• These publications spurred rapid advancement in the previously non-existent field of cancer chemotherapy, and a wealth of new alkylating agents with therapeutic effect were discovered over the following two decades. (wikipedia.org)
  • In the Anatomical Therapeutic Chemical Classification System, alkylating agents are classified under L01A. (wikipedia.org)
  • These findings urge further investigations to avoid the potential risks in current empiric continuous low-dose chemotherapy regimens with antineoplastic agents. (researchsquare.com)
  • 4. Pharmaceuticals used to destroy cancer cells are called anticancer, chemotherapeutic, antineoplastic, or cytotoxic 5. (studylib.net)
  • Stomatitis and ulcerative stomatitis represent cytotoxic reactions to topically applied agents, e.g. (dentalcare.com)
  • or may result from the systemic administration of cytotoxic drugs, e.g., antineoplastic agents, which damage not only tumor cells, but all rapidly dividing normal cell populations. (dentalcare.com)
  • Anticancer agents based on natural product models / edited by John M. Cassady, John D. Douros. (who.int)
  • These agents inhibit cell growth and proliferation. (medscape.com)
  • These agents inhibit key factors involved in immune reactions. (medscape.com)
  • Antineoplastic agents inhibit cell growth and proliferation. (medscape.com)
  • Agents in this class halt the cell cycle at the G1 phase in tumor cells. (medscape.com)
  • 7. Drugs that exert their influence during any phase of the cell cycle are called Cell cycle nonspecific (CCNS) drugs and include Alkylating agents, hormones and anti-tumor antibiotics. (studylib.net)
  • There are indications that certain antineoplastic agents at low dosages may exhibit abnormal pharmacological actions, such as promoting tumor growth. (researchsquare.com)
  • This study observes a previously neglected pharmacological phenomenon and investigates its mechanism of that the continuous low-dose administration of some antineoplastic agents in certain dose ranges can promote tumorigenesis and tumor progression in vitro and in vivo , through stimulation of tumor cell functions directly as well as enhancement of tumor angiogenesis by BMDCs recruitment indirectly. (researchsquare.com)
  • 12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key 1 Define the following terms: 1. (studylib.net)
  • 12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key excretion of cellular breakdown products and to reduce the risk of hemorrhagic cystitis. (studylib.net)
  • 12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key 3 greater, brimmed hats, and lightweight, long-sleeved shirts). (studylib.net)
  • An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (CnH2n+1) to DNA. (wikipedia.org)
  • Alkylating agents are used to treat several cancers. (wikipedia.org)
  • Most of the alkylating agents are also carcinogenic. (wikipedia.org)
  • Before their use in chemotherapy, alkylating agents were better known for their use as sulfur mustard, ("mustard gas") and related chemical weapons in World War I. The nitrogen mustards were the first alkylating agents used medically, as well as the first modern cancer chemotherapies. (wikipedia.org)
  • These include true alkyl groups, and have been known for a longer time than some of the other alkylating agents. (wikipedia.org)
  • Nitrogen mustards Cyclophosphamide - the most widely used alkylating agent of modern times. (wikipedia.org)
  • Chlormethine also known as mechlorethamine or mustine (HN2) - the first alkylating agent to receive regulatory approval. (wikipedia.org)
  • Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. (pharmacycode.com)
  • Alkylating agents are cell cycle-nonspecific. (pharmacycode.com)
  • Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death. (pharmacycode.com)
  • Cyclophosphamide/Alkylating Agent Concept/Action/Use Assessment Immunity CCNS Damage cell's DNA preventing reproduction of cancer cells. (studylib.net)
  • Antineoplastic with alkylating activity. (cancer.gov)
  • Drugs used to manage connective tissue disease (CTD) associated with interstitial lung disease (ILD) (CTD-ILD) include nintedanib, corticosteroids, and antineoplastic agents. (medscape.com)
