APOEChylomicronsGenotypeLipoproteinsELISALipoproteinCholesterolAPOA1ApoB-100PolymorphismsSerumAlleleGeneMetabolismLipidsAllelesAntibodyGenotypesPolymorphismAtherosclerosisVLDLProteinsProtein is produced2019Specific receptorsMetricsAlzheimer'sDensityShorterMolecularConcentrationsBiologicalComponentType
APOE6
- Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
- The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
- Apolipoprotein E (ApoE) is involved on cholesterol and triglycerides metabolism regulation. (biomedcentral.com)
- The characteristic components of the syndrome are mostly determined by apolipoprotein E (ApoE) modulation of atherogenic plasma Apo-B containing lipoproteins. (biomedcentral.com)
- Should the apolipoprotein E (ApoE) genotype be a covariate for clinical trials in Alzheimer disease (AD)? (biomedcentral.com)
- With regard to therapeutic drug trials in Alzheimer disease (AD), a frequent and appropriate concern is whether the apolipoprotein E (ApoE) genotype should be taken as a covariate in statistical analyses regarding efficacy or adverse effects. (biomedcentral.com)
Chylomicrons4
- Plasma phospholipid levels are very low, while plasma apolipoprotein B, chylomicrons, very-low-density lipoproteins (VLDLs), and low-density lipoproteins (LDLs) are absent. (medscape.com)
- The normal-length apolipoprotein B-48 can form chylomicrons normally, but the abnormally short apolipoprotein B-100 produced in the liver is less able to produce lipoproteins. (medlineplus.gov)
- Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). (assaygenie.com)
- This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. (affbiotech.com)
Genotype3
- Moreover, apolipoprotein genotype analysis revealed that AD subjects with the E3/E4 alleles had the highest content of mitochondrial APP. (jneurosci.org)
- Masullo CDaniele AFazio VM et al The apolipoprotein E genotype in patients affected by syndromes with focal cortical atrophy. (jamanetwork.com)
- The neuropathology of stillbirth - correlation with apolipoprotein genotype in a Scottish population based study. (cdc.gov)
Lipoproteins9
- Unlike other lipoproteins, which are mainly produced in the liver, apolipoprotein D is mainly produced in the brain and testes. (wikipedia.org)
- Other apolipoproteins (A, C, D, E, and their subtypes) are soluble and are exchanged between lipoproteins during metabolism. (medscape.com)
- Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. (thermofisher.com)
- Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). (thermofisher.com)
- Apolipoprotein B-100, which is produced in the liver, is a component of several other types of lipoproteins. (medlineplus.gov)
- Triglycerides (TGs) are proatherogenic lipoproteins involving the risk of coronary heart disease (CHD), while apolipoprotein A5 (APOA5) and apolipoprotein C3 (APOC3) are main lipoproteins composing TG-rich lipoproteins. (biomedcentral.com)
- Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
- METHODS: To investigate the kinetics of ApoB-48- and ApoB-100-containing lipoproteins, we performed a secondary analysis of 11 overweight/obese individuals with type 2 diabetes who were treated with lifestyle counselling and on a stable dose of metformin who were from an earlier clinical study, and compared these with 11 control participants frequency-matched for age, BMI and sex. (bvsalud.org)
- CONCLUSIONS/INTERPRETATION: Abnormalities in the metabolism of intestinally derived ApoB-48-containing lipoproteins in individuals with type 2 diabetes on statins may help to explain the residual risk of CVD and may be suitable targets for interventions. (bvsalud.org)
ELISA6
- Mouse Apolipoprotein B48 (apo-B48) ELISA Kit is Available at Gentaur Genprice with the fastest delivery. (joplink.net)
- MIA1609 targets Apolipoprotein B in ELISA, IP and RIA applications and shows reactivity with Human samples. (thermofisher.com)
- Description: A sandwich ELISA kit for detection of Apolipoprotein A1 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (elisastrip.com)
- Description: A sandwich ELISA kit for detection of Apolipoprotein H from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (wildpalm.net)
- Description: A sandwich quantitative ELISA assay kit for detection of Human Apolipoprotein H (APOH) in samples from serum, plasma or other biological fluids. (wildpalm.net)
- Description: Quantitativesandwich ELISA kit for measuring Human Apolipoprotein H (APOH) in samples from serum, plasma, tissue homogenates. (wildpalm.net)
Lipoprotein10
- Each lipoprotein is characterized by its lipid composition and by the type and number of apolipoproteins it possesses. (medscape.com)
- these apolipoproteins have lipid-soluble segments, the beta apolipoproteins, which remain part of the lipoprotein throughout its metabolism. (medscape.com)
