Nrf2GenesEnzymesAnti-inflammatoryTranscriptionalReactive2023PolyphenolEndogenousProteinInducesPathwaysInhibitLiverLuciferaseTranscriptionRegulationCellularAcidVitaminImmuneInterventionMechanismsOxidative damageExhibitCellsVivoNutritionalActivateDietaryRegulatoryNuclear factorHypoxiaSubjectsDiabetesActivitiesActivitySignificantlyCellExposureRole
Nrf224
- The latter DNA sequences have been recognized as antioxidant/electrophile response elements or NF-E2-binding motifs to which Nrf2-sMaf heterodimers and p45 NF-E2-sMaf heterodimer bind, respectively. (wikipedia.org)
- Nrf2-sMaf heterodimer regulates a battery of cytoprotective genes, such as antioxidant/xenobiotic metabolizing enzyme genes. (wikipedia.org)
- Mafk−/− mice fail to activate Nrf2-dependent cytoprotective genes in response to stress. (wikipedia.org)
- While the expression of phase II enzymes (e.g., glutathione S-transferase and NAD(P)H: quinone oxidoreductase) was markedly induced by a phenolic antioxidant in vivo in both wild type and heterozygous mutant mice, the induction was largely eliminated in the liver and intestine of homozygous nrf2-mutant mice. (elsevierpure.com)
- Lycopene upregulates Nrf2 levels in nuclear extracts and increases the transactivity of antioxidant response elements. (nih.gov)
- The Nrf2-regulated antioxidant property plays a pivotal role in the anti-inflammatory mechanism underlying the inhibition of NF-κB activation in lycopene-treated ARPE-19 cells. (nih.gov)
- Because NRF2 binds ARE, suggesting it helps regulate oxidative stress responses, Pickett and his team focused on it next and helped uncover key aspects of how NRF2 itself is regulated. (asbmb.org)
- Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the Nrf2 pathway. (cdc.gov)
- Nrf2 is an antioxidant-activated transcription factor that recently emerged as a critical regulator of cellular defense against oxidative and inflammatory lesions. (cdc.gov)
- Here we analyzed the molecular mechanism of the fibrogenic response to PQ and its inhibition by Res and Nrf2. (cdc.gov)
- Res strongly activated the Nrf2 signaling pathway and induced antioxidant response element-dependent cytoprotective genes. (cdc.gov)
- The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
- Immunoflourescence images of expression of Nrf2 and HO-1 showing thealteration of key protein markers of antioxidant gene expression, read more in 'Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model' from Saha et al, in this edition of Bioscience Reports. (portlandpress.com)
- The present study aimed to investigate the potential hepatoprotective effects of diosmetin on hydrogen peroxide (H2O2)‑induced oxidative damage in L02 cells and attempted to evaluate the role of the nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant response element pathway in this process. (spandidos-publications.com)
- Zhang H, Davies KJA and Forman HJ: Oxidative stress response and Nrf2 signaling in aging. (spandidos-publications.com)
- Nguyen T, Nioi P and Pickett CB: The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. (spandidos-publications.com)
- 2012. Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response. . (oregonstate.edu)
- OBJECTIVE- Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE). (diabetesjournals.org)
- CONCLUSIONS- We conclude that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role. (diabetesjournals.org)
- 6 Martin D, Rojo A I, Salinas M, Diaz R, Gallardo G, Alam J, De Galarreta C M, Cuadrado A. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. (thieme-connect.com)
- The nuclear factor erythroid-derived two-like 2-antioxidant response element (Nrf2-ARE) pathway and its downstream antioxidant enzyme heme oxygenase-1 (HMOX1 or HO-1) play essential roles in H2 O2 -induced oxidative damage in human melanocytes. (nih.gov)
- Keap1 may be viewed as the regulator of Nrf2, and reactive species/free radicals and electrophiles react with the Nrf2-Keap1 complex causing the release of Nrf2, which migrates to the cell nucleus and triggers the expression of selected genes whose products, i.e. proteins with or without enzymatic activity, participate in the antioxidant defense and in the metabolism of xenobiotics in mammals. (databasefootball.com)
- A profound constitutively upregulated cytoprotective response is commonly observed in naturally long-lived species and experimental models of extensions to lifespan (e.g., genetically-altered and/or experimentally manipulated organisms), as indicated by enhanced resistance to stress and upregulated downstream components of the cytoprotective nuclear factor erythroid 2-related factor 2 (Nrf2)-signaling pathway. (dundee.ac.uk)
