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  • Marfan
  • Increasing awareness, saving lives, and improving the quality of life for patients, their families, and medical professionals affected by Marfan syndrome, genetic aortic disorders, and related connective tissue disorders through national programs of education, support, and research. (diseaseinfosearch.org)
  • The study compared the outcomes of 13,205 patients-2,079 with bicuspid aortic valves and 73 with Marfan syndrome-who had AVR replacement between 1995 and 2010. (acc.org)
  • The authors of the study note that these results "provide additional support for the discrete treatment algorithms for patients with bicuspid valve disease," as the operative management of these patients has previously been extrapolated based on Marfan syndrome patients. (acc.org)
  • condition
  • Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives. (diseaseinfosearch.org)
  • aorta
  • Background- The aim of this retrospective study is to investigate efficacy and middle-term results of the stent graft treatment for diseases of descending thoracic aorta. (ahajournals.org)
  • Diseases of the thoracic aorta represent often life-threatening conditions, and despite growing consciousness among the physicians about the role of early diagnosis in determining the appropriate treatment, they are still far from holding precise guidelines in management of acute and chronic aortic syndromes. (ahajournals.org)
  • Aortic resection and replacement with graft interposition has been for many years the preferred method of treatment in the aneurysmatic lesions of thoracic aorta. (ahajournals.org)
  • Moreover, we try to search for the real behavior of native aortic wall in response of modifications in the acute and chronic phase induced by aortic disease as well as by introducing a noncompliant system in a semi-compliant structure such as aorta. (ahajournals.org)
  • Some people come to our Multidisciplinary Aorta Program because they have a genetic condition or other medical conditions that put them at greater risk for aortic disease. (henryford.com)
  • The natural history of the specific acute aortic syndromes that affect the descending thoracic aorta has also been described with more clarity and has become more commonly recognized. (ahajournals.org)
  • The purpose of this scientific statement is to present a contemporary review of the various pathological processes that affect the descending thoracic aorta: Aneurysms, dissections, intramural hematomas (IMHs), penetrating atherosclerotic ulcers (PAUs), and aortic transections. (ahajournals.org)
  • Our goal is to provide the healthcare professional with a better understanding of the pathophysiology of the various disease processes that involve the descending thoracic aorta and to review current outcomes and technical pitfalls associated with these therapies to facilitate strong, evidence-based decision making in the care of these patients. (ahajournals.org)
  • Recently, doctors from the pediatric cardiology and pediatric genetics departments of Amrita Institute of Medical Sciences discovered a unique disease of aorta occurring only in children from the Malabar region of North Kerala. (amrita.edu)
  • The ultrasound test is less useful for diagnosing aneurysms above the level of the kidneys, or aneurysms that affect the aorta in the chest ( thoracic aortic aneurysms ). (hearthealthywomen.org)
  • Subjects diagnosed with a disease of descending thoracic aorta (DTA) and requiring endovascular treatment with Stent Graft. (clinicaltrials.gov)
  • Entering the abdomen through the aortic hiatus, an opening in the diaphragm, the aorta branches off to supply the stomach, kidneys, intestines, gonads, and other organs through extensive arterial networks. (thefreedictionary.com)
  • In man, mammals, and birds, the aorta emerges from the left ventricle of the heart, forming an enlargement at its very beginning, called the aortic spindle, goes up (ascending aorta), turns back and to the left in man and mammals (arch of the aorta) and back and to the right in birds, and goes down (descending or dorsal aorta). (thefreedictionary.com)
  • In amphibians an arterial cone emerges from the only ventricle, and from it one pair (in ecaudates) or two pairs (in caudates) of aortic arches branch out, which form the dorsal aorta when they unite. (thefreedictionary.com)
  • Stenosis of the aortic valve is characterized by a thickening of the valvular annulus or leaflets that limits the ability of blood to be ejected from the left ventricle into the aorta. (wikipedia.org)
  • For aneurysms of the thoracic aorta, thoracic endovascular aortic repair (TEVAR) has become a valid alternative to open repair. (wikipedia.org)
  • The procedure involves the placement of an expandable stent graft within the aorta to treat aortic disease without operating directly on the aorta. (wikipedia.org)
  • dissections
  • Patients with thoracic aortic aneurysms that lead to acute aortic dissections are 12 times more likely to have duplications in the DNA in a region of chromosome 16 (16p13.1) than those without the disease, according to a study led by genetic researchers at The University of Texas Health Science Center at Houston (UTHealth). (redorbit.com)
