- AVP disorders are due either to (1) deficient secretion of antidiuretic hormone (ADH) by the pituitary gland (AVP-D) or to (2) renal tubular unresponsiveness to vasopressin (AVP-R). (medscape.com)
- Demeclocycline, a tetracycline antibiotic, is sometimes used to block the action of vasopressin in the kidney in hyponatremia due to inappropriately high secretion of vasopressin (SIADH), when fluid restriction has failed. (wikipedia.org)
- Release of Vasopressin within the Rat Paraventricular Nucleus in Response to Emotional Stress: A Novel Mechanism of Regulating Adrenocorticotropic Hormone Secretion? (jneurosci.org)
- Central DI is characterized by decreased secretion of antidiuretic hormone (ADH)-also known as arginine vasopressin (AVP)-which gives rise to polyuria and polydipsia by diminishing the person's ability to concentrate urine. (medscape.com)
- Arginine vasopressin deficiency (central diabetes insipidus) is a lack of the hormone vasopressin (antidiuretic hormone) that causes excessive production of very dilute urine (polyuria). (msdmanuals.com)
- Desmopressin Acetate Tablets are a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. (nih.gov)
- AVP resistance (AVP-R) (nephrogenic diabetes insipidus) arises from defective or absent receptor sites at the cortical collecting duct segment of the nephron (X-linked, vasopressin V2 receptor deficiency, locus Xq28) or defective or absent aquaporin, the protein that transports water at the collecting duct (autosomal recessive, locus 12q13). (medscape.com)
- 1-desamino-8-D-arginine vasopressin (DDAVP) is considered a standard vasopressin V2 receptor-selective agonist with a potent antidiuretic effect through V2 receptor without the induction of vasoconstriction through V1a receptor. (nih.gov)
- However, the agonistic activity of DDAVP against the other vasopressin receptor, V1b (or V3), which can accumulate intracellular Ca2+ and which we recently cloned, has not been clarified. (nih.gov)
- Hence, we compared the characteristics of DDAVP on V1b receptor with those on the other vasopressin receptors. (nih.gov)
- In binding experiments, DDAVP more strongly inhibited [3H]arginine vasopressin binding to V1b than to V2 receptor (Ki: 5.84 nM vs 65.9 nM). (nih.gov)
- However, DDAVP behaved as a partial agonist toward rat V1b receptor (intrinsic activity: 0.7, EC50: 43.5 nM), while there was no significant difference in the agonistic properties of arginine vasopressin on human and rat V1b receptor. (nih.gov)
- These findings will allow us to better understand the physiological role of V1b receptor in pancreatic beta cells and in the renal inner medullary collecting duct, and help us to identify as yet unknown vasopressin receptors through which DDAVP cause the accumulation of intracellular Ca2+ in other tissues. (nih.gov)
- Selective vasopressin V2-receptor antagonist. (medscape.com)
- A vasopressin receptor antagonist (VRA) is an agent that interferes with action at the vasopressin receptors. (wikipedia.org)
- Demeclocycline is not a direct antagonist of the vasopressin receptors however, but rather inhibits activation of the intracellular second messenger cascade of this receptor in the kidney by an unknown mechanism. (wikipedia.org)
- V2 receptor antagonism increases plasma vasopressin concentration, which may cause unopposed hyperstimulation of the vasoconstrictor V1 receptor. (wikipedia.org)
- Vasopressin type-2 receptor seems to be particularly impaired in patients with advanced CKD, whereas the signal cascade of the downstream of vasopressin type-2 receptor is relatively preserved. (bvsalud.org)
- Receptor for arginine vasopressin. (hmdb.ca)
- North WG, Fay MJ, Longo KA, Du J: Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. (hmdb.ca)
- Fay MJ, Du J, Yu X, North WG: Evidence for expression of vasopressin V2 receptor mRNA in human lung. (hmdb.ca)
- The arginine vasopressin 1b receptor (Avpr1b) is involved in the modulation of a variety of behaviors and is an important part of the mammalian hormonal stress axis. (frontiersin.org)
- The gene AVPR1a codes for the production of a receptor that enables a hormone, arginine vasopressin, to act on brain cells. (sciencedaily.com)
- El receptor V1 puede subdividirse en V1a y V1b (previamente V3). (bvsalud.org)
- Two types of vasopressin receptor exist, the V1 receptor in the vascular smooth muscle and the V2 receptor in the kidneys. (bvsalud.org)
- therefore, the majority of patients with VWD achieve a clinical and laboratory remission of the disease during pregnancy, and treatment with 1-deamino-8-D-arginine vasopressin (DDAVP) or blood transfusion is usually not necessary. (renalandurologynews.com)
- Oxytocin (OXT) and arginine-vasopressin (AVP) are two phylogenetically conserved neuropeptides that have been implicated in a wide range of social behaviors. (frontiersin.org)
- The effects of emotional stressors on the release of arginine vasopressin (AVP) and oxytocin (OXT) within the rat hypothalamus and the origin and physiological significance of AVP released within the hypothalamic paraventricular nucleus (PVN) were investigated. (jneurosci.org)
- Within the mammalian brain, the nonapeptides arginine vasopressin (AVP) and oxytocin (OXT) are synthesized in, transported by, and secreted from two distinct classes of neurons ( Sofroniew, 1983 ). (jneurosci.org)
- Here we demonstrate that a likely mechanism underlying the orexigenic action of RLN3 is RXFP3-mediated inhibition of oxytocin- and arginine-vasopressin-synthesizing paraventricular nucleus (PVN) magnocellular neurosecretory cells. (jneurosci.org)
