• malignant
  • Publications] Y.Ibayashi: 'Effect of local administration of lymphokine-activated killer cells and interleukin-2 on malignant brain tumor patients' Neurologia medico-chirurgica. (nii.ac.jp)
  • However, many of the biochemical characteristics initially thought to be closely associated with the malignant phenotype of cells in culture were subsequently found to be dissociable from the ability of those cells to produce tumors in animals. (nih.gov)
  • Furthermore, individual cells of malignant tumors growing in animals or in humans exhibit marked biochemical heterogeneity, as reflected in their cell surface composition, enzyme levels, immunogenicity, response to anticancer drugs, and so on. (nih.gov)
  • Recently, however, Hahn and colleagues 28 showed that ectopic expression of the human telomerase catalytic subunit (human telomerase reverse transcriptase [hTERT]) in combination with the oncogenes h- ras and SV40 virus large-T antigen can induce tumorigenic conversion in normal human epithelial and fibroblast cells, suggesting that disruption of the intracellular pathways regulated by these gene products is sufficient to produce a malignant cell. (nih.gov)
  • It is a rare malignant tumor that primarily develops in children, and accounts for approximately 1% of all cancers in children and 79% of all primary liver cancers under the age of 15. (wikipedia.org)
  • a rare malignant tumor in children. (wikipedia.org)
  • Upon discovery of a liver tumor, the main issue in the workup is to determine whether the tumor is benign or malignant. (wikipedia.org)
  • Many imaging modalities are used to aid in the diagnosis of malignant liver tumors. (wikipedia.org)
  • induce
  • To induce sustained immunity against both LeY and GD2, we developed a carbohydrate mimicking peptide (CMP) as a surrogate pan-immunogen that mimics both. (oncotarget.com)
  • Such strategies could produce organisms that perform multistep immune functions such as presenting antigen to and co-stimulating helper T cells in a specific manner, or providing integrated signals to B cells to induce affinity maturation and isotype switching during antibody production. (wikipedia.org)
  • Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. (wikipedia.org)
  • Antigens can be added to the antibody and can induce the dendritic cells to mature and provide immunity to the tumor. (wikipedia.org)
  • antibodies
  • The main objective of this project is to develop a novel immunotherapy for gliomas, in which glycolipid antigens are analyzed and quantified systematically and a set of appropriate antibodies would be selected according to the antigenic profile of an individual glioma. (nii.ac.jp)
  • The reactivity of monoclonal antibodies against those gangliosides was examined next either as chemically isolated antigens or cell surface ones. (nii.ac.jp)
  • Tumor-associated carbohydrate antigens (TACAs) support cell survival that could be interrupted by anti-TACA antibodies. (oncotarget.com)
  • Monoclonal antibodies (mAbs) directed to some TACAs, like those directed to the ganglioside GD2 and the neolactoseries antigen Lewis Y (LeY), are known to inhibit cell signaling that influences cell survival [ 2 - 3 ]. (oncotarget.com)
  • The induction of antibodies to these antigens and related types would therefore be of clinical benefit by providing sustained immunity to inhibit metastatic outgrowth. (oncotarget.com)
  • But TACAs are also associated with cell signaling activities whereby anti-TACA antibodies are capable of direct induction of cell death of number of tumor cell lines, but this activity has not been investigated in great detail ( 9 , 10 ). (frontiersin.org)
  • Antibodies are well suited for eradicating tumor cells from the bloodstream and eliminating early tissue invasion ( 4 ). (aacrjournals.org)
  • For the production of antibodies against defined cell surface antigens such as these, the best approach has been described to include chemical conjugation of the antigen to a highly immunogenic carrier protein plus the use of a potent immunologic adjuvant. (aacrjournals.org)
  • Sandwich ELISA's based on two monoclonal antibodies which specifically recognize Tumor M2-PK (the dimeric form of M2-PK) are available for the quantification of Tumor M2-PK in stool and EDTA-plasma samples respectively. (wikipedia.org)
  • MUC1
  • Serologic responses by ELISA were largely IgM against each antigen with the exception of Tn-MUC1 where both IgM and IgG responses were induced. (aacrjournals.org)
  • It is typically linked to one of several cytotoxic agents, yielding antibody-drug conjugates : Cantuzumab mertansine Cantuzumab ravtansine "HuC242 binds to the extracellular domain of the tumor-associated carbohydrate antigen known as CanAg (a novel glycoform of MUC1). (wikipedia.org)
  • protein
  • Thus, targeting TACAs has the potential to broaden the spectrum of antigens recognized by the immune response, thereby lowering the risk of developing resistant tumors due to the loss of a given protein antigen. (frontiersin.org)
  • He discovered novel blood group and tumor antigen specific lectins and made original contribution towards elucidation of the energetics and mechanism of protein-sugar recognition. (wikipedia.org)
  • He delineated the molecular basis of carbohydrate recognition by legume lectins and demonstrated the novel C-H…O/N hydrogen bond in protein-sugar interactions. (wikipedia.org)
  • Further evidence that MUC16 can protect tumor cells from the immune system is the discovery that the heavily glycosylated tandem repeat domain of MUC16 can bind to galectin-1 (an immunosuppressive protein). (wikipedia.org)
  • The dendritic cells are activated in the presence of tumor antigens, which may be a single tumor-specific peptide/protein or a tumor cell lysate (a solution of broken down tumor cells). (wikipedia.org)
