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  • rats
  • Ernst AM (1967) Mode of action of apomorphine and dexamphetamine in gnawing compulsion in rats. (springer.com)
  • Apomorphine, an unselective dopamine Dl and D2 receptor agonist, induces in laboratory animals (mice and rats), several behavioural phenomena such as stereotyped behaviour, hyperlocomotion, aggressiveness, etc 1-3 . (springer.com)
  • This hypothesis is evidenced by the fact that most of the psychotropic drugs used in clinical practice for the treatment of psychosis attenuate or completely block the apomorphine-induced aggression in adult male Wistar rats. (springer.com)
  • Drugs
  • The recent European approval of Archimedes' innovative fentanyl pectin nasal spray product for of breakthrough cancer pain (PecFent) is one example of a product specifically designed for purpose and there are numerous other nasal drugs in clinical development at Archimedes and elsewhere, including granisetron (nausea/vomiting), diazepam and midazolam (seizures), testosterone (hypogonadism) and apomorphine (Parkinson's disease). (thefreedictionary.com)
  • Whereas hyperreflexic patients improved with apomorphine, and to a lesser extent with L dopa, these drugs had no effect on hyporeflexic patients. (wiley.com)
  • Though the mechanisms of action of those drugs are known, the neurobiology of the apomorphine-induced aggression is not well understood 6 . (springer.com)
  • Parkinsonian
  • Dewey Jr RB, Hutton JT, LeWitt PA, Factor SA (2001) A randomized double-blind, placebo controlled trial of subcutaneously injected apomorphine for Parkinsonian off states. (springer.com)
  • erectile
  • Historically, apomorphine has been tried for a variety of uses including as a way to relieve anxiety and craving in alcoholics, an emetic (to induce vomiting), for treating stereotypies (repeated behaviour) in farmyard animals and more recently in treating erectile dysfunction. (wikipedia.org)
  • A-119637 (0.3 micromol kg(-1), i.p.) tripled the number of erections, and produced a 6 fold increase in the duration of apomorphine-induced erectile responses. (lu.se)
  • behaviour
  • The apomorphine-induced (0.5-1.0 mg/kg, once or twice daily during 10-15 days) aggression has been considered to be an animal model of human psychotic behaviour 4,5 . (springer.com)
  • Erich Harnack
  • Key to the use of apomorphine as a behavioural modifier was the research of Erich Harnack, whose experiments in rabbits (which do not vomit) demonstrated that apomorphine had powerful effects on the activity of rabbits, inducing licking, gnawing and in very high doses convulsions and death. (wikipedia.org)
  • penile
  • Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist. (lu.se)
  • Continuous
  • This use of small, continuous doses (1/30th of a grain, or 2.16mg by Douglas) of apomorphine to reduce alcoholic craving comes some time before Pavlov's discovery and publication of the idea of the "conditioned reflex" in 1903. (wikipedia.org)
  • Therapeutic
  • The emetic properties of apomorphine are exploited in veterinary medicine to induce therapeutic emesis in canines that have recently ingested toxic or foreign substances. (wikipedia.org)
  • antagonists
  • Effects of intracavernous (i.c.) or intraperitoneal (i.p.) administration of alpha(1)-AR antagonists on apomorphine-induced erections were investigated. (lu.se)
  • effects
  • The risk or severity of adverse effects can be increased when Amifostine is combined with Apomorphine. (drugbank.ca)
  • Apomorphine has some of the same effects as a chemical called dopamine, which occurs naturally in your body. (wellspan.org)
  • Some medicines can cause unwanted or dangerous effects when used with apomorphine. (wellspan.org)
  • The pharmacological effects of naturally-occurring apomorphine in the blue lotus (N. caerulea) were known to the ancient Egyptians and Mayans, with the plant featuring in tomb frescoes and associated with entheogenic rites. (wikipedia.org)
  • study
  • A recent study indicates that apomorphine might be a suitable marker for assessing central dopamine system alterations associated with chronic heroin consumption. (wikipedia.org)
  • The TOLEDO study is sponsored by Britannia Pharmaceuticals Ltd., part of the STADA Arzneimittel AG group of companies and manufacturer of apomorphine products. (thailand4.com)
  • phase
  • However, there is a paucity of information on long-term benefits of apomorphine, including no large-scale phase III trial. (springer.com)
  • mass
  • Development of a gas chromatographic/mass spectrometric method to quantify R(-)-apomorphine, R(-)-apocodeine and R(-)-norapomorphine in human plasma and urine. (sigmaaldrich.com)
  • A method was developed and validated for the analysis of R(-)-apomorphine, (R-)-apocodeine and R(-)-norapomorphine in human plasma and urine with N-propylnorapomorphine as internal standard using gas chromatography/mass spectrometry (GC/MS) and single-ion monitoring after a single liquid-liquid extraction and silylation of compounds. (sigmaaldrich.com)