AzactamCAYSTONInjectionMonobactamAntibioticGentamicinImipenemAntibioticsBeta-lactamCeftazidime2023IsolatesBacterialAvibactamCefotaximeTobramycinInfectionsBacteriaRenal insufficiencyAllergicHypersensitivitySerumIntravenouslyIntramuscularSusceptibleResistanceCombinationGenerallyPatientsPregnancyDoseTherapy
Azactam4
- Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa. (wikipedia.org)
- Aztreonam is poorly absorbed when given orally, so it must be administered as an intravenous or intramuscular injection (trade name Azactam), or inhaled (trade name Cayston) using an ultrasonic nebulizer. (wikipedia.org)
- AZACTAM ® (aztreonam for injection, USP) delivers proven efficacy in the management of certain Gram-negative infections. (bmscustomerconnect.com)
- AZACTAM ® (aztreonam for injection, USP) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. (bmscustomerconnect.com)
CAYSTON1
- Do not take CAYSTON if you are allergic to aztreonam, or any of the ingredients in CAYSTON. (cayston.com)
Injection26
- Aztreonam injection is used to treat certain infections that are caused by bacteria, including respiratory tract (including pneumonia and bronchitis), urinary tract, blood, skin, gynecological, and abdominal (stomach area) infections, that are caused by bacteria. (medlineplus.gov)
- Aztreonam injection also may be used before, during, and sometimes for a brief period after surgery in order to prevent the patient from getting an infection. (medlineplus.gov)
- Antibiotics such as aztreonam injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
- Aztreonam injection comes as a powder to be mixed with liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle). (medlineplus.gov)
- How often you receive aztreonam injection and the length of your treatment depends on the type of infection you have and how your body responds to the medication. (medlineplus.gov)
- Your doctor will tell you how long to use aztreonam injection. (medlineplus.gov)
- You may receive aztreonam injection in a hospital, or you may use the medication at home. (medlineplus.gov)
- If you will be using aztreonam injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
- You should begin to feel better during the first few days of treatment with aztreonam injection. (medlineplus.gov)
- Use aztreonam injection until you finish the prescription, even if you feel better. (medlineplus.gov)
- If you stop using aztreonam injection too soon or if you skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
- Aztreonam injection is also sometimes used to treat patients who have fever and are at high risk for infection because they have a low number of white blood cell. (medlineplus.gov)
- If you become pregnant while using aztreonam injection, call your doctor. (medlineplus.gov)
- Aztreonam injection may cause side effects. (medlineplus.gov)
- Aztreonam 1GM Injection - Sold in the Indian market by the brand name Azlock, this injection is rich in the properties of Aztreonam. (medlockhealthcare.in)
- Available in the market with the properties of Aztreonam, Azlock injection belongs to the group of antibiotics that works by destroying the infection-causing bacteria. (medlockhealthcare.in)
- Further, Aztreonam 1GM Injection also stops the bacterial infection from spreading to other body parts as well. (medlockhealthcare.in)
- The usage of Aztreonam 1GM Injection does not usually impair the ability to focus or ability to drive. (medlockhealthcare.in)
- It is suggested by the healthcare experts to use Aztreonam 1GM Injection carefully if you have underlying kidney or liver issues. (medlockhealthcare.in)
- If you are pregnant, breastfeeding, or planning to conceive, then notify your doctor regarding the same before using Aztreonam 1GM Injection. (medlockhealthcare.in)
- Manufacturer of a wide range of products which include aztreonam injection 500 mg, aztreonam 1gm injection and aztrack 250mg azetreonam. (alvislabs.com)
- Aztreonam for Injection may be administered intravenously or by intramuscular injection. (pfizermedicalinformation.com)
- Generally, aztreonam for injection should be continued for at least 48 hours after the patient becomes asymptomatic or evidence of bacterial eradication has been obtained. (pfizermedicalinformation.com)
- Therefore, the dosage of aztreonam for injection should be halved in patients with estimated creatinine clearances between 10 and 30 mL/min/1.73 m 2 after an initial loading dose of 1 or 2 g. (pfizermedicalinformation.com)
- Aztreonam for Injection should be administered intravenously to pediatric patients with normal renal function. (pfizermedicalinformation.com)
- To reduce the development of drug-resistant bacteria and maintain the effectiveness of Aztreonam for Injection, USP and other antibacterial drugs, aztreonam for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. (pfizermedicalinformation.com)
