• Tuberculosis is the most prevalent infectious disease worldwide and a leading killer caused by a single infectious agent, that is, Mycobacterium tuberculosis. (pharmacy180.com)
  • Biological Activity: Antitubercular agent-24 (Compound 1) is an anti-tubercular agent with an extracellular IC 50 of 0.83 μM and an intracellular IC 50 of 0.17 μM against M. tuberculosis H37Rv. (epigenetics-modulation-frontier.com)
  • Manual de normas y procedimientos técnicos para la bacteriolog'ia de la tuberculosis / Comité Asesor de la OPS/OMS en Bacteriolog'ia de la Tuberculosis. (who.int)
  • Comité Asesor de la OPS/OMS en Bacteriolog'ia de la Tuberculosis. (who.int)
  • However, in the case of Mycobacterium tuberculosis ( Mtb ), the causative agent of tuberculosis (TB), Mtb -mediated drug metabolism plays a significant role in treatment outcomes. (nature.com)
  • Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models. (stjude.org)
  • The experimental nitroimidazole TBA-354, under investigation by the TB Alliance, showed potent activity against Mycobacterium tuberculosis in vitro and in animal studies, according to a presentation this week at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) in San Francisco. (hivandhepatitis.com)
  • Discovery of pyrimidine-tethered benzothiazole derivatives as novel anti-tubercular agents towards multi- and extensively drug resistant Mycobacterium tuberculosis . (bvsalud.org)
  • All compounds 3a-e were also evaluated as antitubercular agent against M. tuberculosis H37Rv by MABA method. (ijps.ir)
  • Paser (aminosalicylic acid) is an anti- tuberculosis drug used to treat tuberculosis in combination with other active agents. (rxlist.com)
  • PASER (aminosalicylic acid) is indicated for the treatment of tuberculosis in combination with other active agents. (rxlist.com)
  • Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. (benthamscience.com)
  • Antifungal Agents - Antibiotics : 1. (pharmacy180.com)
  • Amphotericin B is an amphoteric, forming soluble salts in both basic and acidic environments, and due to extensive unsaturation, it is unstable, primarily used as antifungal agents. (pharmacy180.com)
  • From antibiotics to antivirals, pain relievers to anticancer agents, these quizzes offer insights into the diverse world of pharmaceuticals. (proprofs.com)
  • It has been demonstrated using modification at three sites (the hydrazine, amino acid, and the benzodiazole) it is possible to change both the antibacterial activity and cytotoxicity of these molecules whilst not affecting their microbial selectivity, making them attractive architectures for further exploitation as novel antibacterial agents. (worktribe.com)
  • In the present study the synthesis, antitubercular, antifungal, and antibacterial activities and structure activity relationship of aryloxypropanolamine substituted 8-hydroxy quinolines are reported. (nepjol.info)
  • Synthesis and Structure-Activity Relationships of a New Class of Oxadiazoles Targeting DprE1 as Antitubercular Agents. (medchemexpress.cn)
  • TBA-354 is predicted to be effective against TB in both drug-sensitive and MDR-TB patients when administered at low once daily or less frequent doses, lending this compound potential as a next generation nitroimidazole anti-tubercular agent. (hivandhepatitis.com)
  • Finally, the case history of TBA-354 (a novel best-in-class nitroimidazole antitubercular agent currently advancing through Phase I clinical trials) will be described as an illustration of TB Alliance's strategic approach to contemporary drug discovery and development. (optibrium.com)
  • For situations where discontinuation of therapy with one of the active agents of this medicine, or dose reduction is necessary, separate preparations of rifampicin and/or isoniazid should be used. (who.int)
  • Antitubercular agent-39 (Compound P1) is a potent antitubercular agent. (medchemexpress.cn)
  • Compound 3d was showed highest antitubercular activity, with 12.5µg/ml MIC value. (ijps.ir)
  • Antitubercular agent-39 inhibits Mtb strain H37Rv with a MIC less than 1 μM [1] . (medchemexpress.cn)
  • While 2 first-generation compounds -- PA-824 and OPC67683 -- are undergoing clinical testing, researchers are working to identify next-generation agents that may be more potent and easier to use. (hivandhepatitis.com)
  • Antitubercular agent-39 is active against drug-resistant strains and drug-susceptible clinical isolates. (medchemexpress.cn)
  • uric acid lowering agents may be require dosage adjustment. (medscape.com)
  • Considering the range of chemical reactions involved in the biosynthetic pathways of Mtb , information related to the biotransformation of antitubercular compounds would provide opportunities for the development of new chemical tools to study successful TB infections while also highlighting potential areas for drug discovery, host-directed therapy, dose optimization and elucidation of mechanisms of action. (nature.com)
  • A variety of methods for transporting different agents such as pharmaceutical agents, nutrients and genetic materials across a tissue are provided. (justia.com)
  • This invention relates generally to the field of drug delivery and more particularly to methods of transport of agents such as pharmaceutically active agents across tissues, including transport by iontophoresis. (justia.com)
  • In practice, iontophoretic methods generally involve positioning an electrode that includes some type of reservoir or absorbent pad that contains the agent to be transferred on the tissue through which delivery is to occur. (justia.com)
  • Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions. (stjude.org)
  • Antimicrob Agents Chemother Apr 25;63(5), 2019. (stjude.org)
  • It is used mostly in combination with other agents. (harvard.edu)
  • A series of 8-hydroxyquinolines are synthesized and their Antitubercular, antifungal, and antibacterial activities are tested. (nepjol.info)
  • The transport of various agents such as metabolites, drugs and nutrients across tissues is a function primarily of three factors: tissue permeability, the presence or absence of a driving force and the size of the area through which transport occurs. (justia.com)
  • Specific agents should be based on the patient's age and the types of organisms and sensitivities common in the community. (medscape.com)
  • Iontophoresis is an alternative approach that can be utilized to deliver agents across a tissue by the application of an electrical current. (justia.com)
  • In-vivo Anticonvulsant and In-vitro Antitubercular Activity of methyl Indole Derivative of some 6-aryl-4, 5-Dihydropyridazin-3(2H)-ones and their Expected Anticonvulsant Mechanisms', Iranian Journal of Pharmaceutical Sciences , 9(1), pp. 67-80. (ijps.ir)
  • The methods utilize an AC signal to maintain a substantially constant electrical state in a region of the tissue through which transport occurs, thereby allowing agent to be transported across the tissue in a controlled and predictable manner. (justia.com)
  • This network absorbs the agent and subsequently moves it to the main portion of the circulatory system. (justia.com)