• activation
  • CD2/CD58 binding can enhance antigen-specific T cell activation. (novusbio.com)
  • Subsequently, T cell activation causes the CD58-bound CD2 to be recognized and immobilized at sites of cell-cell contact, thereby strengthening T cell-APC adhesion. (ox.ac.uk)
  • gene
  • Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis. (wikipedia.org)
  • model
  • A model for CD2/CD58-mediated adhesion strengthening. (ox.ac.uk)
  • In this paper, we present a theoretical model that simulates the accumulation of CD2 and CD58 in the contact area of a Jurkat T lymphoblast and a CD58-containing substrate. (ox.ac.uk)
  • Among the many tumor antigens described, the model antigen, carcinoembryonic antigen (CEA), is of particular interest because it is widely expressed in gastrointestinal, lung, breast, and other malignancies. (aacrjournals.org)
  • express
  • The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms. (wikipedia.org)