• To study the relationship between carcinoembryonic antigen (CEA) level, intraductal papillary mucinous neoplasm (IPMN) subtype, and the presence of invasive carcinoma. (gastrores.org)
  • Intraductal papillary mucinous neoplasm (IPMN) is a substantial subclass of pancreatic pathology, representing 20-50% of cystic pancreatic neoplasms [ 1 - 3 ]. (gastrores.org)
  • Lymphoid neoplasms with plasmablastic differentiation were classified by the World Health Organization, 2017 as a sub-grouping of several distinct but rare lymphomas in which the malignant cells are B-cell lymphocytes that have become plasmablasts, i.e. immature plasma cells. (wikipedia.org)
  • Due to their malignant nature, however, the plasmablasts in lymphoid neoplasms with plasmablastic differentiation do not mature into plasma cells or form antibodies but rather uncontrollably proliferate in and damage various tissues and organs. (wikipedia.org)
  • Except for human herpesvirus 8-positive diffuse large B-cell lymphoma, not otherwise specified, these lymphoid neoplasms are often associated with Epstein-Barr virus infection of the malignant plasmablastic cells. (wikipedia.org)
  • While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
  • Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
  • 4 Malignant effusions caused by non-epithelial neoplasms are more frequently encountered in children than in adults. (cytojournal.com)
  • In the current World Health Organization (WHO) classification of lymphoid malignant neoplasms, the diagnostic entity termed blastic NK-cell tumors has been proposed for tumors satisfying the diagnostic criteria for CD4/CD56 HN. (medscape.com)
  • Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)
  • Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
  • Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
  • In children, 35% of salivary gland neoplasms are malignant. (medscape.com)
  • Ruella M, Kenderian SS, Shestova O, Klichinsky M, Melenhorst JJ, Wasik MA, Lacey SF, June CH, and Gill S. A Kinase inhibitor ibrutinib to prevent cytokine-release syndrome after anti-CD19 chimeric antigen receptor T cells (CART) for B cell neoplasms . (upenn.edu)
  • The Addition of the BTK inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma. (upenn.edu)
  • The emergence of chimeric antigen receptor T cells (CARTs) has revolutionized the treatment of B-cell neoplasms in the last few years. (ebmt.org)
  • Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. (reference.md)
  • Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. (reference.md)
  • Many neoplasm proteins have been characterized and are used as tumor markers (TUMOR MARKERS, BIOLOGICAL) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. (reference.md)
  • Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm. (reference.md)
  • Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
  • These tumor proteins, when first defined, were referred to as tumor associated antigens. (jcancer.org)
  • We were also able to define immunogenic membrane proteins from lung (squamous and adenoCa) as well as prostate neoplasms. (jcancer.org)
  • myofibroblastoma breast neoplasms aspiration biopsy CD 34 antigens immunohistochemistry Acta Cytologica Fine Needle Aspiration Cytology Presentation of a Cellular Variant. (karger.com)
  • Purpose: Since the United States Food and Drug Administration approved the prostate specific antigen (PSA) blood test as an aid to early prostate cancer detection, using a cutoff of 4.0 ng/ml in 1994, this cutoff has been widely adopted to recommend prostate biopsy. (northwestern.edu)
  • In an attempt to identify pancreatic cystic lesions with an increased risk of associated invasive adenocarcinoma, carcinoembryonic antigen (CEA) level has emerged over the last few decades as a tool to assess pancreatic cystic fluid pre-operatively. (gastrores.org)
  • A research team from the University Hospitals of Cleveland Medical Center in western Pennsylvania has discovered the existence of myeloid neoplasms (MNs) that can undergo plasmacytoid dendritic cell (PDC) differentiation. (news-medical.net)
  • This work builds on existing knowledge that PDCs can be divided into two categories: mature PDC proliferations which result in myeloid neoplasms (MPDMN) and blastic plasmacytoid dendritic cell neoplasm (BPDCN). (news-medical.net)
  • The groups study present evidence of myeloid neoplasms derived from patients with acute leukemias which encompass a spectrum of PDC differentiation which result in outcomes that do not fit into the categories of MPD MN or BPDCN. (news-medical.net)
  • As proof-of-concept, the established target antigen CD44 was identified as a commonly and abundantly expressed surface protein with high endocytic activity. (lu.se)
