• Thymus - Atypical hyperplasia, Lymphocyte in a female p53+/- (C57Bl/6) mouse from a subchronic study. (nih.gov)
  • We have studied the ionic basis for this second or regulatory volume decrease (RVD) phase using lymphocytes from peripheral blood, tonsil, and thymus. (jci.org)
  • The increase in K+ permeability in response to hypotonic challenge was characteristic for T lymphocytes obtained from peripheral blood, tonsil, or thymus. (jci.org)
  • Erowid.org: Erowid Reference 2931 : Cytotoxic Effects Induced by Various Agents in Rat Thymus Lymphocytes. (erowid.org)
  • Thymus derived lymphocytes (T cells) in patients with genital warts. (bmj.com)
  • The analysis was extended to immature lymphocytes of the thymus, and population of thymocytes was identified which was able to form junctions with murine fibroblasts, Swiss 3T3 and a BALB/c 3T3 and the hypoxanthine guanine phosphoribosyl transferase mutant (HGPRT-) subline of BHK/C13 baby hampster kidney fibroblast line TG2. (gla.ac.uk)
  • Thymus, thymic hormones and T lymphocytes / edited by F. Aiuti, H. Wigzell. (who.int)
  • Following exposure to hypotonic media, human peripheral blood lymphocytes swell initially but restore their isotonic volume within minutes. (jci.org)
  • The data confirm that the response of peripheral blood and tonsillar lymphocytes to a hypotonic environment can be accounted for by differences in the proportions of T and B cells, and the differential behaviour of B and T lymphocytes is based on differences in membrane permeability to K+ upon swelling. (jci.org)
  • The LSM 12.125 antibody reacts with the canine form of the 56 kDa transmembrane glycoprotein, CD4, present on the T-helper/inducer subset of normal canine donor peripheral blood lymphocytes. (bdbiosciences.com)
  • The LSM 8.358 antibody reacts with a CD3-like T-cell receptor-associated cell-surface antigen found on thymocytes and peripheral T lymphocytes. (bdbiosciences.com)
  • Production of interferons and change of the lymphocyte subpopulation phenotype in peripheral blood at cervical papillomavirus infection. (wikigenes.org)
  • This study was taken up to evaluate the antigenotoxic potential of ginger in human peripheral blood lymphocytes. (scialert.net)
  • In vitro treatment of peripheral blood lymphocytes with TSO induced significant number of micronuclei in all samples. (scialert.net)
  • The aim of our research was to determine how immunotherapy changes the proportion of lymphocyte subsets in dog peripheral blood and the levels of cytokines secreted by these cells during therapy. (mdpi.com)
  • Clinical studies are also underway to evaluate TIL in earlier stage cancers in combination with currently approved treatments, and to investigate Iovance peripheral blood lymphocyte (PBL) T cell therapy for blood cancers. (biospace.com)
  • Peripheral blood lymphocytes (PBL) were examined, to resolve the conflict in the literature as to the ability of PBL to form communicating junctions. (gla.ac.uk)
  • The NK cells are sometimes labeled "large granular lymphocytes," while the T cells and B cells are labeled as "small lymphocytes. (newworldencyclopedia.org)
  • This lesion is characterized by depletion of small lymphocytes and a diffuse change with loss of the normal thymic corticomedullary junction. (nih.gov)
  • The small lymphocytes became hyperchromatic and enlarged 3 days after antigen administration, and pyanotic in 7 days, an effect enhanced by reserpine and LSD. (erowid.org)
  • In addition, leukocyte and lymphocyte subsets were analyzed via flow cytometry, and the production of lipopolysaccharide-induced interleukin 6 and tumor necrosis factor alpha was measured before and then 5 and 45 min after the orgasm. (karger.com)
  • Conclusions Lymphocyte counts recovered to LLN after a single course of alemtuzumab in approximately 8 months (B cells) and 3 years (T cell subsets), but usually did not recover to baseline values. (bmj.com)
  • The CD8α and β chains (CD8a and CD8b, respectively) form a heterodimer on the surface of most thymocytes and a subpopuplation of mature T-lymphocytes (ie, MHC class I-restricted T cells, including most T suppressor/cytotoxic cells). (bdbiosciences.com)
