Loading...



  • presence
  • By labeling such complementary probe nucleic acids with some readily detectable chemical group, it was then made possible to detect the presence of any polynucleotide sequence of interest in a test medium containing sample nucleic acids in single stranded form. (google.ca)
  • We now know that this effect is due to increased stacking interactions between GC base pairs (and not the presence of three hydrogen bonds) [ DNA Denaturation and Renaturation and the Role of Hydrogen Bonds and Stacking Interactions ]. (blogspot.ca)
  • evolution
  • We have determined genome sequences of B strains [ 5 , 6 ] - REL606, which has been applied to the study of long-term experimental evolution, and BL21(DE3), which has been used as a cell-factory for overproducing recombinant proteins, biofuels, and a variety of bioproducts on an industrial scale. (biomedcentral.com)
  • that its evolution has moved from a non-functional ancestral sequence. (exclusivepapers.com)
  • mutations
  • Based on Hadoop and HBase, we developed SeqHBase, a big data-based toolset for analysing family based sequencing data to detect de novo, inherited homozygous, or compound heterozygous mutations that may contribute to disease manifestations. (bmj.com)
  • The remaining 8 were new mutations and all were single base changes: Four were in families that are strongly associated with cancer pathogenesis (PTPRT, CDH24, PCLKC and SLC15A1). (wikipedia.org)
  • The initiative allows such exceptional patients (who have responded positively for at least six months to a cancer drug that usually fails) to have their genomes sequenced to identify the relevant mutations. (wikipedia.org)
  • Conserved sequences, such as mitochondrial DNA, are expected to accumulate mutations over time, and assuming a constant rate of mutation, provides a molecular clock for dating divergence. (wikipedia.org)
  • contiguous
  • Results show that the use of exponential decay weighting schemes when taking into account non contiguous sequences to compute recommendations enhances the accuracy. (inria.fr)
  • A comprehensive step-by-step protocol on constructing phylogenetic tree, including DNA/Amino Acid contiguous sequence assembly, multiple sequence alignment, model-test (testing best-fitting substitution models) and phylogeny reconstruction using Maximum Likelihood and Bayesian Inference, is available at Nature Protocol Early attempts at molecular systematics were also termed as chemotaxonomy and made use of proteins, enzymes, carbohydrates, and other molecules that were separated and characterized using techniques such as chromatography. (wikipedia.org)
  • genomes
  • Through the partnership, DNAnexus and scientists at Baylor performed the largest cloud-based genomics analysis to date, processing 3,751 whole human genomes and 10,771 exomes. (wikipedia.org)
  • protein
  • The analysis of DNA, RNA and protein sequences is traditionally one of the major application areas for bioinformatics tools and methods. (nbic.nl)
  • tRNA does this by carrying an amino acid to the protein synthetic machinery of a cell (ribosome) as directed by a three-nucleotide sequence (codon) in a messenger RNA (mRNA). (wikipedia.org)
  • In 1999, working with John Carlson at Yale, he developed a novel algorithm for computationally identifying G Protein-Coupled Receptors (GPCR) without using primary sequence homology, which led to the cloning of olfactory receptors in insects. (wikipedia.org)
  • molecular
  • Molecular phylogenetics (/məˈlɛkjʊlər ˌfaɪloʊdʒəˈnɛtɪks, mɒ-, moʊ-/) is the branch of phylogeny that analyses hereditary molecular differences, mainly in DNA sequences, to gain information on an organism's evolutionary relationships. (wikipedia.org)
  • With the invention of Sanger sequencing in 1977 it became possible to isolate and identify these molecular structures. (wikipedia.org)
  • Its molecular structure has DNA bases attached to a backbone of methylenemorpholine rings linked through phosphorodiamidate groups. (wikipedia.org)
  • methods
  • All this, combined with the limited availability or complete lack of other experimental data, creates a pressing need for novel bioinformatics methods that can infer biological functions and processes directly from sequence-level information. (nbic.nl)
  • detect
  • DNA denaturation can also be used to detect sequence differences between two different DNA sequences. (wikipedia.org)
  • In the context of a single isolated region of DNA, denaturing gradient gels and temperature gradient gels can be used to detect the presence of small mismatches between two sequences, a process known as temperature gradient gel electrophoresis. (wikipedia.org)
  • homology
  • examined misidentification of VGS submitted to antimicrobial surveillance programs as pneumococci and found that the distinction of S. pneumoniae from the VGS can be difficult, which is not surprising in light of the fact that S. mitis and S. oralis possess >99% sequence homology with S. pneumoniae (47). (wikipedia.org)
  • restriction