- We found significant dysregulation of genes encoding drug-metabolizing enzymes and stress response components of the NRF2- mediated oxidative damage pathway, potentially representing key genes in African-American esophageal squamous carcinogenesis. (biomedcentral.com)
Genes4
- The antioxidant response element, or ARE, present in the promoters of many antioxidant protein genes is a major regulatory lynchpin in this cellular response. (asbmb.org)
- Their work made it clear that antioxidant genes such as GST have multiple regulatory elements in their promoters that are responsive to specific cellular stressors. (asbmb.org)
- Subsequent work by Pickett's lab and others helped identify the transcription factors that recognize the ARE and activate the transcription of GST and other oxidative stress response genes. (asbmb.org)
- systematic review of epidemiologic data on birth defects in relation to folic acid intake and variation in the methylenetetrahydrofolate reductase ( MTHFR ) gene illustrates 'Mendelian randomization' ( 14 ), in which the effects of specific environmental exposures, such as dietary elements, drugs or toxins, are either accentuated or mitigated in persons with different variants of genes involved in physiologic response. (cdc.gov)
Enzymes5
- While this group of enzymes is believed to be under the transcriptional control of antioxidant response elements (AREs), this contention is experimentally unconfirmed. (elsevierpure.com)
- Activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were measured in ellagic acid-treated V79-4 cells. (nutrimedical.com)
- These antioxidant enzymes include glutathione S -transferase, or GST, NADPH:quinone oxidoreductase 1, thioredoxin and hemeoxygenase-1. (asbmb.org)
- antioxidant enzymes. (researchgate.net)
- Selenium is a component of the antioxidant enzymes glutathione peroxidase and thioredoxin reductase (which indirectly reduce certain oxidized molecules in animals and some plants). (cdc.gov)
Anti-inflammatory4
- Echinocystic acid (EA), a natural triterpone enriched in various herbs, shows a range of pharmacological activities including anti-inflammatory and antioxidant e. (targetmol.com)
- Eburicoic acid exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in studies about. (targetmol.com)
- Moreover, carnosic acid exhibits the ability to modulate the immune response, acting as an anti-inflammatory agent. (databasefootball.com)
- Diets rich in anti-inflammatory components and antioxidants, and low in harmful dietary elements, can influence fat mass, inflammation and even muscle tone, all of which are relevant to OSA risk. (msdmanuals.com)
Transcriptional2
- 2009. Transcriptional regulation of rat gamma-glutamate cysteine ligase catalytic subunit gene is mediated through a distal antioxidant response element. . (oregonstate.edu)
- The plasmid contains a luciferase gene (reporter gene) which is under transcriptional control of an antioxidant response element (ARE) of the rat NQO1 gene. (europa.eu)
Reactive4
- Antioxidant intervention is considered to inhibit reactive oxygen species (ROS) and alleviate hyperglycemia. (elifesciences.org)
- Carnosic acid is an antioxidant, meaning that it may decrease the impact of reactive species/free radicals in biological systems. (databasefootball.com)
- The ability of carnosic acid in exerting antioxidant effects is not associated only with its chemical structure, i.e. carnosic acid is not just a scavenger of reactive species. (databasefootball.com)
- Differences between reactive oxygen species and antioxidant defense system unbalance the redox status. (bvsalud.org)
20231
- Microorganisms as a Source of Antioxidant Compounds" Encyclopedia , https://encyclopedia.pub/entry/45106 (accessed December 07, 2023). (encyclopedia.pub)
Polyphenol1
- Trans-resveratrol is a polyphenol with great antioxidant action that reduces the oxidative stress. (bvsalud.org)
Endogenous2
- Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. (oregonstate.edu)
- Selenomethionine (SeMet) is an organic form of selenium (Se), an essential trace element that functions in the regulation of the immune response by both bolstering the endogenous thioredoxin and glutathione antioxidant defence systems and by directly scavenging damaging oxidant species. (greenmedinfo.com)
Protein1
- The more extensive surgeries, such as biliary-pancreatic diversion surgery or more extended Roux-en-Y gastric bypass surgery, may result in more protein malabsorption . (medscape.com)
Induces1
- Hormesis is a process through which moderate stress induces a body response that is protective against insults, confers health and possibly even longevity benefits. (anti-agingfirewalls.com)
