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  • nitrogen
  • Aza-Cope rearrangements are generally classified by the position of the nitrogen in the molecule (see figure): The first example of an aza-Cope rearrangement was the ubiquitous cationic 2-aza-Cope Rearrangement, which takes place at temperatures 100-200 °C lower than the Cope rearrangement due to the facile nature of the rearrangement. (wikipedia.org)
  • The presence of the ionic nitrogen heteroatom accounts for the more facile rearrangement of the cationic 2-aza-Cope rearrangement in comparison to the Cope rearrangement. (wikipedia.org)
  • IUPAC
  • A stannatrane (IUPAC: 1-aza-5-stannabicyclo[3.3.ndecane) is a tin-based atrane belonging to the larger class of organostannanes. (wikipedia.org)
  • synthetic
  • These characteristics explain the great difficulty encountered when trying to prepare this compound from simple precursors, using methods of synthetic organic chemistry. (wikipedia.org)
  • The 1- and 3-aza-Cope rearrangements have high activation barriers and limited synthetic applicability, accounting for their relative obscurity. (wikipedia.org)
  • To maximize its synthetic utility, the cationic 2-aza-Cope rearrangement is normally paired with a thermodynamic bias toward one side of the rearrangement. (wikipedia.org)
  • This tandem aza-Cope/Mannich reaction is characterized by its mild reaction conditions, diastereoselectivity, and wide synthetic applicability. (wikipedia.org)
  • It is the most extensively studied of the aza-Cope rearrangements due to the mild conditions required to carry the arrangement out, as well as for its many synthetic applications, notably in alkaloid synthesis. (wikipedia.org)
  • reactions
  • Rearrangements, especially those that can participate in cascade reactions, such as the aza-Cope rearrangements, are of high practical as well as conceptual importance in organic chemistry, due to their ability to quickly build structural complexity out of simple starting materials. (wikipedia.org)
  • reaction
  • High molecular weight linear polycarbonates are prepared by continuous condensation of organic dihydroxy compounds and phosgene in two reaction zones, a mixture of an aqueous-alkaline solution of the organic dihydroxy compound and an aqueous catalyst solution being introduced at the rate of from 1 to. (google.com)
  • Thermodynamically, the general 2-aza-Cope rearrangement does not have a product bias, as the bonds broken and formed are equivalent in either direction of the reaction, similar to the Cope rearrangement. (wikipedia.org)
  • Aza-Cope rearrangement Beckmann rearrangement Eschenmoser's salt Duff reaction Stephen reaction Vilsmeier-Haack reaction Pictet-Spengler Mannich reaction Iminylium ions have the general structure R2C=N+. (wikipedia.org)
  • This makes the DAINV reaction particularly useful in natural product syntheses, where the target compounds often contain heterocycles. (wikipedia.org)
  • As stated in the introduction, strictosidine synthase catalyzes the biological Pictet-Spengler reaction of tryptamine and secologanin to stereoselectively form 3-alpha(S)-strictosidine, the universal precursor for monoterpenoid indole alkloid compounds. (wikipedia.org)
  • organic compound
  • As a technique for improving the sulfide-series secondary battery so as to deal with a large current, as disclosed in JP-A-5-74459, an electrode material in which an organic compound having a thiadiazole ring and a disulfide group are combined with a conductive polymer, such as polyaniline, has been proposed. (google.com)
  • Diethyl azodicarboxylate, conventionally abbreviated as DEAD and sometimes as DEADCAT, is an organic compound with the structural formula CH3CH2O2CN=NCO2CH2CH3. (wikipedia.org)
  • alkaloid
  • Originally isolated from the plant Rauvolfia serpentina, a medicinal plant widely used in Indian folk medicine, this enzyme participates in terpenoid biosynthesis and indole and ipecac alkaloid biosynthesis, both of which produce many compounds with significant physiological and medicinal properties. (wikipedia.org)
  • donor
  • Crystal and molecular structure of 1-AZA-5-STANNA-5-methyltricyclo[3.3.3.01,ndecane evidence for a transannular donor−acceptor interaction in a tetraorganotin compound - ScienceDirect" (PDF). (wikipedia.org)
  • observation
  • An interesting observation made with all the aza-bridgehead compounds as well as with NGP1-01, was their tendency to increase intracellular calcium levels at low concentrations. (nwu.ac.za)
  • Thus
  • Thus, in general DEAD is an aza-dienophile and dehydrogenating agent, converting alcohols to aldehydes, thiols to disulfides and hydrazo groups to azo groups. (wikipedia.org)
  • Thus the cationic-aza-Cope rearrangement proceeds more quickly than more concerted processes such as the Cope rearrangement. (wikipedia.org)
  • novel
  • The novel substance is a peptide compound having a novel structure, wherein the peptide chains have ketone radicals. (google.com)
  • intermediate
  • The more recent x-ray crystal structure of 1-aza-3,5,7-trimethyladamantan-2-one is a good model for cationic tetrahedral intermediate. (wikipedia.org)
  • Unlike the mechanisms behind the formation of several Pictet-Spengler compounds, a spiroindolenine intermediate containing a five-membered ring does not form during strictosidine synthesis. (wikipedia.org)