  • A multi-institutional team led by Dianna Milewicz, M.D., Ph.D., of The University of Texas Health Science Center at Houston (UTHealth) has found a recurrent genetic mutation that has been linked to deadly thoracic aortic dissections in family members as young as 17 years of age. (redorbit.com)
  • The majority of the affected family members suffered acute aortic dissections at young ages (17 to 51 years). (redorbit.com)
  • Using this management protocol, acute aortic dissections and the associated premature deaths can be prevented. (redorbit.com)
  • He was also found to have aortic root dilation and because of his family history of early thoracic aortic dissections at diameters smaller than 5 centimeters, he elected to have surgery. (redorbit.com)
  • and nephew, 23, all died from thoracic aortic dissections. (redorbit.com)
  • In uncomplicated aortic dissections, no benefit has been demonstrated over medical management alone. (wikipedia.org)
  • GeneReviews/NIH/NCBI/UW entry on Thoracic Aortic Aneurysms and Aortic Dissections Human ACTA2 genome location and ACTA2 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • surgical
  • This has occurred against a backdrop of improved identification of various disease processes and better results with open surgical repair. (ahajournals.org)
  • If thoracic aortic disease can be detected early and managed, it gives us the opportunity to select patients for surgical or endovascular repair when the patient is stable," said Loren F. Hiratzka, M.D., who chaired the guidelines writing committee and is the medical director of cardiac surgery for TriHealth, Inc. (Bethesda North and Good Samaritan Hospitals) in Cincinnati, OH. (medicalxpress.com)
  • More appreciable insufficiency it is typically the result of damage to the valve due to cardiac catheterization, aortic balloon pump insertion, or other surgical manipulations. (wikipedia.org)
  • The conventional approach for treatment of aortic valve stenosis is surgical replacement of the aortic valve. (wikipedia.org)
  • However, TAVI (transcatheter aortic valve implantation) has emerged as a valid alternative for patients in whom conventional surgical techniques are considered too invasive and risky. (wikipedia.org)
  • Insufficiency
  • Stenosis and insufficiency/regurgitation represent the dominant functional and anatomic consequences associated with valvular heart disease. (wikipedia.org)
  • Aortic insufficiency, or regurgitation, is characterized by an inability of the valve leaflets to appropriately close at end systole, thus allowing blood to flow inappropriately backwards into the left ventricle. (wikipedia.org)
  • Causes of aortic insufficiency in the majority of cases are unknown, or idiopathic. (wikipedia.org)
  • Processes that lead to aortic insufficiency usually involve dilation of the valve annulus, thus displacing the valve leaflets, which are anchored in the annulus. (wikipedia.org)
  • Additionally, insufficiency may be the result of carcinoid syndrome, inflammatory processes such a rheumatoid disease or endocarditis, or congenital malformations. (wikipedia.org)
  • Atherosclerosis
  • Risk factors for TAD include poorly controlled high blood pressure, advancing age, male gender, atherosclerosis, inflammatory diseases that damage the blood vessels, and certain genetic conditions that weaken connective tissue, such as Marfan syndrome. (medicalxpress.com)
  • coronary heart d
  • The Framingham Risk Score was first developed based on data obtained from the Framingham Heart Study, to estimate the 10-year risk of developing coronary heart disease. (wikipedia.org)
  • In order to assess the 10-year cardiovascular disease risk, cerebrovascular events, peripheral artery disease and heart failure were subsequently added as disease outcomes for the 2008 Framingham Risk Score, on top of coronary heart disease. (wikipedia.org)
  • For example, nearly 30% of coronary heart disease (CHD) events in both men and women were singularly attributable to blood pressure levels that exceeded high normal (≥130/85), showing that blood pressure management and monitoring is paramount both to cardiovascular health and prediction of outcomes. (wikipedia.org)
  • Coronary heart disease (CHD) risk at 10 years in percent can be calculated with the help of the Framingham Risk Score. (wikipedia.org)
  • If a group of 100 persons all have a 20% ten-year risk of cardiovascular disease it means that we should expect that 20 of these 100 individuals will develop cardiovascular disease (coronary heart disease or stroke) in the next 10 years and eighty of them will not develop cardiovascular disease in the next 10 years. (wikipedia.org)
  • It includes: 1) Coronary heart disease (CHD): Myocardial infarction (MI), angina pectoris, heart failure (HF), and coronary death. (wikipedia.org)
  • Surgery
  • In October 2012, Anthony Estrera, M.D., associate professor of cardiovascular surgery at the UTHealth Medical School and the Memorial Hermann Heart and Vascular Institute, performed the graft replacement of his aortic root. (redorbit.com)
