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  • In addition, these membranes show a distict chemical alteration c haracterized by a significant decrease in lysine, accoumpanied by an equivalent increase in hydroxylysine and hydroxylysine-linked disaccharide units. (sciencemag.org)
  • Antibody
  • The syndrome is now defined as an autoimmune disorder consisting of the triad of glomerulonephritis, lung hemorrhage, and antiglomerular basement membrane antibody formation, and it includes a broad spectrum of clinical features, ranging from massive pulmonary hemorrhage with little overt evidence of renal disease to fulminant crescentic glomerulonephritis and little overt evidence of pulmonary hemorrhage (24). (springer.com)
  • Dixon and coworkers (4, 5) showed that in one particular type of glomerulonephritis, originally described by Ernest Goodpasture in 1919 (6) and subsequently referred to as Goodpastures syndrome (7), the disease was caused by an antibody response against antigens present in the glomerular basement membrane (GBM). (bio-medicine.org)
  • Anti-glomerular basement membrane antibody (anti-GBM Ab) is an antibody which is found in Goodpasture's syndrome but not found in microscopic polyangiitis. (wikipedia.org)
  • plasma membrane
  • The apical plasma membrane displays compositional variations that change at the time of implantation. (wikipedia.org)
  • The lateral plasma membrane domain is responsible for cell adhesion and is believed to control the paracellular transport of fluid and electrolytes, that is transport of fluid between the cells. (wikipedia.org)
  • These features include a loss of apical microvilli such that the apical plasma membrane becomes flattened. (wikipedia.org)
  • Collectively, these plasma membrane changes have been termed the plasma membrane transformation. (wikipedia.org)
  • During the early stages of pregnancy, prior to implantation, the tight junction complex, which is the main regulator of paracellular flow, extends 0.4 µm down the lateral plasma membrane with little cross-linking of the tight junctional strands. (wikipedia.org)
  • At the time of implantation the tight junctions extended further down the lateral plasma membrane (1 µm) and there was a significant increase in the cross-linking of the tight junctional strands. (wikipedia.org)
  • They also bind to cell membranes through integrin receptors and other plasma membrane molecules, such as the dystroglycan glycoprotein complex and Lutheran blood group glycoprotein. (wikipedia.org)
  • molecules
  • Some specialized subtypes of these molecules are only found in specialised basement membranes such as the GBM. (edren.org)
  • The basement membrane controls the traffic of the cells and molecules between the dermis and epidermis but also serves, through the binding of a variety of cytokines and growth factors, as a reservoir for their controlled release during physiological remodeling or repair processes. (wikipedia.org)
  • capillaries
  • Dryll A, Lansaman J, Cazalis P, Peltier AP, DeSeze S (1977) Light and electron microscopy study of capillaries in normal and inflammatory human synovial membrane. (springer.com)
  • cells
  • While primarily made of proteins, the exact composition of the basement membrane varies according to the cells that produce it. (reference.com)
  • It surrounds some cells, such as muscle cells, which are all separated by the basement membrane. (reference.com)
  • A simple epithelium has cells that form a single layer that are attached to the basement membrane. (reference.com)
  • Invasion of cells through basement membrane barriers is a key aspect of many normal and pathological processes, including organ development and cancer cell metastasis. (pnas.org)
  • Here we show that invading cells in C. elegans apply forces via actin assembly to break through basement membrane, and that force production is one of the key features of invasion. (pnas.org)
  • During invasion, cells breach basement membrane (BM) barriers with actin-rich protrusions. (pnas.org)
  • Alveoli are composed of a single layer of secretory polarized cells that surround a lumen and interact both with one another and with their basement membrane. (springer.com)
  • The change in the structure affects the epithelium, some cells of which may become entrapped in the rugged membrane and fail to migrate to the surface where they should undergo desquamation. (wikipedia.org)
  • To help achieve this, the cells of transitional epithelium are connected by tight junctions, or virtually impenetrable junctions that seal together to the cellular membranes of neighboring cells. (wikipedia.org)
  • These cells contain a prominent Golgi apparatus and an array of membrane-bound vesicles. (wikipedia.org)
  • All cells touch the basement membrane. (wikipedia.org)
  • These tonofibrils converge at hemidesmosomes to attach the cells at the basement membrane. (wikipedia.org)
  • type
  • Dean DC, Barr JF, Freytag JW, Hudson BG: Isolation of type IV procollagen-like polypeptides from glomerular basement membrane. (springer.com)
  • The membrane is made up of a hexagonal lattice put together in the Golgi apparatus and implanted into the surface of the cell by reverse pinocytosis, a type of exocytosis. (wikipedia.org)
  • gaps
  • FLOATING SLAB Design and style - Perimeter drainage gaps around the flooring are built to permit seeping h2o to trickle down foundation partitions, into large gaps, and down below the basement floor. (isblog.net)
  • Not the best of concepts mainly because large gaps while in the basement will very easily permit in gases and moisture. (isblog.net)
  • floor
  • It was not without a host of challenges, however-including replacing siding, plugging unseen leaks, pouring a new basement floor, and finding the best possible workers. (homeenergy.org)