• cytokine
  • Altogether, the present data indicate that PGE2 stimulates human CD40-activated B cell growth, but differently modulates cytokine-induced differentiation. (jimmunol.org)
  • peptides
  • Once at the lymph nodes, the APC begin to present antigen peptides that are bound to Class II MHC, allowing CD4+ T cells that express the specific TCRs against the peptide/MHC complex to activate. (wikipedia.org)
  • affinity
  • Transfer of CD40L proportional to the amount of antigen presented by individual B cells may allow T cells to selectively deliver a sustained signal required for survival of higher affinity mutant B cells. (ohsu.edu)
  • Glycan structure does not influence binding affinity to CD40. (abcam.com)
  • interact
  • In addition, PGE2 inhibited IgE production by naive surface IgD+ B cells cultured in the CD40 system, suggesting that PGE2 may interact with mechanisms involved in IgE switching. (jimmunol.org)
  • CD40 (protein) has been shown to interact with TRAF2, TRAF3, TRAF6, TRAF5 and TTRAP. (wikipedia.org)
  • cell
  • Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers and irritants in the FSDC cell line. (semanticscholar.org)
  • In Chapter 3 of this dissertation, I describe my novel finding that CD40L does not remain on the T cell surface but is actually transferred to antigen-presenting B cells. (ohsu.edu)
  • ANTIGENS, CD40) on B - cells , inducing B - cell proliferation . (dictionary.net)
  • The variable region determines what antigen the T cell can respond to. (wikipedia.org)
  • With the assistance of a phosphatase present on the intracellular section of CD45 (common leukocyte antigen), these molecules activate major Th cell intracellular pathways. (wikipedia.org)
  • CD40L plays a central role in costimulation and regulation of the immune response via T cell priming and activation of CD40-expressing immune cells. (wikipedia.org)
  • The B cell can present antigens to helper T cells. (wikipedia.org)
  • T cells must be activated by interacting with a professional APC presenting an antigen which their T cell receptor recognizes before they can divide and perform their function. (wikipedia.org)
  • An additional co-stimulatory signal is then produced by the antigen-presenting cell, leading to activation of the T cell. (wikipedia.org)
  • It also upregulates several co-stimulatory molecules required for T cell activation, including CD40 and B7. (wikipedia.org)
  • Follicular B helper T cells (also known as just follicular helper T cells or TFH), are antigen-experienced CD4+ T cells found in the periphery within B cell follicles of secondary lymphoid organs such as lymph nodes, spleens and Peyer's patches, and are identified by their constitutive expression of the B cell follicle homing receptor CXCR5. (wikipedia.org)
  • OX40's value as a drug target primarily lies in the fact that, being transiently expressed after T-cell receptor engagement, it is only upregulated on the most recently antigen-activated T cells within inflammatory lesions. (wikipedia.org)
  • bind
  • The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations. (google.com)