  • Dr. Hans Joachim Schafers, Director, Department of Thoracic & Cardiovascular Surgery, Saarland, University Medical Center, Germany, said that bicuspid aortic valve disease roughly affects 1 to 2% of population. (amrita.edu)
  • The authors concluded that endovascular thoracic repair reduces perioperative mortality and major neurological injury in stable patients with descending thoracic aortic aneurysms compared to open surgery. (york.ac.uk)
  • To compare the effects of endovascular stenting with open surgery for thoracic aortic disease (TAD). (york.ac.uk)
  • Another important concept in hybrid procedures is completion angiography, as described above, which in the case of congenital heart disease surgery may detect residual structural lesions, thus reduce postoperative complications. (wikipedia.org)
  • His clinical interests include: Adult and pediatric cardiac surgery Cardiac transplantation Marfan syndrome Mitral valve repair Aortic surgery including valve-sparing aortic root replacement He is the editor, along with Stephan C. Yang of Current Therapy in Thoracic and Cardiovascular Surgery. (wikipedia.org)
  • In 2003, EVAR surpassed open aortic surgery as the most common technique for repair of AAA, and in 2010, EVAR accounted for 78% of all intact AAA repair in the United States. (wikipedia.org)
  • The options for repair include traditional open aortic surgery or endovascular repair. (wikipedia.org)
  • patients
  • From March 1999 to October 2003, 132 consecutive patients (113 male and 19 female) were admitted with clinical and instrumental diagnosis of either acute (44) or chronic (88) aortic disease. (ahajournals.org)
  • The results of this study could affect clinical care because it appears patients with 16p13.1 duplications have an aggressive form of the thoracic aortic disease that causes aneurysms to dissect at smaller diameters," Milewicz said. (redorbit.com)
  • Some of the patient samples used for this study were obtained from GenTAC, a National Institutes of Health (NIH)-funded registry of patients with thoracic aortic disease. (redorbit.com)
  • Stress management for patients with an Aortic Disease. (ottawaheart.ca)
  • At the Center for Aortic Disease, our team of specialists works together to provide effective, long-term and comprehensive care for our patients. (umms.org)
  • Collaboration is at the core of what we do since many of our patients have both aortic disease and high blood pressure (hypertension). (umms.org)
  • At the Center for Aortic Disease, we form a unique plan for each of our patients because we know that no condition is the same. (umms.org)
  • Watch and read stories about patients treated for aortic disease at the University of Maryland Medical Center. (umms.org)
  • 5,6 Despite these improvements in outcomes with open repair, a less invasive approach is quite appealing, especially in older patients and in patients with significant concomitant comorbid diseases, many of whom would be unsuitable candidates for conventional open repair. (ahajournals.org)
  • Now, new clinical guidelines spearheaded by the American College of Cardiology (ACC) and the American Heart Association (AHA) not only offer new recommendations for the diagnosis and management of thoracic aortic disease (TAD), they deliver a powerful message to physicians and patients: Early diagnosis and treatment can save lives. (medicalxpress.com)
  • It also has a built-in clinic exclusively for the treatment of Marfan patients suffering from aortic disorders. (amrita.edu)
  • Setting up of this dedicated center for the treatment of complex aortic diseases gives patients immediate access to state-of-the-art diagnostic and treatment services. (amrita.edu)
  • These patients need not only the management of their aortic condition but also comprehensive treatment by genetic specialists and ophthalmologists. (amrita.edu)
  • This with genetic diseases like Marfan's, increasing incidence of hypertension, inflammatory disorders we are looking into an enormous number of potential patients in society which requires centers of excellence for treatment. (amrita.edu)
  • Survival rates at 5 and 10 years were 87% and 53%, respectively, in patients with a thoracic aortic event and 74% and 56% in those without an event (P=.7). (omicsonline.org)
  • Possible reasons for the relatively high mortality after AAA repair include the advanced age of the patients and the presence at operation or afterward of various comorbid conditions, especially cardiovascular disease , cerebrovascular disease, and cancer [ 7 - 9 ]. (omicsonline.org)
  • This procedure has excellent outcomes particularly in younger patients at relatively low-risk and will remain the gold standard for aortic valve replacement in the upcoming years. (wikipedia.org)
  • Duke E. Cameron at Johns Hopkins Medicine Aortic Root Replacement in 372 Marfan Patients: Evolution of Operative Repair Over 30 Years. (wikipedia.org)
  • 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients with Thoracic Aortic Disease. (wikipedia.org)
