Aromatase. Medical search. Frequent questions

Letrozole is an aromatase inhibitor with antiestrogenic effects that is being tested in LAM. (medscape.com)
The aromatase inhibitors include anastrozole, letrozole and exemestane, some of which have been implicated in causing rare instances of clinically apparent liver injury. (nih.gov)
These inhibitors include anastrozole and letrozole which are nonsteroidal, and exemestane which is a steroidal aromatase inhibitor. (nih.gov)
Letrozole is an Aromatase inhibitor. (adooq.com)
IMAGE: This is Gabriel Hortobagyi, M.D. view more Copenhagen, Denmark - In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, ribociclib, in combination with the aromatase inhibitor letrozole, dramatically. (thetutuproject.com)
In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, ribociclib, in combination with the aromatase inhibitor letrozole, dramatically improved progression-free survival (PFS) of post-menopausal women with hormone. (thetutuproject.com)
Recently, body builders and men on TRT have found another, more powerful aromatase inhibitor: Letrozole (the generic name for Femara). (musclemecca.com)

Thus, its not just an interest in maintaining strength, energy, muscle mass and libido in older men that generates the interest in aromatase inhibition. (warddeanmd.com)
These studies provide foundational evidence that sexual behavior may be modified through inhibition or enhancement of brain aromatase enzyme activity and/or utilization of selective estrogen receptor modulators. (northwestern.edu)
5. Inhibition of aromatase with CGS 16949A in postmenopausal women. (nih.gov)
7. In vitro and in vivo studies demonstrating potent and selective estrogen inhibition with the nonsteroidal aromatase inhibitor CGS 16949A. (nih.gov)
12. Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. (nih.gov)
14. An in vitro method to determine the selective inhibition of estrogen biosynthesis by aromatase inhibitors. (nih.gov)

For post-menopausal women with a higher-than-average risk of breast cancer who are considering taking medicine to lower their risk, drugs called aromatase inhibitors (AIs) may be an option instead of tamoxifen or raloxifene. (cancer.org)

Androstenedione + 3O2 + 3NADPH + 3H+ ⇌ {\displaystyle \rightleftharpoons } Estrone + Formate + 4H2O + 3NADP+ Testosterone + 3O2 + 3NADPH + 3H+ ⇌ {\displaystyle \rightleftharpoons } 17β-estradiol + Formate + 4H2O + 3NADP+ Aromatase is expressed in the gonads, placenta, brain, adipose tissue, bone, and other tissues. (wikipedia.org)
Aromatase is an enzyme that converts testosterone to estradiol and androstenedione to the main estrogen source in the postmenopausal female estrone. (standardofcare.com)
Aromatase is the enzyme responsible for the conversion of testosterone to estrone (E1) and androstenedione to estradiol (E2). (nih.gov)
Aromatase is the enzyme that causes the conversion of testosterone into estradiol and androstenedione into estrone. (warddeanmd.com)
Further evidence of chrysins lack of effectiveness in inhibiting aromatase is found in an article in JAMA several years ago.15 Researchers tested an androstenedione product, fortified with chrysin, to determine if chrysin would prevent estradiol levels from increasing. (warddeanmd.com)
We used a human lung cancer xenograph model system to analyze the effect of aromatase or estradiol on tumor growth. (nih.gov)
Many body builders who take testosterone (and also men who are on testosterone replacement therapy (TRT) for medical reasons) need to be aware of the fact that testosterone converts to the female hormone estradiol through the aromatase enzyme . (musclemecca.com)
Tongkat Ali has been shown to inhibit aromatase in vitro, but leads to increased total estradiol in vivo, meaning that Tongkat Ali is not a good aromatase inhibitor if your goal is to lower total estrogen levels in your body. (healthbymushrooms.com)
Free testosterone increased from 9.4 to 12.6pg/ml, which may account for the rise of estradiol, but it only indicates that the Tongkat Ali does not inhibit aromatase in all cases. (healthbymushrooms.com)
This study in vitro(r) found eurycomanone does inhibit aromatase, but if estradiol is still rising even though it does inhibit aromatase, then this is certainly not a good aromatase inhibitor. (healthbymushrooms.com)
A single gene, Cyp19a1, encodes aromatase, the enzyme that catalyzes the conversion of testosterone to estradiol in the testis and brain of male mice. (northwestern.edu)
full sexual behavior, however, was achieved only when both estradiol and testosterone were administered together.Thus, aromatase in the brain is, in part, necessary for testosterone-dependent male sexual activity. (northwestern.edu)