- Apolipoprotein A-I (apo A-I), the main protein component of high-density lipoprotein (HDL), reduces the risk for atherosclerosis by removing cholesterol from the membrane of foam cells. (edpsciences.org)
- Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. (thermofisher.com)
- Apolipoprotein B-48 is produced in the intestine, where it is a building block of a type of lipoprotein called a chylomicron. (medlineplus.gov)
- Total cholesterol (TC), high density lipoprotein (HDL), triglycerides (TG), and apolipoproteins A 1 and B were assayed in blood serum prior to (assay A) and after (assay B) both exposures to +Gz. (aaem.pl)
- Relationship of skeletal muscle fiber type to serum high density lipoprotein cholesterol and apolipoprotein A₁ levels. (aaem.pl)
- Plasma concentration of Apolipoprotein B and Lipoprotein a are strongest predictors of cardiovascular risk events. (natap.org)
- Apolipoprotein B (apoB) is a nonexchangeable lipoprotein that exists in two forms in humans, apoB-100 and apoB-48. (medscape.com)
- Lipoprotein (a) (Lp[a]) is composed of a low density lipoprotein (LDL) particle with an apolipoprotein B-100 (apo B100) component that is covalently linked via a disulfide bridge to an apolipoprotein (a) molecule, which is highly homologous to plasminogen. (medscape.com)
Cholesterol5
- These particles consist of a core of cholesterol esters and triglycerides surrounded by a monolayer of free cholesterol, phospholipids, and proteins (apolipoproteins). (medscape.com)
- Ala-Korpela, M 2019, ' The culprit is the carrier, not the loads: cholesterol, triglycerides and apolipoprotein B in atherosclerosis and coronary heart disease ', International Journal of Epidemiology , vol. 48, no. 5, pp. 1389-1392. (bris.ac.uk)
- All of these protein changes lead to a reduction of functional apolipoprotein B. As a result, the transportation of dietary fats and cholesterol is decreased or absent. (medlineplus.gov)
- Apolipoprotein (Apo) A1 is the major component of HDL protein that facilitates cholesterol efflux from peripheral cells through ABCA1. (biomedcentral.com)
- The apolipoproteins have a primary responsibility for the transport of lipids and cholesterol. (medscape.com)
APOA12
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Apolipoprotein A1 (APOA1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (elisastrip.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Apolipoprotein A1 (APOA1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (elisastrip.com)
ApoB-1004
- Normal plasma apolipoprotein B levels are around 800mg/L. Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100. (thermofisher.com)
- The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. (thermofisher.com)
- ApoB-100, which is synthesized by the liver, is larger than apoB-48, being made up of 4536 amino acids. (medscape.com)
- It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. (affbiotech.com)
Polymorphisms2
- Benn M, Nordestgaard BG, Jensen JS, Tybjaerg-Hansen A. Polymorphisms in apolipoprotein B and risk of ischemic stroke. (prosci-inc.com)
- We tried to identify the interaction between dietary quality indices and apolipoprotein B Ins/Del and EcoR1 polymorphisms on cardio-metabolic risk factors in patients with type 2 diabetes mellitus (T2DM). (researchsquare.com)
Serum2
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Apolipoprotein H (APOH) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (wildpalm.net)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Apolipoprotein H (APOH) in serum, plasma and other biological fluids. (wildpalm.net)
Allele9
- Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. (jamanetwork.com)
- The apolipoprotein E allele ϵ4 is overrepresented in patients with the Lewy body variant of Alzheimer's disease. (jamanetwork.com)
- St Clair DNorrman JPerry RYates CWilcock GBrookes A Apolipoprotein E ϵ4 allele frequency in patients with Lewy body dementia, Alzheimer's disease and age-matched controls. (jamanetwork.com)
- Apolipoprotein E ϵ4 allele in Alzheimer's disease and vascular dementia. (jamanetwork.com)
- SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E ϵ4 allele. (jamanetwork.com)
- Juottonen KLehtovirta MHelisalmi SRiekkinen Sr PJSoininen H Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E ϵ4 allele. (jamanetwork.com)
- Farrer LAAbraham CRVolicer L et al Allele ϵ4 of apolipoprotein E shows a dose effect on age at onset of Pick disease. (jamanetwork.com)
- Frisoni GBCalabresi LGeroldi C et al Apolipoprotein E ϵ4 allele in Alzheimer's disease and vascular dementia. (jamanetwork.com)
- Geschwind DKarrim JNelson SFMiller B The apolipoprotein E ϵ4 allele is not a significant risk factor for frontotemporal dementia. (jamanetwork.com)
Gene7
- Apolipoprotein D (ApoD) is a protein that in humans is encoded by the APOD gene. (wikipedia.org)
- The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA. (thermofisher.com)
- Neuropathological evaluation and apolipoprotein E gene polymorphism analysis in diffuse Lewy body disease. (jamanetwork.com)
