• Cluster
  • CD34 is a cluster of differentiation first described independently by Civin et al. (wikipedia.org)
  • Duffy antigen/chemokine receptor (DARC), also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234), is a protein that in humans is encoded by the DARC gene. (wikipedia.org)
  • Thy-1 or CD90 (Cluster of Differentiation 90) is a 25-37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen. (wikipedia.org)
  • molecular
  • Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
  • molecules
  • The allergen binds to the antigen-binding sites, which are situated on the variable regions of the IgE molecules bound to the mast cell surface. (wikipedia.org)
  • The rolling mechanism helps the L-selectin molecules on the surface of naive T cells to weakly interact with GlyCAM-1 and CD34 molecules on HEV cells. (wikipedia.org)
  • neuronal
  • Giant cell glioblastoma and pleomorphic xanthoastrocytoma show different immunohistochemical profiles for neuronal antigens and p53 but share reactivity for class III beta-tubulin. (nih.gov)
  • chemokine
  • Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. (wikipedia.org)
  • gene
  • Using gene array studies, we examined CD34(+) cells isolated from a cohort of longstanding diabetic individuals, free of microvascular complications despite suboptimal glycemic control, and found that the cells exhibited reduced transcripts of both TGF-β1 and PAI-1 compared to age, sex, and degree of glycemic control-matched diabetic individuals with microvascular complications. (nih.gov)
  • The Duffy antigen gene was the fourth gene associated with the resistance after the genes responsible for sickle cell anaemia, thalassemia and glucose-6-phosphate dehydrogenase. (wikipedia.org)
  • The gene was first localised to chromosome 1 in 1968, and was the first blood system antigen to be localised. (wikipedia.org)
  • retrieval
  • Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. (abcam.com)
  • cells
  • A concurrent patient group meeting eligibility but not receiving CD34+ cells will be evaluated similar to the treated group to assess the rate of significant spontaneous improvement in cardiac function without CD34+cell infusion. (bioportfolio.com)
  • C) CD34(+) cells are frozen at a concentration of 1 x 10(6)/ml, and D) a thawing temperature of 37 degrees C is used. (biomedsearch.com)
  • Enhancing the function of CD34(+) cells by targeting plasminogen activator inhibitor-1. (nih.gov)
  • CD34(+) cells from diabetic subjects with microvascular complications consistently exhibited higher PAI-1 mRNA than age-matched non-diabetic controls. (nih.gov)
  • The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes. (wikipedia.org)
  • The Fc region of immunoglobulin E (IgE) becomes bound to mast cells and basophils and when IgE's paratopes bind to an antigen, it causes the cells to release histamine and other inflammatory mediators. (wikipedia.org)
  • The Duffy antigen is located on the surface of red blood cells, and is named after the patient in which it was discovered. (wikipedia.org)
  • It was originally named theta (θ) antigen, then Thy-1 (THYmocyte differentiation antigen 1) due to its prior identification in thymocytes (precursors of T cells in the thymus). (wikipedia.org)
  • T cells become activated by recognising foreign antigens bound to antigen presenting cells (APC), in particular, dendritic cells. (wikipedia.org)
  • In order for naïve T cells to bind to their specific antigen, they need to experience physical contact with those cells. (wikipedia.org)
  • Therefore, T cells need a region where they can go to sample foreign antigens that have entered the body. (wikipedia.org)
  • cell
  • Previously, we showed that transient inhibition of TGF- β1 resulted in correction of key aspects of diabetes-induced CD34(+) cell dysfunction. (nih.gov)
  • Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration. (wikipedia.org)
  • When they encounter such an antigen, the cell becomes activated, resulting in the immune system mounting a response against the causative agent of the infection. (wikipedia.org)
  • ELISA
  • MA5-17829 targets CD34/gp105-120 in ELISA, FACS, IHC (F), IHC (P), IP, and WB applications and shows reactivity with Mouse samples. (thermofisher.com)
  • Functions
  • Effector memory T-lymphocytes do not express L-selectin, as they circulate in the periphery and have immediate effector functions upon encountering antigen. (wikipedia.org)
  • express
  • Central memory T-lymphocytes, which have encountered antigen, express L-selectin to localize in secondary lymphoid organs. (wikipedia.org)
  • expression
  • BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression. (nih.gov)
  • blood
  • It carries the antigenic determinants of the Duffy blood group system which consist of four codominant alleles-FY*A and FY*B-coding for the Fy-a and Fy-b antigens respectively, FY*X and FY*Fy, five phenotypes (Fy-a, Fy-b, Fy-o, Fy-x and Fy-y) and five antigens. (wikipedia.org)
  • Since antigen levels are usually low, contact in blood circulation would be unlikely. (wikipedia.org)