Anastrozole is a third-generation nonsteroidal selective aromatase inhibitor. (adooq.com)
Arimidex ( anastrozole ) is a non-steroidal aromatase inhibitor used to treat breast cancer in postmenopausal women. (rxlist.com)
ARIMIDEX ( anastrozole ) tablets for oral administration contain 1 mg of anastrozole, a non-steroidal aromatase inhibitor . (rxlist.com)

This condition is due to mutations in the CYP19A1 gene which encodes aromatase. (wikipedia.org)
Mutations in the CYP19A1 gene cause aromatase deficiency. (medlineplus.gov)
The CYP19A1 gene provides instructions for making an enzyme called aromatase. (medlineplus.gov)
CYP19A1 gene mutations that cause aromatase deficiency decrease or eliminate aromatase activity. (medlineplus.gov)
In both primary and metastatic tissues, cyclin A1 expression was also correlated with aromatase (CYP19A1), a key enzyme that directly regulates the local balance of androgens to estrogens. (lu.se)
The regulation of aromatase gene (CYP19A1) in BAT is complex, and the mechanisms linking obesity and aromatase dysregulation are not fully understood. (abo.fi)
An obesity‐associated factor that could regulate aromatase is the CC chemokine ligand (CCL) 2, a pro‐inflammatory factor that also activates signaling pathways implicated in CYP19A1 transcription. (abo.fi)
By using human primary breast adipose stromal cells (ASCs) and aromatase reporter (hARO‐Luc) mouse mammary adipose explants, we demonstrated that CCL2 enhances the glucocorticoid‐mediated CYP19A1 transcription. (abo.fi)
We also showed that CCL2 contributes to the pro‐inflammatory milieu and aromatase expression in obesity, evidenced by increased expression of CCL2 and CYP19A1 in mammary tissues from obese hARO‐Luc mice, and subcutaneous adipose tissue from obese women. (abo.fi)

Aromatase (EC 1.14.14.14), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. (wikipedia.org)
In particular, aromatase is responsible for the aromatization of androgens into estrogens. (wikipedia.org)
During fetal development, aromatase converts androgens to estrogens in the placenta, which is the link between the mother's blood supply and the fetus. (medlineplus.gov)
A shortage of functional aromatase results in an inability to convert androgens to estrogens before birth and throughout life. (medlineplus.gov)
Two-thirds of breast cancers have aromatase activity creating estrogens available for breast cancer cells so that aromatase inhibitors decrease circulating levels of estrogen and local estrogen production in the breast cancer. (standardofcare.com)
However, aromatase is also found in other tissues, such as liver, kidney, adrenals, brain, muscle and subcutaneous fat where it is also active in producing estrogens, although at low levels. (nih.gov)
In obese men, the increased expression of the aromatase enzyme in adipose tissue leads to high conversion of androgens to estrogens contributing to hypogonadotropic hypogonadism (HHG). (frontiersin.org)
C 19 steroids are converted to estrogens in a number of tissues by a specific form of cytochrome P450, namely aromatase cytochrome P450 (P450arom). (northwestern.edu)
In summary, our results indicate that postmenopausal obesity may promote CCL2 production in BAT, leading to exacerbation of the menopause‐related inflammatory state and further stimulation of local aromatase and estrogens. (abo.fi)
Anti-Aromatase вЂ" Used to block the conversion of aromatizing AAS to estrogen, and actually block the production of estrogens in the body through binding to the enzyme aromatase. (roids.biz)
Clomid is often lumped in with anti-estrogens or anti-aromatase/ aromatase inhibiting drugs, but it is something different altogether. (roids.biz)

Studies designed to investigate whether increased local aromatase activity in breast adipose tissue influences the growth of breast cancers have yielded discrepant results. (northwestern.edu)
Here we demonstrate that local aromatase expression and estrogen production in the brain is partially required for male sexual behavior and sex hormone homeostasis. (northwestern.edu)

To assure that vitamin D3 does not abrogate the clinical benefits of aromatase inhibitors, the effect of vitamin D3 supplements on estrogen production and on serum levels of aromatase inhibitor needs to be evaluated. (nih.gov)

Evaluation of the safety of vitamin D3 supplements in women treated with aromatase inhibitors is crucial. (nih.gov)

