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  • proteins
  • This thesis aimed to characterize integral outer membrane proteins which play a role in solute and nutrient uptake, and provides support for their role in the environmental adaptation of Borrelia. (diva-portal.org)
  • In this thesis, three B. burgdorferi proteins, P13, BBA01 and P66, were shown to be porins, and characterized structurally and functionally using a combination of biochemical, biophysical and genetic methods. (diva-portal.org)
  • protein
  • Alterations in protein expression due to the different environments Borrelia encounters during its complicated life cycle require advanced adaptation mechanisms. (diva-portal.org)
  • Finally, the biological relevance of two porins, P13 and P66, was demonstrated in a double mutant displaying a stress response as revealed by increased sensitivity to high osmolarity and elevated expression of the B. burgdorferi heat-shock protein HtrA homolog. (diva-portal.org)
  • Porin activity of the native and recombinant outer membrane protein Oms28 of Borrelia burgdorferi. (atcc.org)
  • It also has a role in the resistance against attack by the human complement system a Bacteriophage lambda outer membrane protein, Lom OspA/B are Lipoproteins from Borrelia burgdorferi. (wikipedia.org)
  • OspA from Borrelia burgdorferi is an unusual outer surface protein, it has two globular domains which are connected with a single-layer β-sheet. (wikipedia.org)
  • plasmids
  • The nucleotide sequence of a linear plasmid of Borrelia burdorferi reveals similarities to those of circular plasmids of other prokaryotes. (atcc.org)
  • vector
  • One of the keys of the success of I. scapularis as a Borrelia vector relies on its ability to limit the proliferation of the spirochaete. (wikipedia.org)
  • coli
  • While the Lac porters consist of two polypeptide chains (IIA and IICB), the Chb porters of E. coli and B. burgdorferi consist of three (IIA, IIB and IIC). (wikipedia.org)
  • antibodies
  • All of the mice developed antibodies to B. burgdorferi which reached a peak indirect immunofluorescent (IFA) geometric mean antibody titer of 10 log 2 21 days post-inoculation. (ajtmh.org)
  • Each of these contact-exposed P. leucopus and P. maniculatus developed antibodies to B. burgdorferi, and B. burgdorferi was isolated from the blood of 1 contact-exposed P. maniculatus 42 days post-initial contact. (ajtmh.org)
  • blood
  • B. burgdorferi was recovered from the blood of 1 P. maniculatus 21 days post-inoculation. (ajtmh.org)
  • Direct tests include culture of Borrelia from skin, blood, or cerebrospinal fluid (CSF) and detection of genetic material by polymerase chain reaction in skin, blood, or synovial fluid. (wikipedia.org)
  • direct
  • To determine if B. burgdorferi was being transmitted by direct contact, 5 uninfected P. leucopus and 5 uninfected P. maniculatus were caged with 3 B. burgdorferi infected P. leucopus and 3 infected P. maniculatus , respectively. (ajtmh.org)