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  • blood vessels
  • X-rays may show an increased density in the medullary cavity of the affected bones, often near the nutrient foramen (where the blood vessels enter the bone). (wikipedia.org)
  • Over time, healing occurs by new blood vessels infiltrating the dead bone and removing the necrotic bone which leads to a loss of bone mass and a weakening of the femoral head. (wikipedia.org)
  • The decreased supply of copper can reduce the activity of numerous copper-containing enzymes that are necessary for the structure and function of bone, skin, hair, blood vessels and the nervous system such as lysyl oxidase. (wikipedia.org)
  • In the Golgi apparatus, ATP7A protein provides copper to certain enzymes that are critical for the structure and function of bone, skin, hair, blood vessels, and the nervous system. (wikipedia.org)
  • Christ, B (1997), "On the bifurcation of blood vessels-Wilhelm Roux's doctoral thesis (Jena 1878)--a seminal work for biophysical modelling in developmental biology. (wikipedia.org)
  • Cerebral Palsy
  • Common special needs include learning disabilities (such as dyslexia), communication disorders, emotional and behavioral disorders (such as ADHD and ADD), physical disabilities (such as Brittle Bone Disease, Cerebral Palsy, Muscular Dystrophy, Spinal Bifida, and Frederich's Ataxia), and developmental disabilities (such as autism spectrum disorders and intellectual disability). (wikipedia.org)
  • skeletal
  • Hemophilia , finally, is a generalized hereditary condition that affects the skeletal system only secondarily by bleeding in the bones and joints. (britannica.com)
  • This decrease in collagen secretion can lead to the bone defects that are also characteristic of the disease, such as skeletal dysplasia and under-ossification. (wikipedia.org)
  • FGD1 is expressed in areas of bone formation and post-natally in skeletal tissue, the perichondrium, joint capsule fibroblasts and resting chondrocytes. (wikipedia.org)
  • The embryo may also develop shorter bones, miss any skeletal elements, or lack multiple articulating joints. (wikipedia.org)
  • proteins
  • It localizes preferentially to the trans-Golgi network (TGN) of mammalian cells and regulates, for example, the secretory transport of bone-specific proteins from the Golgi complex. (wikipedia.org)
  • seizures
  • Disseminated disease occurs when the fungus has spread outside of the lungs and may include clinical signs such as lameness, pain, seizures, anterior uveitis, and localized swelling. (wikipedia.org)
  • Menkes Disease is also characterized by seizures, failure to thrive, subnormal body temperature, and strikingly peculiar hair, which is kinky, colorless or steel-colored, and easily broken. (wikipedia.org)
  • short stature
  • Albright's Hereditary Osteodystrophy is a rare autosomal dominant disease characterized by a constellation of physical features including short stature, central obesity, round face, brachydactyly, subcutaneous calcifications and mental retardation. (clinicaltrials.gov)
  • occur
  • It can also occur when the bone tissue in the neck of the femur is softer than normal, causing it to bend under the weight of the body. (wikipedia.org)
  • This is pertinent in humans as well, because many diseases stemming from organ fibrosis occur via the EMT process. (wikipedia.org)
  • treatment
  • Patients may continue treatment in the absence of toxicity and disease progression. (clinicaltrials.gov)
  • Secondary efficacy measures during Phase 2a include change in height SDS and change in bone age after 6 months VRS-317 treatment. (clinicaltrials.gov)
  • Being the craniostenoses sutural basically a disease, the fact that the brain being trapped in an enclosure that does not have complacency required to accompany their growth constitutes the challenge of treatment, which aims to restore the complacency of the suture and correct the stenotic compensatory cranial deformity. (clinicaltrials.gov)
  • Though the children affected with CLSD will have problems throughout life, the treatment for this disease thus far is symptomatic. (wikipedia.org)