  • NK cells are a type of cytotoxic (cell toxic) lymphocyte that represent a major component of the inherent immune system. (differencebetween.net)
  • Identification of type-specific cytotoxic T lymphocyte responses to homologous viral proteins in laboratory workers accidentally infected with HIV-1. (jci.org)
  • Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. (jci.org)
  • Activation of Cytotoxic Lymphocytes Through CD6 Enhances Killing of Cancer Cells. (bvsalud.org)
  • Tumor -infiltrating cytotoxic lymphocytes were found in higher proportions and were activated in UMCD6-treated mice compared to controls. (bvsalud.org)
  • Thus, the CD6-CD318 axis can regulate the activation state of cytotoxic lymphocytes and their positioning within the tumor microenvironment . (bvsalud.org)
  • Now-a-days, the market of immunotherapy is more attributed towards developing Tumor-Infiltrating Lymphocytes for causing complete remission of the tumor cells from the cancer patients. (researchandmarkets.com)
  • The treatment regimen associated with the TIL therapy comprises of collection of lymphocytes that have the ability to engage themselves in the tumor cells destruction. (researchandmarkets.com)
  • PD-L1 was expressed mainly by macrophages (not by tumor cells) and PD-1 by lymphocytes. (lu.se)
  • To assess whether HBoV is present in tonsillar lymphocytes and therefore possibly explain the high rate of PCR positives obtained by Longtin et al. (cdc.gov)
  • In contrast, tonsillar lymphocytes demonstrate a similar initial phase of swelling but fail to restore their isotonic volume. (jci.org)
  • Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. (nature.com)
  • Wang, J. (2014) The Clinical Significance of Tumor-Infiltrating Neutrophils and Neutrophil-to-CD8+ Lymphocyte Ratio in Patients with Resectable Esophageal Squamous Cell Carcinoma. (scirp.org)
  • What causes high neutrophils, low lymphocytes & WBC? (healthtap.com)
  • What dose it mean when your WBC high at 12.6 my segmented neutrophils is high 88.5 my lymphocytes is low 6.9? (healthtap.com)
  • HIV infection is characterized by a decrease and, eventually, a depletion of CD4+ T-lymphocytes (helper T cells). (cdc.gov)
  • Using immunophenotyping, HIV-positive blood samples and age-matched controls were tested for the proportion of lymphocytes that are T cells, B cells, natural killer (NK) cells, CD4+ T cells (helper T cells), and CD8+ T cells (suppressor/inducer T cells). (cdc.gov)
  • Detection of gene expression specific for different kind of immune cell populations can then be used to determine the degree of lymphocyte infiltration as has been shown in breast cancer. (wikipedia.org)
  • Thus, women with greater lymphocyte tumor infiltration had better outcome and PD-L1/PD-1 expression, regardless of PD-1/PD-L1 being markers for immune suppressive pathways, conferred a survival benefit in our cohort. (lu.se)
  • Bare lymphocyte syndrome type I (BLS I) is an inherited disorder of the immune system (primary immunodeficiency). (medlineplus.gov)
  • A lymphocyte is a type of white blood cell (leukocyte) in the vertebrate immune system . (newworldencyclopedia.org)
  • Other lymphocyte-like cells are commonly known as natural killer cells, or NK cells, and are part of the innate immune system . (newworldencyclopedia.org)
  • The two main categories of lymphocytes are the B lymphocytes ( B cells ) and T lymphocytes ( T cell ), both of which are involved in the adaptive immune system (Alberts 1989). (newworldencyclopedia.org)
  • In addition, lymphocyte-like cells called natural killer (NK) cells are involved in the immune system, albeit part of the innate immune system . (newworldencyclopedia.org)
  • The adaptive immune system is based on dedicated lymphocytes. (newworldencyclopedia.org)
  • Lymphocytes are a type of white blood cells in the immune system. (differencebetween.net)
  • The immune system can remember every antigen encountered because after an encounter, some lymphocytes develop into memory cells. (msdmanuals.com)
  • Identification of differences between the two major lymphocyte subpopulations. (jci.org)