  • citation needed] While a postdoctoral fellow with Hamilton O. Smith at the Johns Hopkins University School of Medicine during 1969-70, Kelly determined the DNA sequences recognized by type II restriction enzymes, which subsequently became major tools in recombinant DNA research. (wikipedia.org)
  • canonical
  • In the canonical Watson-Crick base pairing, adenine (A) forms a base pair with thymine (T) and guanine (G) forms one with cytosine (C) in DNA. (wikipedia.org)
  • Examples include universal bases, which can pair with all four canonical bases, and phosphate-sugar backbone analogues such as PNA, which affect the properties of the chain (PNA can even form a triple helix). (wikipedia.org)
  • The viral polymerase incorporates these compounds with non-canonical bases. (wikipedia.org)
  • These nucleoside triphosphates possess a non-canonical sugar, dideoxyribose, which lacks the 3' hydroxyl group normally present in DNA and therefore cannot bond with the next base. (wikipedia.org)
  • analysis
  • we would like to do some sequence analysis with the students. (bioinformatics.org)
  • DNAnexus is an American company that provides a cloud-based data analysis and management platform for DNA sequence data. (wikipedia.org)
  • DNAnexus was founded in early 2009 as a spin-off from Stanford University to address the need for computing infrastructure in DNA sequence analysis. (wikipedia.org)
  • Customers of DNAnexus use those computational resources to run analysis programs on DNA sequence data and to store that data. (wikipedia.org)
  • In September 2013, the company began offering its cloud-based platform-as-a-service to clinical testing laboratories for DNA sequence data analysis. (wikipedia.org)
  • DNAnexus Aims to Alleviate Next-Gen Sequence Analysis Headache with Cloud-based Service. (wikipedia.org)
  • http://www.genomeweb.com/sequencing/dnanexus-aims-alleviate-next-gen-sequence-analysis-headache-cloud-based-service Ricketts, Camille. (wikipedia.org)
  • http://www.fiercebiotechit.com/special-reports/fierce-s-top-10-biotech-techies/andreas-sundquist-fierces-top-10-biotech-techies http://genengnews.com/gen-news-highlights/baylor-39-s-hgsc-dnanexus-amazon-team-up-in-cloud-based-analysis/81249025/?kwrd=dnanexus Grens, Kerry. (wikipedia.org)
  • targets
  • The subjects were instructed to voluntarily control a virtual cursor in multiple trials to hit different pre-programmed targets on a screen in an optimized sequence. (springer.com)
  • user's
  • This paper describes a new approach of generating suitable recommendations based on the active user's navigation stream. (inria.fr)
  • This approach is derived from a basic shared control strategy where the robotic arm is responsible for carrying out complex maneuvers based on the user's intention. (springer.com)
  • wobble
  • In RNA, thymine is replaced by uracil (U). Alternate hydrogen bonding patterns, such as the wobble base pair and Hoogsteen base pair, also occur-particularly in RNA-giving rise to complex and functional tertiary structures. (wikipedia.org)
  • The GU wobble base pair, with two hydrogen bonds, does occur fairly often in RNA. (wikipedia.org)
  • The first anticodon base, or wobble-position, is sometimes modified to inosine (derived from adenine), pseudouridine or lysidine (derived from cytosine). (wikipedia.org)
  • Some anticodons can pair with more than one codon due to a phenomenon known as wobble base pairing. (wikipedia.org)
  • naturally
  • Naturally occurring bases can be divided into two classes according to their structure: pyrimidines are six-membered heterocyclic with nitrogen atoms in position 1 and 3. (wikipedia.org)
  • patterns
  • Recurrent Neural Networks (RNNs) have become the state-of-the-art choice for extracting patterns from temporal sequences. (arxiv.org)
  • different
  • If the 16S sequence is different, you can be sure that the isolates are different strains. (criver.com)
  • PG validation requires a specific durability test sequence for every segment of commercial vehicles due to different customer usage applications and terrain conditions. (sae.org)
  • Typically the analogue nucleobases confer, among other things, different base pairing and base stacking properties. (wikipedia.org)
  • representation
  • DNA samples from two groups of Italian Large White pigs with divergent estimating breeding value (EBV) for BFT were separately pooled and sequenced, after preparation of reduced representation libraries (RRLs), on the Ion Torrent technology. (hindawi.com)
  • Methodology
  • For building the optimized test schedule, frequency based pseudo damage methodology called Relative Damage Spectrum (RDS) is incorporated.This method enhances the proving ground durability validation process by providing optimized test schedules to prevent redundant vehicle testing. (sae.org)
  • purely
  • This study investigated whether negative priming can be observed in a sequence learning that is purely perceptual-based. (arvojournals.org)
  • A library providing persistent (purely functional) vectors for Haskell based on array mapped tries. (haskell.org)
  • typical
  • they also lack either the polysaccharide-based capsule typical of S. pneumoniae or the Lancefield antigens of the pyogenic members of the genus. (wikipedia.org)
  • specific