  • Atrimustine (INN) (developmental code name KM-2210), also known as bestrabucil or busramustine, is a nitrogen mustard alkylating antineoplastic drug that was under development in Japan by Kureha Chemicals (now Kureha Corporation) for the treatment of breast cancer and non-Hodgkin's lymphoma as well as for the prevention of graft-versus-host disease in bone marrow transplant recipients. (wikipedia.org)
  • Also in the treatment of tibial non-union, frequently in cases where a bone graft has failed. (wikipedia.org)
  • BMP7 also has the potential for treatment of chronic kidney disease. (wikipedia.org)
  • Kidney disease is characterized by derangement of the tubular architecture by both myofibroblast buildup and monocyte infiltration Because endogenous BMP-7 is an inhibitor of the TGF-β signaling cascade that induces fibrosis, the use of exogenous recombinant BMP-7 (rhBMP-7) could be a viable treatment of chronic kidney disease. (wikipedia.org)
  • This includes providing therapeutic treatment in circumstances where movement and function are threatened by aging, injury, disease or environmental factors. (wikipedia.org)
  • Stem cell transplantation may be used if the disease recurs following standard treatment. (wikipedia.org)
  • femoral
  • Legg believed the cause was impairment of blood supply to the femoral epiphysis, Calve believed rickets, and Perthes deduced an infection possibly causing degenerative arthritis leads to LCP disease. (wikipedia.org)
  • The disease is theorized to include the artery of the ligmentum teres femoris being constricted or even blocked too early, not allowing for time when the medial circumflex femoral artery takes over. (wikipedia.org)
  • humans
  • Some of these diseases are unique to dogs or closely related species, while others are found in other animals, including humans. (wikipedia.org)
  • Rabies (hydrophobia) is a fatal viral disease that can affect any mammal, although the close relationship of dogs with humans makes canine rabies a zoonotic concern. (wikipedia.org)
  • Rocky Mountain spotted fever* is a rickettsial disease that occurs in dogs and humans. (wikipedia.org)
  • Blastomycosis* is a fungal disease caused by Blastomyces dermatitidis that affects both dogs and humans. (wikipedia.org)
  • Histoplasmosis* is a fungal disease caused by Histoplasma capsulatum that affects both dogs and humans. (wikipedia.org)
  • Sporotrichosis is a fungal disease caused by Sporothrix schenckii that affects both dogs and humans. (wikipedia.org)
  • joints
  • It is characterized by calcium deposits in a bone at the base of the skull (occipital bone), coarse hair, loose skin, and joints. (wikipedia.org)
  • After the development of orthopedics in the eighteenth century, machines like the Gymnasticon were developed to treat gout and similar diseases by systematic exercise of the joints, similar to later developments in physical therapy. (wikipedia.org)
  • protein
  • Noggin, also known as NOG, is a protein that is involved in the development of many body tissues, including nerve tissue, muscles, and bones. (wikipedia.org)
  • It is released from the notochord and regulates bone morphogenic protein (BMP4) during development. (wikipedia.org)
  • progression
  • Although the available treatments (beta-blockers, BBs) improve the evolution of the disease, they do not protect MFS patients from progression of ARD and dissection. (clinicaltrials.gov)
  • Compare the number of adverse events or clinical manifestations of disease progression occurring in these patients. (clinicaltrials.gov)
  • If disease progression is diagnosed in the control group, patients will then receive interferon gamma in combination with calcitriol. (clinicaltrials.gov)
  • This is a randomized, double-blind, placebo-controlled study comparing the safety and efficacy of 2 dosage regimens of palovarotene versus placebo in preventing disease progression in pediatric subjects with multiple osteochondromas (MO). (clinicaltrials.gov)
  • cardiac
  • Some people with LSDhave enlarged livers (hepatomegaly) and enlarged spleens (splenomegaly), pulmonary and cardiac problems, and bones that grow abnormally. (wikipedia.org)
  • defect
  • The primary defect lies in the growth zone of the long bones. (britannica.com)
  • This form of osteotomy was therefore chosen by the authors to induce bone compliance areas of secondary defect that should expand or compress indirectly during the process of dynamic remodeling of primary defect with springs. (clinicaltrials.gov)
