Bk virus. Medical search. Frequent questions

In some renal transplant patients, the necessary use of immunosuppressive drugs has the side-effect of allowing the virus to replicate within the graft, a disease called BK nephropathy. (wikipedia.org)
From 1-10% of renal transplant patients progress to BK virus associated nephropathy (BKVAN) and up to 80% of these patients lose their grafts. (wikipedia.org)
This assay detects and quantifies the level of BK virus (BKV) DNA present in the urine of kidney transplant recipients who are at risk of developing BKV-associated nephropathy or hemorrhagic cystitis leading to decreasing renal function and eventual renal failure. (marshfieldlabs.org)
Nephropathy due to BK virus (BKV) infection is an evolving challenge in patients undergoing hematopoietic stem cell transplantation (HSCT). (elsevierpure.com)

These are known as primary BK infections. (wikipedia.org)
Las Vegas, Nevada, United States) As per DelveInsight's assessment, globally, BK virus infections pipeline constitutes 4+ key companies continuously working towards developing 4+ BK virus infections treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight. (openpr.com)
BK virus infections Pipeline Insight, 2023" report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the BK virus infections Market. (openpr.com)
The BK virus infections Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. (openpr.com)
Companies across the globe are diligently working toward developing novel BK virus infections treatment therapies with a considerable amount of success over the years. (openpr.com)
Emerging BK virus infections therapies in the different phases of clinical trials are- BK virus antiviral therapy, AIC 468, AntiBKV antibody, Brincidofovir, MAU868, ALVR 105, and others are expected to have a significant impact on the BK virus infections market in the coming years. (openpr.com)
BK virus infections pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. (openpr.com)
On December 17, 2021, Vera Therapeutics, Inc. (Nasdaq: VERA), a clinical-stage biotechnology company focused on developing treatments for immunological diseases that improve patients' lives, announced that it has acquired MAU868, a first-in-class monoclonal antibody to treat BK virus (BKV) infections, and has entered into a credit facility with Oxford Finance LLC (Oxford) to provide borrowing capacity up to $50 million. (bioquicknews.com)
Certain viruses can live in your body and cause active infections when your immune system is weak. (nih.gov)
human polyomavirus 1) infections are asymptomatic in most individuals, and the virus persists throughout life without harm. (simonsfoundation.org)
After transplantation, the patient tested positive for recurrent blood cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections, and on March 31, 2020, he underwent lung lavage because of bilateral pneumonia. (biomedcentral.com)
A slow virus, BK establishes latent infections in B-lymphocytes and attacks an immunosuppressed host upon reactivation. (stanford.edu)
Posoleucel is the first T-cell therapy to target BK virus, which can cause severe, painful bladder infections requiring immediate treatment. (scienceboard.net)
There were 70 total viral infections in the trial population, primarily from CMV and BK virus. (scienceboard.net)
CMV shares many attributes with other herpes viruses, including genome, virion structure, and the ability to cause latent and persistent infections. (medscape.com)
However, the clinical success of this therapy is marred by the morbidity associated with viral infections, which are frequent (cytomegalovirus 15.6-28%, adenovirus 3-21%, BK virus 18.5-20.7%) post-transplant. (nih.gov)
Viruses are also responsible for the common cold, childhood exanthems (such as chickenpox, measles, rubella), latent infections (such as herpes simplex), some cancers or lymphomas (such as Epstein-Barr virus), and diseases of all organ systems. (unboundmedicine.com)
The virus is harmless to macaques or may cause only a herpetic rash in macaques, but in humans it often produces fatal infections of the brain and meninges. (unboundmedicine.com)

Posoleucel, an allogeneic therapy comprising donor T cells, targets six of the most common viruses in patients following allo-SCT: adenovirus, BK virus, cytomegalovirus (CMV), Epstein-Barr virus, human herpes virus 6, and JC virus. (scienceboard.net)
Cytomegalovirus (CMV) is a double-stranded DNA virus and is a member of the Herpesviridae family. (medscape.com)
The result is a transient period of immune compromise when hematopoietic stem cell transplant recipients are at risk of infectious complications associated with both latent (cytomegalovirus, Epstein-Barr virus, BK virus, human herpes virus 6, herpes simplex virus, varicella-zoster virus) and community-acquired viruses including adenovirus, respiratory syncytial virus, and parainfluenza virus. (nih.gov)

