• Drugs
  • Whereas hyperreflexic patients improved with apomorphine, and to a lesser extent with L dopa, these drugs had no effect on hyporeflexic patients. (wiley.com)
  • blockade
  • The present findings show that there is a functional predominance of the alpha(1D)-AR subtype in the rat erectile tissue, and that blockade of this receptor facilitates rat penile erection induced by a suboptimal dose of apomorphine. (lu.se)
  • Continuous
  • This use of small, continuous doses (1/30th of a grain, or 2.16mg by Douglas) of apomorphine to reduce alcoholic craving comes some time before Pavlov's discovery and publication of the idea of the "conditioned reflex" in 1903. (wikipedia.org)
  • erectile
  • Historically, apomorphine has been tried for a variety of uses including as a way to relieve anxiety and craving in alcoholics, an emetic (to induce vomiting), for treating stereotypies (repeated behaviour) in farmyard animals and more recently in treating erectile dysfunction. (wikipedia.org)
  • A-119637 (0.3 micromol kg(-1), i.p.) tripled the number of erections, and produced a 6 fold increase in the duration of apomorphine-induced erectile responses. (lu.se)
  • Erich Harnack
  • Key to the use of apomorphine as a behavioural modifier was the research of Erich Harnack, whose experiments in rabbits (which do not vomit) demonstrated that apomorphine had powerful effects on the activity of rabbits, inducing licking, gnawing and in very high doses convulsions and death. (wikipedia.org)
  • Indications
  • We have examined our experience of apomorphine over the last 10 years, to assess indications, pattern of use, efficacy, and side effect profile. (springer.com)
  • penile
  • Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist. (lu.se)
  • patients
  • Complications included skin problems in 16 patients, 2 had symptomatic hypotension, 2 worsening confusion, 1 new confusion and 5 new hallucinations (after sometime on apomorphine). (springer.com)
  • Sixteen patients have stopped using apomorphine completely. (springer.com)
  • Based on one study of 29 participants, which the authors stated provided the most extensive data on adverse events in apomorphine-naive patients, several adverse events were reported. (york.ac.uk)
  • In patients with PD, apomorphine is effective at providing prompt and consistent rescue from 'off' episodes. (york.ac.uk)
  • Therapeutic
  • The emetic properties of apomorphine are exploited in veterinary medicine to induce therapeutic emesis in canines that have recently ingested toxic or foreign substances. (wikipedia.org)
  • antagonists
  • Effects of intracavernous (i.c.) or intraperitoneal (i.p.) administration of alpha(1)-AR antagonists on apomorphine-induced erections were investigated. (lu.se)
  • In animals, unlike D2 receptor antagonists like haloperidol, sonepiprazole does not block the behavioral effects of amphetamine or apomorphine, does not alter spontaneous locomotor activity on its own, and lacks extrapyramidal and neuroendocrine effects. (wikipedia.org)
  • effects
  • The risk or severity of adverse effects can be increased when Amifostine is combined with Apomorphine. (drugbank.ca)
  • Apomorphine has some of the same effects as a chemical called dopamine, which occurs naturally in your body. (wellspan.org)
  • Some medicines can cause unwanted or dangerous effects when used with apomorphine. (wellspan.org)
  • Furthermore, studies conducted by nastech pharmaceutical company inc into the intranasal delivery of apomorphine indicated that more than 2 mg of apomorphine can be administered in this manner, in a clinical setting, without causing unacceptable side effects. (tripod.com)
  • nausea
  • To prevent these symptoms, you may be given anti-nausea medication to start taking a few days before you start using apomorphine. (wellspan.org)
  • mass
  • Development of a gas chromatographic/mass spectrometric method to quantify R(-)-apomorphine, R(-)-apocodeine and R(-)-norapomorphine in human plasma and urine. (sigmaaldrich.com)
  • A method was developed and validated for the analysis of R(-)-apomorphine, (R-)-apocodeine and R(-)-norapomorphine in human plasma and urine with N-propylnorapomorphine as internal standard using gas chromatography/mass spectrometry (GC/MS) and single-ion monitoring after a single liquid-liquid extraction and silylation of compounds. (sigmaaldrich.com)
  • treat
  • Douglas saw two purposes for apomorphine: [it can be used to treat] a paroxysm of dipsomania [an episode of intense alcoholic craving]. (wikipedia.org)