  • Goodman, Gilman, and others began studying nitrogen mustards at Yale in 1942, and, following the sometimes dramatic but highly variable responses of experimental tumors in mice to treatment, these agents were first tested in humans late that year. (wikipedia.org)
  • Cyclophosphamide, together with its active metabolites, aldophosphamide, acrolein and nitrogenated mustard, is an antineoplastic from the group of nitrogen mustards with very marked immunosuppressive properties. (e-lactancia.org)
  • Cardiovascular Drugs / Antilipemic Agents / HMG-CoA Reductase Inhibitors (i.e. (tevausa.com)
  • Everyday healthcare workers face hazardous work conditions due to exposures to infectious agents and hazardous drugs and chemicals. (cdc.gov)
  • The goal of the healthcare worker survey is to collect information describing exposures, safety and health practices, and use of exposure controls for several targeted hazards including chemotherapeutic drugs, chemical sterilants, high level disinfectants, anesthetic gases, surgical smoke, aerosolized medications, and cleaning and disinfection agents. (cdc.gov)
  • Any antifungal agent used to prevent or treat fungal infections in humans or animals. (ebi.ac.uk)
  • Several experimental and pharmacologic trials have demonstrated its efficacy in the role as an anti-inflammatory agent. (nuutro.co.uk)
  • Curcumin is a natural anti-inflammatory agent that has been used for treating medical conditions for many years. (nuutro.co.uk)
  • 22, 24 The degree of tissue damage depends on the specific agent, dosage, dosage schedule, and patient-related variables. (dentalcare.com)
  • The most active agents for pancreatic cancer have been 5-fluorouracil (5-FU) and gemcitabine. (medscape.com)
  • Antineoplastic agent used in other gastrointestinal neuroendocrine tumors (including pancreatic islet cell and carcinoid tumors). (medscape.com)
  • Which medications in the drug class Antineoplastic Agents, mTOR Kinase Inhibitors are used in the treatment of Non-Hodgkin Lymphoma (NHL)? (medscape.com)
  • Prednisolone is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. (pharmacycode.com)
  • 5 Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Universitat Autònoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Bellaterra, Spain. (nih.gov)
  • Bryostatin 1, a novel antineoplastic agent and protein kinase C (PKC) activator, has been found to induce myalgia (muscle pain) 48 h after administration in clinical trials. (ox.ac.uk)
  • In general, the rate of absorption of local anesthetic agents following topical application occurs most rapidly after intratracheal administration. (nih.gov)
  • Gingival enlargement may be associated with the administration of calcium-channel blocking agents, phenytoin, and cyclosporine. (dentalcare.com)
  • Agents that interfere with male hormones or with hormonal feedback (e.g., testosterone, luteinizing hormone [LH]) may also affect production of healthy sperm, thus affecting fertility [Osorio and Windham 2004]. (cdc.gov)
  • Fedorova T.M., Ashmarin I.P. (1980) Effect of DNA-tropic antineoplastic and antiparasitic agents on DNAase I activity. (msk.ru)
  • Any antiviral agent which inhibits the activity of coronaviruses. (ebi.ac.uk)
  • activity of a new antineoplastic agent. (bvsalud.org)
  • Consider potential additive immunosuppressive effects in patients receiving or who previously received antineoplastic, immunosuppressive, or immunomodulating therapies. (drugs.com)
  • However, the conventional chemotherapy with antineoplastic agents at the maximum tolerated dose (MTD) is typically administrated in short cycles, obligatorily separated by long treatment breaks (e.g., 3 weeks), and unfortunately accompanied by serious toxic side effects. (researchsquare.com)
  • Studies of lidocaine metabolism following intravenous bolus injections have shown that the elimination half-life of this agent is typically 1.5 to 2.0 hours. (nih.gov)
  • Agents that interfere with the menstrual cycle and ovulation, such as hormonally active agents, may affect fertility [Windham and Osorio 2004]. (cdc.gov)
  • An agent that suppresses immune function by one of several mechanisms of action. (ebi.ac.uk)