  • It also catalyses the formation of 12-aza-strictosidine, an important intermediate for cytotoxic alkaloids, from coupling secologanin with 7-aza-tryptamine. (wikipedia.org)
  • molecular
  • To explore the possibility of electrostatic interactions, the use of molecular electrostatic potentials (MEP) were employed with model compound 34 (replacing the phenyltropane moiety with a methyl group). (wikipedia.org)
  • protein
  • These results indicate that in some cellular context, the cell sensitivity to PRIMA-1 could depend on the abolition of a gain-of-function activity of the mutated p53, through a protein degradation pathway specifically induced by this compound. (biomedsearch.com)
  • Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. (patents.com)
  • present
  • Many more compounds, related to azadirachtin, are present in the seeds as well as in the leaves and the bark of the neem tree which also show strong biological activities among various pest insects Effects of these preparations on beneficial arthropods are generally considered to be minimal. (wikipedia.org)
  • useful
  • The most common and synthetically useful strategy couples the cationic 2-aza-Cope rearrangement with a Mannich cyclization, and is the subject of much of this article. (wikipedia.org)
  • form
  • Dimers of phenyltropanes, connected in their dual form using the C2 locant as altered toward a carboxamide structural configuring (in contrast and away from the usual inherent ecgonine carbmethoxy), as per Frank Ivy Carroll's patent inclusive of such chemical compounds, possibly so patented due to being actively delayed pro-drugs in vivo. (wikipedia.org)
  • Name
  • Aza", most probably the name of its founder. (wikipedia.org)
  • The name "Aza Khel" is given to this piece of land after its founder "Aza Khan" or "Raza Khan",who was considered as one of the great Afghan warriors. (wikipedia.org)
  • group
  • Assuming that the disulfide compound is represented by R--S--S--R (R denotes an organic functional group), the disulfide bond (S--S bond) is cleaved by supply of two electrons by electrolytic reduction. (google.com)
  • Proceedings of the Seventh Conference on Zoo and Wildlife Nutrition, AZA Nutrition Advisory Group, Knoxville, TN. (nagonline.net)
  • gives
  • In an attempt to persuade the two girls to stop pursuing the elder Pickett, Davis gives Aza $100,000 taken from his father's various stashes around the house, which she splits with Daisy. (wikipedia.org)
  • example
  • For example, a sulfide compound having a triazine ring or a thiadiazole ring has been used as an electrode material. (google.com)
  • In 1950, Horowitz and Geissman reported the first example of the 2-aza-Cope rearrangement, a surprising result in a failed attempt to synthesize an amino alcohol. (wikipedia.org)
  • examples
  • The aza-Cope rearrangements are examples of heteroatom versions of the Cope rearrangement, which is a [3,sigmatropic rearrangement that shifts single and double bonds between two allylic components. (wikipedia.org)
  • high
  • Among them, an electrode material using a disulfide compound (hereinafter referred to as 'disulfide electrode material') has been noticeable because of its relatively high energy density as disclosed in U.S. Pat. (google.com)
  • The story centers around 16-year-old Aza Holmes, a high school student living with multiple anxiety disorders, and her search for a fugitive billionaire. (wikipedia.org)
  • Aza Holmes is a 16-year-old high school student in Indianapolis who struggles with anxiety, mostly stemming from a fear of the human microbiome. (wikipedia.org)
  • means
  • Identification of the compounds was achieved by means of Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS) and Infrared (IR) techniques. (nwu.ac.za)
  • search
  • Tempted by the reward of $100,000 for information leading to Pickett's arrest, Daisy takes Aza on a search for the missing billionaire. (wikipedia.org)
  • function
  • PRIMA-1 has been identified as a compound that restores the transactivation function to mutant p53 and induces apoptosis in cells expressing mutant p53. (biomedsearch.com)
  • addition
  • In addition to these characteristics that might define them as NMDAR antagonists, the triquinylamines also share structural similarities to the pentacycloundecane cage compounds. (nwu.ac.za)
  • Because pure neem oil contains other insecticidal and fungicidal compounds in addition to azadirachtin, it is generally mixed at a rate of 1 ounce per gallon (7.8 ml/l) of water when used as a pesticide. (wikipedia.org)
  • study
  • In order to determine a more specific site of action for these compounds, a competition radioligand binding study was performed. (nwu.ac.za)
  • The potent phencyclidine binding site blocker, [3H]MK-801, served as reference compound in this study. (nwu.ac.za)
  • activity
  • This dualistic feature of these compounds can be attributed to activity on both the sigma receptors and calcium channels, as the PC-12 cells distinctly express both these pharmacological entities. (nwu.ac.za)
  • These compounds also have an endopeptidase inhibition activity. (google.com)
  • material
  • The facile nature of this rearrangement is attributed both to the fact that the cationic 2-aza-Cope is inherently thermoneutral, meaning there's no bias for the starting material or product, as well as to the presence of the charged heteroatom in the molecule, which lowers the activation barrier. (wikipedia.org)