• These data suggest that systemic activation of complement induces C5a-dependent apoptosis of thymocytes and that the blockade of C5a during sepsis rescues thymocytes from apoptosis. (jci.org)
  • ATZ also induces morphological changes similar to apoptosis and initiates mitochondria-dependent cell death in several experimental models. (frontiersin.org)
  • Finally, analysis of the mechanism by which multimeric alpha-lactalbumin induces apoptosis in transformed epithelial cells could lead to the design of antitumor agents. (lu.se)
  • The short-chain fatty acid butyrate induces apoptosis in col. (lww.com)
  • and Tumor Necrosis Factor-α Induces Apoptosis through Downregulation of Bcl-2 and Release of Cytochrome c from Mitochondria. (caltagmedsystems.co.uk)
  • 6-OAP induces apoptosis in multiple myeloma (MM) cells, as detected by DNA fragmentation assay. (spandidos-publications.com)
  • It has been demonstrated that Cd induces cancer by multiple mechanisms and the most important among them are aberrant gene expression, inhibition of DNA damage repair, induction of oxidative stress, and inhibition of apoptosis. (cdc.gov)
  • Some factors like Fas receptors and caspases promote apoptosis, while some members of the Bcl-2 family of proteins inhibit apoptosis. (wikipedia.org)
  • Our resources and products to study apoptosis include apoptosis kits and antibodies to key proteins such as caspases and the Bcl-2 family. (abcam.com)
  • It presents a focused yet extensive discussion on proteolytic enzymes such as caspases, HtrAs, granzymes, calpains and cathepsins as well as laboratory protocols related to enzymology and apoptosis. (springer.com)
  • The finding suggests that during apoptosis, caspases do not attack APP directly, but that they somehow increase BACE levels. (alzforum.org)
  • TUNEL and western blot assay showed that KTC could induce apoptosis of endometriotic tissues, accompanied with the increased protein expression of caspases 8 and 9, activated caspase-3, and cytochrome c in a dose-dependent manner. (hindawi.com)
  • One of the most consistently observed characteristics of apoptosis is the activation of a series of cytosolic proteases called caspases. (bdbiosciences.com)
  • Caspases are activated upon cleavage at aspartate residues during the earliest stages of apoptosis. (bdbiosciences.com)
  • Active caspases can then cleave many proteins, including poly-ADP ribose polymerase (PARP), other caspases and other protein substrates en masse. (bdbiosciences.com)
  • Caspases-9, -8 and -3 have been implicated in apoptosis-caspase-9 in the mitochondrial pathway, caspase-8 in the Fas/CD95 pathway, and caspase-3 more downstream, activated by multiple pathways. (bdbiosciences.com)
  • Caspases are proteases that take part in the intracellular signaling pathways that cause apoptosis in different cell types. (isciii.es)
  • However, some studies have shown that other molecules apart from caspases are activated during apoptosis in the retina. (isciii.es)
  • Detect the early stages of apoptosis with a simple staining procedure in only 10 minutes. (abcam.com)
  • Since externalization of PS occurs in the earlier stages of apoptosis, FITC Annexin V staining can identify apoptosis at an earlier stage than assays based on nuclear changes such as DNA fragmentation. (bdbiosciences.com)
  • The finding builds on previous studies by the team on the molecular mechanism of membrane-bound Bcl-2 to inform a full understanding of the early stages of apoptosis. (labmate-online.com)
  • The findings suggest that while apoptosis sets off a proteolytic cascade that devours many cellular proteins, it somehow spares BACE. (alzforum.org)
  • Loss of mitochondrial membrane potential, upregulation of proapoptotic proteins, activation of MCL-1, PARP-1 and Caspase 9 suggest that MESF treatment leads to activation of mitochondrial pathway of apoptosis. (nature.com)
  • Importantly, the mitochondrial association of n-cofilin and ADF had no impact on apoptosis signaling because ablation of either n-cofilin, ADF, or both proteins together did not change cell death progression. (nature.com)
  • There is some evidence that Bcl-2 pro-survival proteins (which normally keep cells alive by inhibiting the cell death program of apoptosis) are expressed at unusually high levels in melanoma compared to normal melanocytes. (edu.au)
  • The first is to use an in vivo approach to analyse transgenic mice in which the autophagy regulator known as Beclin has been engineered to either disrupt or enhance its regulation by key components (i.e. proteins) of the apoptosis pathways. (edu.au)