  • This is often found in patients with diabetes mellitus (41% of patients with peripheral arterial disease (PAD) have diabetes), renal failure or heavy smokers, and toe pressure is a valuable complement to avoid some of these problems. (wikipedia.org)
  • arterial
  • Endovascular procedures aim to reduce the morbidity and mortality of treating arterial disease in a patient population that is increasingly older and less fit than when major open repairs were developed and popularized. (wikipedia.org)
  • 3) Peripheral arterial disease, intermittent claudication and significant limb ischemia. (wikipedia.org)
  • Valvular Heart D
  • Valvular heart disease is any disease process involving one or more of the four valves of the heart (the aortic and bicuspid valves on the left side of heart and the pulmonary and tricuspid valves on the right side of heart. (wikipedia.org)
  • Stenosis
  • About.com: Explains what aortic stenosis is and looks at when it should be treated and what options there are. (dmoztools.net)
  • Stenosis is typically the result of valvular calcification, but may be the result of a congenitally malformed bicuspid aortic valve. (wikipedia.org)
  • Mitral stenosis is caused largely by rheumatic heart disease, though is rarely the result of calcification. (wikipedia.org)
  • Mitral stenosis is uncommon and not as age dependent as other types of valvular disease. (wikipedia.org)
  • congenital
  • These conditions occur largely as a consequence of aging, but may also be the result of congenital (inborn) abnormalities or specific disease or physiologic processes including rheumatic heart disease and pregnancy. (wikipedia.org)
  • Clinic
  • Steve Harris traveled to Houston to consult with Milewicz and the clinical team at the Multidisciplinary Aortic and Vascular Disease Clinic. (redorbit.com)
  • Please contact Kathryn McLean, Nurse Coordinator, Aortic Clinic at 613-696-7237 or email to aorticclinic@ottawaheart.ca . (ottawaheart.ca)
  • vascular diseases
  • Mutations in genes encoding smooth muscle contractile proteins, ACTA2 and MYH11, cause hyperplastic vasculomyopathy and lead to diffuse and diverse vascular diseases. (wikipedia.org)
  • repair
  • Along with a short proximal aortic neck, necks with any of these characteristics are called "hostile necks" and endovascular repair can be either contraindicated or associated with early late complications of endoleak, or endograft migration, or both. (wikipedia.org)
  • disorders
  • These include heart muscle diseases such as hypertrophic cardiomyopathy, dilated cardiomyopathy, noncompaction cardiomyopathy, and arrhythmogenic cardiomyopathy (also known as arrhythmogenic right ventricular dysplasia), as well as inherited arrhythmia disorders such as long QT syndrome and Brugada syndrome. (wikipedia.org)
  • diagnose
  • Discovery of this disease now allows us to manage it better and diagnose it during pregnancy itself," he added. (amrita.edu)
  • Marfan
  • Increasing awareness, saving lives, and improving the quality of life for patients, their families, and medical professionals affected by Marfan syndrome, genetic aortic disorders, and related connective tissue disorders through national programs of education, support, and research. (diseaseinfosearch.org)
  • The study compared the outcomes of 13,205 patients-2,079 with bicuspid aortic valves and 73 with Marfan syndrome-who had AVR replacement between 1995 and 2010. (acc.org)
  • The authors of the study note that these results "provide additional support for the discrete treatment algorithms for patients with bicuspid valve disease," as the operative management of these patients has previously been extrapolated based on Marfan syndrome patients. (acc.org)
  • condition
  • Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives. (diseaseinfosearch.org)
  • dissection
  • What blood pressure goals are recommended for a patient with acute aortic dissection? (wordpress.com)
  • Upregulation of PHACTR1 by transforming growth factor (TGF)-β has been described in breast cancer cell lines, potentially pointing to a connection with the TGF-β signaling pathway, which is also implicated in genetic predisposition to migraine9 and has a key role in Marfan and Loeys-Dietz syndromes, two inherited connective tissue disorders causing aortic dissection. (wikipedia.org)
  • carotid
  • While we practice the gamut of vascular surgery, we have particular expertise and experience in the management of carotid, aortic, peripheral vascular disease, venous disease, end-stage renal disease, and thoracic outlet syndrome. (rochester.edu)
  • Upon extension of the arterial wall by the raising of the blood pressure, the baroreceptors (stretch receptors) generate an impulse depending on the arterial pressure via the glossopharyngeal nerve (CN IX) from the carotid sinus and via the vagus nerve (CN X) from the aortic arch, and transmit the signals to the nucleus tractus solitarius (NTS) in the medulla ( Iwase, 2002 , 2006 , 2009 ). (frontiersin.org)
  • arch
  • The atrial septum is removed, the aortic arch is reconstructed to remove any hypoplasia, and then the main pulmonary artery is connected into this reconstructed arch, resulting in the right ventricle ejecting directly into systemic circulation. (wikipedia.org)