  • Known as a target antigen in paraneoplastic motor disorder. (bvsalud.org)
  • she returned for next pregnancy in the second trimester, with both twins crawling at her sides, Hepatitis B surface antigen had turned negative. (scirp.org)
  • To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)
  • Several CTAs, including NY-ESO-1, MAGE-A3, and MAGE-A4, have been or are being studied as target antigens in vaccine clinical trials for various types of tumors, including non-small-cell lung cancer, ovarian cancer, gastrointestinal carcinoma, and urothelial carcinoma ( 7, 9 - 13 ). (aacrjournals.org)
  • Follow-up with periodical serum prostate specific antigen (PSA) dosages is used to determine the effectiveness of treatment. (usp.br)
  • The identification of putative prognostic factors in canine mammary neoplasms (CMNs) has been focused on tissue-specific biomarkers, but the serum biomarkers, including cancer antigen 15-3 (CA 15-3), c-reactive protein (CRP), and lactate dehydrogenase (LDH) have been demonstrated to display clinical application in cases of CMNs. (scielo.br)
  • This includes the amount of shed antigen in the serum at the time of treatment that could initiate immune complex formation as well as the shedding of inhibitory material into the serum possibly effecting an immune response. (jcancer.org)
  • cancer is combined digital rectal exam and Blood samples were taken and 1 mL of determination of serum prostate specific centrifuged serum was used for the PSA antigen (PSA) level. (who.int)
  • Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
  • SCC antigen is useful in the clinical management of advanced cervical cancer. (medscape.com)
  • Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. (duke.edu)
  • Vaccination against human cancer is a promising therapeutic approach but the optimal antigen or antigens remain undefined. (aacrjournals.org)
  • Cancer-testis antigens (CTA), a family of tumor-associated antigens, have both potent immunogenicity and restricted expression patterns in normal adult tissues, highly desirable characteristics for targets of anticancer vaccines. (aacrjournals.org)
  • These antigens were evaluated for both the degree of expression and prognostic value in cancer of the urothelium. (aacrjournals.org)
  • Cancer-testis antigens (CTA) are named after their pattern of expression, as they are found in various types of cancers but only in testicular germ cells of normal adult tissues ( 1 ). (aacrjournals.org)
  • Not long ago, prostate cancer was commonly detected with a digital rectal examination, which revealed palpable neoplasms. (anh-usa.org)
  • Prostate Specific Antigen (PSA), a tumor marker for adenocarcinoma of the prostate, can predict residual tumor in the post-operative phase of prostate cancer. (codemap.com)
  • Di Gioia D, Blankenburg I, Nagel D, Heinemann V, Stieber P. Tumor markers in the early detection of tumor recurrence in breast cancer patients: CA 125, CYFRA 21-1, HER2 shed antigen, LDH and CRP in combination with CEA and CA 15-3. (scielo.br)
  • [2]. The specific prostate antigen is a protein created by the prostatic epithelium that is specific to the organ but not to cancer because it can be elevated in pathologies such as prostatitis and benign prostatic hyperplasia, among others. (bvsalud.org)
  • A few notes on each cancer site and its subgroups staining techniques (e.g., glandular and diffuse neoplasms of are included in this chapter. (who.int)
  • The sample second after lung cancer as the most preva- size was calculated with level of 0.05 and lent neoplasm in men. (who.int)
  • Mib-1 monoclonal antibody recognizes the proliferation-related antigen Ki-67. (lu.se)
  • This monoclonal antibody reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. (novusbio.com)
  • Here, we are reporting a case of a 53-year-old male with simultaneous presence of JAK2 V617F-positive myeloproliferative neoplasm with features favoring prefibrotic phase of primary myelofibrosis (pre-PMF) in combination with monoclonal gammopathy of undetermined significance (MGUS). (bvsalud.org)
  • Female canine mammary neoplasms (CMNs) are defined as a heterogeneous group of diseases of complex classification, diagnosis, and prognosis. (scielo.br)
  • It has a non-debatable contribution to the diagnosis of hematolymphoid neoplasm as well as in minimal residual disease. (ijpmonline.org)
  • Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
  • The animal had multiple oral tumors characterized by proliferation of latent nuclear antigen 1-positive spindle cells and was not co-infected with immunosuppressive simian viruses, suggesting that it had Kaposi sarcoma caused by this novel rhadinovirus. (cdc.gov)