  • This article reviews the research progress of apoptosis mechanism during flaviviruses infection, including flaviviruses proteins and subgenomic flaviviral RNA to regulate apoptosis by interacting with host proteins, as well as various signaling pathways involved in flaviviruses-induced apoptosis, which provides a scientific basis for understanding the pathogenesis of flaviviruses and helps in developing an effective antiviral therapy. (physiciansweekly.com)
  • C1QBP significantly increased ROS level, apoptosis, and the expression of apoptotic proteins such as cleaved caspase-3 and bax/bcl2 via regulating XDH. (medsci.org)
  • A large group of proteins that control APOPTOSIS. (bvsalud.org)
  • However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. (frontiersin.org)
  • This study was conducted to evaluate ultrastructure, oxidative stress, and apoptosis in sperm of mice treated with 150 mg/l NaF for 49 days. (fluoridealert.org)
  • Based on these findings, it was proposed that oxidative stress induced by excessive ROS may trigger sperm apoptosis through mitochondrial impairment, resulting in decreased fertility in mice exposed to fluoride. (fluoridealert.org)
  • However, the role of C1QBP in metabolism, oxidative stress, and apoptosis of renal cell carcinoma (RCC) cells have not yet been explored. (medsci.org)
  • The available evidence indicates that, perhaps, oxidative stress plays a central role in Cd carcinogenesis because of its involvement in Cd-induced aberrant gene expression, inhibition of DNA damage repair, and apoptosis. (cdc.gov)
  • Discover pathways on apoptosis induction, caspase activation and phagocytosis of apoptotic cells. (abcam.com)
  • They found that the protein was degraded by none other than caspase-3 following induction of apoptosis. (alzforum.org)
  • As these studies also revealed impaired cytochrome c release and a block in apoptosis upon small interfering RNA-mediated n-cofilin knockdown, n-cofilin was postulated to be essential for apoptosis induction. (nature.com)
  • Thus, we conclude that ADF/cofilin activity is not generally required for induction or progression of apoptosis in mammalian cells. (nature.com)
  • We found that, upon induction of apoptosis in control MEFs, n-cofilin, and its homolog ADF translocated to mitochondria together with actin. (nature.com)
  • In summary, our work demonstrates that in mammalian cells ADF/cofilin activity is not generally required for efficient induction of apoptosis. (nature.com)
  • Several modes of apoptosis induction and responsible viral genes have been proposed ( 8 - 13 ). (cdc.gov)
  • Apoptosis induction potential of each compound determined by mitochondrial membrane potential analysis (Rho123), cleaved caspase-3 expression analysis by flow cytometry and immunofluorescent staining and cell morphology analysis by giemza, hematoxylin and eosin and Papanicolaou protocols. (ijpsonline.com)
  • Therefore, based on clinical experience as well as cytotoxic activity against multiple human cancer cells, we hypothesized that induction of apoptosis is the underlying mechanism for the treatment of psoriasis. (hindawi.com)
  • These findings indicate that sesamin inhibits cervical cancer cell proliferation, and its mechanism may be attributed to the induction of p53/PTEN-mediated apoptosis. (medsci.org)
  • The mechanism of 6‑OAP cytotoxicity in all cell lines was associated with the induction of apoptosis with the presence of cleaved caspase‑3 and PARP. (spandidos-publications.com)
  • The average adult human loses between 50 and 70 billion cells each day due to apoptosis. (wikipedia.org)
  • For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. (wikipedia.org)
  • Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytes are able to engulf and remove before the contents of the cell can spill out onto surrounding cells and cause damage to them. (wikipedia.org)
  • Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unnecessary cells, and unhealthy cells. (rxlist.com)
  • When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia . (rxlist.com)
  • When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. (rxlist.com)
  • When the scientists induced apoptosis in neuroblastoma cells, they detected an increase in Aβ and also in C99, the C-terminal portion of APP left over after BACE cleavage. (alzforum.org)
  • In fact, Tesco and colleagues found that BACE protein levels were elevated up to ninefold in cells following apoptosis and that it became more stable. (alzforum.org)
  • CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
  • Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
  • Apoptosis is an organized process that signals cells to self-destruct for cell renewal or to control aberrant cell growth. (bdbiosciences.com)
  • As cells become damaged or are no longer needed, they undergo apoptosis or programmed cell death, a normal physiological process that occurs during embryonic development and tissue homeostasis. (bdbiosciences.com)
