Loading...

  • B220
  • B220 expression is not restricted to B cells and can also be expressed on activated T cells, on a subset of dendritic cells and other antigen-presenting cells. (wikipedia.org)
  • peptides
  • Once at the lymph nodes, the APC begin to present antigen peptides that are bound to Class II MHC, allowing CD4+ T cells that express the specific TCRs against the peptide/MHC complex to activate. (wikipedia.org)
  • recognises
  • When a Th cell encounters and recognises the antigen on an APC, the TCR-CD3 complex binds strongly to the peptide-MHC complex present on the surface of professional APCs. (wikipedia.org)
  • dendritic cells
  • Phagocytosis is the main process of macrophages and antigen presentation the main property of dendritic cells (so called because of their star-like cytoplasmic processes). (wikipedia.org)
  • citation needed] Follicular dendritic cells are localized in germinal centers of lymphoid follicles and have an integral role in regulation of the germinal center reaction and present antigens to B cells. (wikipedia.org)
  • Specialised antigen presenting cells are primarily dendritic cells, macrophages and B cells, although dendritic cells are the only cell group that expresses MHC Class II constitutively (at all times). (wikipedia.org)
  • Some APCs also bind native (or unprocessed) antigens to their surface, such as follicular dendritic cells, but unprocessed antigens do not interact with T cells and are not involved in their activation. (wikipedia.org)
  • hematopoietic cells
  • It is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T and B cell antigen receptor signaling. (novusbio.com)
  • CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells, but CD45 positioning within lipid rafts is modified during their oncogenic transformation to acute myeloid leukemia. (wikipedia.org)
  • molecule
  • Ink4a(-/-) tumors exhibited increased CD45 expression, reflective of immune cell infiltration and upregulation of gene networks associated with the cytoskeleton, DNA damage response, and small molecule transport. (biomedsearch.com)
  • These T cells bind to the MHC II-antigen molecule and cause activation of the B cell. (wikipedia.org)
  • CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation antigen - an immunologically significant molecule. (wikipedia.org)
  • cell
  • Immunohistochemical study showed positivity for leukocytic common antigen (CD45), B-cell marker (CD20) and bcl 6. (curehunter.com)
  • Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. (abcam.com)
  • For example, when an antigen-presenting cell expresses an antigen on MHC class II, a CD4+ cell will aid those cells through a combination of cell to cell interactions (e.g. (wikipedia.org)
  • It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. (wikipedia.org)
  • The variable region determines what antigen the T cell can respond to. (wikipedia.org)
  • This gene encodes the Ig-beta protein of the B-cell antigen component. (wikipedia.org)
  • The CD79a protein together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells, thus forming the B-cell antigen receptor (BCR). (wikipedia.org)
  • This occurs in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface. (wikipedia.org)
  • Play media In immunology, an immunological synapse (or immune synapse) is the interface between an antigen-presenting cell or target cell and a lymphocyte such as an effector T cell or Natural Killer cell. (wikipedia.org)
  • The process of formation begins when the T-cell receptor (TCR) binds to the peptide:MHC complex on the antigen-presenting cell. (wikipedia.org)
  • After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which are taken up by the B cell through receptor-mediated endocytosis and processed. (wikipedia.org)
  • This process favors, by selection for the ability to bind antigen with higher affinity, the activation and growth of B cell clones able to secrete antibodies of higher affinity for the antigen. (wikipedia.org)
  • Since B cell maturation also involves somatic hypermutation (a process completed before differentiation into a plasma cell), these antibodies frequently have a very high affinity for their antigen. (wikipedia.org)
  • In other words, every B cell is specific to a single antigen, but each cell can produce several thousand matching antibodies per second. (wikipedia.org)
  • CD15
  • Sialyl Lewis X CD15 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Kerr MA, Stocks SC (November 1992). (wikipedia.org)
  • cells
  • CD45 is a protein antigen expressed on all haemopoietic white cells and "gating" the CD45 antigen positive cells in each sample was performed as part of the DHR assay in this study. (thefreedictionary.com)
  • This antigen is found on B cells, approximately 50% of bone marrow cells, all CD8+ve T cells, but splits CD4+ve T cells into two populations,CD4+ CD45RC (Th 1-like) and CD4+ CD45RC low (Th-2 like). (novusbio.com)
  • The cytoplasmic domain of CD45 is one of the largest known and it has an intrinsic phosphatase activity that removes an inhibitory phosphate group on a tyrosine kinase called Lck (in T cells) or Lyn/Fyn/Lck (in B cells) and activates it. (wikipedia.org)