  • The tumors are highly vascularized and characterized by proliferation of spindle cells that contain KSHV DNA and antigen ( 2 , 3 ). (cdc.gov)
  • Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)
  • Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
  • Its oncologic properties are still under investigation, as well as the most suitable therapeutic measures for this type of neoplasm. (thieme-connect.de)
  • The MVX-ONCO-2 consists of two components: 1) biocompatible capsules, loaded with a genetically modified cell-line that secretes a strong immune-booster GM-CSF (granulocyte-macrophage stimulating factor) and 2) irradiated autologous patients' tumor cells, isolated from patients which serve as tumor antigens. (b3cnewswire.com)
  • His particular interest is in transplantation for multiple myeloma, lymphoma, myelodysplastic syndrome, acute leukemia and myeloproliferative neoplasms. (lvhn.org)
  • Blastic natural killer (NK) cell lymphoma ( also termed CD4+CD56+ hematodermic neoplasm ) is a recently described entity, with the first case reported in 1994. (medscape.com)
  • Blastic natural killer (NK) cell lymphoma, also termed CD4+CD56+ hematodermic neoplasm (CD4/CD56 HN) is a rare clinical entity encompassing distinct genetic, morphologic, etiologic, and diagnostic criteria. (medscape.com)
  • Cite this: Blastic NK-Cell Lymphomas (Agranular CD4+CD56+ Hematodermic Neoplasms) - Medscape - May 01, 2005. (medscape.com)
  • Normally, B-cells take up foreign antigens, move to the germinal centers of secondary lymphoid organs such the spleen and lymph nodes, and at these sites are stimulated by T-cell lymphocytes to differentiate (i.e. change their cell type) into plasmablasts and thereafter mature plasma cells. (wikipedia.org)
  • The lymphoid neoplasms with plasmacytic differentiation are: 1) Plasmablastic lymphoma: The most common of these lymphoid neoplasms. (wikipedia.org)
  • 2) Plasmablastic plasma cell lymphoma or plasmablastic plasmacytoma: A lymphoid neoplasm that disseminates widely like the plasma cell lesions in multiple myeloma or is localized like the plasma cell lesions in plasmacytoma. (wikipedia.org)
  • 6) Human herpesvirus 8-positive diffuse large B-cell lymphoma, not otherwise specified: This lymphoid neoplasm usually arises from the lymphoproliferative disease, idiopathic multicentric Castleman disease. (wikipedia.org)
  • In cases so infected, the lymphoid neoplasm may result, at least in part, from this viral infection and therefore can be considered as examples of the Epstein-Barr virus-associated lymphoproliferative diseases. (wikipedia.org)
  • Plasmablasts, and to a greater extent, plasma cells make and secrete antibodies that bind the antigens to which their predecessor B-cells were previously exposed (see plasma cell differentiation). (wikipedia.org)
  • The Advent of CAR T-Cell Therapy for Lymphoproliferative Neoplasms: Integrating Research into Clinical Practice. (upenn.edu)
  • Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
  • Hematologic malignancies are most commonly associated with paraneoplastic pemphigus, although it can also be associated with carcinomas, sarcomas, and benign neoplasms. (medscape.com)
  • Paraneoplastic pemphigus is an autoimmune disorder initiated by an underlying neoplasm. (medscape.com)
  • PDCs are a class of specialized dendritic cells that play a role in immunomodulatory functions and antigen presentation. (news-medical.net)
  • HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. (novusbio.com)
  • The high proportion of mitotic cells and resemblance to well-differentiated adenocarcinoma of the large intestine suggested that this neoplasm was adenocarcinoma rather than adenoma. (hindawi.com)
  • Combination of analysis of fluorescence labeling and light scatter properties of cells allows rapid and better determination of target cell antigens. (ijpmonline.org)
  • Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. (lu.se)
  • 44 distinct CTA gene or antigen families such as MAGE, GAGE, BAGE, and NY-ESO-1 have been identified ( 7, 8 ). (aacrjournals.org)
  • Most series report that about 80% of parotid neoplasms are benign, with the relative proportion of malignancy increasing in the smaller glands. (medscape.com)
  • The authors reported five patients with underlying neoplasms who developed oral erosions and bullous skin eruptions. (medscape.com)
  • Below is the selection of side effect reports (a.k.a. adverse event reports) related to Eligard (Leuprolide) where reactions include prostatic specific antigen increased. (druglib.com)