  • Apoptosis controls the orderly death of damaged cells, whereas necrosis occurs as a result of tissue damage, causing the loss of both damaged and surrounding cells. (bdbiosciences.com)
  • Methods for detecting apoptosis or dead cells (viability) by cell preparation type. (bdbiosciences.com)
  • Cancer cells exhibit an elevated apoptotic threshold and peptides that are able to induce apoptosis in tumor cells are increasingly seen as promising candidates for the development of new effective anticancer therapeutics. (eurogentec.com)
  • Moreover, TGFBR2 was a direct target of miR-128-3p, and its overexpression reversed the inhibitory effects of miR-128-3p overexpression on inflammation and apoptosis in LPS-induced HK2 cells. (degruyter.com)
  • miR-128-3p could inhibit apoptosis and inflammation by targeting TGFBR2 in LPS-induced HK2 cells, which might provide therapeutic strategy for the treatment of sepsis. (degruyter.com)
  • Untreated cells were primarily FITC Annexin V and PI negative, indicating that they were viable and not undergoing apoptosis. (bdbiosciences.com)
  • After a 4 hour treatment (bottom panels), there were primarily two populations of cells: Cells that were viable and not undergoing apoptosis (FITC Annexin V and PI negative) and cells undergoing apoptosis (FITC Annexin V positive and PI negative). (bdbiosciences.com)
  • A minor population of cells were observed to be FITC Annexin V and PI positive, indicating that they were in end stage apoptosis or already dead. (bdbiosciences.com)
  • This format retains its high affinity for PS and thus serves as a sensitive probe for flow cytometric analysis of cells that are undergoing apoptosis. (bdbiosciences.com)
  • These proteases are responsible for the dismantling of cells during apoptosis. (nature.com)
  • To test the relevance of ADF/cofilin activity for apoptotic processes, we here employed a genetically well-defined system of mouse embryonic fibroblasts (MEFs) devoid of any ADF/cofilin activity and challenged these cells with well-characterized apoptosis inducers. (nature.com)
  • Apoptosis was observed in alveolar epithelial cells, which is the major target cell type for the viral replication. (cdc.gov)
  • Our data suggest that apoptosis may play a major role in the pathogenesis of influenza (H5N1) virus in humans by destroying alveolar epithelial cells. (cdc.gov)
  • Infection of epithelial cells and lymphocytes has been shown to induce apoptosis in vitro ( 4 - 8 ). (cdc.gov)
  • In the cell morphology analyzes, chromatin condensation and marginalization, changes in the cell membrane, ghost cells and apoptotic bodies were observed as evidence of apoptosis formation. (ijpsonline.com)
  • The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)
  • Apoptosis in epithelioid histiocytes and inflammatory cells seems to participate in the course of granulomatous inflammation. (ersjournals.com)
  • The best studied is apoptosis, a form of programmed cell death used by all multicellular organisms to eliminate cells that are damaged, no longer needed or which might become a threat to the organism. (edu.au)
  • Apoptosis is a form of programmed cell death, which maintains cellular homeostasis by eliminating pathogen-infected cells. (physiciansweekly.com)
  • To investigate the effect of icariin on cell cycle and apoptosis of medulloblastoma cells and its mechanism. (ijpsonline.com)
  • Icariin can inhibit the proliferation and colony forming ability of medulloblastoma cells, induce cell arrest in synthesis phase by inhibiting the expression of cyclin A, cyclin-dependent kinase 2 and cyclin B1, and induce cell apoptosis by regulating the expression of B-cell lymphoma 2, cleaved caspase-3, cleaved caspase-9 and cleaved poly (ADP-ribose) polymerase protein. (ijpsonline.com)
  • Earlier studies from Dr. Kaufmann's Anticancer Drug Action Lab provided some of the first biochemical evidence that conventional and targeted anti-cancer drugs induce programed cell death, also called apoptosis, in susceptible cells. (mayo.edu)
  • One pathway leading to apoptosis, the so-called extrinsic or death receptor pathway, involves tumor cell killing that is initiated by cytotoxic T lymphocytes and natural killer cells. (mayo.edu)
  • Nearly half of neural cells die by apoptosis during brain development. (jneurosci.org)
  • Here, we explored whether sesamin activates p53, which is widely inhibited in cervical cancer cells, thereby inducing p53-mediated apoptosis. (medsci.org)
  • Pifithrin-α also reduced apoptosis and restored the proliferation of HeLa and SiHa cells exposed to sesamin. (medsci.org)
  • Inhibition of the processes that result in retinal cell apoptosis could decrease the number of dead cells and prevent the irreversible loss of visual function associated with some pathologies such as glaucoma. (isciii.es)
