• interactions
  • MIT researchers have discovered why an unusually short bacterial protein can have many more interactions than would normally be expected of something its size. (phys.org)
  • These crystal structures unravel a complex choreography of protein-protein interactions that will aid in the design of new antibacterial drugs," said Huilin Li, a biophysicist at the U.S. Department of Energy's Brookhaven National Laboratory and a professor at Stony Brook University, who participated in the research with a number of collaborators in the U.S. and in Europe. (phys.org)
  • Attachment further allows more interactions and increase of biofilm formation to aid bacterial colonization. (wikipedia.org)
  • The role of single-stranded DNA binding (SSB) protein during DNA replication in Escherichia coli cells has been studied, specifically the interactions between SSB and the χ subunit of DNA polymerase III in environments of varying salt concentrations. (wikipedia.org)
  • pathogens
  • Recent studies have revealed that viruses and bacterial pathogens exploit the host ubiquitination pathways to gain entry and to aid their survival/replication inside host cells. (frontiersin.org)
  • This review will summarize recent developments in understanding the biochemical and structural mechanisms utilized by bacterial pathogens to interact with the host ubiquitination pathways. (frontiersin.org)
  • They correspond to functions allowing opportunistic pathogens to colonise the mucus layers, breach the host barriers and invade the mucosae, which could still be aggravated by decreased host-derived pancreatic zymogen granule membrane protein GP2 in CD patients. (bmj.com)
  • Apoptosis
  • Similarly, the Shigella effectors IpgD and OspG (a homolog of NleH) block apoptosis, the former by phosphorylating and stabilizing the double minute 2 protein (MDM2) which in turn leads to a block of NF-kB-induced apoptosis. (wikipedia.org)
  • transporter
  • At the European Synchrotron Radiation Facility in Grenoble, France, the Washington University/UK group determined the atomic-level crystal structure of the entire transporter protein, known as an "usher," bound to the sticky adhesin subunit that forms the end of a pilus and another helper protein, called a chaperone, that shuttles the pilus subunits to the usher one at a time. (phys.org)
  • Yersinia
  • A hallmark of Yersinia type III machines is the presence of needles extending from the bacterial surface. (wikipedia.org)
  • Yersinia inhibits phagocytosis through the concerted actions of several effector proteins, including YopE which acts as a RhoGAP and inhibits Rac-dependent actin polymerization. (wikipedia.org)
  • yeast
  • Martin and graduate student Robert Abramovitch previously found that AvrPtoB, a protein Pseudomonas injects into plants, disables PCD in a variety of susceptible plants and in yeast (a single-celled ancestor of both plants and animals). (innovations-report.com)
  • closely related
  • The integration host factor (IHF), a dimer of closely related chains which is suggested to function in genetic recombination as well as in translational and transcriptional control is found in Enterobacteria and viral proteins including the African swine fever virus protein A104R (or LMW5-AR). (wikipedia.org)
  • found that the protein
  • The team, led by biology professor Graham Walker, found that the protein, UmuD, belongs to a recently discovered class of proteins called intrinsically disordered proteins. (phys.org)
  • When they injected Cb- -Rho into E. coli to examine the protein's function, they found that the protein misfolded in a prion-like manner, rendering it nonfunctional and allowing genes normally suppressed by Rho to be expressed. (the-scientist.com)
  • Explore
  • Here we explore the feasibility of extracting bacterial protein signals relevant to CD, by interrogating myriads of intestinal bacterial proteomes from a small number of patients and healthy controls. (bmj.com)
  • mechanism
  • This thesis addresses different aspects of the question about accuracy of protein synthesis: i) the mechanism of tRNA selection during translation ii) study of ribosomal mutations that affect accuracy and iii) the choice of aminoacyl-tRNA isoacceptors on synonymous codons. (diva-portal.org)
  • species
  • Many proteins, largely derived from Bacteroides species, were over-represented, while under-represented proteins were mostly from Firmicutes and some Prevotella members. (bmj.com)
  • researchers
  • For this, the researchers need to integrate the individual components - which include bacterial proteins, dyes, and aptamers - into a sensor chip. (ecnmag.com)
  • To identify the protein composition of the aphid saliva, the researchers collected saliva from more than 100,000 aphids. (redorbit.com)
  • single protein
  • Thus, GDF and GEF activity can be promoted by a single protein, and GDF activity can coordinate Rab1 recruitment from the GDI-bound pool. (sciencemag.org)
  • Another shared trait of bikonts is the fusion of two genes into a single unit: the genes for thymidylate synthase (TS) and dihydrofolate reductase (DHFR) encode a single protein with two functions. (wikipedia.org)
  • interact
  • A protein like UmuD, which is made of fewer amino acids, would not be expected to have enough binding sites to interact with very many other proteins. (phys.org)
  • UmuD's ability to interact with multiple partner proteins allows it to control the function of two translesion polymerases, coordinating their action with DNA replication. (phys.org)
  • synthesis
  • that during translation the ribosomal A site is not blocked by unspecific binding of the non-cognate tRNAs which would inhibit the speed of protein synthesis. (diva-portal.org)
  • In the living cell the availability of cognate tRNAs versus the demand for them (the frequency of codon usage) is finely balanced to ensure critical protein synthesis in stress conditions. (diva-portal.org)
  • cells
  • The YadA protein domain adheres to the following substrates: epithelial cells extracellular matrix collagen cellular fibronectin laminin The C-terminal domain consists of 120 amino acids which belong to a family of surface-exposed bacterial proteins. (wikipedia.org)
  • structure
  • Normally, proteins form a specific structure with binding sites where other proteins can attach. (phys.org)
  • UmuD usually is found in groups of two, which implies that it must have some kind of stable protein structure, said Sharotka Maria Simon, lead author of the paper and an MIT Ph.D. recipient now at Brandeis University. (phys.org)
  • This three-dimensional structure of the TSST-1 protein was determined by purifying the crystals of the protein. (wikipedia.org)
  • These software related to protein structure prediction may also appear in lists of protein structure prediction software. (wikipedia.org)
  • inactive
  • These changes rendered Pseudomonas harmless to susceptible tomato plants, and made the purified protein inactive. (innovations-report.com)
  • Meanwhile, Li's group worked at the National Synchrotron Light Source at Brookhaven to produce new images of the unbound usher protein in its closed, inactive state. (phys.org)
  • EspG functions as a Rab GTPase-activating protein (Rab-GAP), trapping Rab-GTPases in their inactive GDP bound form, and reducing ER-Golgi transport (of IL-8 and other proteins). (wikipedia.org)
  • activation
  • Activation of Neutrophils via IP3 Pathway Following Exposure to Demodex-Associated Bacterial Proteins. (sigmaaldrich.com)
  • In addition, neutrophils exposed to pure and crude B. oleronius proteins (2 μg/ml) demonstrated increased release of internally stored calcium (Ca(2+)), a hallmark of the IP3 pathway of neutrophil activation. (sigmaaldrich.com)
  • It is believed that specialized proteins are required to displace GDI from Rab GTPases before Rab activation by guanosine diphosphate-guanosine 5′-triphosphate (GDP-GTP) exchange factors (GEFs). (sciencemag.org)
  • complexes
  • The research also reveals that the usher protein has two binding sites for chaperone-subunit complexes. (phys.org)