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  • receptor
  • As in the case of the CD4 antigen, the CD8 antigen appears to serve as a receptor for nonpolymorphic regions of products of the major histocompatibility complex and has been implicated in the regulation of T-cell growth. (pnas.org)
  • Transduced hHSC expressing an HLA-A*0201-restricted melanoma-specific T-cell receptor were introduced into humanized mice, resulting in the generation of a sizeable melanoma-specific naïve CD8 + T-cell population. (pnas.org)
  • In this study, using islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-reactive CD8 T cell receptor NY8.3 transgenic nonobese diabetic mice, we demonstrated that MyD88 strongly modulates CD8 + T cell-mediated T1D development via the gut microbiota. (rupress.org)
  • The data support a stabilizing role of CD8 through its binding to the same class I (but not class II) molecule on the target cell bound by the T cell antigen receptor. (rupress.org)
  • The CD8 alphabetaT cell receptor repertoire in joint fluid of individuals with active psoriatic arthritis contained an average of 32 major oligoclonal expansions in many variable genes of the TCR beta chain (BV) families, as shown by beta-chain CDR3 length analysis. (nih.gov)
  • In the present work, we induced CD8 + T cell cytotoxicity by targeting of Ag to XCR1, a chemokine receptor exclusively expressed on murine and human cross-presenting DC. (jimmunol.org)
  • When the T cell receptor is engaged by the specific antigen presented by MHC, Lck acts to phosphorylate the intracellular chains of the CD3 and ζ-chains of the TCR complex, allowing another cytoplasmic tyrosine kinase called ZAP-70 to bind to them. (wikipedia.org)
  • Rudd's work has had important clinical outcomes as it laid the foundation for chimeric antigen receptor (CAR) cancer therapy that has been pioneered by Zelig Eshhar (Israel) and Carl June (USA). (wikipedia.org)
  • clonal
  • Psoriatic arthritis joint fluids are characterized by CD8 and CD4 T cell clonal expansions appear antigen driven. (nih.gov)
  • The findings support a model of psoriatic arthritis inflammation involving extensive and selective Ag, likely autoantigen, driven intra-articular CD4, and CD8 T cell clonal expansions. (nih.gov)
  • activation
  • These results demonstrate the potential of pH-responsive polymeric micelles for use in vaccine applications that rely on CD8(+) T cell activation. (sigmaaldrich.com)
  • Human MSCs (hMSCs) can alter multiple aspects of murine T cell activation induced by stimulation with specific antigen, including: reduced proliferation, inhibited or stimulated cell surface marker expression (CD25, CD69, CD44 and CD62L), inhibited mRNA expression of transcription factors (T-bet and GATA-3) and decreased cytokine expression (interferon-gamma, interleukin-10). (biomedcentral.com)
  • The affinity between CD8 and the MHC molecule keeps the TC cell and the target cell bound closely together during antigen-specific activation. (wikipedia.org)
  • complexes
  • Taken together, these results demonstrate, for the first time, that T. cruzi subverts sialylation to attenuate CD8(+) T cell interactions with peptide-major histocompatibility complex class I complexes. (unifesp.br)
  • selectively
  • In contrast, an anti-CD8 antibody selectively inhibited the B27- but not the DR2-directed killing by these clones. (rupress.org)
  • In this report, tetramers with mutated CD8 binding site selectively stain higher avidity human and murine CTL capable of recognizing physiological levels of Ag. (ox.ac.uk)
  • mice
  • Herein, we investigated the impact of sialylation mediated by trans-sialidase, a specific and unique Trypanosoma transglycosylase for sialic acid, on CD8(+) T cell response of mice infected with T. cruzi. (unifesp.br)
  • It has been shown that IL-21R knock-out mice express higher levels of IgE and lower levels of IgG1 than normal mice after antigen exposure. (wikipedia.org)
  • antibody
  • The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for detecting and quantifying antigens of interest. (biocompare.com)
  • clones
  • Alloreactive cytolytic T cell clones with dual recognition of HLA-B27 and HLA-DR2 antigens. (rupress.org)
  • The results indicate that these clones display dual recognition for HLA-B27.1 and for HLA-DR2 and suggest that HLA-B27.1 may share at least one epitope that is closely related to some stimulatory Dw determinants present on the HLA-DR2 antigens. (rupress.org)
  • The inferred amino acid sequence of a single CD8 oligoclonal expansion revealed that they usually are composed of one or a few structurally related clones at the amino acid sequence level with beta-chains that encode identical or highly homologous CDR3 motifs. (nih.gov)
  • p56lck
  • In this study, we reveal that the human CD8 antigen is also associated with the T-cell-specific protein-tyrosine kinase (p56lck). (pnas.org)