  • In this study we aim to review the basic research studies published in the last years in order to know the molecules and pathways involved in the processes which cause apoptosis of the different types of retinal cells. (isciii.es)
  • Micronuclei-bearing cells frequently underwent apoptosis but not multipolar mitosis. (figshare.com)
  • Suppresses apoptosis in a variety of cell systs including factor-dependent lymphohatopoietic and neural cells. (joplink.net)
  • Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. (joplink.net)
  • The incompletely differentiated plasma cells are characterized by deregulated apoptosis ( 1 ). (spandidos-publications.com)
  • C1QBP knockdown and overexpression cells were established via lentiviral infection and subjected to apoptosis and ROS assay in vitro . (medsci.org)
  • C1QBP promotes the catabolism of hypoxanthine and elevates the apoptosis of RCC cells by modulating XDH-mediated ROS generation. (medsci.org)
  • Erythropoietin prevents dialysis fluid-induced apoptosis of mesothelial cells. (bvsalud.org)
  • An introductionto the mechanisms of apoptotic cell death and apoptosis assays and markers. (abcam.com)
  • With the addition of these new formats, more complex assays can be developed to look at apoptosis within heterogeneous cell subsets. (bdbiosciences.com)
  • During apoptosis, PS translocates to the outer leaflet of the plasma membrane and can be detected by flow cytometry and cell imaging through binding to fluorochrome-labeled annexin V when calcium is present. (bdbiosciences.com)
  • Cell apoptosis was analyzed by flow cytometry. (degruyter.com)
  • Cell apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling and Hoechst 33342 staining, and quantified by flow cytometry. (wjgnet.com)
  • Furthermore, Tan IIA-induced apoptosis and mitochondrial membrane potential changes were also further demonstrated by DNA fragmentation, single-cell gel electrophoresis assay (SCGE), and flow cytometry methods. (hindawi.com)
  • Cell proliferation, cell cycle distribution, and apoptosis were evaluated by the CCK-8 assay and flow cytometry using PI/Annexin V staining, respectively. (medsci.org)
  • Weak external signals may also activate the intrinsic pathway of apoptosis. (wikipedia.org)
  • The other major pathway leading to apoptosis is the intrinsic pathway, called the mitochondrial pathway. (mayo.edu)
  • In the present study, we evaluated the role of the intrinsic pathway in neuronal apoptosis at different stages of rat brain development and during maturation of primary cortical neurons in vivo as well as in response to brain injury. (jneurosci.org)
  • It would therefore be equally appealing and informative to scientists working in the field of apoptosis and those who are investigating mechanisms of proteases and enzymes in general. (springer.com)
  • Professor Gerhard Gröbner, University of Umeå and co-lead author said: "The unique findings here will not only have a significant impact in the field of apoptosis research but will also open gateways for exploring Bax and its relatives as interesting targets in cancer therapy such as by tuning up their cell-killing potential. (labmate-online.com)
  • Communication between the cell survival pathway of autophagy and the cell death pathway of apoptosis is crucial for determining the best outcome for the cell, and ultimately its fate. (edu.au)
  • Complementary projects in the lab focus on autophagy, a cell survival process that has significant cross-talk with apoptosis. (edu.au)
  • These potent effects are driven by curcumin's ability to induce G2/M cell cycle arrest, induce autophagy, activate apoptosis, disrupt molecular signaling, inhibit invasion and metastasis, and increase the efficacy of current chemotherapeutics. (wellnessresources.com)
  • For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
  • Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
  • JAM3 knockdown additionally inhibited trophoblast proliferation and increased the number of trophoblasts in the sub-G1 and G2/M phases, indicating cell-cycle disturbance and apoptosis. (bioone.org)
  • Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
  • Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
  • Apoptosis is a mechanism of programmed cell death that occurs in multicellular organisms. (abcam.com)
  • These results directly demonstrate that FasL-mediated apoptosis is a major mechanism responsible for enterocyte death in CD. (nih.gov)
  • In those cases, multiple aspects of apoptosis might need to be analyzed to confirm the mechanism of cell death. (bdbiosciences.com)
  • Interestingly, mitochondrial association of ADF and n-cofilin during apoptosis was preceded by, and dependent on, actin that translocated by a yet unknown mechanism to mitochondria during cell death. (nature.com)
