• Vivo
  • Combining the most potent CD4(+) and CD8(+) CAR-expressing subsets resulted in synergistic antitumor effects in vivo. (fredhutch.org)
  • proliferation
  • Human MSCs (hMSCs) can alter multiple aspects of murine T cell activation induced by stimulation with specific antigen, including: reduced proliferation, inhibited or stimulated cell surface marker expression (CD25, CD69, CD44 and CD62L), inhibited mRNA expression of transcription factors (T-bet and GATA-3) and decreased cytokine expression (interferon-gamma, interleukin-10). (biomedcentral.com)
  • antibody
  • The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for detecting and quantifying antigens of interest. (biocompare.com)
  • In contrast, an anti-CD8 antibody selectively inhibited the B27- but not the DR2-directed killing by these clones. (rupress.org)
  • Murine
  • Mechanistic studies in a murine dendritic cell line (DC 2.4) demonstrated micelle-mediated enhancements in intracellular antigen retention and cytosolic antigen accumulation. (sigmaaldrich.com)
  • In this report, tetramers with mutated CD8 binding site selectively stain higher avidity human and murine CTL capable of recognizing physiological levels of Ag. (ox.ac.uk)
  • activation
  • These results demonstrate the potential of pH-responsive polymeric micelles for use in vaccine applications that rely on CD8(+) T cell activation. (sigmaaldrich.com)
  • The affinity between CD8 and the MHC molecule keeps the TC cell and the target cell bound closely together during antigen-specific activation. (wikipedia.org)
  • intracellular
  • When the T cell receptor is engaged by the specific antigen presented by MHC, Lck acts to phosphorylate the intracellular chains of the CD3 and ζ-chains of the TCR complex, allowing another cytoplasmic tyrosine kinase called ZAP-70 to bind to them. (wikipedia.org)
  • vitro
  • Conjugation of ovalbumin to the micelles significantly enhanced antigen cross-presentation in vitro relative to free ovalbumin, an unconjugated physical mixture of ovalbumin and polymer, and a non-pH-responsive micelle-ovalbumin control. (sigmaaldrich.com)
  • protein
  • In this study, using islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-reactive CD8 T cell receptor NY8.3 transgenic nonobese diabetic mice, we demonstrated that MyD88 strongly modulates CD8 + T cell-mediated T1D development via the gut microbiota. (rupress.org)
  • The functions of CD8 in the TCR complex are thought to be signaling through the association of CD8 with the protein tyrosine kinase p56lck and adhesion to MHC class I through the alpha 3 domain. (rupress.org)
  • This question is of interest because CD8 T cell response to alum-precipitated protein is under debate. (kserre.net)
  • It is also required for induction of cytotoxic immunity by vaccination with protein antigens, for example, tumour vaccination. (wikipedia.org)
  • Humans
  • Most notably, Dr. Old discovered the LY-B antigen, later renamed CD8 in humans. (wikipedia.org)
  • Because of this and the fact that cows are a natural host of Mycobacterium bovis, a pathogen in humans as well, it is hoped that studying cows will yield insights into the group 1 CD1 antigen-presenting system. (wikipedia.org)
  • mice
  • It has been shown that IL-21R knock-out mice express higher levels of IgE and lower levels of IgG1 than normal mice after antigen exposure. (wikipedia.org)
  • molecule
  • The data support a stabilizing role of CD8 through its binding to the same class I (but not class II) molecule on the target cell bound by the T cell antigen receptor. (rupress.org)
  • Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts. (rupress.org)
  • The TCR complex and CD4 each bind to distinct regions of the antigen-presenting MHCII molecule - α1/β1 and β2, respectively. (wikipedia.org)
  • If the TCR is specific for that antigen, it binds to the complex of the class I MHC molecule and the antigen, and the T cell destroys the cell. (wikipedia.org)
  • In order for the TCR to bind to the class I MHC molecule, the former must be accompanied by a glycoprotein called CD8, which binds to the constant portion of the class I MHC molecule. (wikipedia.org)
  • cognate
  • Furthermore, we demonstrate that CD8 binding significantly enhances the avidity as well as the stability of interactions between CTL and cognate tetramers. (ox.ac.uk)
  • endogenous
  • Access of antigen to the MHC class I presentation pathway was originally thought to be restricted to endogenous proteins, i.e., those expressed within the cytoplasm of the cell presenting the antigen. (rupress.org)
  • clones
  • The results indicate that these clones display dual recognition for HLA-B27.1 and for HLA-DR2 and suggest that HLA-B27.1 may share at least one epitope that is closely related to some stimulatory Dw determinants present on the HLA-DR2 antigens. (rupress.org)
  • influenza
  • Nventa is also developing two additional therapeutic vaccine programs based on its CoVal technology-a Hsp - HBV (hepatitis B) fusion, and prototypes of Hsp fusion proteins with influenza antigens. (wikipedia.org)