Within six weeks of treatment, 83% of the 12 adenovirus patients responded, as did 100% of the 27 BK virus patients, 96% of the 24 CMV patients, 100% of the two Epstein-Barr virus patients, and 75% of the four human herpes virus 6 patients. (scienceboard.net)

Serum antibodies against BK virus have also been found in spontaneous abortion affected women as well as in women who underwent voluntary interruption of pregnancy. (wikipedia.org)
In a case-control study nested within the EPIC-Oxford cohort, there were no statistically significant differences in the prevalence or titre of antibodies against BK virus measured in plasma taken prior to diagnosis between cases with cancer of the prostate (n=31), kidney (n=5) or bladder (n=9) and controls (n=45). (ox.ac.uk)

I am hopeful, like you, that because BK virus is common with kidney transplants maybe there is an established protocol that resolves it. (mayoclinic.org)
In immunocompromised populations, such as patients with AIDS and recipients of solid organ and hematopoietic stem cell transplants, BK polyomavirus (BKPyV) can reactivate and cause several diseases, which can lead to death in their severe forms. (biomedcentral.com)
Immunosuppression reactivates BK virus replication and is linked to hemorrhagic cystis in bone marrow transplants. (stanford.edu)

Nipah virus infection causes febrile encephalitis and aseptic meningitis. (stanford.edu)

Past infection with the BK virus is widespread, but significant consequences of infection are uncommon, with the exception of the immunocompromised and the immunosuppressed. (wikipedia.org)
Infection with the BK virus (BKV): In 1971, a renal transplant recipient suffering from ureteric stenosis had the BK virus isolated from his urine. (openpr.com)

Parainfluenza virus (PIV) is second in importance only to RSV as a cause of lower respiratory tract disease in children and pneumonia and bronchiolitis in infants younger than 6 months. (medscape.com)

I understand that said virus is common in kidney transplant recipients and should be addressed quickly. (mayoclinic.org)
We report 2 cases of kidney ± pancreas transplant recipients with evidence of BK polyomavirus reactivation, who developed aggressive urinary bladder urothelial carcinomas with adenocarcinomatous and/or micropapillary differentiation. (northwestern.edu)
The BK polyomavirus role in promoting urothelial neoplasia in transplant recipients may be partly indirect, based on the demonstration by polymerase chain reaction in both tumors of BK polyomavirus with intact open reading frames and close phylogenetic clustering with known replication- competent strains, and viral capsid protein VP1 messenger RNA and intranuclear virions by electron microscopy in 1 tumor. (northwestern.edu)
Clinical vigilance is warranted for early diagnosis of BK polyomavirus-related urothelial malignancies in transplant recipients. (northwestern.edu)
Comparison of polyomavirus (BK virus and JC viruses) viruria in renal transplant recipients with and without kidney dysfunction. (ac.ir)

It has been suggested that this virus may be transmitted through respiratory fluids or urine, since infected individuals periodically excrete virus in the urine. (wikipedia.org)
Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory tract infection in infants and children and the second most common viral cause of pneumonia in adults. (medscape.com)
In healthy individuals BK produces no clinical outcome or mild respiratory disease. (stanford.edu)

Taking everolimus may decrease your ability to fight infection from bacteria, viruses, and fungi and increase the risk that you will get a serious or life-threatening infection. (medlineplus.gov)
The 400 known viruses are classified in several ways: by genome core (RNA or DNA), host (animals, plants, or bacteria), method of reproduction (such as retrovirus), mode of transmission (such as enterovirus), and disease produced (such as hepatitis virus). (unboundmedicine.com)

It is thought that up to 80% of the population contains a latent form of this virus, which remains latent until the body undergoes some form of immunosuppression. (wikipedia.org)

The other family members include herpes simplex virus type 1 (HSV-1 or HHV-1) and herpes simplex virus type 2 (HSV-2 or HHV-2), varicella zoster virus (VZV), human herpes virus (HHV)-6, HHV-7, and HHV-8. (medscape.com)

The BK polyomavirus-induced profound effects on cell activation, cell cycle shift to proliferation, and apoptosis inhibition, in the context of marked immunosuppression, constitute a potentially ideal background for malignant transformation. (northwestern.edu)
The webinar will feature a presentation from Key Opinion Leader (KOL) Stanley C. Jordan, MD (Cedar Sinai), who will discuss the BK Virus (BKV), a polyoma virus that can be reactivated in settings of immunosuppression, such as in kidney transplant. (lifescievents.com)