  • 8 Recently, it was shown that n-cofilin translocates to mitochondria during the early phase of apoptosis, but the mechanism for this translocation remained obscure. (nature.com)
  • Researchers led by Dr Luke Clifton at the Science and Technology Facilities Council (STFC) ISIS Neutron and Muon Source (ISIS) in Oxfordshire and including partners from the University of Umea and European Spallation Source in Sweden, have been able to characterise the molecular mechanism of the early stages of programmed cell death (apoptosis) a process which plays a crucial role in the prevention of cancer. (labmate-online.com)
  • In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. (wikipedia.org)
  • Kerr had initially used the term programmed cell necrosis, but in the article, the process of natural cell death was called apoptosis. (wikipedia.org)
  • Radio-frequency dose-dependent apoptosis, necrosis and cell death monitored by annexin V-BD Horizon™ V450. (bdbiosciences.com)
  • Radio-frequency dose-dependent apoptosis, necrosis and cell death monitored by annexin V-BD Horizon™ V450 in pancreatic carcinoma cell lines treated with a low dose of cetuximab targeted gold nanoparticles. (bdbiosciences.com)
  • As the RF field power increases, the temperature increases, and a shift from apoptosis (lower right quadrant) to frank necrosis (upper left quadrant) is seen. (bdbiosciences.com)
  • The 2002 Nobel Prize in Medicine was awarded to Sydney Brenner, H. Robert Horvitz and John Sulston for their work identifying genes that control apoptosis. (wikipedia.org)
  • We use a combination of biochemical, cell biology, structural biology and medicinal chemistry approaches to understand the precise molecular mechanisms that control apoptosis. (edu.au)
  • The genes were identified by studies in the nematode C. elegans and homologues of these genes function in humans to regulate apoptosis. (wikipedia.org)
  • Following cecal ligation and puncture (CLP) in rats, thymocytes underwent apoptosis in a time-dependent manner. (jci.org)
  • An increased ROS and a decreased TAC accompanied with distinct morphological changes and significant apoptosis were observed in mice sperm from the fluoride group. (fluoridealert.org)
  • We found a significant correlation between the degree of villous atrophy, morphometrically evaluated, and the level of enterocyte apoptosis, suggesting that mucosal flattening is a consequence of exaggerated epithelial cell death. (nih.gov)
  • Apoptosis factor EI24/PIG8 is a novel endoplasmic reticulum-localized Bcl-2-binding protein which is associated with suppression of breast cancer invasiveness.Zhao X., Ayer R.E., Davis S.L., Ames S.J., Florence B., Torchinsky C., Liou J.S., Shen L., Spanjaard R.A.Cancer Res. (joplink.net)
  • 4 Although the mechanisms of caspase activation in the cytosol are well characterized, the steps that control cytochrome c release from mitochondria and thereby activate the apoptosis program have remained largely elusive. (nature.com)
  • There was also no translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus in apoptotic keratinocytes, indicating Tan IIA-induced apoptosis occurs mainly through the caspase pathway. (hindawi.com)
  • Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (joplink.net)
  • Mitochondrial regulation of apoptosis further downstream was investigated, showing changes in the mitochondrial membrane potential, cytochrome c release into the cytoplasm, and enhanced activation of cleaved caspase-3 and Poly ADP-ribose polymerase (PARP). (hindawi.com)
  • Improve your apoptosis detection skills with our free apoptosis application ebook. (abcam.com)
  • To support this spectrum of requirements, BD Biosciences offers a full range of apoptosis detection tools and technologies for measuring indicators at different stages across the apoptotic process. (bdbiosciences.com)
  • Achieve quick and reliable detection of early cell apoptosis with Annexin V stand-alone conjugates for apoptosis detection. (thermofisher.com)
  • The detection of caspase activity is crucial for apoptosis research. (caltagmedsystems.co.uk)
  • Eldadah and Faden, 2000 ), we hypothesized that suppression of apoptotic capability during maturation of mammalian brain results from repression of genes involved in the caspase-3 activation pathway, and that injury-induced neuronal apoptosis in the mature brain results from reactivation of these genes. (jneurosci.org)
  • For many years, neither "apoptosis" nor "programmed cell death" was a highly cited term. (wikipedia.org)
  • While slowly unravelling the complexities of apoptosis in chapter one, the next three chapters individually elaborate on different classes of proteases that play key roles in the initiation, progression and execution of programmed cell death. (springer.com)