Abstract: DESCRIPTION (provided by applicant): This project will determine the efficacy and safety of vitamin D3 supplements for reducing side effects of treatment with aromatase inhibitors in women with breast cancer. (nih.gov)
We predict that women whose lung cancers have higher levels of aromatase might be good candidates for targeted treatment with aromatase inhibitors. (nih.gov)

Steroidal inhibitors, such as exemestane, work by permanently binding to the aromatase enzyme. (bitrebels.com)
Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women. (adooq.com)

When Do Symptoms of Aromatase deficiency Begin? (nih.gov)
Aromatase deficiency is a condition characterized by reduced levels of the female sex hormone estrogen and increased levels of the male sex hormone testosterone. (medlineplus.gov)
There are other features associated with aromatase deficiency that can affect both males and females. (medlineplus.gov)
so people with aromatase deficiency can have abnormally high blood sugar (glucose), a condition known as hyperglycemia. (medlineplus.gov)
Women who are pregnant with fetuses that have aromatase deficiency often experience mild symptoms of the disorder even though they themselves do not have the disorder. (medlineplus.gov)
In affected individuals, these abnormal hormone levels lead to impaired female sexual development, unusual bone growth, insulin resistance, and other signs and symptoms of aromatase deficiency. (medlineplus.gov)
In women who are pregnant with an affected fetus, excess androgens in the placenta pass into the woman's bloodstream, which may cause her to have temporary signs and symptoms of aromatase deficiency. (medlineplus.gov)
Can aromatase deficiency lead to height gain? (ndtv.com)
Home » Frequently asked Questions on Health » Can aromatase deficiency lead to height gain? (ndtv.com)
Persons who have aromatase deficiency will have low levels of estrogen and will grow tall but bones will be osteoporotic. (ndtv.com)
Global Aromatase Deficiency market is anticipated to reach a value of over USD xx billion by 2028 and register a CAGR of xx% for the forecast period 2022-2028. (articlebowl.com)
Acronym AROD Synonyms Pseudohermaphroditism female due to placental aromatase deficiency Keywords Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. (symptoma.com)

The increased expression of the aromatase enzyme in the adipose tissue of obese men leads to a greater conversion of androgens to estrogen ( 5 ). (frontiersin.org)
Due to the high aromatase expression in the adipose tissue, it is possible that the administration of testosterone in obese men with HHG will only perpetuate the cycle of obesity and hypogonadism rather than correct the underlying problem. (frontiersin.org)
Aromatase activity as well as P450arom transcripts primarily reside in the stromal cell component of the adipose tissue. (northwestern.edu)
Obesity‐related inflammation upregulates aromatase expression, the rate‐limiting enzyme for estrogen synthesis, in breast adipose tissue (BAT), increasing estrogen production and cancer risk. (abo.fi)

Aromatase is a cytochrome P450 enzyme involved in the synthesis of estrogen and aromatase in inhibitors function as anti-estrogen by decreasing the biosynthesis of estrogen from androgens, the primary estrogen biosynthesis pathway in postmenopausal women. (standardofcare.com)
Fadrozole is a nonsteroidal aromatase inhibitor exhibiting a very potent and selective inhibitory effect of the aromatase enzyme system in vivo and estrogen biosynthesis in vivo. (adooq.com)
3. The effects of CGS 16949A, an aromatase inhibitor on adrenal mineralocorticoid biosynthesis. (nih.gov)

4. The effect of the aromatase inhibitor, rogletimide (pyridoglutethimide), on guinea pig adrenal cell steroidogenesis and placental microsomal aromatase activity: comparison with aminoglutethimide and CGS 16949A. (nih.gov)

Aromatase inhibitors markedly reduce estrogen levels in postmenopausal women by deactivating or inhibiting aromatase, the enzyme responsible for estrogen synthesis from androgens. (standardofcare.com)
Aromatase inhibitors (AIs), are effective in reducing estrogen by blocking the enzyme aromatase, which is responsible for the peripheral conversion of androgens to estrogen. (standardofcare.com)
They work by inhibiting the activity of the aromatase enzyme, which converts androgens into estrogen. (bitrebels.com)
Aromatase, a cytochrome P450, catalyzes three consecutive hydroxylation reactions converting C19 androgens to aromatic C18 estrogenic steroids. (aacrjournals.org)
Aromatase inhibitors work by stopping androgens from being changed to oestrogen. (canceraustralia.gov.au)