Pathways1
- Kaempferol-3-O-glucorhamnoside, a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPK and NF-κB pathways in vitro and i. (targetmol.com)
Inhibit1
- Antioxidants are compounds that inhibit oxidation. (targetmol.com)
Liver4
- The antioxidant status was disturbed with the decrease in SOD, GST and catalase in the liver and membrane-ATPases as well. (nature.com)
- Here, by comparing exercise and antioxidant intervention on type 2 diabetic rats, we found moderate exercise upregulated compensatory antioxidant capability and reached a higher level of redox balance in the liver. (elifesciences.org)
- Hu Y, Wang S, Wang A, Lin L, Chen M and Wang Y: Antioxidant and hepatoprotective effect of Penthorum chinense Pursh extract against t-BHP-induced liver damage in L02 cells. (spandidos-publications.com)
- Because alpha-lipoic acid seems to work like an antioxidant, it might provide protection to the brain and also be helpful in certain liver diseases. (medlineplus.gov)
Luciferase2
- Cells co-transfected with an estrogen response element (ERE)-driven luciferase (Luc) reporter gene and an ERalpha- or ERbeta-expression vector were exposed to graded concentrations of ellagic acid. (nutrimedical.com)
- With stably-transfected HepG2 cells, the three isolates activated antioxidant response element (ARE) luciferase activation with (EC 50 ) values of 56.7, 3.7 and 1.8 μM, respectively. (edu.hk)
Transcription1
- encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
Regulation1
- CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
Cellular1
- Espinosa-Diez C, Miguel V, Mennerich D, Kietzmann T, Sánchez-Pérez P, Cadenas S and Lamas S: Antioxidant responses and cellular adjustments to oxidative stress. (spandidos-publications.com)
Acid9
- Antioxidant and apoptosis-inducing activities of ellagic acid. (nutrimedical.com)
- BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. (nutrimedical.com)
- Several antioxidants like SOD, CAT, epigallocatechin-3-O-gallate, lycopene, ellagic acid, coenzyme Q10, indole-3-carbinol, genistein, quercetin, vitamin C and vitamin E have been found to be pharmacologically active as prophylactic and therapeutic agents for above mentioned diseases. (nutrimedical.com)
- 2005. Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex. . (oregonstate.edu)
- 2 Satoh T, Izumi M, Inukai Y, Tsutumi Y, Nakayama N, Kosaka K, Kitajima C, Itoh K, Yokoi T, Shirasawa T. Carnosic acid protects neuronal HT22 cells through activation of the antioxidant-responsive element in free carboxylic acid- and catechol hydroxyl moieties-dependent manners. (thieme-connect.com)
- 5 Aruoma O I, Halliwell B, Aeschbach R, Lolingers J. Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid. (thieme-connect.com)
- Antioxidants such as thiols or ascorbic acid (vitamin C) terminate these chain reactions. (targetmol.com)
- Overall, carnosic acid exposure caused an adaptive response in the cells, which become more resistant than in the absence of carnosic acid. (databasefootball.com)
- Alpha-lipoic acid is an antioxidant that is made naturally in the body and also found in foods. (medlineplus.gov)
Vitamin2
- If confirmed by other studies, this finding might suggest a simple intervention---antioxidant vitamin supplementation---for children with asthma who are exposed to ozone. (cdc.gov)
- With the fat-soluble vitamins (eg, vitamin A, keratins), patients may have some common visual symptoms and also some elements of very nonspecific things, such as dry skin, dry hair, and pruritus. (medscape.com)
Immune1
- They occasionally exhibit toxic, mutagenic or carcinogenic effects, or they modulate immune responses. (cdc.gov)
Intervention3
- In contrast, antioxidant intervention achieved a low-level redox balance by inhibiting oxidative stress. (elifesciences.org)
- Overall, our results illustrate that both exercise and antioxidant intervention improve blood glucose control in diabetes by promoting redox balance, despite different levels of redox state(s). (elifesciences.org)
- Utilizing the in-vitro studies as well as rats models, this manuscript illustrates the different regulatory mechanisms of exercise and antioxidant intervention on redox balance/redox state(s) that are linked to improved glucose control and thereby effective management of diabetes. (elifesciences.org)
Mechanisms1
- To counter high ROS levels, cells have antioxidant mechanisms that reduce the excess ROS in the cell and keep the 'redox' (from reduction and oxidation) balance of the cell. (elifesciences.org)
Oxidative damage1