Monobactam3
- Aztreonam is in a class of medications called monobactam antibiotics. (medlineplus.gov)
- The combination antibiotic consists of aztreonam, a monobactam β-lactam and avibactam, a broad-spectrum β-lactamase inhibitor. (empr.com)
- NCT03580044 ) studies were conducted to evaluate the efficacy and safety of the novel antibiotic combination, which consists of a monobactam β-lactam (aztreonam) and a broad-spectrum β-lactamase inhibitor (avibactam). (empr.com)
Antibiotic5
- The investigational antibiotic combination aztreonam-avibactam was found to be effective for treating serious bacterial infections caused by Gram-negative bacteria, according to findings from two phase 3 studies. (empr.com)
- Aztreonam is a synthetic β-lactam antibiotic originally isolated from Chromobacterium violaceum . (toku-e.com)
- Aztreonam is a broad-spectrum antibiotic commonly used in plant tissue culture to control bacterial contamination from Gram-negative species. (toku-e.com)
- Aztreonam is commonly used to treat people who are allergic to some beta-lactam antibiotics and is used in combination with other antibiotics to treat certain antibiotic-resistant bacteria. (msdmanuals.com)
- Aztreonam Aztreonam is the only antibiotic in an antibiotic class called monobactams, which are a subclass of beta-lactam antibiotics (antibiotics that have a chemical structure called a beta-lactam ring). (merckmanuals.com)
Gentamicin1
- Combined aztreonam and gentamicin therapy for pseudomonal lower respiratory tract infections. (druglib.com)
Imipenem1
- aztreonam and imipenem are also potential third line drugs. (pediatriconcall.com)
Antibiotics4
- Because of the unfused beta-lactam ring there is somewhat lower cross-reactivity between aztreonam and many other beta-lactam antibiotics, and it may be safe to administer aztreonam to many patients with hypersensitivity (allergies) to penicillins and nearly all cephalosporins. (wikipedia.org)
- There is a much lower risk of cross-sensitivity between aztreonam and other beta-lactam antibiotics than within other beta-lactam antibiotics. (wikipedia.org)
- We believe these data demonstrate that [aztreonam-avibactam], if approved, could be an important treatment option for patients with life-threatening bacterial infections that are resistant to almost all currently available antibiotics," said James Rusnak, Senior Vice President and Chief Development Officer, Internal Medicine, Anti-Infectives and Hospital, Pfizer. (empr.com)
- Like the other beta-lactam antibiotics, aztreonam works by preventing bacteria from forming this cell wall, resulting in death of the bacteria. (msdmanuals.com)
Beta-lactam1
- Aztreonam-flucloxacillin double beta-lactam treatment as empirical therapy of serious infections in very elderly patients. (druglib.com)
Ceftazidime4
- Aztreonam can be safely used in patients with a penicillin or cephalosporin allergy (except for patients with a ceftazidime allergy as ceftazidime and aztreonam share a similar side chain). (wikipedia.org)
- In these circumstances aztreonam is combined with avibactam (ceftazidime/avibactam). (wikipedia.org)
- Multicenter Evaluation of an MIC-Based Aztreonam and Ceftazidime-Avibactam Broth Disk Elution Test. (bvsalud.org)
- Due to limited therapeutic options, there is a clinical need to assess the in vitro activity of the combination of aztreonam (ATM) and ceftazidime -avibactam (CZA) to guide the therapeutic management of multidrug-resistant (MDR) Gram-negative organism infections . (bvsalud.org)
20231
- 2023. https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/51088/all/aztreonam. (unboundmedicine.com)
Isolates3
- The combination of aztreonam and avibactam has demonstrated to be active against 80% of MBL isolates reaching a clinical infection resolution in 80% of MBL-infected patients. (wikipedia.org)
- Aztreonam is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against negative microbial isolates. (toku-e.com)
- all three isolates were aztreonam resistant, presumably by a different mechanism. (cdc.gov)
Bacterial1
- Aztreonam inhibits cell wall synthesis by blocking peptidoglycan crosslinking to cause bacterial death. (wikipedia.org)
Avibactam7
- The combination of aztreonam and avibactam are in phase 3 clinical trails. (wikipedia.org)
- Study participants were randomly assigned to receive aztreonam-avibactam ± metronidazole or meropenem ± colistin. (empr.com)
- The clinical cure rates in the intention-to-treat analysis sets were reported to be 76.4% (95% CI, 70.3-81.8) and 45.9% (95% CI, 34.9-57.3) among patients with cIAI and HAP/VAP treated with aztreonam-avibactam ± metronidazole, respectively. (empr.com)