January 13, 2023 -- Baylor College of Medicine and Washington University School of Medicine researchers studied posoleucel, an investigational off-the-shelf T-cell therapy that simultaneously targets six different viruses. (scienceboard.net)

MAU868 is the first neutralizing antibody targeting the BK Virus, to which Vera holds an exclusive worldwide license for the development and commercialization in all indications from Pfizer. (lifescievents.com)
Antibody levels against BK virus and prostate, kidney and bladder cancers in the EPIC-Oxford cohort. (ox.ac.uk)

I had the CMV virus eight months after my transplant which is now resolved. (mayoclinic.org)
In my reading, I see that it's not a problem to get a 2nd transplant after BK virus is cleared. (mayoclinic.org)
You have a great attitude and I hope you can recover from BK soon and get off dialysis/get second transplant. (mayoclinic.org)
I understand that said virus is common in kidney transplant. (mayoclinic.org)
In people who have had a kidney transplant , BK virus infection may cause loss of the kidney. (drugs.com)
BK polyomavirus (BKPyV) is a member of the Polyomaviridae family, and it was first identified in 1971 by electron microscopy of the urine and uroepithelial cells of a renal transplant recipient [ 1 ]. (biomedcentral.com)

In October 2021, Posoleucel (ViralymM, ALVR105) was given Orphan Drug Designation (ODD) by the US Food and Drug Administration (FDA) to treat virus-associated hemorrhagic cystitis (HC). (openpr.com)

This virus can be diagnosed by a BKV blood test or a urine test for decoy cells, in addition to carrying out a biopsy in the kidneys. (wikipedia.org)
An 'Undetected' test result indicates the absence of BK virus (BKV) DNA in the urine. (marshfieldlabs.org)
Diagnose the presence of the BK Virus in the blood or urine. (redcliffelabs.com)
Detect and qualifies the level of BK Virus in blood and urine. (redcliffelabs.com)
Your doctor may call for a blood or urine test to detect the BK Virus Infection. (redcliffelabs.com)

CMV has the largest genome of the herpes viruses. (medscape.com)

In March 2021, In order to assess ALVR105 (Viralym-M), an allogeneic, commercially available multi-virus specific T cell treatment, AlloVir started a Phase III trial. (openpr.com)

The BK virus, also known as Human polyomavirus 1, is a member of the polyomavirus family. (wikipedia.org)
A. BK Virus is an infection that belongs to the polyomavirus family that most people get in childhood and be active only when their immune system stops working. (redcliffelabs.com)

Although without any clinical symptoms, footprints of BK virus have been detected in specimens from females affected by spontaneous abortion. (wikipedia.org)
A relativiely quick virus, clinical manifestations of Nipah infection occur shortly after handling infected pigs. (stanford.edu)
Thus, a number of groups have explored the clinical potential of adoptively transferred virus-specific T cells (VSTs) as an approach to prevent/treat virus-associated complications. (nih.gov)
See Herpes Simplex Viruses: Test Your Knowledge , a Critical Images slideshow, for more information on clinical, histologic, and radiographic imaging findings in HSV-1 and HSV-2. (medscape.com)

The virus then disseminates to the kidneys and urinary tract where it persists for the life of the individual. (wikipedia.org)
In immunosuppressed individuals the virus can lead to hemorrhagic cystis, ureteral stenosis and some urinary tract illnesses.ic meningitis. (stanford.edu)

An accurate and early etiologic diagnosis is important because specific therapies are used against certain viruses. (medscape.com)
These guidelines update previous CDC recommendations for the diagnosis, treatment, and prevention of tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) in the United States. (cdc.gov)

The influenza viruses are the most common viral cause of pneumonia. (medscape.com)
Influenza pneumonia: Amantadine hydrochloride and rimantadine hydrochloride are approved for the prevention and treatment of influenza A virus infection. (medscape.com)
The common influenza viruses have antigens that mutate or combine readily, requiring new vaccines with each mutation. (unboundmedicine.com)

Viruses account for the largest proportion of childhood pneumonia. (medscape.com)
DNA and RNA viruses are involved in the etiology of viral pneumonia. (medscape.com)