  • In addition, CD45 was shown to be the target of the species D adenovirus 19a E3/49K protein to inhibit the activation of NK and T cells. (wikipedia.org)
  • CD45 colocalizes with lipid rafts on AML cells, which contributes to elevated GM-CSF signal intensity involved in proliferation of leukemic cells. (wikipedia.org)
  • Langerhans cells are antigen-presenting cells but have undergone further differentiation. (wikipedia.org)
  • Due to the unavailability of antibodies from the rest of the body (few antibodies are small enough to cross the blood-brain barrier), microglia must be able to recognize foreign bodies, swallow them, and act as antigen-presenting cells activating T-cells. (wikipedia.org)
  • Naïve T cells are those T cells that have never been exposed to the antigen that they are programmed to respond to). (wikipedia.org)
  • During an immune response, professional antigen-presenting cells (APCs) endocytose foreign material (typically bacteria or viruses), which undergoes processing, then travel from the infection site to the lymph nodes. (wikipedia.org)
  • Upon subsequent encounters with a given antigen, memory T cells are re-activated using the same TCR pathways. (wikipedia.org)
  • First, the B cells have to encounter a foreign antigen, and are then required to be activated by T helper cells before they differentiate to specific cells. (wikipedia.org)
  • They divide rapidly and are still capable of internalizing antigens and presenting them to T cells. (wikipedia.org)
  • It is also called Lewis x and SSEA-1 (stage-specific embryonic antigen 1) and represents a marker for murine pluripotent stem cells, in which it plays an important role in adhesion and migration of the cells in the preimplantation embryo. (wikipedia.org)
  • gene
  • The CD45 family consists of multiple members that are all products of a single complex gene. (wikipedia.org)
  • variants
  • CD45 exists in multiple forms, such as the restricted variants and as allelic forms CD45.1/Ly5.1 and CD45.2/Ly5.2. (abcam.com)
  • Mice
  • There are two identifiable alleles of CD45 in mice: CD45.1 (Ly5.1 historically) and CD45.2 (Ly5.2 historically). (wikipedia.org)
  • hematopoietic
  • CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells, but CD45 positioning within lipid rafts is modified during their oncogenic transformation to acute myeloid leukemia. (wikipedia.org)
  • antibody
  • Unlike their precursors, they cannot switch antibody classes , cannot act as antigen-presenting cells because they no longer display MHC-II, and do not take up antigen because they no longer display significant quantities of immunoglobulin on the cell surface. (wikipedia.org)
  • CD45 phosphatase is not completely excluded from the close-contact zone and thus the signal generated in the case of a conventional antibody is weaker. (wikipedia.org)
  • CD22
  • RSH cells typically express CD15 and CD30, whereas LP cells lack expression of these markers, but express B cell markers like CD20, CD22, and CD79a and also express the common leukocyte antigen CD45, which is uncommon on RSH cells. (wikipedia.org)
  • distinguish
  • The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms. (wikipedia.org)
  • regulation
  • citation needed] Follicular dendritic cells are localized in germinal centers of lymphoid follicles and have an integral role in regulation of the germinal center reaction and present antigens to B cells. (wikipedia.org)
  • extracellular
  • The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. (wikipedia.org)
  • surface
  • Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. (wikipedia.org)
  • This occurs in a similar manner to the association of CD3 with the T-cell receptor, and enables the cell to respond to the presence of antigens on its surface. (wikipedia.org)
  • It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor. (wikipedia.org)
  • Dimerization of identical RPTP proteins at the cell surface leaves the PTP domains either in an open active conformation, as in the case of PTPmu and LAR, or in an inhibited conformation that leaves the catalytic domain inaccessible, in the case of CD45, PTPalpha, and PTPzeta/beta. (wikipedia.org)
  • express
  • Activated and memory T lymphocytes express the shortest CD45 isoform, CD45R0, which lacks RA, RB, and RC exons. (wikipedia.org)
  • foreign
  • First, the B cells have to encounter a foreign antigen, and are then required to be activated by T helper cells before they differentiate to specific cells. (wikipedia.org)
  • Regulatory T cells (Tregs) are essential to provide immune tolerance to self as well as to certain foreign antigens. (jove.com)
  • chain
  • T-/B+ SCID (T cells predominantly absent): γc deficiency, JAK3 deficiency, interleukin 7 receptor chain α deficiency, CD45 deficiency, CD3δ/CD3ε deficiency. (wikipedia.org)
  • expression
  • B220 expression is not restricted to B cells and can also be expressed on activated T cells, on a subset of dendritic cells and other antigen-presenting cells. (wikipedia.org)