  • What could it mean that my mother has high WBC(11600) & lymphocyte countis very low(22), and slightly low neutrophil count. (healthtap.com)
  • The effect of PSK, a protein-bound polysaccharide and an immunomodulator, on lymphocytes was examined in vitro for 36 patients with gastric cancer and 26 with colorectal cancer. (unboundmedicine.com)
  • Our findings thus show that the in vitro activation of lymphocytes by PSK can help identify the candidates with either gastric or colorectal cancer who are the best suited to undergo immunochemotherapy including treatment with PSK. (unboundmedicine.com)
  • Thymocytes were fractionated using a range of monoclonal antibodies specific for a range of lymphocyte surface antigens using complement mediated cytotoxicity (CMC) and fluorescence activated cell sorting (FACS). (gla.ac.uk)
  • Lymphocytes enable the body to remember antigens and to distinguish self from harmful nonself (including viruses and bacteria). (msdmanuals.com)
  • In several models of lymphocyte apoptosis, two alterations of mitochondrial function precede advanced DNA fragmentation: (1) a reduction of mitochondrial transmembrane potential (delta psi m) and (2) an increase in mitochondrial generation of superoxide anion. (nih.gov)
  • The process can also involve a preliminary chemotherapy regimen to deplete endogenous lymphocytes in order to provide the adoptively transferred TILs with enough access to surround the tumor sites. (wikipedia.org)
  • High levels of interleukin-2 receptors (IL-2R) can be found mainly on the surface of activated T lymphocytes (both CD4+ and CD8+, mainly Th1 lymphocytes) [ 1 - 3 ] after endogenous stimulation. (springer.com)
  • Autoradiographic studies of chromosomes after pulse-labelling with 3 H-thymidine during the terminal 6 h of phytohaemagglutinin-stimulated lymphocyte cultures revealed a differential pattern of distribution of the radionucleotide in the chromosomes of megaloblastic lymphocytes as compared to those from normal lymphocytes. (karger.com)
  • While offering protection against millions of possible invaders, including viruses , bacteria , are cancer cells, lymphocytes allow normal body cells and helpful, symbiotic bacteria to flourish at the same time. (newworldencyclopedia.org)
  • Meanwhile, the two types of W.B.C.'s under agranulocytes are monocytes which consume bacteria and lymphocytes which was elaborated above. (differencebetween.net)
  • To demonstrate the relation between optic neuritis (ON) and systemic inflammation markers as neutrophil lymphocyte ratio (N/L ratio), platelet count, mean platelet volume (MPV), and red cell distribution width (RDW) and furthermore to evaluate the utilization of these markers to predict the frequency of the ON episodes. (hindawi.com)
  • Neutrophil lymphocyte ratio (N/L ratio) is an effective, easy, and inexpensive method to determine systemic inflammation in various diseases such as cancer, hypertension, diabetes mellitus, and coronary artery disorders [ 10 , 11 ]. (hindawi.com)
  • Neutrophil lymphocyte (N/L) ratio was assessed before second line chemotherapy. (scirp.org)
  • Wang, X. (2014) Neutrophil to Lymphocyte Ratio in Relation to Risk of All-Cause Mortality and Cardiovascular Events among Patients Undergoing Angiography or Cardiac Revascularization: A Meta-Analysis of Observational Studies. (scirp.org)
  • Xue, P. (2014) Neutrophil-to-Lymphocyte Ratio for Predicting Palliative Chemotherapy Outcomes in Advanced Pancreatic Cancer Patients. (scirp.org)
  • The Neutrophil to Lymphocyte Ratio (NLR) calculator is created by QxMD. (qxmd.com)
  • The aim of this study was finding dependence between otitis media with effusion and coexistent hypertrophy adenoids, and percentage of lymphocytes CD19+ with expression of antigen CD23+ in hypertrophy adenoids. (unboundmedicine.com)
  • As regards on different functions of antigen CD23+ the assessment of percentage lymphocytes B with expression of CD23+ can be additional marker in course immunological and inflammatory processes to occur in hypertrophy adenoids at children are sick otitis media with effusion. (unboundmedicine.com)
