• CD24
  • catenin, but not E-cadherin, and CD24, but not CD44, were involved in the effect of growth inhibition induced by HSS. (biomedsearch.com)
  • In addition, variations in CD44 are reported as cell surface markers for some breast and prostate cancer stem cells.In breast cancer research CD44+/CD24- expression is commonly used as a marker for breast CSCs and is used to sort breast cancer cells into a population enriched in cells with stem-like characteristics and has been seen as an indicator of increased survival time in epithelial ovarian cancer patients. (wikipedia.org)
  • ALDH(high) and ALDH(low) cell populations were further examined for co-expression of CD44 and/or CD24. (nih.gov)
  • ALDH(high)/CD44(+)/CD24(+) or ALDH(low)/CD44(+)/CD24(+) phenotypes do not appear to significantly contribute to tumor formation at low numbers of inoculated tumor cells. (nih.gov)
  • In breast cancer cells expressing CD44 and CD24, DHRS7B expression was observed to be down regulated. (wikipedia.org)
  • Anti-CD44
  • Furthermore, because alternative splicing and posttranslational modifications generate many different CD44 sequences, including, perhaps, tumor-specific sequences, the production of anti-CD44 tumor-specific agents may be a realistic therapeutic approach. (wikipedia.org)
  • HCELL
  • One critical modification involves discrete sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). (wikipedia.org)
  • Splice variants of CD44 on colon cancer cells display sialofucosylated HCELL glycoforms that serve as P-, L-, and E-selectin ligands and fibrin, but not fibrinogen, receptors under hemodynamic flow conditions pertinent to the process of cancer metastasis. (wikipedia.org)
  • Ex vivo glycan engineering of the surface of live cells has been used to enforce HCELL expression on any cell that expresses CD44. (wikipedia.org)
  • By modifying CD44 antigens using glycosyltransferase-programmed stereosubstitution (GPS), the HCELL expression on the surfaces of human mesenchymal stem cells and hematopoietic stem cells can be enforced, effectively homing those cells to the bone marrow of their host. (wikipedia.org)
  • hyaluronan
  • Link domain, which includes the Link module of TSG-6 [ PMID: 12972412 ] (a hyaladherin with important roles in inflammation and ovulation) and the hyaluronan binding domain of CD44 (which contains extra N-terminal beta-strand and C-terminal beta-hairpin) [ PMID: 14992719 ]. (ebi.ac.uk)
  • Gene
  • In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11. (wikipedia.org)
  • CD44 gene transcription is at least in part activated by beta-catenin and Wnt signalling (also linked to tumour development). (wikipedia.org)
  • HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene. (wikipedia.org)
  • effector-memory
  • two highly related effector memory sub-types, which strongly express genes for molecules essential to the cytotoxic function of CD8 T cells: effector memory (TEM) effector memory RA (TEMRA) More recently, antigen-experienced CD8+ T cells with apparent self-renewal capabilities have been described in mice. (wikipedia.org)
  • protein
  • Glutathione S Transferase (GST) fusion protein corresponding to the variable domains (v3 to v10) of human CD44. (novusbio.com)
  • Tumor restriction of Thomsen-Friedenreich antigen may therefore be determined either by the protein backbone or by the beta-glycosidic linkage of the carbohydrate structure to the protein. (wikipedia.org)
  • prognosis
  • Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells. (thermofisher.com)
  • Additionally, in many cases different research groups analyzing the same neoplastic disease reached contradictory conclusions regarding the correlation between CD44 expression and disease prognosis, possibly due to differences in methodology. (wikipedia.org)
  • lymphocytes
  • Naive lymphocytes (those with no history of contact with antigens) travel from the bone marrow or high endothelial venules of the thymus where they develop as lymphoblasts, to lymph nodes, where they mature. (wikipedia.org)
  • genes
  • In humans, the carcinoembryonic antigen family consists of 29 genes, 18 of which are normally expressed. (wikipedia.org)
  • cells
  • The expression of Lgr5 and CD44 staining were used to observe intestinal stem cells (ISCs). (hindawi.com)
  • Memory T cells have become "experienced" by having encountered antigen during a prior infection, encounter with cancer, or previous vaccination. (wikipedia.org)
  • Central memory T cells also have intermediate to high expression of CD44. (wikipedia.org)
  • Note- CD44 expression is usually used to distinguish murine naive from memory T cells). (wikipedia.org)
  • Some have suggested that antigen-inexperienced memory T cells should be separated into 'innate memory' T cells and 'virtual memory' T cells. (wikipedia.org)
  • Antigen-specific memory T cells against viruses or other microbial molecules can be found in both TCM and TEM subsets. (wikipedia.org)
  • Antigens are also presented on the surface of dendritic cells. (wikipedia.org)
  • human
  • MA5-13887 targets CD44 in FACS, IHC (P), IP, ICC/IF and WB applications and shows reactivity with Human and Non-human primate samples. (thermofisher.com)
  • expression
  • However, in many cancers (renal cancer and non-Hodgkin's lymphomas are exceptions), a high level of CD44 expression is not always associated with an unfavorable outcome. (wikipedia.org)
  • The expression of Lgr5 and the integrated option density (IOD) of CD44 stain were increased significantly by SXD. (hindawi.com)
  • They also have intermediate to high expression of CD44. (wikipedia.org)