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  • differentiation
  • This is highly relevant with respect to human allergy and autoimmunity because a possible modulation of B cell differentiation by basophils could point to new therapeutic targets. (jimmunol.org)
  • Using two different methods to induce PC differentiation, we found that human basophils enhance B cell proliferation, class switching, differentiation into PC, maturation of PC, and production of Igs, especially IgG. (jimmunol.org)
  • Basophil supernatants enhanced the expression of the B cell markers CD23 and CD40, which are important for B cell differentiation into IgG-producing PC. (jimmunol.org)
  • Thus, human basophils modulate B cell differentiation into Ab-producing PC. (jimmunol.org)
  • Our data demonstrate that human basophils support PC differentiation in an IL-3- and IL-4-dependent way. (jimmunol.org)
  • bind
  • Several minutes at room temperature gives the marker time to bind to the CD63 proteins on the cell membrane of the basophil. (wikipedia.org)
  • severity
  • B cell-basophil interaction might also impact the pathogenesis of autoimmune diseases as indicated by the fact that basophils are differently activated in systemic lupus erythematosus (SLE) depending on the disease severity ( 10 ). (jimmunol.org)
  • systemic
  • The term cutaneous basophil hypersensitivity (CBH) initially referred to a systemic but evanescent pattern of delayed-onset reactivity in guinea pigs sensitized to protein antigens administered without mycobacterial adjuvants (Richerson et al . (springer.com)
  • Basophils from patients with systemic lupus erythematosus show an activated phenotype, correlating to disease activity. (jimmunol.org)
  • human
  • Therefore, the interaction between human B cells and basophils and the mechanism underlying this interaction were investigated in detail. (jimmunol.org)
  • Human basophils are known to play a role in Th2 responses by producing IL-4 ( 21 ), and could theoretically support IgG and IgE production. (jimmunol.org)
  • In the current study, we therefore investigated whether human basophils and B cells interact and which mechanisms underlie this interaction. (jimmunol.org)
  • markers
  • Basophils also express several surface markers that stimulate surrounding cells, for example CD62L ( 10 ), CD40L ( 11 ), OX40-L ( 12 ), and receptor activator of NF-κB ligand ( 13 , 14 ). (jimmunol.org)
  • functions
  • Thus, basophils are well equipped to react to a wide range of signals, and to influence the functions of other cells such as B cells. (jimmunol.org)
  • Source
  • Recent evidence suggests that basophils are an important source of the cytokine, interleukin-4, perhaps more important than T cells. (wikipedia.org)