2, which includes most neurons of cerebral cortex and hippocampus. (nih.gov)
- Transient forebrain ischemia leads to delayed death of the CA1 neurons in the hippocampus. (nih.gov)
- Immunohistochemical and biochemical investigations of Ca2+/calmodulin-dependent protein kinase II(CaM kinase II) and protein phosphatase (calcineurin) after transient forebrain ischemia demonstrated that the activity of CaM kinase II was decreased in the CA1 region of the hippocampus early (6-12 hours) after ischemia. (nih.gov)
- The rat hippocampus is hypersensitive to secondary cerebral ischemia after mild traumatic brain injury (TBI). (utmb.edu)
Stroke14
- This leads to poor oxygen supply or cerebral hypoxia and thus leads to the death of brain tissue or cerebral infarction/ischemic stroke. (wikipedia.org)
- Other effects that may result from brain ischemia are stroke, cardiorespiratory arrest, and irreversible brain damage. (wikipedia.org)
- citation needed] Other pathological events that may result in brain ischemia include cardiorespiratory arrest, stroke, and severe irreversible brain damage. (wikipedia.org)
- In the treatment of acute ischemic stroke, immediate recanalization of the occluded artery, using systemic or local thrombolysis, is optimal for restoring the blood flow and rescuing the ischemic brain from complete infarction. (nih.gov)
- Much like an adult who has survived a stroke, an infant with brain ischemia may have severe developmental lapses and disorders after the event has passed. (cullanlawaz.com)
- It was under investigation by Acea Pharmaceuticals as a neuroprotective agent for the treatment of cerebral ischemia associated with stroke and head injuries but was ultimately never marketed. (wikipedia.org)
- Ischemia and reperfusion can cause serious brain damage in stroke or cardiac arrest. (benbest.com)
- Excessive glutamate release resulting in excessive Ca +2 entry into cells is the excitotoxicity which initiates the brain ischemic damage seen in stroke and cardiac arrest. (benbest.com)
- Altered inflammation in Tlr2-deficient mice was accompanied by enhanced elements of post-stroke repair, in particular during the chronic phase of recovery, but also with delayed final consolidation of the brain lesion. (ulaval.ca)
- I am particularly interested in developing novel MRI methodologies for examining brain function, investigating the role of sex and steroid hormones in ischaemic stroke/cognitive decline and increasing the translational relevance of experimental models of CNS injury and disease. (nottingham.ac.uk)
- Multicenter cohort study of patients with acute ischemic stroke who underwent a brain computed tomography perfusion and were scheduled to undergo reperfusion therapy. (medscape.com)
- Migraine is likely to increase individual vulnerability to ischemic stroke during the process of acute brain ischemia and might represent, therefore, a potential new therapeutic target against occurrence and progression of the ischemic damage. (medscape.com)
- [ 1 ] A recent hypothesis to explain the migraine-stroke association, based on experimental data obtained in mice expressing familial hemiplegic migraine type 1 mutations, is that the cerebral hyperexcitability phenotype associated with migraine might sensitize brain tissue to ischemia. (medscape.com)
- Based on these premises, taking advantage of the reliability of computed tomography perfusion (CTP) imaging in the estimation of cerebral tissue viability in both clinical and research settings, [ 4 ] we conducted a case-control study comparing CTP maps of migraineurs and nonmigraineurs patients with acute ischemic stroke aimed at investigating whether a personal history of migraine is associated with vulnerability to brain ischemia. (medscape.com)
Symptoms of brain ischemia5
- The main symptoms of brain ischemia involve impairments in vision, body movement, and speaking. (wikipedia.org)
- Symptoms of brain ischemia can include unconsciousness, blindness, problems with coordination, and weakness in the body. (wikipedia.org)