  • tissues
  • It is the benzoate ester of an ester conjugate of estradiol and chlorambucil, which results in targeted/site-directed DNA alkylating activity toward estrogen receptor-positive tissues such as breast and bone. (wikipedia.org)
  • Excessive
  • The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, white blood cells, and platelets. (wikipedia.org)
  • fibrous
  • It is most commonly a sequela of osteogenesis imperfecta, Pagets disease, osteomyelitis, tumour and tumour-like conditions (e.g. fibrous dysplasia). (wikipedia.org)
  • syndrome
  • TGF-β levels play a major role in the pathogenesis of Marfan syndrome, a disease characterized by disproportionate height, long extremities, lens dislocation in the eyes and heart complications such as mitral valve prolapse and aortic enlargement increasing the likelihood of aortic dissection. (clinicaltrials.gov)
  • Most of these disorders are autosomal recessively inherited such as Niemann-Pick disease, type C, but a few are X-linked recessively inherited, such as Fabry disease and Hunter syndrome (MPS II). (wikipedia.org)
  • clinical
  • Canine coronavirus is a gastrointestinal disease that is usually asymptomatic or with mild clinical signs. (wikipedia.org)
  • According to a study performed in the Tucson and Phoenix area, 28% of dogs will test positive for exposure to the fungus by two years of age, but only 6% of the dogs will be ill with clinical disease. (wikipedia.org)
  • Onset
  • Onset of the disease is in neonatal development and infancy, and symptoms tend to become evident soon after birth. (wikipedia.org)
  • Canine
  • Canine distemper is an often fatal infectious disease that mainly has respiratory and neurologic signs. (wikipedia.org)
  • Canine influenza is a newly emerging infectious respiratory disease. (wikipedia.org)
  • Infectious canine hepatitis is a sometimes fatal infectious disease of the liver. (wikipedia.org)
  • Canine herpesvirus is an infectious disease that is a common cause of death in puppies less than three weeks old. (wikipedia.org)
  • Canine minute virus is an infectious disease that can cause respiratory and gastrointestinal signs in young puppies. (wikipedia.org)
  • noggin
  • Experiments in mice have shown that noggin also plays a role in learning, cognition, bone development, and neural tube fusion. (wikipedia.org)
  • Known
  • Although no one has identified the cause of Perthes disease, a reduction in blood flow to the joint is known. (wikipedia.org)
  • Therapeutic
  • Ambroxol has recently been shown to increase activity of the lysosomal enzyme glucocerebrosidase, so it may be a useful therapeutic agent for both Gaucher disease and Parkinson's disease. (wikipedia.org)
  • infectious
  • Jim Wilson , MD, a pediatrician and infectious disease expert with AscelBio and a SERMO correspondent, relating some of the breaking news to his peers comments on the expanded Ebola threat, "In this part of Africa , what we've noticed on satellite imagery is there's been a pattern of deforestation and encroachment of human beings on ecosystems that up until now has been fairly isolated. (bio-medicine.org)
  • Together with the age-related thymic involution, and the consequent age-related decrease of thymic output of new T cells, this situation leaves the body practically devoid of virgin T cells, which makes the body more prone to a variety of infectious and non-infectious diseases. (wikipedia.org)
  • They pioneered in photomicrographic techniques, established a library and cataloging system which later formed the basis for the National Library of Medicine (NLM), and led the AMM into research on infectious diseases while discovering the cause of yellow fever. (wikipedia.org)
  • Anatomy
  • The NMHM embodies five collections consisting of about 25 million artifacts, including 5,000 skeletal specimens, 8,000 preserved organs, 12,000 items of medical equipment, an archive of historic medical documents, and collections related to neuroanatomy and developmental anatomy. (wikipedia.org)
  • skull
  • More recent theories, noting the presence of blood vessels in the skull bones of ceratopsids, find it more probable that these features were primarily used in identification, courtship and dominance displays, much like the antlers and horns of modern reindeer, mountain goats, or rhinoceros beetles. (wikipedia.org)