18. Potency and selectivity of the non-steroidal aromatase inhibitor CGS 16949A in postmenopausal breast cancer patients. (nih.gov)

The replacement of tamoxifen with aromatase inhibitors results in a 2.7% reduction in the rate of reoccurrence at five years. (standardofcare.com)
The sequential use of aromatase inhibitors after tamoxifen results in an absolute reduction of 2 1/2 percentage points in the rate of recurrence. (standardofcare.com)
Aromatase Inhibitors cause more vaginal dryness than tamoxifen, likely due to the pro estrogen effect of the latter on the vagina and endometrium. (standardofcare.com)
The aromatase inhibitors block estrogen synthesis and are used as therapy of estrogen receptor positive breast cancer, usually after resection and as a first line treatment or after failure of tamoxifen (another antiestrogen that acts by blocking the estrogen receptor). (nih.gov)

Cite this: Cognitive Dysfunction in Postmenopausal Breast Cancer Patients on Aromatase Inhibitors - Medscape - Aug 01, 2011. (medscape.com)

Thus, the aromatase gene evolved early in chordate evolution and does not appear to be present in nonchordate invertebrates (e.g. insects, molluscs, echinoderms, sponges, corals). (wikipedia.org)
It varies from species to species whether it is the aromatase protein that has different activity at different temperatures or whether the amount of transcription undergone by the aromatase gene is what is temperature-sensitive, but in either case, differential development is observed at different temperatures. (wikipedia.org)
RT-PCR showed that expression of aromatase, 3βHSD, estrogen receptor-β, and progesterone receptor gene decreased, while estrogen receptor-α increased after EAE induction. (listlabs.com)
Naringenin improved aromatase immunopositivity rates and gene expression in both prophylactic and therapeutic use. (listlabs.com)
Alice: Diferenças entre valores genéticos de indivíduos com diferentes genótipos para o gene da aromatase. (embrapa.br)
We aim to investigate the role of the HOXC11 target gene prosaposin (PSAP) in aromatase inhibitor resistance and assess the impact of PSAP and androgen receptor (AR) on clinical outcome. (rcsi.com)

The lecture, titled "Breast Cancer Prevention with Anti-aromatase Phytochemicals in Grapes and Mushrooms", relates to the major research focus of Dr. Chen's laboratory which is to investigate the roles of aromatase in breast cancer development. (nih.gov)

13. CGS 16949A, a new nonsteroidal aromatase inhibitor: effects on hormone-dependent and -independent tumors in vivo. (nih.gov)

However, we are unable to determine from the above studies whether these same effects take place in vivo (inside us) or what the proper dosages would be to get an inhibitory effect on aromatase. (warddeanmd.com)

TBT to reduce aromatase inhibitor induced musculoskeletal symptoms. (mayo.edu)
These symptoms, referred to as aromatase inhibitor-associated musculoskeletal symptoms (AIMSS), decrease quality of life and medication adherence. (nih.gov)

In this study, eight human aromatase mutants (I133Y, I133W, F235L, I395F, I474Y, I474W, I474M, and I474N) were prepared to evaluate the active site and a proposed hydrophobic pocket of the enzyme that exists in an aromatase model based on the X-ray structure of cytochrome P450cam. (aacrjournals.org)

Aromatase, an enzyme produced by fat cells, takes the testosterone a man's body produces and converts it into estrogen - a necessary hormone for men in low quantity, but also a fat- storage hormone. (bodyhealth.com)

Aromatase inhibitors are only effective for women who have gone through menopause permanently. (canceraustralia.gov.au)

Aromatase inhibitors and the risk of colorectal cancer in post-menopausal women with breast cancer. (cnodes.ca)

Because of the role of vitamin D in muscle cell physiology and musculoskeletal pain, there is reason to believe that vitamin D3 may decrease symptoms associated with the use of aromatase inhibitors. (nih.gov)

It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids. (adooq.com)
In a nutshell, as with all aromatase inhibitors, the mechanism of action is to block the conversion of aromatizable steroids to estrogen. (roids.biz)

Aromatase inhibitors (AIs) lower estrogen levels by stopping an enzyme in fat tissue (called aromatase ) from changing other hormones into estrogen. (cancer.org)
Aromatase inhibitors are a class of compounds that play a pivotal role in controlling estrogen levels in the body. (bitrebels.com)