- The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V1A, V1B and V2). (wikipedia.org)
- Desmopressin acetate tablets contain as active substance, desmopressin acetate, a synthetic analogue of the natural hormone arginine vasopressin. (nih.gov)
- The change in structure of arginine vasopressin to desmopressin acetate resulted in less vasopressor activity and decreased action on visceral smooth muscle relative to enhanced antidiuretic activity. (nih.gov)
- Also acting as antagonists of the antidiuretic action of arginine vasopressin are compounds of the formula ##STR2## wherein X and Z are as above and n is 4 or 5. (utoledo.edu)
- Other antagonists of the antidiuretic action of arginine vasopressin are of the formula ##STR3## wherein X and n are as above and Z' is (D- or L-)Orn or (D- or L-)Lys. (utoledo.edu)
- Arginine vasopressin deficiency has several causes, including a brain tumor, a brain injury, brain surgery, tuberculosis, and some forms of other diseases. (msdmanuals.com)
- The study was undertaken to obtain simultaneous measurements of circulating anterior pituitary hormone levels after the i.v. injection of arginine-vasopressin (AVP). (lu.se)
- Arginine vasopressin antagonist (V1A, V2) indicated for euvolemic (dilutional) and hypervolemic hyponatremia. (medscape.com)
- Vasopressin has a direct action on the kidney. (imedi.co.uk)
- Lithium, as lithium carbonate, possesses similar properties to those of demeclocycline on the action of vasopressin in the kidney, and was used clinically before demeclocycline, which largely superseded it for this indication. (wikipedia.org)
- Altered arginine vasopressin-cyclic AMP-aquaporin 2 pathway in patients with chronic kidney disease. (bvsalud.org)
- In the collecting ducts of the kidney , arginine vasopressin (AVP), cyclic adenosine monophosphate (cAMP), and aquaporin 2 (AQP2) play a pivotal role in maintaining fluid volume and serum osmolality in humans . (bvsalud.org)
- Association of copeptin, a surrogate marker of arginine vasopressin, with decreased kidney function in sugarcane workers in Guatemala. (cdc.gov)
- Background: Vasopressin is elevated in response to heat and dehydration and has been postulated to have a role in the chronic kidney disease of unknown origin being observed in Central America. (cdc.gov)
- The aims of this study were to examine whether the vasopressin pathway, as measured by copeptin, is associated with the presence of kidney dysfunction, and to examine whether higher fluid intake is associated with lower circulating copeptin and thereby preserves kidney health among sugarcane workers exposed to hot conditions. (cdc.gov)
- It is well-established that the neuropeptide arginine vasopressin (Avp) is important to the neural modulation of mammalian behavior. (frontiersin.org)
- METHODS: Using in situ hybridization, we determined the amount of vasopressin messenger ribonucleic acid (mRNA) in the PVN and SON in postmortem brain tissue of nine depressed subjects (six with the melancholic subtype) and eight control subjects. (herseninstituut.nl)
- RESULTS: In the SON, a 60% increase of vasopressin mRNA expression was found in depressed compared with control subjects. (herseninstituut.nl)
- Vasopressin is a potent peripheral vasoconstrictor. (imedi.co.uk)
- Because a diuretic is a substance that increases urine production, vasopressin previously was referred to as anti diuretic hormone. (msdmanuals.com)
- Plasma arginine vasopressin levels, serum osmolality, urine osmolality and fluid intakes were measured in thirteen asphyxiated and nineteen control newborn infants during the first seventy-two hours of life. (houstonmethodist.org)
- Specific molecular sites or proteins on or in cells to which VASOPRESSINS bind or interact in order to modify the function of the cells. (bvsalud.org)
- Polycystin defects increase intracellular cAMP, secondary messenger for vasopressin acting at V2R, leading to cyst development. (wikipedia.org)
- AVP-D with an autosomal dominant pattern inheritance is due to a mutation in the prepro-arginine vasopressin ( prepro-AVP2 ) gene, mapped to locus 20p13. (medscape.com)
- BACKGROUND: Elevated arginine vasopressin (AVP) plasma levels have been observed in major depression, particularly in relation to the melancholic subtype. (herseninstituut.nl)
- Arginine-vasopressin (AVP) plays an important role in regulating water balance in humans. (unisa.it)
- The data presented in this study support the concept that arginine vasopressin release occurs following perinatal asphyxia in term newborn infants. (houstonmethodist.org)
- Studies in experimental subjects have shown differing responses of plasma arginine vasopressin in hypoxia. (houstonmethodist.org)
- Arginine vasopressin (AVP) and terlipressin were proposed as alternatives to catecholamines in shock states characterized by decreased plasma AVP concentrations. (silverchair.com)
- The aim of this study was to establish which structure is responsible for the increased vasopressin plasma levels in depression. (herseninstituut.nl)
- In contrast, swapping carboxy-terminal phosphatidylinositol 4,5-bisphosphate (PIP 2 ) binding domains, or the entire C terminus, was without effect on the forskolin response, but the latter conferred responsiveness to arginine-vasopressin (an inhibitory PKC-dependent response). (aspetjournals.org)
- We are working to determine the relative contributions of circadian function in vasopressin, VIP, kisspeptin and GnRH neurons in order to reveal the loci at which the clock controls ovulation. (umass.edu)