- The symptoms of brain ischemia reflect the anatomical region undergoing blood and oxygen deprivation. (wikipedia.org)
- The symptoms of brain ischemia range from mild to severe. (wikipedia.org)
- The exact effects will depend on which section of the brain became damaged and lost blood flow, but the symptoms of brain ischemia often become apparent soon after birth. (cullanlawaz.com)
Hypoxia6
- Similar to cerebral hypoxia, severe or prolonged brain ischemia will result in unconsciousness, brain damage or death, mediated by the ischemic cascade. (wikipedia.org)
- Real-time monitoring of L-glutamate release from various neuronal regions of mouse hippocampal slices under ischemia (a glucose-free hypoxia condition) is described. (elsevierpure.com)
- TACE induced a reduction in tumor size mainly due to ischemia resulting from embolization 11 which expose tumor to acute hypoxia. (nature.com)
- Autopsy findings indicated acute brain and spinal cord damage due to hypoxia/ischemia (lack of oxygen), apparently a result of the cardiac arrest. (cdc.gov)
- The death certificate, completed by the coroner of the deceased fire fighter's county, listed "Hypoxia / Ischemia, Acute [of the brain and spinal cord]" as the immediate cause of death, various autopsy findings as intermediate causes, and "Overexertion from responding to a fire call with Fire Dept" as the underlying cause. (cdc.gov)
- This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). (bvsalud.org)
Transient focal1
- Nifedipine treatment reduces brain damage after transient focal ischemia, possibly through its antioxidative effects. (kyushu-u.ac.jp)
Infarction7
- If the brain becomes damaged irreversibly and infarction occurs, the symptoms may be permanent. (wikipedia.org)
- Several acquired lesions of the central nervous system (CNS) specifically affect infants born prematurely and result in long-term disability, including GM/IVH, periventricular white matter injury (eg, cystic periventricular leukomalacia [CPVL], periventricular hemorrhagic infarction [PVHI]), hemorrhage, and diffuse injury to the developing brain. (medscape.com)
- The autopsy found arteriosclerosis of some of the arteries to the brain, and atherosclerotic coronary artery disease, but no coronary artery thrombosis or other signs of myocardial infarction. (cdc.gov)
- Transient Ischemic Attack (TIA) A transient ischemic attack (TIA) is focal brain ischemia that causes sudden, transient neurologic deficits and is not accompanied by permanent brain infarction (eg, negative results on diffusion-weighted. (msdmanuals.com)
- Brain edema is maximal and risk of vasospasm and subsequent infarction (called angry brain) is highest between 72 hours and 10 days. (msdmanuals.com)
- metabolic acidosis, arrhythmias, myocardial ischemia or infarction, and noncardiogenic pulmonary edema, although any organ system might be involved. (cdc.gov)
- Prolonged ischemia is associated with BRAIN INFARCTION. (bvsalud.org)
Subarachnoid hemorrhage1
- Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. (medscape.com)
Occlusion2
- Magnetic resonance imaging (MRI) and histological studies in rat focal ischemia models using transient middle cerebral artery (MCA) occlusion indicate that reperfusion after an ischemic episode of 2- to 3-hour duration does not result in reduction of the size of the infarct. (nih.gov)
- This study aimed to investigate whether resuscitation after a hemorrhagic shock (HS) and/or mild cerebral ischemia caused by a unilateral common carotid artery occlusion (UCCAO) can cause brain injury and concomitant neurological dysfunction, and explore the potential mechanisms. (medsci.org)
Tissue7
- and global ischemia, which encompasses wide areas of brain tissue. (wikipedia.org)
- Take the brain and store at -20℃, 1% TTC (W/V), 37℃ water bath for TTC dissolved, the frozen brain tissue slices, placed in 10ml TTC solution, 37℃, 10min. (uscnk.com)
- Normal brain tissue staining is bright red, and the infarct area is pale. (uscnk.com)