  • The treatment consists of removal of antigen-presenting cells from blood by leukapheresis and growing them with the fusion protein PA2024 made from GM-CSF and prostate-specific prostatic acid phosphatase (PAP) and reinfused. (wikipedia.org)
  • The name selectin comes from the words "selected" and "lectins," which are a type of carbohydrate-recognizing protein. (wikipedia.org)
  • They have remarkably similar protein folds and carbohydrate binding residues, leading to overlap in the glycans to which they bind. (wikipedia.org)
  • peptide
  • Here, we discuss our experience examining the immunological aspects and implications of carbohydrate-peptide mimicry. (frontiersin.org)
  • I-peptide inhibited lung colonization of FUT3-B16 cells in E-/P-selectin doubly deficient mutant mice, suggesting the existence of an as yet unidentified carbohydrate-binding endothelial receptor distinct from E-/P-selectins. (springer.com)
  • Fukuda MN, Ohyama C, Lowitz K, Matsuo O, Pasqualini R, Ruoslahti E, Fukuda M (2000) A peptide mimic of E-selectin ligand inhibits sialyl Lewis X-dependent lung colonization of tumor cells. (springer.com)
  • vaccine
  • Among the most challenging of antigen targets for vaccine design are glycans ( 1 ). (frontiersin.org)
  • This heptavalent-KLH conjugate plus QS21 vaccine safely induced antibody responses against five of seven antigens. (aacrjournals.org)
  • Immune response to the hepatitis B antigen in the RTS,S/AS01 malaria vaccine, and co-administration with pneumococcal conjugate and rotavirus vaccines in African children: a randomized controlled trial. (bioportfolio.com)
  • 2017
  • In 2017 Kymriah (or tisagenlecleucel), a chimeric antigen receptor (CAR) therapy, was approved by FDA to treat acute lymphoblastic leukemia. (wikipedia.org)
  • cells
  • The ultimate criterion that establishes whether or not cells have been transformed, however, is their ability to form a tumor in an appropriate host animal. (nih.gov)
  • RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. (bioportfolio.com)
  • Drugs used in chemotherapy use different ways to stop tumor cells from. (bioportfolio.com)
  • When M2-PK is mainly in the dimeric form, which is the case in tumor cells, all phosphometabolites above pyruvate kinase accumulate and are channelled into synthetic processes which branch off from glycolytic intermediates, such as nucleic acids, phospholipids and amino acids, important cell building blocks for highly proliferating cells such as tumor cells. (wikipedia.org)
  • Active cellular therapies usually involve the removal of immune cells from the blood or from a tumor. (wikipedia.org)
  • alternatively, immune cells can be genetically engineered to express a tumor-specific receptor, cultured and returned to the patient. (wikipedia.org)
  • Dendritic cells are antigen presenting cells (APCs) in the mammalian immune system. (wikipedia.org)
  • Dendritic cells can also be activated in vivo by making tumour cells express GM-CSF. (wikipedia.org)
  • This can be achieved by either genetically engineering tumor cells to produce GM-CSF or by infecting tumor cells with an oncolytic virus that expresses GM-CSF. (wikipedia.org)
  • In patients who lack the Lewis antigen (a blood type antigen on red blood cells), which is about 10% of the Caucasian population, CA 19-9 is not expressed, even in those with large tumors. (wikipedia.org)
  • Each selectin has a carbohydrate recognition domain that mediates binding to specific glycans on apposing cells. (wikipedia.org)
  • biochemical
  • Publications] B.O.Choi: 'Biochemical analysis of cytokine effect on the glycosphingolipid expression of human glioma cell lines' Tumor Res.28. (nii.ac.jp)
  • mediate
  • Among TACAs that mediate cell survival signals are the neolactoseries antigen Lewis Y (LeY) and the ganglioside GD2. (oncotarget.com)
  • sarcoma
  • Tumors of the blood vessels (angiosarcoma and hemangioendothelioma, embryonal sarcoma and fibrosarcoma are produced from a type of connective tissue known as mesenchyme. (wikipedia.org)
  • reactivity
  • We are now focusing on the glycolipid analysis of surgical specimens of glioma tissue as well as on the factors participating in the antibody reactivity against those antigens. (nii.ac.jp)
  • In contrast to the studies performed in the past, immunohistochemical results using this antibody 82-A6 did not exhibit a reactivity clearly restricted to tumors. (wikipedia.org)
  • epithelial
  • Hepatic adenomas: These benign epithelial liver tumors develop in the liver and are also an uncommon occurrence, found mainly in women using estrogens as contraceptives, or in cases of steroid abuse. (wikipedia.org)
  • EDTA
  • As a biomarker, the amount of Tumor M2-PK in stool and EDTA-plasma reflects the specific metabolic status of the tumors. (wikipedia.org)
  • An important application of the Tumor M2-PK test in EDTA-plasma is for follow-up during tumor therapy, to monitor the success or failure of the chosen treatment, as well as predicting the chances of a "cure" and survival. (wikipedia.org)
  • biological
  • Among biological characteristics of tumors, Ki-67 labeling index was higher in tumors with low GnT-V expression than in those with high GnT-V expression, although this difference was not statistically significant ( P = 0.09). (aacrjournals.org)
  • therefore
  • Therefore, the measurement of tumor M2-PK in stool samples, with follow-up by colonoscopy to clarify the tumor M2-PK positive results, may prove to be an advance in the early detection of colorectal carcinomas. (wikipedia.org)
  • lectins
  • His studies showed that the monomers of legume lectins have the necessary structural features for carbohydrate recognition and that oligomerization imparts them with topology necessary for their biologic activities such as agglutination, mitogenesis etc. (wikipedia.org)
  • epitope
  • It is expressed as a carbohydrate epitope that contains a sulfoglucuronyl residue in several adhesion molecules of the nervous system. (wikipedia.org)
  • This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). (wikipedia.org)