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  • OLIG2
  • Here, we developed a library of stabilized α-helices of OLIG2 (SAH-OLIG2) to test the capacity of hydrocarbon-stapled peptides to disrupt OLIG2 homodimerization, which drives the development and chemoresistance of glioblastoma multiforme, one of the deadliest forms of human brain cancer. (uu.nl)
  • mice
  • In mice, pancreatic progenitor cells give rise to functional endocrine cells through an endocrine progenitor intermediate that expresses the basic helix-loop-helix (bHLH) transcription factor Neurogenin3 (Neurog3) ( 1 - 4 ). (diabetesjournals.org)
  • Neurog3 is required for development of all pancreatic endocrine cell types in mice ( 5 - 7 ) and does this through direct and indirect regulation of downstream targets, including the transcription factors NeuroD1 ( 8 ), Rfx6 ( 9 ), Pax4 ( 10 ), Nkx6.1 ( 11 , 12 ), Arx ( 13 ), and others. (diabetesjournals.org)
  • This was observed in mice lacking Ngn2 and mash-1 (another proneural bHLH transcription factor), which have more glia in the cortex and decreased capacity to generate neurons. (wikipedia.org)
  • This transcription factor is the earliest of all MRFs to be expressed in the embryo, where it is only markedly expressed for a few days (specifically around 8 days post-somite formation and lasting until day 14 post-somite in mice). (wikipedia.org)
  • nucleus
  • These Ras-mediated pathways lead to the increase in transcription of cyclin D1, and inhibit its proteolysis and export from the nucleus. (wikipedia.org)
  • Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription. (wikipedia.org)
  • mutations
  • She discovered that similar mutations in the same gene, fibroblast growth factor receptor 2 or FGFR2, cause both Jackson-Weiss syndrome and Crouzon syndrome. (wikipedia.org)
  • circadian
  • Here, we identify the circadian clock transcription factor SHARP1 as a novel oncogenic target in MLL-AF6 AML, which has the worst prognosis among all subtypes of MLL-rearranged AMLs. (eur.nl)
  • fibroblast
  • The induction of Hand2 by progesterone-dependent mechanisms in uterine stromal tissue suppresses fibroblast growth factors (FGFs) that would otherwise stimulate estrogen producing pathways and impair embryo implantation. (wikipedia.org)
  • STAT
  • In the presence of Ngn1, the leukemia inhibitory factor (LIF) pathway is inhibited by Ngn1 blocking STAT activation. (wikipedia.org)
  • In the absence of Ngn1, the LIF pathway is able to activate STAT1/3, which allows for the promotion of GFAP transcription via the STAT binding site. (wikipedia.org)