- Among cIAI patients, the all-cause mortality rates were 1.9% with aztreonam-avibactam ± metronidazole vs 2.9% with meropenem ± colistin. (empr.com)
- Among those with HAP/VAP, the all-cause mortality rates were 10.8% and 19.4% in the aztreonam-avibactam ± metronidazole and meropenem ± colistin groups, respectively. (empr.com)
- These findings were further supported by results from the ASSEMBLE study, which included 15 adult patients and compared aztreonam-avibactam to best available therapy. (empr.com)
- Findings from REVIST and ASSEMBLE will form the basis of the regulatory submission for aztreonam-avibactam. (empr.com)
Cefotaxime1
- Naber KG, Dette GA, Kees F, Knothe H, Grobecker H. Pharmacokinetics, in vitro activity, therapeutic efficacy, and clinical safety of aztreonam vs. cefotaxime in the treatment of complicated urinary tract infections. (druglib.com)
Tobramycin2
- Staphylococcus aureus 8 - >128 μg/ml Staphylococcus epidermidis 8 - 32 μg/ml Streptococcus pyogenes 8 - ≥128 μg/ml Synergism between aztreonam and arbekacin or tobramycin against P. aeruginosa has been suggested. (wikipedia.org)
- Moreau-Marquis S, Coutemarsh B, Stanton BA (2015) Combination of hypothiocyanite and lactoferrin (ALX-109) enhances the ability of tobramycin and aztreonam to eliminate biofilms growing on cystic fibrosis airway epithelial cells. (toku-e.com)
Infections3
- Aztreonam use has been recently reconsidered for human infections sustained by metallo-beta-lactamase (MBL)-producing Gram-negative bacteria. (wikipedia.org)
- Aztreonam in the treatment of serious gram-negative infections in the elderly. (druglib.com)
- Aztreonam is effective against infections caused by Gram-negative bacteria but must be used in combination to provide Gram-positive coverage. (toku-e.com)
Bacteria3
- Aztreonam has strong activity against susceptible gram-negative bacteria, including Pseudomonas aeruginosa. (wikipedia.org)
- Aztreonam is effective against Gram-negative bacteria. (toku-e.com)
- has been identified as the 2nd most consensus (ERIC) sequences which · 60 environmental samples were tak- frequent organism causing ventilator- are common to Gram-negative enteric en throughout the ICU, including associated pneumonia, the 4th most bacteria [11,12]. (who.int)
Renal insufficiency2
- Safety of aztreonam and SQ 26,992 in elderly patients with renal insufficiency. (druglib.com)
- Prolonged serum levels of aztreonam may occur in patients with transient or persistent renal insufficiency. (pfizermedicalinformation.com)
Allergic1
- Those who are allergic to other β-lactam have a low rate of allergy to aztreonam. (wikipedia.org)
Hypersensitivity1
- This preparation is contraindicated in patients with known hypersensitivity to aztreonam or any other component in the formulation. (druglib.com)
Serum1
- If necessary, aztreonam may be cleared from the serum by hemodialysis and/or peritoneal dialysis. (druglib.com)
Intravenously1
- When aztreonam is injected intravenously, it is usually infused (injected slowly) over a period of 20 minutes to 1 hour. (medlineplus.gov)
Intramuscular1
- Of 108 consecutive patients with urogenital gonorrhoea treated with a single 1 g intramuscular dose of aztreonam, 102 were suitable for evaluation. (bmj.com)
Susceptible1
- Acinetobacter anitratus, Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis are generally susceptible to aztreonam, while some staphylococci, Staphylococcus aureus, Staphylococcus haemolyticus and Xanthomonas maltophilia are resistant to it. (wikipedia.org)
Resistance2
- and Streptococcus pyogenes have developed resistance to aztreonam to varying degrees. (wikipedia.org)
- In vitro resistance to aztreonam was not noted. (bmj.com)
Combination1
- Data from both trials also showed that the combination treatment was well tolerated and had a similar safety profile to aztreonam alone . (empr.com)
Generally1
- Use of aztreonam during breastfeeding is generally considered acceptable. (msdmanuals.com)
Patients3
- Jones PG et al (1986) Aztreonam therapy in neutropenic patients with cancer. (toku-e.com)
- En Égypte, des isolats prélevés sur les tubulures d'appareils d'aspiration et de respiration artificielle (A8) et sur les cuvettes (A7) étaient liés à ceux prélevés chez les patients ayant ces antibiotypes. (who.int)
- En Égypte, les isolats des patients étaient de types ERIC VII, VIII et IX et correspondaient à ceux des tubulures des appareils d'aspiration et de respiration artificielle et des cuvettes. (who.int)
Pregnancy1
- Aztreonam should be taken during pregnancy only when the benefits of treatment outweigh the risks. (msdmanuals.com)
Dose1
- Single dose aztreonam in treating gonorrhoea. (bmj.com)
Therapy1
- Aztreonam is used in microbiology, cancer therapy, and plant tissue culture applications. (toku-e.com)