- Traumatic Brain Injury (TBI) Traumatic brain injury (TBI) is physical injury to brain tissue that temporarily or permanently impairs brain function. (msdmanuals.com)
- Cerebral hyperexcitability in migraine experiencers might sensitize brain tissue to ischemia. (medscape.com)
- Along with the observation that migraine mutants had an elevated minimum cerebral blood flow threshold required for tissue survival and developed larger infarcts, these findings directly support the hypothesis that brain tissue in migraineurs is more susceptible to ischemic injury. (medscape.com)
- Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. (bvsalud.org)
Neuroprotection2
- The development of effective neuroprotection methods and the establishment of reliable imaging modalities for an early and accurate diagnosis of the extent and degree of the ischemia are imperative. (nih.gov)
- Therefore, over the past several years, research has been directed to limit the brain lesions produced by acute ischemia (neuroprotection) and to increase the recovery, plasticity and neuroregenerative processes that complement rehabilitation and enhance the possibility of recovery and return to normal functions (neurorepair). (mdpi.com)
Neuronal7
- Nitric oxide (NO) is key free-radical messenger and neuronal signal which is closely related to many brain diseases. (rsc.org)
- We hypothesized that an imbalance of Ca2+/calmodulin dependent protein phosphorylation-dephosphorylation may be involved in delayed neuronal death after ischemia. (nih.gov)
- The logistic regression curve demonstrated a close relationship between duration of ischemic depolarization and neuronal damage and showed a rightward shift by lowering the brain temperature. (elsevierpure.com)
- The results also indicate that the neureprotective effect at 31°C is about three times greater than that at 34°C and that neuronal cells can withstand 2.9 times longer duration of ischemia at 31°C than at 37°C. (elsevierpure.com)
- Tlr2 Deficiency is Associated with Enhanced Elements of Neuronal Repair and Caspase 3 Activation Following Brain Ischemia. (ulaval.ca)
- The time-resolved amounts of L-glutamate released at various neuronal regions (CA1, CA3 and DG) of mouse hippocampal slices were quantified and compared with the reported L-glutamate fluxes using difference-image analysis during ischemia. (elsevierpure.com)
- When combined with an HS, an UCCAO is associated with ischemic neuronal injury in the ipsilateral hemisphere of adult rat brain, which can be attenuated by therapeutic hypothermia. (medsci.org)
Rats4
- Zapp, M, Kofke, WA & Davis, DW 1992, ' Comparison of the effects of volatile anesthetics in varying concentrations on brain energy metabolism with brain ischemia in rats ', Neurochemical Research , vol. 17, no. 4, pp. 301-305. (psu.edu)
- Using laser Doppler flowmetry (LDF), relative changes in regional hippocampal CA1 blood flow (hCBF) were recorded continuously to quantitatively characterize hCBF before, during, and after 6 min of forebrain ischemia in either normal or mildly traumatized rats. (utmb.edu)
- Group 1 (n = 6) rats were given 6 minutes of transient forebrain ischemia using bilateral carotid clamping and hemorrhagic hypotension. (utmb.edu)
- Group 2 (n = 6) rats were subjected to mild (0.8 atm) fluid percussion TBI followed i h after trauma by 6 min of transient forebrain ischemia. (utmb.edu)
Cerebrovascular2
- Vascular dementia (VaD) is characterized by a decline in brain function resulting in a cognitive impairment syndrome that is caused by various cerebrovascular diseases such as ischemic, hemorrhagic, chronic, and polar hypoxic cerebrovascular diseases. (hindawi.com)
- The department studies the biological bases and molecular mechanisms of brain aging and brain pathologies, including neurodegenerative, cerebrovascular, and neuroinflammatory diseases. (csic.es)
Neuroinflammation2
- Infarct volume, brain edema , neuroinflammation , microvascular structure, regional cerebral blood flow (rCBF), cerebral metabolic rate of oxygen (CMRO2), and the production of reactive oxygen species (ROS) were examined following the reperfusion . (bvsalud.org)