  • Two-dimensional nonequilibrium pH-gradient gel electrophoresis and sodium dodecyl sulfate/polyacrylamide gel electrophoresis demonstrated the similarity of p56lck to the protein-tyrosine kinase associated with the CD4 antigen. (pnas.org)
  • Last, we demonstrate directly that members of the CD3 complex, including the gamma, delta, and epsilon chains, as well as a putative zeta subunit, can be phosphorylated at tyrosine residues by the CD4/CD8.p56lck complex. (pnas.org)
  • The functions of CD8 in the TCR complex are thought to be signaling through the association of CD8 with the protein tyrosine kinase p56lck and adhesion to MHC class I through the alpha 3 domain. (rupress.org)
  • cytotoxicity
  • Selective involvement of CD8 in their class I--directed cytotoxicity. (rupress.org)
  • Current subunit vaccines are incapable of inducing Ag-specific CD8 + T cell cytotoxicity needed for the defense of certain infections and for therapy of neoplastic diseases. (jimmunol.org)
  • Human
  • Human cytomegalovirus (HCMV) antigens in glioblastoma (GBM) present opportunities for personalised immunotherapy. (sigmaaldrich.com)
  • Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts. (rupress.org)
  • Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. (wikipedia.org)
  • molecule
  • The TCR complex and CD4 each bind to distinct regions of the antigen-presenting MHCII molecule - α1/β1 and β2, respectively. (wikipedia.org)
  • If the TCR is specific for that antigen, it binds to the complex of the class I MHC molecule and the antigen, and the T cell destroys the cell. (wikipedia.org)
  • In order for the TCR to bind to the class I MHC molecule, the former must be accompanied by a glycoprotein called CD8, which binds to the constant portion of the class I MHC molecule. (wikipedia.org)
  • vitro
  • Conjugation of ovalbumin to the micelles significantly enhanced antigen cross-presentation in vitro relative to free ovalbumin, an unconjugated physical mixture of ovalbumin and polymer, and a non-pH-responsive micelle-ovalbumin control. (sigmaaldrich.com)
  • strongly
  • Inhibition of the parasite's native trans-sialidase activity during infection strongly decreased CD8(+) T cell sialylation, reverting it to the glycosylation status expected in the absence of parasite manipulation increasing mouse survival. (unifesp.br)
  • cognate
  • Furthermore, we demonstrate that CD8 binding significantly enhances the avidity as well as the stability of interactions between CTL and cognate tetramers. (ox.ac.uk)
  • Humans
  • Most notably, Dr. Old discovered the LY-B antigen, later renamed CD8 in humans. (wikipedia.org)
  • Because of this and the fact that cows are a natural host of Mycobacterium bovis, a pathogen in humans as well, it is hoped that studying cows will yield insights into the group 1 CD1 antigen-presenting system. (wikipedia.org)
  • specific
  • The magnitude of the antigen-specific component versus the bystander component of a primary T cell response remains controversial. (semanticscholar.org)
  • Our data demonstrate that T. cruzi uses its trans-sialidase enzyme to resialylate the CD8(+) T cell surface, thereby dampening antigen-specific CD8(+) T cell response that might favor its own persistence in the mammalian host. (unifesp.br)
  • High avidity antigen-specific CTL identified by CD8-independent tetramer staining. (ox.ac.uk)
  • Tumor-reactive antigen-specific CTL generated by priming in the presence of IL-21 led to a stable, 'helper-independent' phenotype. (wikipedia.org)
  • As yet unpublished pre-clinical data indicate that Poly-ICR, in combination with a tumor-associated antigen, increases antigen-specific CD8 T-cell levels, while both inducing regression of tumors and preventing tumor growth in mouse models. (wikipedia.org)
  • proteins
  • Access of antigen to the MHC class I presentation pathway was originally thought to be restricted to endogenous proteins, i.e., those expressed within the cytoplasm of the cell presenting the antigen. (rupress.org)
  • Nventa is also developing two additional therapeutic vaccine programs based on its CoVal technology-a Hsp - HBV (hepatitis B) fusion, and prototypes of Hsp fusion proteins with influenza antigens. (wikipedia.org)
  • effector
  • however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease. (wikipedia.org)
  • It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. (wikipedia.org)
  • bind
  • Supertypes are groups of human leukocyte antigen (HLA) alleles which bind overlapping sets of peptides due to sharing specific residues at the anchor positions-the B and F pockets-of the peptide-binding region (PBR). (springer.com)
  • exposure
  • Immunosenescence can also be sometimes envisaged as the result of the continuous challenge of the unavoidable exposure to a variety of antigens such as viruses and bacteria. (wikipedia.org)
  • taken
  • However, cross-reactivities (or the lack of them) between hantaviruses should be taken into consideration when choosing the right antigen in a given geographical area, or when interpreting the exact infecting agent. (springer.com)