  • The method includes the step of discriminating base-specific labels of heavy elements using a magnified image of elongated single-chain DNA or RNA produced by a transmission electron microscope (TEM). (freepatentsonline.com)
  • c) obtaining a magnified image of a portion of the base-specific heavy element labeled elongated single-chain DNA or RNA, wherein the portion of DNA or RNA does not cross itself using a transmission electron microscope and discriminating said base-specific labels of heavy elements using the obtained magnified image. (freepatentsonline.com)
  • recognition
  • EcoRII is a bacterial Type IIE REase that interacts with two or three copies of the pseudopalindromic DNA recognition sequence 5'-CCWGG-3' (W = A or T), one being the actual target of cleavage, the other(s) serving as the allosteric activator(s). (wikipedia.org)
  • require
  • Even with the sparse updates imposed by the oscillation, the Phased LSTM network achieves faster convergence than regular LSTMs on tasks which require learning of long sequences. (arxiv.org)
  • bioinformatics
  • https://bioinformatics.org/sms/ It contains all basic manipulations to a DNA sequence, it is implemented by javascript, and is web based, you can also download and have a local copy on you computer, it only need unzip, no installation. (bioinformatics.org)
  • S. Andrews, "FastQC: a quality control tool for high throughput sequence data," 2010, http://www.bioinformatics.bbsrc.ac.uk/projects/fastqc/ . (hindawi.com)
  • high
  • Our proposed BMI platform yielded a high success rate of 70% in a sequence-based manipulation task after only a short time of training (10 min). (springer.com)
  • High-throughput sequencing may also be used to obtain the transcriptome of an organism, allowing inference of phylogenetic relationships using transcriptomic data. (wikipedia.org)
  • current
  • These forward-looking statements are based upon management's current expectations, are subject to known and unknown risks, and involve assumptions that may never materialize or may prove to be incorrect. (cnbc.com)
  • a substantial sample of individuals of the target species or other taxon is used, however many current studies are based on single individuals. (wikipedia.org)
  • slower
  • Updating an element at an index in a vector is slower than updating an index in a Sequence (but still faster than an IntMap). (haskell.org)
  • presence
  • By labeling such complementary probe nucleic acids with some readily detectable chemical group, it was then made possible to detect the presence of any polynucleotide sequence of interest in a test medium containing sample nucleic acids in single stranded form. (google.ca)
  • We now know that this effect is due to increased stacking interactions between GC base pairs (and not the presence of three hydrogen bonds) [ DNA Denaturation and Renaturation and the Role of Hydrogen Bonds and Stacking Interactions ]. (blogspot.ca)
  • evolution
  • We have determined genome sequences of B strains [ 5 , 6 ] - REL606, which has been applied to the study of long-term experimental evolution, and BL21(DE3), which has been used as a cell-factory for overproducing recombinant proteins, biofuels, and a variety of bioproducts on an industrial scale. (biomedcentral.com)
  • that its evolution has moved from a non-functional ancestral sequence. (exclusivepapers.com)
  • fragments
  • So they wanted to focus on genetic fragments containing paternally inherited sequences the mother did not share, but had traveled from the fetal blood into the maternal blood through the placenta. (wikipedia.org)
  • Phage eluted in the final step can be used to infect a suitable bacterial host, from which the phagemids can be collected and the relevant DNA sequence excised and sequenced to identify the relevant, interacting proteins or protein fragments. (wikipedia.org)
  • strains
  • 2010). Although A. acroporae has been found on the GBR, the natural origin and biogeographic range of the aquarium strains of AEFWs are unclear and no natural predators are known, making it difficult to control infestations in land-based Acropora cultures. (advancedaquarist.com)
  • Analysis
  • This apparent discrepancy between structural and sequence based similarities is really intriguing and requires further analysis. (burnham.org)
  • Based on this distribution of values, it would appear from our preliminary analysis that almost half of the individuals sampled from the Harappa cemetery have isotope values outside the local baseline (0.7158-0.7189). (blogspot.com)
  • An analysis of DNA sequences indicate Geogenanthus is closely related to the genus Plowmanianthus followed by Cochliostema. (wikipedia.org)
  • Analysis of morphological characters in Commelinaceae indicate Geogenanthus is closely related to Dichoriscantieae and Siderasis, but Geogenanthus is placed as the sister to Dichoriscantieae and Siderasis in the cladogram from the combined morphology and sequence analysis, with high bootstrap value supporting the placement. (wikipedia.org)
  • protein
  • These displaying phages can then be screened against other proteins, peptides or DNA sequences, in order to detect interaction between the displayed protein and those other molecules. (wikipedia.org)
