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  • lactate
  • In this article, we show that infection with lactate dehydrogenase-elevating virus, a benign mouse arterivirus, exacerbates the pathogenicity of IgM anti-platelet, but not anti-erythrocyte autoantibodies. (jimmunol.org)
  • In vivo, mouse infection with lactate dehydrogenase-elevating virus (LDV) strongly enhances the pathogenicity of both anti-erythrocyte and anti-platelet IgG autoantibodies, leading to severe anemia and thrombocytopenia, respectively ( 18 - 20 ). (jimmunol.org)
  • persistent infection
  • The arteriviruses are highly species specific, but share many biological and molecular properties, including virion morphology, a unique set of structural proteins, genome organization and replication strategy, and the ability to establish prolonged or true persistent infection in their natural hosts. (wikipedia.org)
  • horses
  • In one fatal human case the clinical syndrome resembled in general that observed in horses while in a second case death occurred after a prolonged clinical course including signs of central nervous system dysfunction one year after infection. (thefreedictionary.com)
  • Following infection, the first sign is fever, peaking at 41 °C (106 °F), followed by various signs such as depression, nasal discharge, "pink eye" (conjunctivitis), swelling over the eye (supraorbital edema), urticaria, and swelling of the limbs and under the belly (the ventral abdomen) which may extend to the udder in mares or the scrotum of male horses. (wikipedia.org)