- The APOB gene provides instructions for making two versions of the apolipoprotein B protein, a short version called apolipoprotein B-48 and a longer version known as apolipoprotein B-100. (medlineplus.gov)
- Most APOB gene mutations that cause FHBL lead to the production of apolipoprotein B that is abnormally short. (medlineplus.gov)
- The severity of the condition largely depends on the length of the abnormal apolipoprotein B. Some mutations in the APOB gene lead to the production of a protein that is shorter than apolipoprotein B-100, but longer than apolipoprotein B-48. (medlineplus.gov)
- Recombinant Human Apolipoprotein B-100 is produced by our E.coli expression system and the target gene encoding Glu28-Ser127 is expressed with a 6His tag at the N-terminus. (assaygenie.com)
Metabolism1
- Apolipoprotein M in lipid metabolism and cardiometabolic diseases. (nih.gov)
Lipids1
- The double belt model for lipid-bound discoidal apolipoprotein A-I consists of two alpha-helical monomers bound about an unilamellar bilayer of lipids. (elsevierpure.com)
Alleles1
- Kalaria RNCohen DLPremkumar DRD Apolipoprotein E alleles and brain vascular pathology in Alzheimer's disease. (jamanetwork.com)
Antibody1
- The following product was used in this experiment: Apolipoprotein B Monoclonal Antibody (F2C9) from Thermo Fisher Scientific, catalog # MIA1609, RRID AB_11152638. (thermofisher.com)
Genotypes2
- Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes. (jamanetwork.com)
- Mesulam MMJohnson NGrujic ZWeintraub S Apolipoprotein E genotypes in primary progressive aphasia. (jamanetwork.com)
Polymorphism2
- Apolipoprotein E polymorphism in patients with different neurodegenerative disorders. (jamanetwork.com)
- Helisalmi SLinnaranta KLehtovirta M et al Apolipoprotein E polymorphism in patients with different neurodegenerative disorders. (jamanetwork.com)
Atherosclerosis1
- Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. (thermofisher.com)
VLDL1
- During the postprandial period, ApoB-48 particles accounted for a higher proportion of total VLDL in individuals with type 2 diabetes (44%) compared with control participants (25%), and these ApoB-48 VLDL particles exhibited a fivefold longer residence time in the circulation (p (bvsalud.org)
Proteins1
- In this experiment we measured three acute phase proteins, cortisol, and plasma IgG to determine if they are good indicators of stress in neonates and to establish normal neonatal concentrations of haptoglobin, alpha-1 acid glycoprotein and apolipoprotein-B. Eight calves were blocked by sex and date of birth. (usda.gov)
Protein is produced1
- In these cases, no normal-length apolipoprotein B protein is produced. (medlineplus.gov)
20191
- 2019 Oct 1;48(5):1389-1392. (bris.ac.uk)
Specific receptors1
- Apolipoprotein B-100 allows LDLs to attach to specific receptors on the surface of cells, particularly in the liver. (medlineplus.gov)
Metrics1
- The current usage metrics is available 48-96 hours after online publication and is updated daily on week days. (edpsciences.org)
Alzheimer's2
- Gomez-Isla TWest HLRebeck GW et al Clinical and pathological correlates of apolipoprotein E ϵ4 in Alzheimer's disease. (jamanetwork.com)
- Gustafson LAbrahamson MGrubb ANilsson KFex G Apolipoprotein-E genotyping in Alzheimer's disease and frontotemporal dementia. (jamanetwork.com)
Density1
- Compared with control participants, in individuals with type 2 diabetes, chylomicron TG and ApoB-48 levels exhibited an approximately twofold higher response to the fat-rich meal, and a twofold higher increment was observed in ApoB-48 particles in the VLDL1 and VLDL2 density ranges (all p (bvsalud.org)
Shorter2
- Other mutations result in a protein that is shorter than both apolipoprotein B-48 and apolipoprotein B-100. (medlineplus.gov)
- Generally, if both versions of the protein are shorter than apolipoprotein B-48, the signs and symptoms are more severe than if some normal length apolipoprotein B-48 is produced. (medlineplus.gov)
Molecular2
- MIA1609 detects Apolipoprotein B which has a predicted molecular weight of approximately 502 kDa. (thermofisher.com)
- Caulfield, TR 2011, ' Inter-ring rotation of apolipoprotein A-I protein monomers for the double-belt model using biased molecular dynamics ', Journal of Molecular Graphics and Modelling , vol. 29, no. 8, pp. 1006-1014. (elsevierpure.com)
Concentrations1
- Apolipoprotein-B increased from d 1 to d 3 (385 to 515 micro/ml), then gradually fell to near d 1 concentrations by d 42. (usda.gov)
Biological1
- Adsorption of apolipoprotein A-I to biological membranes. (edpsciences.org)
Component1
- Apolipoprotein D (ApoD) is a component of HDL that has no marked similarity to other apolipoprotein sequences. (wikipedia.org)
Type1
- Isoe KUrakami KSato KTakahashi K Apolipoprotein E in patients with dementia of the Alzheimer type and vascular dementia. (jamanetwork.com)