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  • distal peripheral
  • By comparing morphological and molecular changes in spinal motoneurons after L4-L5 ventral root avulsion (VRA) and distal peripheral nerve axotomy (PNA) 7 and 14 days postoperatively, we aimed to gain more insight about the mechanism behind injury-induced motoneuron degeneration. (diva-portal.org)
  • axon
  • An axotomy is the cutting or otherwise severing of an axon. (wikipedia.org)
  • Laser axotomy is a technique is under development that allows for precise axon severing. (wikipedia.org)
  • Laser axotomy could enable doctors to better understand the downstream effects of a severed axon so that they can develop more effective treatment arms. (wikipedia.org)
  • Because axon regeneration was assessed only 1 h after axotomy, however, it is possible that axons may still be regeneration-competent in the context of sialidase antagonism, albeit on a slower timescale. (jneurosci.org)
  • occurs
  • Regeneration occurs because of microglial hyperplasia and astroglial hypertrophy, activities that are lacking in the central axotomy response. (wikipedia.org)
  • Although many times axotomy occurs due to intended surgical treatment, it is also often directly related to one of many pathologies/injuries. (wikipedia.org)
  • More often, secondary axotomy occurs, evolving over time and ultimately leading to disconnection. (wikipedia.org)
  • synthesis
  • The results indicate that axotomy should be a useful technique for studying the mechanism of regulation of the synthesis of a secretory organelle. (jneurosci.org)
  • results demonstrate
  • The results demonstrate that central chemo-axotomy of the TRPV1+ afferents underlies RTX analgesia and refine the neurobiology underlying effective clinical use of TRPV1 agonists for pain control. (jci.org)
  • significantly
  • We found both in the in vivo and in vitro studies that inhibition of neural activity in the supraoptic nucleus (SON) by tetrodotoxin (TTX) significantly increased the extent of MCN degeneration after axotomy. (jneurosci.org)
  • cell
  • Raising the extracellular KCl in the culture medium to 25 mM rescued the MCNs from the axotomy- and TTX-induced cell death. (jneurosci.org)
  • It is an induced response of the cell usually triggered by axotomy, ischemia, toxicity to the cell, cell exhaustion, virus infections, and hibernation in lower vertebrates. (wikipedia.org)
  • response
  • Using what is known about the axotomy response, doctors and researchers are looking to implement neuro-protective rehabilitation to patients suffering in the early stages of multiple sclerosis in order to prevent the disease from running its course and causing irreversible disability. (wikipedia.org)
  • These therapies rely on the scientific understanding of the axotomy response. (wikipedia.org)
  • times
  • Ultrastructural analysis of the optic nerves was also performed at different times after axotomy with and without treatment. (arvojournals.org)
  • large
  • After painful axotomy K ATP channels are downregulated in large, myelinated somata and also in SLI, which are also of smaller size compared to controls. (springer.com)