• Membrane
  • The benefit of creating a membrane of proteins using these molecules means it can be both bioactive and easily handled to apply over injured areas in the bone," Co-author Esther Tejeda-Montes, also from QMUL, added. (india.com)
  • It relies on an inert membrane covering a bone substitute placed over the bony site requiring augmentation. (clinicaltrials.gov)
  • The bone substitute provides a scaffold to alveolar regeneration by the host's osteoblasts while the membrane prevents unwanted epithelial cells to migrate to the bony defect area. (clinicaltrials.gov)
  • The device incorporates a structurally stable membrane (4, 4′, 34, 35) that incorporates a surface (15) to be bonded to a tissue to be regenerated, specifically a vital bone (2, 22, 38, 39). (google.es)
  • Means ( 9, 5, 6, 25, 36 ) are additionally provided whereby the membrane ( 4, 4′, 24, 35 ) is movable for the regeneration with a certain pulling force and speed. (google.es)
  • According to the invention the membrane ( 4, 4′, 24, 35 ) has, on its surface facing the tissue or bone, means ( 16 ) for the biological anchoring and adhesion for tissue or bone cells. (google.es)
  • These means ( 16 ) for the biological anchoring of tissue cells are specifically bone cells, protein molecules and/or osteoblasts ( 17 ), as well as indentations ( 45, 46, 48 ) and surface peaks ( 50 ) of the membrane. (google.es)
  • 2 . A process according to claim 1 , characterized in that the membrane ( 4 , 4 ′), prior to placing it on the tissue or vital bone ( 2 ), is provided with osteoblasts ( 18 ) on the surface ( 15 ) to be placed against the vital bone ( 2 ). (google.es)
  • 3 . A process according to claim 1 , characterized in that the membrane ( 4 , 4 ′) is moved away from the tissue or vital bone ( 2 ) by means of at least one magnet ( 9 ) or mechanical pulling means ( 5 , 6 ), at the speed of 0.5 to 2 mm per day. (google.es)
  • In this surgical technique video, Dr. Tomohiro Ishikawa demonstrates, in great detail, the clinical step-by-step techniques required for successful GBR procedures utilizing a collagen membrane, titanium mesh and autogenous bone grafts. (dentalxp.com)
  • A three-layered nano-carbonated hydroxyapatite/collagen/PLGA composite membrane for guided tissue regeneration," Biomaterials , vol. 26, no. 36, pp. 7564-7571, 2005. (hindawi.com)
  • Barrier membrane is utilized in GBR technique to cover the bone defect and create a secluded space, which prevents the connective tissue from growing into the space and facilitates the growth priority of bone tissue. (wikipedia.org)
  • In 1994, Nowzari challenged membrane guided tissue regeneration through a series of research publications, showing that the membrane is actually a source of infection to the grafted site. (wikipedia.org)
  • A barrier membrane is a device used in oral surgery and periodontal surgery to prevent epithelium, which regenerates relatively quickly, from growing into an area in which another, more slowly growing tissue type, such as bone, is desired. (wikipedia.org)
  • PETTI Gustavo From Cagliari, Italy has been the first one to have had: "A new attachment: guided tissue regeneration using an amniotic membrane and fibrin glue" Publication: Petti G. (1989) "La rigenerazione parodontale guidata con membrana amniotica e colla di fibrina. (wikipedia.org)
  • resorption
  • After extraction of a tooth, the bony socket heals naturally but due to the absent of the tooth and any presence of support in the socket, bone resorption occur both vertically and bucco lingually or bucco palataly. (clinicaltrials.gov)
  • In cases where augmentation materials used are autografts or allografts the bone density is quite low and resorption of the grafted site in these cases can reach up to 30% of original volume. (wikipedia.org)
  • Bone resorption caused by metabolism of acidic substances produced by cysts contributes to cyst growth. (wikipedia.org)
  • While bone marrow expresses low levels of RANKL, it plays a critical role for adequate bone metabolism, this surface-bound molecule (also known as CD254) found on osteoblasts serves to activate osteoclasts, which are critically involved in bone resorption. (wikipedia.org)
  • autograft
  • There are many types of spinal fusion and each technique involves using bone grafting - either from the patient (autograft), donor (allograft), or artificial bone substitutes - to help the bones heal together. (wikipedia.org)
  • Though PDGF is synthesized, stored (in the alpha granules of platelets), and released by platelets upon activation, it is also produced by other cells including smooth muscle cells, activated macrophages, and endothelial cells Recombinant PDGF is used in medicine to help heal chronic ulcers and in orthopedic surgery and periodontistry as an alternative to bone autograft to stimulate bone regeneration and repair. (wikipedia.org)
  • cartilage
  • This particular type of stem cell has the future potential to differentiate into a variety of other cell types including: Myocardiocytes to repair damaged cardiac tissue following a heart attack Neuronal to generate nerve and brain tissue Myocytes to repair muscle Osteocytes to generate bone Chondrocytes to generate cartilage Adipocytes to generate fat Bone and tissue from the oral cavity. (wikipedia.org)
  • These molecules have revolutionized the field of bioactive materials for regenerative medicine, with potential applications in bone and cartilage regeneration, angiogenesis for ischemia or peripheral artery disease, cancer therapy, novel therapies for neurodegenerative diseases, stem cell differentiation, spinal cord injury, diabetes, and many other areas. (wikipedia.org)
  • Bioactive Glass
