• proteins
  • This thesis aimed to characterize integral outer membrane proteins which play a role in solute and nutrient uptake, and provides support for their role in the environmental adaptation of Borrelia. (diva-portal.org)
  • In this thesis, three B. burgdorferi proteins, P13, BBA01 and P66, were shown to be porins, and characterized structurally and functionally using a combination of biochemical, biophysical and genetic methods. (diva-portal.org)
  • plasmids
  • The nucleotide sequence of a linear plasmid of Borrelia burdorferi reveals similarities to those of circular plasmids of other prokaryotes. (atcc.org)
  • homolog
  • Finally, the biological relevance of two porins, P13 and P66, was demonstrated in a double mutant displaying a stress response as revealed by increased sensitivity to high osmolarity and elevated expression of the B. burgdorferi heat-shock protein HtrA homolog. (diva-portal.org)
  • vector
  • One of the keys of the success of I. scapularis as a Borrelia vector relies on its ability to limit the proliferation of the spirochaete. (wikipedia.org)
  • protein
  • Alterations in protein expression due to the different environments Borrelia encounters during its complicated life cycle require advanced adaptation mechanisms. (diva-portal.org)
  • OspA from Borrelia burgdorferi is an unusual outer surface protein, it has two globular domains which are connected with a single-layer β-sheet. (wikipedia.org)