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  • antibody
  • Therefore, in the absence of TFH cells, similar to B cell activation by T-cell independent antigens, a quick burst of low affinity plasma cell production is formed but this does not lead to germinal center induction nor permit antibody affinity maturation or the differentiation of effective memory B cells which are essential in fortifying the body against subsequent infections. (wikipedia.org)
  • Dendritic cell receptors such as TLR3, TLR7, TLR8 or CD40 have been used as antibody targets. (wikipedia.org)
  • tumor
  • Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary. (wikipedia.org)
  • Those that bind to tumor antigens treat cancer. (wikipedia.org)
  • protein
  • Cluster of differentiation 40, CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. (wikipedia.org)
  • The treatment consists of removal of antigen-presenting cells from blood by leukapheresis and growing them with the fusion protein PA2024 made from GM-CSF and prostate-specific prostatic acid phosphatase (PAP) and reinfused. (wikipedia.org)
  • expresses
  • For example, when an antigen-presenting cell expresses an antigen on MHC class II, a CD4+ cell will aid those cells through a combination of cell to cell interactions (e.g. (wikipedia.org)
  • As a result, the macrophage expresses more CD40 and TNF receptors on its surface, which helps increase the level of activation. (wikipedia.org)
  • activation
  • An additional co-stimulatory signal is then produced by the antigen-presenting cell, leading to activation of the T cell. (wikipedia.org)
  • TFH cell-dependent paracrine activation of B cell CD40 results in B cell survival and differentiation, including the induction of AID (activation-induced (cytidine) deaminase). (wikipedia.org)
  • After activation by antigen, these B cells proliferate. (wikipedia.org)
  • target
  • OX40's value as a drug target primarily lies in the fact that, being transiently expressed after T-cell receptor engagement, it is only upregulated on the most recently antigen-activated T cells within inflammatory lesions. (wikipedia.org)
  • cytokine
  • Altogether, the present data indicate that PGE2 stimulates human CD40-activated B cell growth, but differently modulates cytokine-induced differentiation. (jimmunol.org)
  • affinity
  • Transfer of CD40L proportional to the amount of antigen presented by individual B cells may allow T cells to selectively deliver a sustained signal required for survival of higher affinity mutant B cells. (ohsu.edu)
  • Glycan structure does not influence binding affinity to CD40. (abcam.com)
  • cell
  • Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSDC cell line. (semanticscholar.org)
  • In Chapter 3 of this dissertation, I describe my novel finding that CD40L does not remain on the T cell surface but is actually transferred to antigen-presenting B cells. (ohsu.edu)
  • The variable region determines what antigen the T cell can respond to. (wikipedia.org)
  • The B cell can present antigens to helper T cells. (wikipedia.org)
  • T cells must be activated by interacting with a professional APC presenting an antigen which their T cell receptor recognizes before they can divide and perform their function. (wikipedia.org)
  • An additional co-stimulatory signal is then produced by the antigen-presenting cell, leading to activation of the T cell. (wikipedia.org)
  • Follicular B helper T cells (also known as just follicular helper T cells or TFH), are antigen-experienced CD4+ T cells found in the periphery within B cell follicles of secondary lymphoid organs such as lymph nodes, spleens and Peyer's patches, and are identified by their constitutive expression of the B cell follicle homing receptor CXCR5. (wikipedia.org)
  • TFH cell-dependent paracrine activation of B cell CD40 results in B cell survival and differentiation, including the induction of AID (activation-induced (cytidine) deaminase). (wikipedia.org)
  • CD40 signaling is known to 'license' dendritic cells to mature and thereby trigger T-cell activation and differentiation. (wikipedia.org)
  • OX40's value as a drug target primarily lies in the fact that, being transiently expressed after T-cell receptor engagement, it is only upregulated on the most recently antigen-activated T cells within inflammatory lesions. (wikipedia.org)