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  • CD19
  • CLL lymphocytes coexpress the B-cell antigens CD19 and CD20 along with the T-cell antigen CD5. (cancer.gov)
  • Waldenström macroglobulinemia has a natural history and therapeutic options similar to CLL, with the exception of hyperviscosity syndrome associated with macroglobulinemia as a result of elevated immunoglobulin M. Prolymphocytic leukemia (PLL) is a rare entity characterized by excessive prolymphocytes in the blood with a typical phenotype that is positive for CD19, CD20, and surface-membrane immunoglobulin and negative for CD5. (cancer.gov)
  • 2 The tumour cells express monotypic surface Ig (sIg) and sometimes cytoplasmic Ig (cIg) (usually IgM), moreover the pan B cell antigens CD19, CD20, CD22, and CD79a. (bmj.com)
  • The neoplastic cells infiltrate the reactive follicles, showing follicular colonization, and have typical lymphoepithelial lesion [ 3 ].The neoplastic cells express pan B-cell antigens (CD19, CD20, CD22). (ispub.com)
  • In B-PLL patients there is strong expression of surface immunoglobulin - a membrane-bound form of an antibody, b-lymphocyte surface antigens CD19, CD20, CD22, CD79a and FMC7, and weak expression of CD5 and CD23. (wikipedia.org)
  • B-cell-associated antigens such as CD19, CD20, CD22, and CD79a are usually expressed. (wikipedia.org)
  • Cells can be identified and placed into two categories "B1a" or B1b" using flow cytometry looking for surface expression of CD19, B220, and CD5. (wikipedia.org)
  • CD23
  • 2 ] In this disorder, lymphocyte counts in the blood are usually greater than or equal to 5,000/mm 3 with a characteristic immunophenotype (CD5- and CD23-positive B cells). (cancer.gov)
  • In contrast to small lymphocytic lymphoma and MCL, staining for CD5 is usually negative, and these lymphomas can be further distinguished with CD23 (positive in small lymphocytic lymphoma) and CyclinD1 (positive in MCL). (wikipedia.org)
  • The MZ B cells within this region typically express high levels of IgM, CD21, CD1, CD9 with low to negligible levels of secreted-IgD, CD23, CD5, and CD11b that help to distinguish them phenotypically from follicular (FO) B cells and B1 B cells. (wikipedia.org)
  • CD10
  • Immunophenotyping helps distinguish B-PLL from similar diseases, one of its key identifiers is the absence in expression of the surface antigens CD10, CD11c, CD25, CD103 and cyclin D1 - an important regulator of cell-cycle progression. (wikipedia.org)
  • immunoglobulin
  • Thy-1 or CD90 (Cluster of Differentiation 90) is a 25-37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen. (wikipedia.org)
  • bacterial
  • CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. (wikipedia.org)
  • These polyspecific immunoglobulins often have a preference for other immunoglobulins, self antigens and common bacterial polysaccharides. (wikipedia.org)
  • It is believed they are especially reactive to bacterial cell wall components and self-antigens which are the products of aging. (wikipedia.org)
  • Primary
  • Antigen Shift released Primary Causation in 2001, a limited edition CD that was sold at the first installment of the Providence Noise festival. (wikipedia.org)
  • MALT
  • We report a 35-year-old woman with multicentric CD5-positive mucosa associated lymphoid tissue (MALT) lymphoma of conjunctival region. (ispub.com)
  • The occurrence of multicentric conjunctival CD5-positive MALT lymphoma in the younger age further support to the notation that CD5+ MALT-lymphomas arising in the ocular adnexa might be characterized by an unusual clinical course. (ispub.com)
  • In recent studies, several cases of conjunctival CD5-positive MALT lymphoma have been reported [ 3 5 6 ]. (ispub.com)
  • Fig . 2B ) With exception of CD5 expression, the morphological findings and growth pattern of the neoplastic cells, led us to diagnosis of a malignant small cell B-cell non-Hodgkin lymphoma and sub-typed as extranodal marginal zone B-cell lymphoma of MALT type. (ispub.com)
  • cell
  • Immunohistochemically, the malignant cells expressed markers of B-cell lineage and unusually CD5 positive. (ispub.com)
  • In the thymus, there is a correlation with CD5 expression and strength of the interaction of the T cell towards self-peptides. (wikipedia.org)
  • About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia and mantle cell lymphoma (both being B cell malignancies). (wikipedia.org)
  • The absence of CD5 in T cell acute lymphoblastic leukemia, while relatively rare, is associated with a poor prognosis. (wikipedia.org)
  • There are only about 15,000 patients presently in the U.S. MCL is a subtype of B-cell lymphoma, due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. (wikipedia.org)
  • CD5-CD72 is thought to mediate B cell-B cell interaction. (wikipedia.org)
  • Hence, there appears to be a role for self or foreign antigen in shaping the repertoire of the B-1 B cell compartment. (wikipedia.org)
  • McHeyzer-Williams LJ, McHeyzer-Williams MG. Antigen-specific memory B cell development. (wikipedia.org)
  • The antigen Thy-1 was the first T cell marker to be identified. (wikipedia.org)
  • cells
  • CD5 is a cluster of differentiation expressed on the surface of T cells (various species) and in a subset of murine B cells known as B-1a. (wikipedia.org)
  • There is no confirmed ligand for CD5 but there is evidence that CD72, a C-type lectin, may be a ligand or that CD5 may be homophilic, binding CD5 on the surface of other cells. (wikipedia.org)
  • T cells express higher levels of CD5 than B cells. (wikipedia.org)
  • CD5 is upregulated on T cells upon strong activation. (wikipedia.org)
  • CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3. (wikipedia.org)
  • Pan-T antigens are antigens found on all T cells. (wikipedia.org)
  • B-1 B cells, in the mouse, can be further subdivided into B-1a (CD5+) and B-1b (CD5−) subtypes. (wikipedia.org)
  • The MZ B cells are especially well positioned as a first line of defense against systemic blood-borne antigens that enter the circulation and become trapped in the spleen. (wikipedia.org)
  • The processes of beta-selection, positive selection, and negative selection shape the population of thymocytes into a peripheral pool of T cells that are able to respond to foreign pathogens and are immunologically tolerant towards self antigens. (wikipedia.org)
  • and no CD1 or CD5, readily distinguishing this compartment from B1 B cells and marginal zone B-cells. (wikipedia.org)
  • It was originally named theta (θ) antigen, then Thy-1 (THYmocyte differentiation antigen 1) due to its prior identification in thymocytes (precursors of T cells in the thymus). (wikipedia.org)
  • marker
  • It has thought that CD5-expression is a marker for unusual and aggressive clinical course. (ispub.com)
  • findings
  • These findings have led to the view that (auto)antigen drive is a promoting factor in the development and evolution of CLL and have been a pivotal in refining patient prognosis. (wikipedia.org)
  • release
  • In 2013, SIGNIFIER officially signed Antigen Shift for the release of "Brotherhood", Antigen Shift's first studio album since 2006's "The Way of the North" (AD NOISEAM). (wikipedia.org)
  • several
  • Also in 2006, Antigen Shift playing several live dates in support of TWOTN, including participation at the 2006 Providence Noise fest, several European dates in Germany, Austria and Greece, as well as the annual Maschinenfest festival in Krefeld, and finally the Indoctrination Festival in Chicago. (wikipedia.org)
  • Stage
  • In the summer of 2010 it was announced that Antigen Shift would be returning to both the studio and the stage, with three shows in support of Iszoloscope and Ad·ver·sary. (wikipedia.org)