- Ent2 deletion reduced the infarct volume, brain edema , and neuroinflammation in mice with cerebral ischemia - reperfusion . (bvsalud.org)
Traumatic Brain1
Pathological1
- 5. 24h after operation, neurological function score is evaluated, and then the mice are anesthetized, and the brains are stained with TTC and pathological staining. (uscnk.com)
Vasospasm2
- For this reason, routine surveillance imaging studies are carried out to supplement the neurologic examination with the aim of diagnosing vasospasm before the onset of delayed cerebral ischemia (DCI). (medscape.com)
- Secondary vasospasm (causing focal brain ischemia), meningismus, seizures, and hydrocephalus (causing persistent headache and obtundation) are common. (msdmanuals.com)
Oxygen8
- citation needed] Compression of blood vessels may also lead to brain ischemia, by blocking the arteries that carry oxygen to the brain. (wikipedia.org)
- Whether you're a newborn or a senior, brain ischemia can deprive you of vital oxygen and cause lasting brain damage. (cullanlawaz.com)
- Pregnancy is a complex and difficult physiological process that can come with many complications - and one of the primary concerns is oxygen flow to the infant's brain. (cullanlawaz.com)
- Lack of blood flow causes decreased oxygen which leads to the infant's brain cell death. (cullanlawaz.com)
- This is when the brain becomes so starved for oxygen that the cells begin to shut down, damaging essential functions in the cerebral cortex. (cullanlawaz.com)
- Brain ischemia refers to a condition where the brain doesn't receive enough blood flow and oxygen, leading to a lack of nutrients and the death of brain cells. (birthinjurylawyer.com)
- Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
- Its effects are caused not only by impaired oxygen delivery but also by disrupting oxygen utilization and respiration at the cellular level, particularly in high-oxygen demand organs (i.e., heart and brain). (cdc.gov)
Neurons2
- In the first minute after stoppage of blood flow to the brain, ATP in neurons is primarily regenerated from ADP by phosphate from PhosphoCreatine ( PCr ). (benbest.com)
- This confirms that this model of TBI followed by forebrain ischemia is well suited for evaluating changes in the sensitivity of CA1 neurons to cerebral ischemia rather than assessing differences in relative ischemia. (utmb.edu)
Cerebral bloo2
- An unconfirmed assumption in previous studies of mild TBI followed by forebrain ischemia has been that antecedent TBI did not alter cerebral blood flow (CBF) dynamics in response to secondary ischemia. (utmb.edu)
- An UCCAO caused a slight cerebral ischemia (cerebral blood flow [CBF] 70%) without hypotension (MABP 85 mmHg), systemic inflammation, multiple organs injuries, or neurological injury. (medsci.org)
Severe5
- The severe damage that VaD causes to the brain parenchyma greatly affects patients' learning ability and memory function, as well as their daily lives and health [ 1 ]. (hindawi.com)
- Location of Neutrophils in Different Compartments of the Damaged Mouse Brain After Severe Ischemia/Reperfusion. (csic.es)
- We hypothesized that malignant patterns on electroencephalography are associated with evidence of more severe brain injury on MR imaging. (ajnr.org)
- Malignant electroencephalography patterns were generally more frequent in subjects with less severe brain injury by MR imaging. (ajnr.org)
- However, combined an UCCAO and an HS caused a severe cerebral ischemia (18% of the original CBF levels), a moderate hypotension (MABP downed to 17 mmHg), systemic inflammation, peripheral organs damage, and neurological injury, which can be attenuated by whole body cooling. (medsci.org)
Carotid1
- Ischemia within the arteries branching from the internal carotid artery may result in symptoms such as blindness in one eye, weakness in one arm or leg, or weakness in one entire side of the body. (wikipedia.org)
Hypothermia1
Dysfunction1
