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  • 2017
  • Ballante F, Reddy DR, Zhou NJ et al (2017) Structural insights of SmKDAC8 inhibitors: targeting schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy. (springer.com)
  • Reddy DR, Ballante F, Zhou NJ et al (2017) Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitors. (springer.com)
  • alpha 1-antitryps
  • The genetic code of protein C inhibitor is similar to alpha 1-antitrypsin and alpha 1-antichymotrypsin. (wikipedia.org)
  • Current R&D Projects (April 2014) Fully pharmaceutically licensed, SD-treated, freeze-dried, non-blood-type-specific plasma in bags A new Fibrinogen product Next generation Immunoglobulin A human growth factor product G-CSF (Granulocyte colony-stimulating factor, long acting) Alpha-1-Antitrypsin C1-Esterase-Inhibitor Human coagulation factor VII Octapharma converts source plasma into plasma protein products through fractionation and processing. (wikipedia.org)
  • Protease inhibitory activity in blood plasma was first reported in the late 1800s, but it was not until the 1950s that the serpins antithrombin and alpha 1-antitrypsin were isolated. (wikipedia.org)
  • disorders
  • While traditional thromboelastography is a global assay for blood clotting disorders and drug effects, TEM is primarily used in combination with appropriate differential assays. (wikipedia.org)
  • Patients in 113 countries are treated with products in the following therapeutic areas: Haematology: high-purity coagulation factor concentrates for patients with bleeding disorders Haemophilia A, B and von Willebrand Disease. (wikipedia.org)
  • Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e., it has a thrombolytic activity)[citation needed], and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. (wikipedia.org)
  • Disorders of coagulation are disease states which can result in bleeding (hemorrhage or bruising) or obstructive clotting (thrombosis). (wikipedia.org)
  • clot
  • Following injury to the endothelium and vessel wall, a series of molecular and cellular events occur leading to the formation of a blood clot. (bloodjournal.org)
  • CT (Clotting time): The CT is the latency time from adding the start reagent to blood until the clot starts to form. (wikipedia.org)
  • Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot. (wikipedia.org)
  • hemostasis
  • It is an essential part of hemostasis and works by stopping blood loss from damaged blood vessels. (wikipedia.org)
  • Thromboelastometry (TEM), previously named rotational thromboelastography (ROTEG) or rotational thromboelastometry (ROTEM), is an established viscoelastic method for hemostasis testing in whole blood. (wikipedia.org)
  • Hemostasis or haemostasis is a process which causes bleeding to stop, meaning to keep blood within a damaged blood vessel (the opposite of hemostasis is hemorrhage). (wikipedia.org)
  • When endothelial injury occurs, the endothelial cells stop secretion of coagulation and aggregation inhibitors and instead secrete von Willebrand factor which initiate the maintenance of hemostasis after injury. (wikipedia.org)
  • Hemostasis occurs when blood is present outside of the body or blood vessels. (wikipedia.org)
  • Hemostasis is maintained in the body via three mechanisms: Vascular spasm (Vasoconstriction) - Vasoconstriction is produced by vascular smooth muscle cells, and is the blood vessel's first response to injury. (wikipedia.org)
  • It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. (wikipedia.org)
  • tissue
  • The process includes the following steps: Following damage to the blood vessel, FVII leaves the circulation and comes into contact with tissue factor (TF) expressed on tissue-factor-bearing cells (stromal fibroblasts and leukocytes), forming an activated complex (TF-FVIIa). (wikipedia.org)
  • gene
  • Functionally, miRNAs are opposite to transcription factors, which turn on genes, while miRNAs function as modulators by down-regulating gene expression , . (pubmedcentralcanada.ca)
  • The human C1-inhibitor gene (SERPING1) is located on the eleventh chromosome (11q11-q13.1). (wikipedia.org)
  • Mutations in the gene that codes for C1-inhibitor, SERPING1, may also play a role in the development of age related macular degeneration. (wikipedia.org)
  • Water N, Tan T, Ashton F, O'grady A, Day T, Browett P, Ockelford P, Harper P. Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia. (wikipedia.org)
  • thrombocytopenia
  • Diseases that cause prolonged bleeding time include thrombocytopenia, disseminated intravascular coagulation (DIC), Bernard-Soulier disease, and Glanzmann's thrombasthenia. (wikipedia.org)
  • andexanet alfa
  • Andexanet alfa is a biologic agent, a modified recombinant derivative of factor Xa (fXa). (wikipedia.org)
  • In rats anticoagulated by enoxaparin and fondaparinux, andexanet alfa was successful in completely reversing the increased blood losses to normal levels in a dose-dependent fashion. (wikipedia.org)
  • venous
  • Therefore activated factor X inhibitors, are among the agents under investigation as treatments for the spectrum of thromboembolic diseases involving either the arterial or the venous system. (clinicaltrials.gov)
  • A blood pressure cuff is used above the wound, to maintain venous pressure at a specified value. (wikipedia.org)
  • concentrates
  • The rapid availability of results helps to discriminate surgical bleeding from a true haemostasis disorder and improves the therapy with blood products, factor concentrates, anticoagulants and protamine, hemostyptic and antifibrinolytic drugs. (wikipedia.org)
  • hirudin
  • During his years in Birmingham and Edinburgh, John Berry Haycraft had been actively engaged in research and published papers on the coagulation of blood, and in 1884, he discovered that the leech secreted a powerful anticoagulant, which he named hirudin, although it was not isolated until the 1950s, nor its structure fully determined until 1976. (wikipedia.org)
  • dependent
  • Fernandez AZ, Tablante A, Bartoli F, Beguin S, Hemker HC, Apitz-Castro R. Expression of biological activity of draculin, the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule. (wikipedia.org)
  • VIII
  • Octapharma's inaugural product was the first Factor VIII concentrate using what was then innovative solvent detergent virus inactivation technology. (wikipedia.org)
  • Pool's major observation was that factor VIII can be simply and cheaply prepared from human plasma, and can be easily and safely given to hemophilic patients. (wikipedia.org)