• Many studies have focused on the association between the apolipoprotein A5 (ApoA5) polymorphism and the risk of metabolic syndrome (MetS). (nih.gov)
  • Previous studies suggested that apolipoprotein A5 (ApoA5) genetic polymorphisms (SNPs) may result in lipid metabolism disorders. (biomedcentral.com)
  • ApoA5 is an important apolipoprotein which involved in plasma lipid metabolism. (biomedcentral.com)
  • 26. Identifying functional non-coding variants in APOA5/A4/C3/A1 gene cluster associated with coronary heart disease. (nih.gov)
  • 31. SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/A4/C3/A1 locus on chromosome 11q23 in the Northern Irish population. (nih.gov)
  • 37. Impact of apolipoprotein A5 (APOA5) polymorphisms on serum triglyceride levels in schizophrenic patients under long-term atypical antipsychotic treatment. (nih.gov)
  • However, for 13 percent of the study population with a specific allele of the apolipoprotein A5 gene (APOA5), higher dietary fat was not related to a greater BMI. (science20.com)
  • Background: Apolipoprotein A5 (APOA5) is involved in serum triglyceride (TG) regulation. (bvsalud.org)
  • Methods We assessed the −1131T>C (rs662799) promoter polymorphism of the apolipoprotein A5 (APOA5) gene in relation to triglyceride concentration, several other risk factors, and risk of coronary heart disease. (le.ac.uk)
  • Human apolipoprotein E (apoE) is one of the major determinants in lipid transport, playing a critical role in atherosclerosis and other diseases. (nih.gov)
  • To determine the associations between apolipoprotein E ( APOE ) genotypes and serum levels of glucose, total cholesterol, and triglycerides in a cognitively normal aging Han Chinese population. (dovepress.com)
  • and (3) E2/4, E3/4, or E4/4 ( APOE E4). (dovepress.com)
  • Apolipoprotein E (APOE), a major cholesterol carrier in the brain, has been proven to be associated with the pathology of Alzheimer's disease (AD). (dovepress.com)
  • APOE has three common alleles including E2, E3, and E4, encoding three protein isoforms. (dovepress.com)
  • The ε4 allele, compared with the common ε3 allele, of the human apolipoprotein E gene (ApoE) is associated with accelerated cognitive decline and increased risks for Alzheimer's disease (AD). (nih.gov)
  • There are three main forms or alleles of APOE - APOE e2 , APOE e3 and APOE e4 . (genebase.com)
  • E1/E2 heterodimer binds host apolipoproteins such as APOB and APOE thereby forming a lipo-viro-particle (LVP) (PubMed:25122793, PubMed:29695434, PubMed:24838241). (proteopedia.org)
  • The interaction between E2 and host apolipoprotein E/APOE allows the proper assembly, maturation and infectivity of the viral particles (PubMed:25122793, PubMed:29695434). (proteopedia.org)
  • A major and most common isoform of apolipoprotein E. Therefore, it is also known as apolipoprotein E (ApoE). (nih.gov)
  • Although there is no specific gene that has been identified to cause late-onset AD, carrying a variant form of the Apolipoprotein E (APOE) gene affects an individual's risk of developing the disease. (pharmacytimes.com)
  • But for carriers of e3 and e4, the risk reduction associated with CHIP was comparable to or greater than that of APOE e2," Jaiswal said. (pharmacytimes.com)
  • The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. (medlineplus.gov)
  • It is thought that the apolipoprotein E produced from the e4 allele of the APOE gene may disrupt the transport of a protein called alpha-synuclein into and out of cells. (medlineplus.gov)
  • Literature review suggests a close relationship between estrogen and apolipoprotein E (ApoE) in the central nervous system. (elsevierpure.com)
  • To investigate how PARP accelerates atherogenesis, apolipoprotein E knockout mice (Apoe -/- ) were treated with the PARP inhibitor INO-1001. (biomedcentral.com)
  • Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
  • 28. Association of apolipoprotein A-V concentration with apolipoprotein A5 gene -1131T>C polymorphism and fasting triglyceride levels. (nih.gov)
  • C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study. (science20.com)
  • Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. (niagads.org)
  • Apolipoprotein E4 (APOE4) allele is a major risk factor for late-onset familial and sporadic Alzheimer disease (AD). (niagads.org)
  • The human apolipoprotein E4 allele may be associated with risk of more severe COVID-19 infection and clinical outcomes compared to the E3 allele. (taconic.com)
  • Line 1549 is homozygous for the E4 allele, line 1548 is homozygous for the E3 allele, and line 1547 is homozygous for the E2 allele. (taconic.com)
  • Taconic can produce custom hybrids which carry one E3 and one E4 allele upon request. (taconic.com)
  • The most common allele is e3, which is found in more than half of the general population. (medlineplus.gov)
  • The Vif protein interacts with APOBEC3 (A3) proteins promoting their accelerated degradation by the 26S proteosome. (ku.edu)
  • Sequence analysis of Vif proteins from different lentiviruses revealed that there are two highly conserved domains in the carboxyl terminus that are required for recruitment of the of the Vif-CBF-β-Cul5/Elongin B/C/Rbx-1 E3 ubiquitin ligase complex. (ku.edu)
  • 85%) were in the context of 5'-T85%) were in the context of 5'-TC (minus strand) and not 3'-CC, suggesting that one or more of the rhesus A3 proteins may be responsible for the observed mutational patterns. (ku.edu)
  • Several studies have indicated that cholesterol and associated proteins, especially apolipoproteins (Apos), may play an important role in the diagnosis, prognosis, and susceptibility of suicide. (preprints.org)