- The Critical Role of Equilibrative Nucleoside Transporter-2 in Modulating Cerebral Damage and Vascular Dysfunction in Mice with Brain Ischemia-Reperfusion. (bvsalud.org)
Injury induced1
- Here, we review the information linking the adaptor protein p66Shc with cardiac injury induced by ischaemia and reperfusion (I/R), including the contribution of risk factors, such as metabolic syndrome and ageing. (nih.gov)
Vivo4
- It is a challenge to develop a sensitive and reliable biosensor for in vivo monitoring of NO in the brain. (rsc.org)
- The aim of this study was to apply multimodal in vivo imaging to assess the influence of altered innate immunity on brain repair after ischemic lesion. (ulaval.ca)
- Multimodal in vivo imaging involved a combination of 3 modalities: (1) magnetic resonance imaging by T2-weighted scans to assess brain lesion size, (2) bioluminescence imaging of Gap43-luc/gfp transgenic mice to visualize the axonal remodeling, and (3) caged-luciferin bioluminescence imaging of DEVD-luciferin allowing for visualization of caspase 3 and 7 activity in Gap43-luc/gfp mice. (ulaval.ca)
- The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments). (nottingham.ac.uk)
Neurological1
Extracellular2
- Adenosine modulates vascular flow and exhibits neuroprotective effects , in which brain extracellular concentration of adenosine is dramatically increased during ischemic events and ischemia - reperfusion . (bvsalud.org)
- Within two minutes of ischemia, extracellular pH can drop from about 7.3 to about 6.7. (benbest.com)
MCAO1
- Absence of MCPIP1 leaded to significant increase in FITC-dextran leakage in peri-infarct brain, significant upregulation of MMP-9, MMP-3 and reduced levels of tight junction components, claudin-5 and ZO-1 in the brain after MCAO. (preprints.org)
Disruption3
- Our data demonstrate that absence of MCPIP1 exacerbates ischemia-induced blood-brain barrier disruption by enhancing the expression of matrix metalloproteinases and degradation of tight junction proteins. (preprints.org)
- Overall data indicate that MCPIP1 is important protective role against BBB disruption in cerebral ischemia. (preprints.org)
- tMCAO-induced disruption of brain microvessels was ameliorated in Ent2-/- mice , with a reduced expression of matrix metalloproteinases -9 and aquaporin -4 proteins . (bvsalud.org)
Diagnosis1
- We conclude that brain DECT may be useful for both the diagnosis and the effectivity of treatment in patients with carbon monoxide intoxication who had neurologic symptoms. (uludag.edu.tr)
Damage5
- An interruption of blood flow to the brain for more than 10 seconds causes unconsciousness, and an interruption in flow for more than a few minutes generally results in irreversible brain damage. (wikipedia.org)
- Accordingly, this discovery raised the possibility of intervening after brain ischemia before the damage becomes irreversible. (wikipedia.org)
- The chief aim in this study was to investigate whether changing temperature during and after ischemia could minimize this damage by reducing the inflammatory injury. (banglajol.info)
- Although securing financial recovery may not undo the brain damage, it can provide you with peace of mind as you prepare for the costs of your child's medical treatments and other needs. (cullanlawaz.com)
- Initial brain computed tomography failed to show any damage. (uludag.edu.tr)
Mice6
- 4. Ischemia 60 mins and pull the suture, a 7-0 silk ligates artery proximal, 5-0 silk suture wounds on the neck, povidone iodine disinfection wound, put mice in a heating pad, and feed on constant temperature raising box after mice awaked. (uscnk.com)
- Mice received either saline or fingolimod (0.5 mg/kg or 1 mg/kg) at 2, 24, and 48 h post-ischaemia via intraperitoneal injection. (ucc.ie)
- Results: Fingolimod significantly increased the frequency of Tregs within the CD4+ T cell population in blood and spleen post-ischaemia in all three mouse cohorts compared to untreated ischemic mice. (ucc.ie)
- The most pronounced effects were seen when mice were treated for 10 days post-ischaemia. (ucc.ie)
