• lymphocyte
  • 2010 Application of HLA-A*0201/WT1 pentamer combined with intracellular IFNgamma+ staining in detecting circulating WT1 specific T cells in leukemia 2010 "Comparison of Wilms' tumor antigen 1-specific T lymphocyte generation soon after nonmyeloablative allergenic stem-cell transplantation in acute and chronic leukemia patients", published in Int J Hematol. (wikipedia.org)
  • gene
  • Duffy antigen/chemokine receptor (DARC), also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234), is a protein that in humans is encoded by the DARC gene. (wikipedia.org)
  • The Duffy antigen gene was the fourth gene associated with the resistance after the genes responsible for sickle cell anaemia, thalassemia and glucose-6-phosphate dehydrogenase. (wikipedia.org)
  • The gene was first localised to chromosome 1 in 1968, and was the first blood system antigen to be localised. (wikipedia.org)
  • cellular
  • 2 Although the precise function of CD31/PECAM-1 is not known in all the cell types that express it, recent investigations have demonstrated its ability to function as a cellular adhesive molecule. (ahajournals.org)
  • macrophages
  • This role is important in chronic inflammation, as the early stages of inflammation are dominated by neutrophils, which are ingested by macrophages if they come of age (see CD31 for a description of this process). (wikipedia.org)
  • molecules
  • Both of those populations are able to induce CD8 T cell tolerance by presentation of the endogenous antigens on MHCI molecules and even the CD4 T cell tolerance by the presentation of the peptide-MHCII complexes, which they acquired from the DCs. (wikipedia.org)
  • Without pro-inflammatory cytokines, co-stimulatory molecules will not be expressed on the surface of the antigen presenting cell, and so anergy will result if there is an MHC-TCR interaction between the T cell and the APC. (wikipedia.org)
  • In the example of CD4 & CD8, these molecules are critical in antigen recognition. (wikipedia.org)
  • blood
  • It carries the antigenic determinants of the Duffy blood group system which consist of four codominant alleles-FY*A and FY*B-coding for the Fy-a and Fy-b antigens respectively, FY*X and FY*Fy, five phenotypes (Fy-a, Fy-b, Fy-o, Fy-x and Fy-y) and five antigens. (wikipedia.org)
  • Anatomical barriers can separate the lymphocytes from the antigen, an example is the central nervous system (the blood-brain-barrier). (wikipedia.org)