• nuclear
  • Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription. (wikipedia.org)
  • p300
  • Since Ngn1 is the limiting factor, CBP/p300/Smad1 is able to interact with STAT1/3 and induce gliogenesis. (wikipedia.org)
  • vascular smooth
  • To investigate the role of platelet-derived growth factor receptor (PDGFR)β in development of epicardial-derived vascular smooth muscle cells (VSMCs), we examined PDGFR β −/− and PDGFR β epicardial mutant hearts. (ahajournals.org)
  • STAT
  • In the presence of Ngn1, the leukemia inhibitory factor (LIF) pathway is inhibited by Ngn1 blocking STAT activation. (wikipedia.org)
  • In the absence of Ngn1, the LIF pathway is able to activate STAT1/3, which allows for the promotion of GFAP transcription via the STAT binding site. (wikipedia.org)
  • pathways
  • Increasing cyclin D1 levels during the G1 phase is induced by mitogenic growth factors primarily through Ras mediated pathways, and hormones. (wikipedia.org)
  • acts
  • In males, INSL3 regulates testicular descent during fetal life, whereas in adults, it acts as a germ cell survival factor. (biomedsearch.com)
  • mice
  • This transcription factor is the earliest of all MRFs to be expressed in the embryo, where it is only markedly expressed for a few days (specifically around 8 days post-somite formation and lasting until day 14 post-somite in mice). (wikipedia.org)
  • research
  • Wendell Cathcart will intern with Judge Wingate this summer, working with his law clerks and performing basic research for upcoming cases. (hendrix.edu)
  • The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. (frontiersin.org)