• peptides
  • Once at the lymph nodes, the APC begin to present antigen peptides that are bound to Class II MHC, allowing CD4+ T cells that express the specific TCRs against the peptide/MHC complex to activate. (wikipedia.org)
  • CD45RO
  • The alterations of CD45RA and CD45RO antigens expression on T helper cells in prediabetics suggest the significant role of naive or/and memory CD4+ T cell subsets in the pathogenesis of diabetes type 1. (curehunter.com)
  • stimulation
  • However, cross-linking of CD3 ( 5 ), CD2 ( 6 ), B cell surface Ig ( 7 ), CD44 ( 8 ), MHC class II ( 9 ), or CD45 ( 10 ) with specific mAbs or stimulation of cells with PMA results in a rapid enhancement of LFA-1-mediated cell adhesion to ICAM-1. (jimmunol.org)
  • Differentiation through a T cell-independent antigen stimulation (stimulation of a B cell that does not require the involvement of a T cell) can happen anywhere in the body and results in short-lived cells that secrete IgM antibodies. (wikipedia.org)
  • molecule
  • Ink4a(-/-) tumors exhibited increased CD45 expression, reflective of immune cell infiltration and upregulation of gene networks associated with the cytoskeleton, DNA damage response, and small molecule transport. (biomedsearch.com)
  • These T cells bind to the MHC II-antigen molecule and cause activation of the B cell. (wikipedia.org)
  • CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation antigen - an immunologically significant molecule. (wikipedia.org)
  • CD40
  • It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. (wikipedia.org)
  • CD15
  • RSH cells typically express CD15 and CD30, whereas LP cells lack expression of these markers, but express B cell markers like CD20, CD22, and CD79a and also express the common leukocyte antigen CD45, which is uncommon on RSH cells. (wikipedia.org)
  • Sialyl Lewis X CD15 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Kerr MA, Stocks SC (November 1992). (wikipedia.org)
  • marker
  • Immunohistochemical study showed positivity for leukocytic common antigen (CD45), B-cell marker (CD20) and bcl 6. (curehunter.com)
  • It is also called Lewis x and SSEA-1 (stage-specific embryonic antigen 1) and represents a marker for murine pluripotent stem cells, in which it plays an important role in adhesion and migration of the cells in the preimplantation embryo. (wikipedia.org)
  • cytoplasmic
  • The cytoplasmic domain of CD45 is one of the largest known and it has an intrinsic phosphatase activity that removes an inhibitory phosphate group on a tyrosine kinase called Lck (in T cells) or Lyn/Fyn/Lck (in B cells) and activates it. (wikipedia.org)
  • cells
  • This antigen is found on B cells, approximately 50% of bone marrow cells, all CD8+ve T cells, but splits CD4+ve T cells into two populations,CD4+ CD45RC (Th 1-like) and CD4+ CD45RC low (Th-2 like). (novusbio.com)
  • In addition, CD45 was shown to be the target of the species D adenovirus 19a E3/49K protein to inhibit the activation of NK and T cells. (wikipedia.org)
  • CD45 colocalizes with lipid rafts on AML cells, which contributes to elevated GM-CSF signal intensity involved in proliferation of leukemic cells. (wikipedia.org)
  • Langerhans cells are antigen-presenting cells but have undergone further differentiation. (wikipedia.org)
  • Due to the unavailability of antibodies from the rest of the body (few antibodies are small enough to cross the blood-brain barrier), microglia must be able to recognize foreign bodies, swallow them, and act as antigen-presenting cells activating T-cells. (wikipedia.org)
  • For example, when an antigen-presenting cell expresses an antigen on MHC class II, a CD4+ cell will aid those cells through a combination of cell to cell interactions (e.g. (wikipedia.org)
  • Na├»ve T cells are those T cells that have never been exposed to the antigen that they are programmed to respond to). (wikipedia.org)
  • During an immune response, professional antigen-presenting cells (APCs) endocytose foreign material (typically bacteria or viruses), which undergoes processing, then travel from the infection site to the lymph nodes. (wikipedia.org)
  • Upon subsequent encounters with a given antigen, memory T cells are re-activated using the same TCR pathways. (wikipedia.org)
  • The CD79a protein together with the related CD79b protein, forms a dimer associated with membrane-bound immunoglobulin in B-cells, thus forming the B-cell antigen receptor (BCR). (wikipedia.org)
  • First, the B cells have to encounter a foreign antigen, and are then required to be activated by T helper cells before they differentiate to specific cells. (wikipedia.org)
  • They divide rapidly and are still capable of internalizing antigens and presenting them to T cells. (wikipedia.org)
  • differentiation
  • Since B cell maturation also involves somatic hypermutation (a process completed before differentiation into a plasma cell), these antibodies frequently have a very high affinity for their antigen. (wikipedia.org)
  • variants
  • CD45 exists in multiple forms, such as the restricted variants and as allelic forms CD45.1/Ly5.1 and CD45.2/Ly5.2. (abcam.com)
  • Mice
  • There are two identifiable alleles of CD45 in mice: CD45.1 (Ly5.1 historically) and CD45.2 (Ly5.2 historically). (wikipedia.org)