- Since the equilibrative nucleoside transporter -2 (Ent2) is important in regulating brain adenosine homeostasis , the present study aimed to investigate the role of Ent2 in mice with cerebral ischemia - reperfusion . (bvsalud.org)
- Our data revealed that following ischemia, Tlr2-deficient mice had higher Gap43 expression and higher levels of caspases 3 and 7 activity, which was accompanied by enhanced levels of synaptic plasticity markers DLG4 and synaptophysin when compared to wild type controls. (ulaval.ca)
Abstract2
- abstract = "Background and Purpose: We tested the hypothesis that intravenous administration of basic fibroblast growth factor (bFGF) during 4 hours of permanent focal ischemia would affect acute brain injury. (elsevierpure.com)
- abstract = "The effects of varying concentrations and types of volatile anesthetics on neurochemical sequelae of brain ischemia were evaluated in the rat. (psu.edu)
Hypotension2
- This was followed by preischemic plasma glucose sampling, 5 min hypotension (30 mmHg) and 5 min decapitation cerebral ischemia. (psu.edu)
- An HS caused a moderate cerebral ischemia (52% of the original CBF levels), a moderate hypotension (MABP downed to 22 mmHg), systemic inflammation, and peripheral organs injuries. (medsci.org)
Sickle4
- The causes of brain ischemia vary from sickle cell anemia to congenital heart defects. (wikipedia.org)
- Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison to the average population. (wikipedia.org)
- Sickle cell anemia may cause brain ischemia associated with the irregularly shaped blood cells. (wikipedia.org)
- Sickle shaped blood cells clot more easily than normal blood cells, impeding blood flow to the brain. (wikipedia.org)
Vascular2
- The expression of vascular endothelial growth factor following ischemia showed an inverse pattern. (nih.gov)
- The findings are consistent with abundant other research supporting IHD as a source of cognitive decline, but with a twist: accelerated brain aging seemed caused by more than just vascular disease. (medscape.com)
Occurs2
- Brain ischemia occurs whenever blood flow to the brain becomes blocked. (cullanlawaz.com)
- Intraparenchymal hemorrhage is another type of brain injury that also occurs in this population and has similar risk factors and, possibly, pathophysiology to GM/IVH. (medscape.com)
Congenital1
- citation needed] Congenital heart defects may also cause brain ischemia due to the lack of appropriate artery formation and connection. (wikipedia.org)
Onset1
- Because bFGF afforded protection when administered after the onset of ischemia, bFGF may provide its beneficial effect by limiting progression of injury in ischemic border regions. (elsevierpure.com)
Injuries1
- It's devastating to realize that your child has sustained injuries resulting from brain ischemia, especially if it was preventable by your doctor. (cullanlawaz.com)
Blood flow5
- citation needed] Large blood clots can also cause ischemia by blocking blood flow. (wikipedia.org)
- Untreated heart attacks may slow blood flow enough that blood may start to clot and prevent the flow of blood to the brain or other major organs. (wikipedia.org)
- Infant brain ischemia is entirely preventable in most cases, which means attending physicians have a responsibility to limit the risk of injury - and then take quick action if blood flow becomes blocked. (cullanlawaz.com)
- Results: As measured by the microsphere method, blood flow to ipsilateral caudate nucleus and ipsilateral inferior temporal cortex was decreased similarly during ischemia, before drug administration, in all groups. (elsevierpure.com)
- Conclusions: These data indicate that systemic administration of bFGF ameliorates acute injury in the cerebral cortex without increasing blood flow during focal ischemia in cats. (elsevierpure.com)
Metabolic2
- Brain ischemia is a condition in which there is insufficient bloodflow to the brain to meet metabolic demand. (wikipedia.org)
- Ischemia leads to alterations in brain metabolism, reduction in metabolic rates, and energy crisis. (wikipedia.org)