  • Applications of phage display technology include determination of interaction partners of a protein (which would be used as the immobilised phage "bait" with a DNA library consisting of all coding sequences of a cell, tissue or organism) so that the function or the mechanism of the function of that protein may be determined. (wikipedia.org)
  • available
  • Estimated shipping dates are accurate to the best of our knowledge, based on the latest stock information made available to us from the supplier. (boomkat.com)
  • The Netherlands - November 10, 2017 - Bluebee, a company driving genomic data-driven medicine, announces the successful integration of the SLAMdunk pipeline on Bluebee's private cloud-based platform, making it available to analyze data generated by every user of the SLAMseq Metabolic RNA Labeling Kit from Lexogen. (delftenterprises.nl)
  • Long
  • From the Marianas, the very long-range B-29 Superfortress heavy bombers of the U.S. Army Air Forces (USAAF) could bomb the Japanese home islands from well-supplied air bases - ones with direct access to supplies via cargo ships and tankers. (wikipedia.org)
  • company
  • Kerala Evergreen FC is the first team from Thiruvananthapuram to play in the I-League and will be part of the 2017-18 I-League.The team is owned by a Singapore based company MySports Management and India based company Liwing Sports.The team's home stadium is Trivandrum International Stadium in Thiruvananthapuram, Kerala. (wikipedia.org)
  • Positive
  • Positive territory sequencing should radically be confused with dna profiling, which n't determines the roof that military dairy came from a added school or election, and does primarily contain mobile surgeon on next opponents, violence or design to appropriate contents. (tenant-credit-check.life)
  • However it is easily extended to accept sequences containing negative numbers using an overlap and interleave scheme, in which all values are reassigned to some positive number in a unique and reversible way. (wikipedia.org)
  • order
  • During a period of reevaluation, often occurring around midlife, individuals begin to challenge and slowly disassemble the persona and order their lives based on fundamental preferences. (encyclopedia.com)
  • Based on the estimates of origin and diversification of the order Commelinales, which might have been sometime during the mid to late cretaceous period i.e. between 123 to 66 million years ago, it can be very roughly estimated that the genus Geogenanthus could have originated 66 million years ago. (wikipedia.org)
  • COX-2 is naturally inhibited by Calcitriol (the active form of Vitamin D). Both the peroxidase and PTGS activities are inactivated during catalysis by mechanism-based, first-order processes, which means that PGHS-2 peroxidase or PTGS activities fall to zero within 1-2 minutes, even in the presence of sufficient substrates. (wikipedia.org)
  • Complex
  • siRNA Danshensu of 20 pmol (against TRPC3) or the siRNA bad control complex, having a 1:125 last dilution of Lipofectamine 2000 (Invitrogen) was utilized based on the producers guidelines. (cancercurehere.com)
  • large
  • U.S. Navy, Marine Corps, and Army as well as Australian and New Zealand forces under the command of Admiral Nimitz and Admiral William F. Halsey, Jr. had isolated the large Japanese South Pacific base at Rabaul, New Britain, by capturing a ring of islands around Rabaul, and then building air bases on them from which to bomb and blockade the Japanese forces at Rabaul into military impotence. (wikipedia.org)
  • The story begins on a dark and stormy night as the victim (voiced by Kent Rogers doing an impression of Richard Haydn), presumably the master of the very large "Gruesome Gables" mansion, is reading a book based on the cartoon he's in. (wikipedia.org)
  • already
  • Aircraft carrier-based warplanes were already conducting air strikes and fighter sweeps against the Japanese in the Philippines, especially their military airfields. (wikipedia.org)
  • The sequence -nh- had already undergone a similar change in late Proto-Germanic several hundred years earlier, and affected all Germanic languages, not only the Ingvaeonic subgroup. (wikipedia.org)
  • special
  • FCSRs and LFSRs are special cases of a very general algebraic construction of sequence generators called Algebraic Feedback Shift Registers (AFSRs) in which the integers are replaced by an arbitrary ring R and N is replaced by an arbitrary non-unit in R. A general reference on the subject of LFSRs, FCSRs, and AFSRs is the book. (wikipedia.org)
  • structure
  • Houdini's operator-based structure is divided into several main groups: OBJs - nodes that pass transform information (Traditionally these contain SOPs. (wikipedia.org)
  • similar
  • This node graph architecture is similar to that employed in node-based compositors such as Shake or Nuke. (wikipedia.org)
  • present
  • In accommodation , a pretransition stage, individuals present adaptive characteristics (personae) that are based on environmental demands and expectations, and acquire definitions of self based on what is most adaptive. (encyclopedia.com)