  • The implications of the immature surface antigen expression and the ability to form junctions are discussed and the position of thymocytes which can form junctions in intrathymic lymphocyte differentiation and development are explored. (gla.ac.uk)
  • Thus, this study investigated the effects of masturbation-induced orgasm on lymphocyte circulation and cytokine production in healthy young males. (karger.com)
  • In some cases, T cells may present, as a result of residual autologous cells or transplacentally acquired maternal lymphocytes [ 1 ]. (hindawi.com)
  • B-lymphocytes undergo isotype switching, and IgM, IgG, and IgA antibodies are found in the neuropil adjacent to the lesion. (jneurosci.org)
  • The distribution on lymphocytes for canine is similar to that found for both human and monkey, with the majority of CD4-positive lymphocytes being CD8-negative and lacking reactivity with antibodies to B- or NK-cell markers. (bdbiosciences.com)
  • Lympho-depletion is thought to eliminate the negative effects of other lymphocytes that may compete for growth factors and decrease anti-tumor effects of the TILs, depleting regulatory or inhibitory lymphocyte populations. (wikipedia.org)
  • The origin of the reactive cells in such patients are either thymic release of T-cells that expand at the periphery or transplacentally transfers of maternal T lymphocytes. (hindawi.com)
  • Atypical hyperplasia of the thymic lymphocytes has been described in chemically treated B6C3F1 and p53-deficient mice. (nih.gov)
  • Atypical hyperplasia of the thymic lymphocytes is regarded as a proliferative change that may progress to lymphoma, although it may occur without progression. (nih.gov)
  • Whenever present, atypical hyperplasia of the thymic lymphocytes should be diagnosed and assigned a severity grade. (nih.gov)
  • but many of these morphological chromosomal changes (i.e. despiralization and breaks) persisted in the lymphocytes of a significant proportion of patients for variable periods up to 6-12 months after haematological remission resulting from therapy with the deficient vitamins. (karger.com)
  • In response to short DNA fragments, lymphocytes release mitochondrial DNA that helps trigger an immune response. (the-scientist.com)
  • Here we show that two fluorochromes allow for the identification of analogous mitochondrial perturbations in circulating T lymphocytes from human immunodeficiency virus (HIV)-1+ donors. (nih.gov)
  • In synthesis, it appears that mitochondrial alterations occur in a significant percentage of circulating T lymphocytes from HIV-1 carriers. (nih.gov)
  • Tumor-infiltrating lymphocytes (TIL) are white blood cells that have left the bloodstream and migrated towards a tumor. (wikipedia.org)
  • on cells, including infection-fighting white blood cells (lymphocytes), which is where the condition got its name. (medlineplus.gov)
  • Lymphocytes are white blood cells involved in the immune response, so-called because of their association with lymph tissue. (rkm.com.au)
  • A rogue hybrid lymphocyte, bearing characteristics of both B and T cells, may play a role in driving autoimmunity in the disease, although the mechanism is far from clear. (the-scientist.com)
  • A stained lymphocyte surrounded by red blood cells viewed using a light microscope. (newworldencyclopedia.org)
  • While the autoreactive cells displayed significantly reduced Tregs numbers, the alloreactive transplacentally acquired maternal lymphocytes had high functional Tregs. (hindawi.com)
  • A distinctive feature of SCID patients, which sometimes can clinically resemble Omenn, [ 6 ] is the presence of alloreactive cells originated from transplacentally maternal T lymphocytes. (hindawi.com)
  • 1.Lymphocytes are a type of white blood cells while leukocytes are equivalently termed in general as white blood cells. (differencebetween.net)
  • Chromosomal studies were performed in phytohaemagglutinin-stimulated cultures of lymphocytes and in bone marrow cells without culture from 115 patients with megaloblastic anaemia resulting from nutritional deficiency of folate and vitamin B 12 Essentially similar chromosomal abnormalities were observed in the two cell lines. (karger.com)