Fadrozole hydrochloride is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM. (adooq.com)

I have heard that if your bone planes aren't fused and you want to increase your height, you hold strong possibilities if you have a aromatase inhibitor, which leads to less levels of estrogen in blood. (ndtv.com)

Our objective is to evaluate efficacy and safety of weight loss (WL) plus aromatase inhibitor (AI) therapy in severely obese men with HHG. (frontiersin.org)
To evaluate the efficacy and safety of gonadotropin-releasing hormone agonist (GnRHa) combined with levonorgestrel-releasing intrauterine system (LNG-IUS) or aromatase inhibitor (AI) in women with endometrial carcinoma (EC) and atypical endometrial hyperplasia (AEH) who wish to preserve their fertility. (researchsquare.com)

Inhibitors of aromatase were developed to block the synthesis of estrogen in the peripheral tissues and, thus, as antiestrogen therapy of estrogen receptor positive breast cancer in postmenopausal women. (nih.gov)

This study indicates that obesity-associated systemic IL-6 indirectly enhances pre-adipocyte aromatase expression via increased breast cancer cell PGE2 production. (nih.gov)

Arimidex is often confused with an anti-estrogen, but it is actually an aromatase inhibitor. (roids.biz)
Fortunately, Arimidex doesn't have the side effects of some aromatase inhibitors, such as Cytadren or others and will also develop a high degree of estrogen blocking. (roids.biz)

Summary of medical therapy (chemotherapy and aromatase inhibitors) and measurements of cognitive functioning (neuropsychological testing and functional imaging) and potential confounders encountered within the reviewed literature. (medscape.com)

Chrysin: Is It An Effective Aromatase Inhibitor? (warddeanmd.com)
Chrysin is a flavonoid that has been purported especially in the bodybuilding world to be an effective inhibitor of an enzyme known as aromatase. (warddeanmd.com)
The idea that chrysin might be an effective natural aromatase inhibitor originated by a combination of science and unsubstantiated hype. (warddeanmd.com)
Another study to evaluate the aromatase-inhibiting ability of chrysin was conducted by scientists at the Institute of Biomedicine in Turku, Finland.16 The scientists administered chrysin to rats at a dose of 50 mg/kg body weight, which is considerably more than is found in human diets or dietary supplements (thats about 3.5 grams, human equivalent). (warddeanmd.com)

CGS 20267 is a new non-steroidal compound which potently inhibits aromatase in vitro (IC50 of 11.5 nM) and in vivo (ED50 of 1-3 μg/kg p.o. (adooq.com)

There are a number of in vitro studies which support chrysins aromatase inhibitory activity. (warddeanmd.com)

Cognitive dysfunction has been considered as a morbid condition that may possibly result from aromatase inhibitor therapy, the standard treatment in postmenopausal, estrogen/progesterone receptor-positive breast cancer patients. (medscape.com)
Aromatase inhibitors (AIs) have emerged as the standard therapy for postmenopausal patients with estrogen/progesterone receptor-positive breast cancer. (medscape.com)
Aromatase immunopositivity rates also decreased in EAE, while estrogen receptor α and β, and progesterone receptor immunopositivity rates increased. (listlabs.com)

Anatomy24

Organisms10

Diseases17

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Psychiatry and Psychology3

Phenomena and Processes18

Disciplines and Occupations1

Information Science2

Health Care1

Letrozole7

Inhibition6

Called aromatase inhibitors1

Estradiol12

Anastrozole3

CYP19A19

Estrogens11

Local aromatase2

Benefits of aromatase inhibitors1

Treated with aromatase inhibitors1

Treatment with aromatase inhibitors2

Exemestane2

Deficiency12

Adipose tissue4

Biosynthesis3

Effect of the aromatase1

Androgens5

Steroidal aromatase inhibitor1

Tamoxifen4

Postmenopausal Breast Cancer Patients1

Gene6

Anti aromatase1

Nonsteroidal aromatase1

Inhibitory effect1

Musculoskeletal symptoms2

Cytochrome1

Converts1

Menopause1

Post menopausal women1

Symptoms1

Steroids2

Estrogen levels2

Selective1

Levels of estrogen1

Efficacy and safety2

Synthesis of estrogen1

Obesity1

Arimidex2

Chemotherapy1

Chrysin4

Inhibits1

Vitro studies1

Progesterone receptor3