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  • guanine
  • Dialkylating agents can react with two different 7-N-guanine residues, and, if these are in different strands of DNA, the result is cross-linkage of the DNA strands, which prevents uncoiling of the DNA double helix. (wikipedia.org)
  • Monoalkylating agents can react only with one 7-N of guanine. (wikipedia.org)
  • synthesis
  • Etomidate, an imidazole-derivative anesthetic agent, decreases corticosteroid synthesis in the adrenal cortex by reversibly inhibiting 17-20 yase and 11-beta-hydroxylase at non-hypnotic doses. (medscape.com)
  • Next
  • The coupling agent PyBroP was next used under standard conditions, but only starting material ( 6 and 5-AQ) was detected after 100 h. (nih.gov)
  • several
  • The researchers also recommend several paths of research that should be pursued, namely knowledge of the biological effects of the antineoplastic agents on the thyroid, so they can identify possible preventative strategies and improve the proposed screening strategies. (medindia.net)
  • Mitotane is an adrenolytic agent that acts by inhibiting 11-beta hydroxylase and several cholesterol side-chain cleavage enzymes. (medscape.com)
  • Subsequent tapering of the dose or switching to an oral agent is continued over several weeks to months. (medscape.com)
  • effects
  • To understand the thyroid-related side effects of antineoplastic agents, their frequency, and underlying mechanisms, Ole-Petter Riksfjord Hamnvik, M.D., of the Division of Endocrinology, Diabetes, and Hypertension at Brigham and Women's Hospital in Boston, and colleagues reviewed articles on thyroid dysfunction in cancer patients. (medindia.net)
  • preventative
  • The researchers found that there are no known strategies to prevent thyroid disease in patients receiving these new antineoplastic agents, and that possible preventative measures may be more toxic than the thyroid disease itself. (medindia.net)
  • class
  • Agents in this class that decrease cortisol production and alter the peripheral metabolism of steroids may reduce morbidity. (medscape.com)
  • increase
  • These agents can induce an increase in reticulocyte counts, with a subsequent increase in hematocrit and hemoglobin levels. (medscape.com)
  • It also acts as an anti-inflammatory agent by inhibiting the recruitment of leukocytes and monocyte-macrophages into affected areas via inhibition of chemotactic factors and factors that increase capillary permeability. (medscape.com)
  • potential
  • An immunocytokine of the human monoclonal antibody fragment F16 (scFv) against the extra-domain A1 of tenascin-C fused, via a short 5-amino acid linker, to a recombinant form of the human cytokine interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities. (newyorkoncology.com)
  • result
  • Acute inhalation injury may result from frequent and widespread use of household cleaning agents and industrial gases (including chlorine and ammonia). (wikipedia.org)
  • active
  • Nearly all components of bohemic acid are anthracycline antibiotic agents active against Gram-positive bacteria, but not against Gram-negative bacteria, yeasts or fungi. (wikipedia.org)
  • high
  • Radiolableled amino acid-based agents are useful in PET brain tumor imaging because F-18 fluoro-deoxyglucose (F-18 FDG), commonly used in PET tumor imaging, is relatively insensitive for detecting tumors in the brain due the high levels of glycolytic metabolism in the normal cortex and to a lesser extent in white matter. (newyorkoncology.com)