  • Cultured lymphocytes with PSK at 100 micrograms/ml increased the level of DNA synthesis, as determined by the 3H-thymidine uptake, from 0.9 to 3.0 fold, compared to the PSK non-treated cells. (unboundmedicine.com)
  • median recovery times for CD8 (LLN ≥0.2×10 9 cells/l) and CD4 lymphocytes (LLN ≥0.4×10 9 cells/l) were 20 months and 35 months, respectively. (bmj.com)
  • Tumor infiltrating lymphocyte (TIL) therapy uses a patient's own immune cells to attack cancer. (biospace.com)
  • CD6, expressed by T-lymphocytes and human NK cells , engages in cell - cell interactions by binding to its ligands CD166 ( ALCAM ) and CD318 (CDCP1). (bvsalud.org)
  • Analysis of tumor -infiltrating immune cells showed that augmentation of lymphocyte cytotoxicity by UMCD6 is due to effects of this antibody on NK, NKT and CD8+ T cells . (bvsalud.org)
  • B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
  • Photomicrograph of a blood smear from a dog with a reactive lymphocyte, a nonspecific indicator of immune stimulation. (merckvetmanual.com)
  • The presence of lymphocytes in tumors is often associated with better clinical outcomes (after surgery or immunotherapy). (wikipedia.org)
  • We mapped the presence of macrophages (CD68 and CD163) and lymphocytes (CD3) located within the tumor epithelium, the cell type-specific expression of PD-L1 and PD-1, and their impact on 5-year overall survival (OS) in a consecutive cohort of 130 women diagnosed with advanced HGSC between 2011 and 2015. (lu.se)
  • These findings raise the possibility that milk contributes to mucosal immunity not only by furnishing antimicrobial molecules but also by policing the function of lymphocytes and epithelium. (lu.se)
  • Background Alemtuzumab is a lymphocyte depleting monoclonal antibody that has demonstrated superior efficacy over interferon β-1a for relapsing-remitting multiple sclerosis (MS), and is currently under investigation in phase 3 trials. (bmj.com)
  • Here we demonstrate that disrupting the CD6-CD318 axis with UMCD6, an anti-CD6 monoclonal antibody , prolongs survival of mice in xenograft models of human breast and prostate cancer , treated with infusions of human lymphocytes . (bvsalud.org)
  • Bidirectional mixed cultures were performed with lymphocytes from healthy controls and allergic patients with different time periods of IT, and the supernatants obtained from chromatography were tested to determine their effect on IgE synthesis of normal lymphocytes. (cun.es)
  • Suppressor factors derived from allergic patients had no effect on IgE synthesis of normal lymphocytes. (cun.es)
  • There are reports of oligoclonal bands in the CSF of stroke patients, suggesting that in some people a B-lymphocyte response to stroke may occur in the CNS. (jneurosci.org)
  • 1 ) in their patient controls, we tested DNA extracts of lymphocytes separated by Ficoll-Paque from nasopharyngeal tonsils or adenoids (AL) and palatine/lingual tonsils (TL) from 164 patients (mostly children) undergoing routine adenoidectomies and tonsillectomies for HBoV DNA. (cdc.gov)
  • We discovered that, in mouse models, activated B-lymphocytes infiltrate infarcted tissue in the weeks after stroke. (jneurosci.org)
  • As per "Global Tumor Infiltrating Lymphocytes Immunotherapy Market Opportunity & Clinical Trials Insight 2025" report findings, it is estimated that the innovative research and development sector has excited the oncology researchers for driving the overall oncology pharmaceutical industry. (researchandmarkets.com)
  • The Cambridge Biotech HIV-1 Western Blot Kit is manufactured by Calypte Corporation from HIV-I propagated in an H9/HTLV-IIIb T-lymphocyte cell line. (cdc.gov)
  • Its T-cell receptors (TCR) differentiate themselves from other lymphocyte types. (differencebetween.net)
  • In the study showed higher significant percentage of lymphocytes CD19+ CD23+ at children in otitis media with effusion (20.08+/-2.93) with reference to comparative group, which was only hypertrophy adenoid (18.16+/-2.25). (unboundmedicine.com)
  • These observations may be important for the understanding and for the direct ex vivo quantitation of HIV-triggered lymphocyte destruction. (nih.gov)