BK virus is an abbreviation of the name of the first patient, from whom the virus was isolated in 1971 (the patient was then 29 years old). (wikipedia.org)

In the meantime, I am hopeful that someone on Mayo Connect has had some experience with the BK virus and may be able to give me a little heads up on the treatment, any symptoms, how long it takes to resolve, etc. (mayoclinic.org)
May I pick your brain a little for some details……Did you have any symptoms from the BK? (mayoclinic.org)
hello1234, I did not have any symptoms from the BK virus so it was a surprise to me. (mayoclinic.org)
Every individual shows different symptoms, and thus, doctors order a BK Virus Blood Test to confirm the condition and prescribe treatment according to the need. (redcliffelabs.com)

Under these circumstances, the virus can replicate robustly in proximal tubule epithelial cells (PT). (simonsfoundation.org)
ABBR: AAV A genus in the parvovirus family whose members cannot replicate without the presence of another virus. (unboundmedicine.com)

Studies on community-acquired pneumonias consistently demonstrate viruses to be the second most common etiologic cause (behind Streptococcus pneumoniae ), ranging from 13-50% of diagnosed cases. (medscape.com)

Of the 13 known polyomaviruses, BKvirus is one. (openpr.com)

Despite strong experimental evidence, BK polyomavirus involvement in human cancers has been controversial. (northwestern.edu)
These guidelines update previous CDC recommendations for treating and preventing active tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) (1-3). (cdc.gov)

I know that @caretakermom hubby had a challenge with CMV virus returning until they successfully revised the immune suppression meds. (mayoclinic.org)
A healthy immune system keeps the virus in check, but BK can be reactivated or 'wake up' when the immune system is suppressed, potentially damaging a transplanted kidney. (leeds.ac.uk)
However, these reports have focused on the entire non-specific immune diversity, and not directly on the cellular immunity specific to virus. (nature.com)
Viruses with lipid envelopes have a greater ability to adhere to cell membranes and to avoid destruction by the immune system. (unboundmedicine.com)
Brain infection is thought to occur by means of direct neuronal transmission of the virus from a peripheral site to the brain via the trigeminal or olfactory nerve and indirect immune-mediated processes inducing neuroinflammation. (medscape.com)

This patient also had positive result on polymerase chain reaction assay for herpes simplex virus, which is both sensitive and specific. (medscape.com)

Some of the most virulent diseases are caused by viruses, e.g., the hemorrhagic fever caused by Ebola virus. (unboundmedicine.com)

many people who are infected with this virus are asymptomatic. (wikipedia.org)

The circulating virus amount was reduced by an average of 97% in these patients. (scienceboard.net)

Our local neph does test for CMV and BK and a bunch of other labs periodically, we see him every 2-3 months. (mayoclinic.org)
Yes, my labs showed the BK virus at my 2 year checkup. (mayoclinic.org)
You can book BK Virus Test in Arrha with Redcliffe Labs. (redcliffelabs.com)

Viral architecture is very complex, but every virus contains at least a genome and a capsid. (unboundmedicine.com)

The problem with the virus is that it spreads via the blood and settles silently in the kidneys and sometimes the brain. (redcliffelabs.com)

If you spectate the notification of Behavior:Win64/AbuseCommBack.BK!sms detection, it seems that your PC has a problem. (howtofix.guide)
The Behavior:Win64/AbuseCommBack.BK!sms detection you can see in the lower right side is demonstrated to you by Microsoft Defender . (howtofix.guide)

Show your anger at China's constant lying and allowing this Coronavirus to spread with this China Virus Sucks Face Mask Double Strap Black. (boycottchinanow.com)

BK Virus or BKV Infection is the most common yet serious viral infection that can spread from one person to another during organ transplantation or from a mother to a baby during pregnancy. (redcliffelabs.com)

Improved treatment options are needed, including the ability to target multiple viruses with a single therapy. (scienceboard.net)
A virus with reduced pathogenicity as a result of treatment or repeated passage through hosts. (unboundmedicine.com)

Anatomy10

Organisms113

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Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes44

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Health Care2

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Infections18

Cytomegalovirus3

Adenovirus1

Antibodies against BK virus2

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Parainfluenza1

Recipients5

Respiratory3

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Latent1

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