  • Now first author Giuseppina Tesco and colleagues report that caspase-3, a key player in apoptosis, or programmed cell death, may be the link. (alzforum.org)
  • Apoptosis is a normal physiologic process which occurs during embryonic development as well as in maintenence of tissue homeostasis. (bdbiosciences.com)
  • Apoptosis is essential for many fundamental processes, such as embryogenesis and tissue homeostasis. (nature.com)
  • While studying tissues using electron microscopy, John Kerr at the University of Queensland was able to distinguish apoptosis from traumatic cell death. (wikipedia.org)
  • Apoptosis is a genetically controlled cell death that was initially recognized for its role in development. (jneurosci.org)
  • Multiorgan apoptosis occurs during sepsis. (jci.org)
  • TUNEL was performed to analyze the apoptosis on ectopic endometrium. (hindawi.com)
  • Terminal deoxynucleotidyl transferase-mediated biotin nick end-labelling (TUNEL) was performed to assess deoxyribonucleic acid strand breakages as a characteristic of apoptosis. (ersjournals.com)
  • C5a blockade dramatically reduced thymocyte apoptosis as measured by thymic weight, binding of annexin V to thymocytes, and laddering of thymocyte DNA. (jci.org)
  • To elucidate the general importance of ADF/cofilin activity for apoptosis, we exposed mouse embryonic fibroblasts deficient for n-cofilin, ADF (actin depolymerizing factor), or all ADF/cofilin isoforms to well-characterized apoptosis inducers. (nature.com)
  • BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. (nutrimedical.com)
  • However, whether 6-OAP-induced mitosis arrest and pathway inhibition are followed by apoptosis requires further study. (spandidos-publications.com)
  • Preclinical in vivo models and non-invasive imaging in apoptosis to understand the complexities of disease progression and their contribution toward therapeutics is recounted in the last chapter. (springer.com)
  • Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
  • Mouse model systems and non-invasive imaging techniques in apoptosis-related diseases such as cancer and neurodegeneration are also covered in this book. (springer.com)
  • To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. (wjgnet.com)
  • Flaviviruses such as Dengue virus, Japanese encephalitis virus, and West Nile virus utilize various strategies to activate or inhibit cell apoptosis. (physiciansweekly.com)
  • In the immune system, Fas antigen (Fas) and Fas ligand (FasL) are involved in the down regulation of immune reactions by inducing apoptosis. (ersjournals.com)
  • The Dual Regulation of Apoptosis by Flavivirus. (physiciansweekly.com)
  • Overexpression of miR-128-3p or knockdown of TGFBR2 ameliorated LPS-induced inflammation and apoptosis. (degruyter.com)
  • Therefore, it was hypothesized that the Fas/FasL pathway and apoptosis may be associated with the course of granulomatous inflammation in sarcoidosis. (ersjournals.com)
  • Further studies are needed to determine the role of Fas, FasL and other regulatory factors in apoptosis in the granulomatous inflammation in pulmonary sarcoidosis. (ersjournals.com)
  • The abolishment of enterocyte apoptosis observed in the presence of ZB4 antibody suggests that enterocytes are potential targets of lymphocyte infiltrate. (nih.gov)
  • Infection with virulent influenza (H5N1) virus was also shown to induce lymphopenia and lymphocyte apoptosis in vivo ( 14 ). (cdc.gov)
  • This study provides results of early diminished platelet function in IBS-treated PCs as compared to conventional PCs, i.e., reduced aggregation response to collagen or thrombin and adhesion to collagen or vWF under flow, increased platelet apoptosis, MAPK p38 activation, and glycoprotein Ibα (GPIbα) shedding and enhanced clearance from the circulation of mice. (haematologica.org)
  • This is a comprehensive overview of the mechanisms of apoptosis, with a particular emphasis on proteases. (springer.com)
  • Our aim was to evaluate whether increased enterocyte apoptosis was responsible for mucosal flattening in celiac disease (CD), and, since the mechanisms responsible for tissue injury in this condition are unknown, we studied the possibility that the Fas-Fas ligand (FasL) system may be involved. (nih.gov)
  • The aim of the study was to investigate the influence of chronic fluorosis on apoptosis and the expression of Bax and Bcl-2 in the cerebral cortices of rats in an attempt to elucidate molecular mechanisms. (fluoridealert.org)
  • Review our assay kits for the study of apoptosis. (abcam.com)
  • Analysis of this effect revealed that a component of milk in a particular physical state--multimeric alpha-lact-albumin--is a potent Ca(2+)-elevating and apoptosis-inducing agent with broad, yet selective, cytotoxic activity. (lu.se)
  • Recent studies reported a mitochondrial translocation of n-cofilin during apoptosis. (nature.com)