• guanine
  • Dialkylating agents can react with two different 7-N-guanine residues, and, if these are in different strands of DNA, the result is cross-linkage of the DNA strands, which prevents uncoiling of the DNA double helix. (wikipedia.org)
  • Monoalkylating agents can react only with one 7-N of guanine. (wikipedia.org)
  • synthesis
  • Etomidate, an imidazole-derivative anesthetic agent, decreases corticosteroid synthesis in the adrenal cortex by reversibly inhibiting 17-20 yase and 11-beta-hydroxylase at non-hypnotic doses. (medscape.com)
  • effects
  • To understand the thyroid-related side effects of antineoplastic agents, their frequency, and underlying mechanisms, Ole-Petter Riksfjord Hamnvik, M.D., of the Division of Endocrinology, Diabetes, and Hypertension at Brigham and Women's Hospital in Boston, and colleagues reviewed articles on thyroid dysfunction in cancer patients. (medindia.net)
  • The researchers also recommend several paths of research that should be pursued, namely knowledge of the biological effects of the antineoplastic agents on the thyroid, so they can identify possible preventative strategies and improve the proposed screening strategies. (medindia.net)
  • Thus, it appears that the two opposite effects of anguidine modification of cell kill by cytotoxic agents (protection and potentiation) come about by two different mechanisms, with cell cycle arrest underlying cytoprotection and the mechanism of synergistic toxicity remaining obscure. (aacrjournals.org)
  • Effects of anthrapyrazole antineoplastic agents on lipid peroxidation. (semanticscholar.org)
  • several
  • Mitotane is an adrenolytic agent that acts by inhibiting 11-beta hydroxylase and several cholesterol side-chain cleavage enzymes. (medscape.com)
  • Subsequent tapering of the dose or switching to an oral agent is continued over several weeks to months. (medscape.com)
  • Next
  • The coupling agent PyBroP was next used under standard conditions, but only starting material ( 6 and 5-AQ) was detected after 100 h. (nih.gov)
  • preventative
  • The researchers found that there are no known strategies to prevent thyroid disease in patients receiving these new antineoplastic agents, and that possible preventative measures may be more toxic than the thyroid disease itself. (medindia.net)
  • class
  • Agents in this class that decrease cortisol production and alter the peripheral metabolism of steroids may reduce morbidity. (medscape.com)