• B220
  • In all primary tumors, subpopulations of these CD19(+) IgM(-) CD43(+) were also either B220(+) or B220(-), suggesting a block in differentiation at the pro-B cell stage. (nih.gov)
  • We found that relatively lower densities of Delta1 ext-IgG enhanced the generation of Sca-1 + c-kit + cells, Thy1 + CD25 + early T cell precursors, and B220 + CD43 −/lo cells that, when cocultured with OP9 stroma cells, differentiated into CD19 + early B cell precursors. (rupress.org)
  • Higher densities of Delta1 ext-IgG also enhanced the generation of Sca-1 + c-kit + precursor cells and promoted the development of Thy1 + CD25 + cells, but inhibited the development of B220 + CD43 −/lo cells. (rupress.org)
  • The IL-7 responsive B-lineage cells were clearly defined in vitro using sorted B-cell precursor populations and shown to express B220, CD43 heat stable antigen (HSA), and to carry heavy-chain gene rearrangements (3) . (springer.com)
  • CD44
  • A large proportion of these cells possess a highly activated phenotype (CD44 hi , CD62L lo , CD43 hi , and CD25 hi ) and express immediate effector function as indicated by the production of interferon γ after a 5-h restimulation in vitro. (rupress.org)
  • For sialyl-Lewisx to bind to E-selectin it can be part of either an N-linked or O-linked glycan attached to cell surface glycoproteins such as PSGL-1, CD43 or CD44. (wikipedia.org)
  • molecule
  • Defects in the CD43 molecule are associated with the development of Wiskott-Aldrich syndrome. (wikipedia.org)
  • In this report, we show that TC prestimulation by the CD43 coreceptor molecule before TCR engagement inhibits TCR-dependent c-Cbl tyrosine phosphorylation, c-Cbl interaction with the adapter molecule Crk-L and promotes Cbl-b degradation in a PKCθ-dependent manner. (ox.ac.uk)
  • marker
  • The stages of B- and T-cell progenitor development have been thoroughly defined on the basis of cell surface marker expression, antigen receptor gene rearrangement, and cytokine responsiveness. (springer.com)
  • For example, in the mouse, Sendai virus specific CD8+ T-cells low on CD43 expression mounted a higher memory recall response suggesting that memory CD8 T-cells can also be distinguished from activated effector CD8 T-cells using CD43 marker. (wikipedia.org)
  • In January 2011, human B1 cells were found to have marker profile of CD20+CD27+CD43+CD70- and could either be CD5+ or CD5-, which has been debated since. (wikipedia.org)
  • effector
  • The single unifying theme for all memory T cell subtypes is that they are long-lived and can quickly expand to large numbers of effector T cells upon re-exposure to their cognate antigen. (wikipedia.org)
  • two highly related effector memory sub-types, which strongly express genes for molecules essential to the cytotoxic function of CD8 T cells: effector memory (TEM) effector memory RA (TEMRA) More recently, antigen-experienced CD8+ T cells with apparent self-renewal capabilities have been described in mice. (wikipedia.org)
  • Gene
  • The organization of the SELPLG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters. (wikipedia.org)
  • innate
  • Some have suggested that antigen-inexperienced memory T cells should be separated into 'innate memory' T cells and 'virtual memory' T cells. (wikipedia.org)
  • immune
  • During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. (abcam.com)
  • His another important achievement is the induction of antigen-specific T cell tolerance, which has been a distant dream of immunologists for pinpoint-targeted control of the immune system. (wikipedia.org)
  • infection
  • Memory T cells have become "experienced" by having encountered antigen during a prior infection, encounter with cancer, or previous vaccination. (wikipedia.org)
  • cells
  • B1 cells express IgM in greater quantities than IgG and its receptors show polyspecificity, meaning that they have low affinities for many different antigens. (wikipedia.org)
  • Sialyl Lewis x is an inflammation-associated antigen on liver cells. (wikipedia.org)
  • activation
  • These data indicates that CD43-mediated signals lower the threshold for TC activation by restricting the c-Cbl and Cbl-b inhibitory effects on TCR signaling. (ox.ac.uk)
  • present
  • Although it is present in over 90% of T-cell lymphomas, it is generally less effective at demonstrating this condition than is CD3 antigen. (wikipedia.org)
  • primary
  • A CD19(+) IgM(-) CD43(+) immunophenotype was seen both in primary tumors and two cell lines derived from these tumors. (nih.gov)
  • found
  • Besides, he found the novel antigen JL1 on thymocytes, which has been developed as a therapeutic target for leukemia. (wikipedia.org)