  • valve replacement
  • Once a catheter is in place, it can be used to perform a number of procedures including angioplasty, PCI (percutaneous coronary intervention) angiography, transcatheter aortic valve replacement, balloon septostomy, and an electrophysiology study or catheter ablation. (wikipedia.org)
  • chronic renal d
  • For blood pressure control in ongoing medical management, guidelines recommend antihypertensive therapy to achieve a goal of less than 140/90 mm Hg (patients without diabetes) or less than 130/80 mm Hg (patients with diabetes or chronic renal disease) to reduce the risk of stroke, myocardial infarction, heart failure, and cardiovascular death. (wordpress.com)
  • abdominal
  • The LV apex needs to be within 9 cm of the abdominal wall and the left ventricle outflow track has to be parallel to the intended cannula course in order for the wire to be blindly directed at the aortic valve. (wikipedia.org)
  • hypertrophy
  • The diagnostic features include a poorly contracting left ventricle, aortic valve thickening/restriction, a varying degree of left ventricular hypertrophy and abnormal Doppler flow characteristics in the left heart. (wikipedia.org)
  • recurrent
  • Carbon-ion RT has shown excellent local control for X-ray resistant diseases such as recurrent rectal carcinoma, skull-base tumors, uveal melanoma, non-squamous cell carcinomas of the head and neck, and sarcomas. (biomedcentral.com)
  • include
  • The accurate definition does not include the unconsciousness not caused by cerebral hypoperfusion, for example, epileptic seizures, concussion, and cerebrovascular accidents, which are persistent structural impairments, and persistent states of unconsciousness, for example, coma and cerebrovascular diseases ( Ross, 1988 ). (frontiersin.org)
  • Diseases associated with IL17RD include Hypogonadotropic Hypogonadism 18 With Or Without Anosmia and Kallmann Syndrome . (genecards.org)
  • Lyme
  • Lyme disease, also known as Lyme borreliosis, is an infectious disease caused by bacteria of the Borrelia type which is spread by ticks. (wikipedia.org)
  • Lyme disease is the most common disease spread by ticks in the Northern Hemisphere. (wikipedia.org)
  • Lyme disease was diagnosed as a separate condition for the first time in 1975 in Old Lyme, Connecticut. (wikipedia.org)
  • Chronic symptoms are well described and are known as post-treatment Lyme disease syndrome, often called chronic Lyme disease. (wikipedia.org)
  • Play media Lyme disease can affect multiple body systems and produce a broad range of symptoms. (wikipedia.org)
  • Not all patients with Lyme disease have all symptoms, and many of the symptoms are not specific to Lyme disease, but can occur with other diseases, as well. (wikipedia.org)
  • The classic sign of early local infection with Lyme disease is a circular, outwardly expanding rash called erythema chronicum migrans (EM), which occurs at the site of the tick bite three to 32 days after the tick bite. (wikipedia.org)
  • occur
  • Recurrences of cervical cancer after definitive radiotherapy often occur at common iliac or para-aortic lymph nodes as marginal lymph node recurrences. (biomedcentral.com)
  • severity
  • OBJECTIVE: To compare disease severity classification systems for six-month outcome prediction in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). (okayama-u.ac.jp)
  • both safety and efficacy are evaluated relative to how the treatment is intended to be used, what other treatments are available, and the severity of the disease or condition. (wikipedia.org)
  • patients
  • The two patients showed no evidence of disease for 75 months and 63 months after the initial radiotherapy and for 50 months and 37 months after the carbon-ion radiotherapy, respectively. (biomedcentral.com)
  • blood
  • Blood tests are often negative in the early stages of the disease. (wikipedia.org)
  • Some cells like aortic baroreceptor neurons could have devastating effects including the inability to regulate aortic blood pressure if the onset of synaptic fatigue were to affect them. (wikipedia.org)
  • The aortic valve is a one way valve that is located between the left ventricle and the aorta, keeping blood from leaking back into the ventricle. (wikipedia.org)
  • heart
  • citation needed] It is the most common valvular heart disease in pregnancy. (wikipedia.org)
  • While LVH itself is not a disease, it is usually a marker for disease involving the heart. (wikipedia.org)
  • The sewing rim was bolstered for better and safer attachment to the heart annuli and its shape was anatomically contoured into two different configurations to better fit in the aortic and the atrio-ventricular positions. (wikipedia.org)
  • clinical
  • The integrated vascular surgery residency at the University of Rochester dedicates 5 years to clinical training in vascular surgery combined with core rotations in general surgery and vascular disease. (rochester.edu)
  • years
  • Public education programs about chronic kidney disease (CKD) have been performed in Okayama, Japan for the past 10 years. (okayama-u.ac.jp)