  • Heikkilä JT, Kukkonen J, Aho AJ, Moisander S, Kyyrönen T, Mattila K. Bioactive glass granules: a suitable bone substitute material in the operative treatment of depressed lateral tibial plateau fractures: A prospective, randomized 1 year follow-up study. (springer.com)
  • graft
  • Our work enables the possibility to create robust synthetic bone grafts that can be tuned to stimulate the natural regenerative process, which is limited in most synthetic bone graft alternatives," Mata noted. (india.com)
  • Perhaps this would be a good indication for a bioactive modifier incorporated into the bone graft like PRGF or rhBMP? (dentalxp.com)
  • Additional hardware (screws, plates, or cages) is often used to hold the bones in place while the graft fuses the two vertebrae together. (wikipedia.org)
  • stimulate bone
  • Used together, the two proteins stimulate bone production more dramatically than either does alone. (ucla.edu)
  • In contrast to BMP2, the novel ability of NELL-1 to stimulate bone growth and repress the formation of fat may highlight new treatment approaches for osteoporosis and other therapies for bone loss," Soo said. (ucla.edu)
  • marrow
  • MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay indicated that PGFS were non-cytotoxic against bone marrow stromal cells (bMSCs) after culture for up to 72 h. (springer.com)
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • defects
  • The findings may be a big step toward developing effective therapeutic treatments for bone skeletal defects, bone loss and osteoporosis. (ucla.edu)
  • Before this study, large bone defects in patients were difficult to treat with BMP2 or other existing products available to surgeons," Ting said. (ucla.edu)
  • The combination of NELL-1 and BMP2 may be particularly valuable for healing local bone defects in people who have osteoporosis or for those taking medications, such as steroids, that can inhibit bone growth. (ucla.edu)
  • The researchers' findings have potential to help millions who suffer from osteoporosis and other bone defects. (ucla.edu)
  • Current treatments for destructive periodontal disease are not able to restore damaged bone and connective tissue support for teeth (infra-bony defects). (wikipedia.org)
  • Reconstruction of large size cranial bone defects in rats. (wikipedia.org)
  • proteins
  • The two proteins complement each other in that BMP2 helps to turn non-bone cells into bone-forming cells, and NELL-1 then increases the bone-forming ability of bone cells. (ucla.edu)
  • regenerative
  • Some organizations which perform research into, or conduct regeneration procedures, include the Wake Forest Institute for Regenerative Medicine, the United States Department of Defense, and the California Institute for Regenerative Medicine. (wikipedia.org)
  • Surgery
  • May 2012 Barnard, E. and Wilhite M. Patent application number: 20120136287 "Regeneration of Vaginal Tissue with non-systemic vaginal administration of Estrogen" May 2009 Lyle, J. Patent application number: 20090124584 "Surgical Techniques: Reconstructive Surgery of the Clitoris after Ritual Excision. (wikipedia.org)
  • osteoporosis
  • Patients suffering from osteoporosis or bone fractures might benefit from this new discovery. (india.com)
  • Currently metallic implants are most commonly used, but due to being a much stiffer material than human bones, the implants causes osteoporosis and eventual loosening of the implant. (waikato.ac.nz)
  • synthetic
  • Dr Leandro Bolzoni from the University of Waikato's School of Engineering has been awarded a Health Research Council explorer grant worth $150,000 to research bone regeneration using alternative synthetic materials for joint replacements. (waikato.ac.nz)
  • 1965
  • In 1965, Gavriil Ilizarov determined that bone fragments could be carefully pulled apart without disrupting their alignment. (wikipedia.org)
  • bony
  • The collected bone sample will be subjected to histo-morphometric analysis in order to determine the size, shape and orientation of the bony trabeculae,the size and porosity of the bony cortex in addition to the new bone/ bone substitute ratio. (clinicaltrials.gov)
  • induce
  • But the high concentrations needed to induce human bone formation may have serious side effects, including life-threatening cervical swelling and abnormal and inconsistent bone growth. (ucla.edu)
  • It also showed that BMP2 can induce non-bone cells to form bone, with the potential risk for ectopic bone growth - bone formation in undesirable locations. (ucla.edu)
  • NELL-1, when given systemically, does not appear to induce ectopic bone. (ucla.edu)
  • In contrast, because of its known capacity to induce unwanted bone, BMP2 may not be as appropriate for systemic administration. (ucla.edu)
  • T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (wikipedia.org)
  • Research
  • What is surprising and encouraging about this research is that we can now use this particular molecule to signal cells and enhance bone growth within the body," said co-author Alvaro Mata from Queen Mary University of London (QMUL) in Britain. (india.com)
  • PDGF
  • Maurice, I agree that PRGF,BMP or PDGF would have a positive influence on new bone formation. (dentalxp.com)
  • stimuli
  • 4 . A process according to claim 1 , characterized in that the tissue is one of a type wherein cell proliferation and differentiation is initiated through bio-mechanical transmission of stimuli onto the cytoscleleton and growth or regeneration of tissue can be attained. (google.es)
  • 6 . The process according to claim 5 , further comprising the step of initiating and attaining cell proliferation and differentiation through biomechanical transmission of stimuli onto the cytoskeleton and growth or regeneration of tissue. (google.es)