- The resulting damage cannot be overcome by the antioxidant system to protect the cell from oxidative damage, leading to necrosis, apoptosis, or autophagy of the target cell and tissue ( 10 , 11 ). (spandidos-publications.com)
Exhibit1
- Mogrosides exhibit antidiabetic, antioxidant and anticancer activities. (targetmol.com)
Cells3
- Endometrium-derived epithelial cells (Ishikawa) showed no response to the natural compound by using a cell viability assay (MTT). (nutrimedical.com)
- The oxygen sensing and signal transduction machinery is located in the pulmonary arterial smooth muscle cells (PASMCs) of the pre-capillary vessels, albeit the physiological response may be modulated in vivo by the endothelium. (ersjournals.com)
- This suggests that autophagy is a form of adaptation of the nutritional environment of rapidly growing tumor cells in response to hypoxia. (spandidos-publications.com)
Vivo1
- Importantly, these latter results were replicated within ex-vivo experiments on cultured neutrophils isolated from acute coronary syndrome patients, indicating the ability of SeMet to alter the acute inflammatory response within a clinically-relevant setting. (greenmedinfo.com)
Nutritional2
- Exercise and antioxidant nutritional supplements have attracted much attention as drug-free interventions for diabetes. (elifesciences.org)
- Routine monitoring of albumin in these patients is pretty reasonable, but prealbumin is probably a better short-term assessment here and more variable in response to interventional nutritional efforts. (medscape.com)
Activate1
- Rosmanol has antioxidant activity, it can activate the antioxidant response element. (targetmol.com)
Dietary2
- Antioxidants are part of diet but their bioavailability through dietary supplementation depends on several factors. (nutrimedical.com)
- A response of GSHPx activity in these New Zealand subjects indicates that their dietary Se intake is insufficient to meet recommended intakes based on the criterion of saturation of GSHPx activity, and could reflect a marginal Se status. (cambridge.org)
Regulatory1
- BACKGROUND: The rise in popularity of electronic cigarettes (e-cigarettes) and hookah over recent years has been accompanied by some confusion and uncertainty regarding the development of an appropriate regulatory response towards these emerging products. (who.int)
Nuclear factor1
- 12 Kraft A D, Johnson D A, Johnson J A. Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. (thieme-connect.com)
Hypoxia2
- Hypoxic pulmonary vasoconstriction (HPV), also known as the von Euler-Liljestrand mechanism, is an essential response of the pulmonary vasculature to acute and sustained alveolar hypoxia. (ersjournals.com)
- Hypoxic pulmonary vasoconstriction (HPV), also known as the von Euler-Liljestrand mechanism, is an intrinsic mechanism of the pulmonary vasculature in response to alveolar hypoxia, to match ventilation to perfusion and optimise pulmonary gas exchange ( figure 1 ). (ersjournals.com)
Subjects1
- Effect of the Consumption of a Breakfast With and Without Sweeteners (Stevia and Sucralose) on Postprandial Glycemic Response and Appetite-Satiety Sensation in Subjects With Type 1 Diabetes: A Controlled Clinical Trial. (who.int)
Diabetes1
- These findings provide theoretical evidence for the precise management of diabetes by antioxidants and exercise. (elifesciences.org)
Activities2
- The actinomycetes are gram-positive, aerobic, filamentous, and spore-forming bacteria, with a superior reputation in producing different kinds of metabolites with a broad spectrum of biological activities, including antioxidant, antifungal, antibacterial, and insecticidal activities. (encyclopedia.pub)
- LDL-IN-3 shows anti-atherosclerotic and antioxidant activities. (targetmol.com)
Activity3
- 10-Shogaol is an extract from ginger displaying antioxidant activity. (targetmol.com)
- 1. Luteolin-6-C-glucoside has antioxidant activity. (targetmol.com)
- 1. Methyl linoleate has antioxidant activity. (targetmol.com)
Significantly1
- Principles of novel drug delivery systems need to be applied to significantly improve the performance of antioxidants. (nutrimedical.com)
Cell1
- Idebenone is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). (targetmol.com)
Exposure1
- Male Wistar rats were randomized into four groups: Control Group (CG), Exposure to Smoke Group (ESG), Antioxidant Group (AG) and Exposure to Smoke plus Antioxidant Group (ESAG). (bvsalud.org)
Role2
- Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective. (nutrimedical.com)
- Thus, antiviral drugs are an essential component of pandemic response scenarios and play an important role in reducing disease severity during seasonal influenza epidemics. (frontiersin.org)