  • Open NTDs occur when the brain and/or spinal cord are exposed at birth through a defect in the skull or vertebrae (back bones). (wikipedia.org)
  • cells
  • Osteochondroprogenitor cells are important for bone formation and maintenance. (wikipedia.org)
  • Osteoprogenitor cells can be identified by their associations with existing bone or cartilage structures, or their placement in the embryo, as the sites for osteogenesis and chondrogenesis are now known. (wikipedia.org)
  • Osteoblasts are cells that group together to form units, called osteons, to produce bone. (wikipedia.org)
  • Research
  • Andrew Jeremy Wakefield (born 1957) is a British former gastroenterologist and medical researcher who was struck off the UK medical register for his fraudulent 1998 research paper and other misconduct in support of the now-discredited claim that there was a link between the administration of the measles, mumps and rubella (MMR) vaccine, and the appearance of autism and bowel disease. (wikipedia.org)
  • In November 2011, another report in BMJ revealed original raw data indicating that, contrary to Wakefield's claims in The Lancet, children in his research did not have inflammatory bowel disease. (wikipedia.org)
  • Subsequent research failed to confirm this hypothesis, with a group of experts in Britain reviewing a number of peer-reviewed studies in 1998 and concluding that the measles virus did not cause Crohn's disease, and that the MMR vaccine did not either. (wikipedia.org)
  • The discovery, in 1934, that calorie restriction can extend lifespan by 50% in rats, and the existence of species having negligible senescence and potentially immortal species such as Hydra, have motivated research into delaying and preventing senescence and thus age-related diseases. (wikipedia.org)
  • They contributed to research on vaccinations for typhoid fever, and during World War I, AMM staff were involved in vaccinations and health education campaigns, including major efforts to combat sexually transmissible diseases. (wikipedia.org)
  • cancer
  • The Dutch professor Francois de la Boe Sylvius, a follower of Descartes, believed that all disease was the outcome of chemical processes, and that acidic lymph fluid was the cause of cancer. (wikipedia.org)
  • The first cause of cancer was identified by British surgeon Percivall Pott, who discovered in 1775 that cancer of the scrotum was a common disease among chimney sweeps. (wikipedia.org)
  • known
  • The arrays themselves can be genome-wide (probes distributed over the entire genome) or targeted (probes for genomic regions known to be involved in a specific disease) or a combination of both. (wikipedia.org)
  • cause
  • Wakefield's study and his claim that the MMR vaccine might cause autism led to a decline in vaccination rates in the United States, United Kingdom and Ireland and a corresponding rise in measles and mumps, resulting in serious illness and deaths, and his continued claims that the vaccine is harmful have contributed to a climate of distrust of all vaccines and the reemergence of other previously controlled diseases. (wikipedia.org)
  • Early
  • A study of three tokens of carpal (wrist) bones concluded there were differences from the carpal bones of modern humans and similarities to those of a chimpanzee or an early hominin such as Australopithecus. (wikipedia.org)
  • A study of the bones and joints of the arm, shoulder, and lower limbs also concluded that H. floresiensis was more similar to early humans and other apes than modern humans. (wikipedia.org)
  • blood
  • The human penis differs from those of most other mammals, as it has no baculum, or erectile bone, and instead relies entirely on engorgement with blood to reach its erect state. (wikipedia.org)
  • years
  • and two years later he published a paper in The Lancet proposing a link between the measles vaccine and Crohn's disease. (wikipedia.org)
  • An arm bone provisionally assigned to H. floresiensis is about 74,000 years old. (wikipedia.org)
  • paper
  • After the publication of the paper, other researchers were unable to reproduce Wakefield's findings or confirm his hypothesis of an association between the MMR vaccine and autism, or autism and gastrointestinal disease. (wikipedia.org)