  • While the role of apolipoproteins and low-density lipoproteins (LDL) in cardiovascular disease (CVD) has been understood for some time, emerging research is revealing that these proteins may prove to be valuable biomarkers beyond CVD. (bioradiations.com)
  • Along with other proteins, apolipoproteins bind lipids to form lipoproteins such as high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL). (bioradiations.com)
  • The SAA family of proteins are apolipoproteins that are transferred in plasma mainly bound to high denseness lipoproteins (HDL)10,11. (buyresearchchemicalss.net)
  • that is characterized by arterial, venous, or microvascular thrombosis or recurrent pregnancy loss caused by antibodies directed against one or more phospholipid-bound proteins (eg, beta-2 glycoprotein 1, prothrombin, annexin A5). (msdmanuals.com)
  • Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. (wikipedia.org)
  • The ability of sAPP-α to activate microglia was blocked by prior incubation of the protein with apolipoprotein E3 but not apolipoprotein E4, a variant associated with an increased risk for Alzheimer's 6 . (nature.com)
  • Jose Ordovas, PhD, director of the Nutrition and Genomics Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA), and colleagues found that the apolipoprotein A-II gene (APOA2) is associated with proportions of fat, carbohydrate, and protein in the diet, along with total calories and, therefore, with body-mass-index (BMI). (science20.com)
  • In human, Apo E3 is a 299-amino acid protein with a cysteine at the 112 and an arginine at the 158 position. (nih.gov)
  • 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Lab-and-Diagnostic-Tests/425328/5.1/Apolipoproteins:_A_B_and_E. Accessed December 7, 2023. (unboundmedicine.com)
  • The scientific literature on apolipoproteins in disease, from 1972-2017. (bioradiations.com)
  • rs5092 is a SNP in the apolipoprotein A4 APOA4 gene. (snpedia.com)
  • The defective binding of apolipoprotein (apo) E2 to lipoprotein receptors, an underlying cause of type III hyperlipoproteinemia, results from replacement of Arg 158 with Cys, disrupting the naturally occurring salt bridge between Asp 154 and Arg 158. (rcsb.org)
  • This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. (nih.gov)
  • thus, this study sought to summarize the rhythmic expression of clock genes and lipid metabolism-related apolipoprotein genes within the SCN of Mus musculus. (preprints.org)
  • Out of the 20 apolipoprotein genes that were studied by the published database, all 9 genes were highly expressed in the SCN. (preprints.org)
  • We summarized most studies of lipid-related apolipoprotein genes within limited locations of the SCN and brain to further understand how disordered cerebral lipid metabolism causes multiple brain diseases and disorders. (preprints.org)
  • 32. APOC3/A5 haplotypes, lipid levels, and risk of myocardial infarction in the Central Valley of Costa Rica. (nih.gov)
  • Interactions between the apolipoprotein a1/c3/a5 haplotypes and alcohol consumption on serum lipid levels. (cdc.gov)
  • 1999 . MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B . J Clin Invest 103:773-77810079097. (nih.gov)
  • The Effects of Gene-Environment Interactions Between Cadmium Exposure and Apolipoprotein E4 on Memory in a Mouse Model of Alzheimer's Disease. (nih.gov)
  • Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study. (snpedia.com)
  • The mammalian apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3 or A3) family of cytidine deaminases restrict viral infections by mutating viral DNA and impeding reverse transcription. (opinvisindi.is)
  • While cholesterol levels are still used to measure cardiovascular risk, apolipoproteins have emerged as relevant biomarkers for assessing the risk of various CVD and initiating prophylactic and therapeutic strategies. (bioradiations.com)
  • Objetivo: investigar el efecto del consumo de alcohol general, así como el tipo de bebida alcohólica consumida, en diferentes medidas lipídicas. (bvsalud.org)
  • Método: el efecto del consumo de alcohol fue investigado, así como el tipo de bebida alcohólica, en diferentes medidas lipídicas en ambos sexos de población del Estudio Longitudinal de Salud del Adulto. (bvsalud.org)
  • This study aimed to investigate the relationship between apolipoprotein B (apo B) and bone mineral density (BMD) at different skeletal sites (lumbar spine, femoral neck, and total femur) and to compare the influence of apo B with other traditional lipid markers. (biomedcentral.com)
  • Apolipoprotein E is involved in injury repair and transporting fats between brain cells. (genebase.com)
  • Subjects with hyperhomocysteinaemia had significantly elevated total cholesterol, LDL cholesterol, apolipoprotein A and apolipoprotein B and lower vitamin B levels compared with subjects with 12 normohomocysteinaemia. (who.int)
  • Hcy levels correlated with total cholesterol ( r = 0.09), apolipoprotein A ( r = 0.012), and B ( r = 0.013) levels and total/HDL cholesterol ratio ( r = -0.085). (who.int)
  • However, recent studies indicate that apolipoproteins are critical biomarkers in many other diseases, from autoimmunity to cancer (Table 2). (bioradiations.com)
  • Apolipoprotein CIII is also found on HDL particles. (wikipedia.org)
  • Apolipoprotein of the HDL complex. (antibodies-online.com)
  • Diffusion of the complex E1/E2-EGFR-SCARB1-CD81 to the cell lateral membrane allows further interaction with Claudin 1 (CLDN1) and occludin (OCLN) to finally trigger HCV entry (PubMed:12970454, PubMed:24038151, PubMed:12913001, PubMed:20375010, PubMed:19182773) (By similarity). (proteopedia.org)
  • There are eight classes of apolipoproteins with many subclasses, and each has a unique function in maintaining health or driving disease (Table 1). (bioradiations.com)