• cognate antigen
  • The single unifying theme for all memory T cell subtypes is that they are long-lived and can quickly expand to large numbers of effector T cells upon re-exposure to their cognate antigen. (wikipedia.org)
  • At rest, and for individuals without underlying autoimmunity, the majority of T cells that regularly encounter cognate antigen are FoxP3+ regulatory T cells. (wikipedia.org)
  • FasR
  • Sialidase, in combination with hyaluronidase, is thought to act as a virulence factor responsible for the pathogenicity of the organism, working together as potential promoters of the expression of CD95 (FasR). (wikipedia.org)
  • genes
  • two highly related effector memory sub-types, which strongly express genes for molecules essential to the cytotoxic function of CD8 T cells: effector memory (TEM) effector memory RA (TEMRA) More recently, antigen-experienced CD8+ T cells with apparent self-renewal capabilities have been described in mice. (wikipedia.org)
  • Mycoplasma crocodyli is much less virulent than M. alligatoris, lacking the genes for adhesins, variable surface antigens, and sialidases found in M. alligatoris. (wikipedia.org)
  • There are fewer than 30,000 genes in the human body, so it is impossible to have one gene for every antigen. (wikipedia.org)
  • encounter
  • Memory T cells have become "experienced" by having encountered antigen during a prior infection, encounter with cancer, or previous vaccination. (wikipedia.org)
  • viruses
  • Antigen-specific memory T cells against viruses or other microbial molecules can be found in both TCM and TEM subsets. (wikipedia.org)
  • context
  • TNFRSF25 stimulation is therefore highly specific to T cell mediated immunity, which can be used to enhance or dampen inflammation depending on the temporal context and quality of foreign vs self antigen availability. (wikipedia.org)
  • In this case, the cells would have been presented antigen in the context of MHC1. (wikipedia.org)
  • induction
  • Interestingly, these DEVD-type inhibitors did not block the Fas-induced morphological changes (cell shrinkage and surface blebbing), induction of Apo2.7 antigen, or the cell death (as assessed by the dye exclusion ability). (nih.gov)
  • surface
  • Many cancers contain an oncogene that will inhibit the MHC complex on the cell surface from presenting antigens to immune cells. (wikipedia.org)
  • The activation of cytotoxic T cells is dependent on several simultaneous interactions between molecules expressed on the surface of the T cell and molecules on the surface of the antigen-presenting cell (APC). (wikipedia.org)
  • infection
  • Results of the study showed that M. alligatoris produces an infection that changes the morphology in cardiac fibroblasts, increasing CD95 expression leading to cell death. (wikipedia.org)
  • cells
  • Some have suggested that antigen-inexperienced memory T cells should be separated into 'innate memory' T cells and 'virtual memory' T cells. (wikipedia.org)
  • The double-positive T cells are exposed to a wide variety of self-antigens in the thymus and undergo two selection criteria: positive selection, in which those double-positive T cells that bind to foreign antigen in the presence of self MHC. (wikipedia.org)
  • negative selection, in which those double-positive T cells that bind too strongly to MHC-presented self antigens undergo apoptosis because they could otherwise become autoreactive, leading to autoimmunity. (wikipedia.org)
  • Only those T cells that bind to the MHC-self-antigen complexes weakly are positively selected. (wikipedia.org)
  • Those cells that survive positive and negative selection differentiate into single-positive T cells (either CD4+ or CD8+), depending on whether their TCR recognizes an MHC class I-presented antigen (CD8) or an MHC class II-presented antigen (CD4). (wikipedia.org)
  • It is the CD8+ T-cells that will mature and go on to become cytotoxic T cells following their activation with a class I-restricted antigen. (wikipedia.org)
  • When these cells are infected with a virus (or another intracellular pathogen), the cells degrade foreign proteins via antigen processing. (wikipedia.org)
  • together
  • Similarly, because TNFRSF25 activation is antigen dependent, costimulation of TNFRSF25 together with an autoantigen or with a vaccine antigen can lead to exacerbation of immunopathology or enhanced vaccine-stimulated immunity, respectively. (wikipedia.org)