• The MIH1 monoclonal antibody specifically binds to CD274, which is also known as, B7 homolog 1 (B7-H1), Programmed cell death 1 ligand 1 (PDCD1 ligand, PDCD1L1, PDCD1LG1), or Programmed death ligand 1 (PD-L1, PDL1). (bdbiosciences.com)
  • CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). (biolegend.com)
  • Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. (wikipedia.org)
  • PD-L1 binding to PD-1 also contributes to ligand-induced TCR down-modulation during antigen presentation to naive T cells, by inducing the up-regulation of the E3 ubiquitin ligase CBL-b. (wikipedia.org)
  • Herein we used a single bicistronic lentiviral vector to develop a new combination immunotherapy that consists of human anti-carbonic anhydrase IX (CAIX)-targeted chimeric antigen receptor (CAR) T cells engineered to secrete human anti-programmed death ligand 1 (PD-L1) antibodies at the tumor site. (oncotarget.com)
  • Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. (novoprolabs.com)
  • Programmed death-ligand 1 (PD-L1) in humans is encoded by the CD274 gene. (lucknownewsflash.in)
  • Since then, several antibodies targeting another coinhibitory receptor, the programmed cell death 1 (PDCD1, best known as PD-1) or its main ligand CD274 (best known as PD-L1), have been approved for the treatment of multiple cancers ( 2 ). (aacrjournals.org)
  • They used the inhibition of proprotein convertases ( PCSK1 ) in T cells and programmed death-ligand 1 ( CD274 ) in cancer cells. (emerginginvestigators.org)
  • Most relapsed/refractory large B cell lymphoma (r/rLBCL) patients receiving anti-CD19 chimeric antigen receptor (CAR19) T cells relapse. (stanfordhealthcare.org)
  • We envision these findings will facilitate improved chimeric antigen receptor (CAR) T cells and personalized therapeutic approaches. (stanfordhealthcare.org)
  • Owing to the expression of GPC3 in LUSC tissues, it has been tested as an immunotherapeutic (including chimeric antigen receptor (CAR)- GPC3 T cells), and clinical trials targeting GPC3 are ongoing. (biolifesas.org)
  • Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). (neobiotechnologies.com)
  • Antigen presentation by the professional antigen-presenting cells (APCs) are normally recognized by immune cells via a surface T-cell receptor (TCR), leading to the induction of naive CD8 + T-cell clonal expansion and differentiation and finally resulting in the cell death of APCs. (oaepublish.com)
  • They defined subtype 2 as representing immune response-related processes (antigen presentation, BCR/TNF/Toll-like receptor signaling, TCR signaling, and phagosome). (genomeweb.com)
  • The antigen processing and presentation, natural killer (NK) cell-mediated cytotoxicity and T-cell receptor signaling pathway were enriched in PL compared with LM. (bmj.com)
  • Endometrium from pregnant heifers had greater mRNA abundance for the inhibitory molecules, CD274 and lymphocyte activating gene 3 (LAG3), and greater cytotoxic T lymphocyte-associated protein 4 (CTLA4), molecules that can interact with receptors on antigen-presenting cells and induce lymphocyte tolerance. (psu.edu)
  • The MIH1 antibody blocks CD279 binding to CD274 and can enhance the proliferation and cytokine production of activated T cells. (bdbiosciences.com)
  • This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Cynomolgus PD-L1 / B7-H1 / CD274. (novoprolabs.com)
  • Antibody CD59 (Clone MEM-43) reacts with the CD59-antigen, a PI-linked glycoprotein, molecular weight 18-20kDa, found in all types of leukocytes including platelets. (immunostep.com)
  • also called B7-H1 or CD274), which is expressed on many cancer and immune cells, plays an important part in blocking the 'cancer immunity cycle' by binding programmed death-1 (PD-1) and B7.1 (CD80), both of which are negative regulators of T-lymphocyte activation. (nih.gov)
  • A systematic comparison between mRNA and protein displayed emerging expression patterns of key therapeutic targets (CD274, YAP1, AKT1, and CDH1). (bvsalud.org)
  • Human recombinant protein fragment corresponding to amino acids 19-239 of human PD-L1/CD274(NP_054862) produced in HEK293 cells. (origene.com)
  • PD-L1 (also known as CD274 or B7-homolog 1 [B7-H1]) is a transmembrane protein involved in the immune system suppression. (studylib.net)
  • Our results suggest that the expression of B7-H1 in hepatocarcimona cells can be initiated by HBx antigen, thus inducing T cell apoptosis and finally potentially facilitates the genesis of HCC. (nih.gov)
  • No abstract avDendritic cells (DC) are the most important antigen presenting cells and play a pivotal role in host immunity to infectious agents by acting as a bridge between the innate and adaptive immune systems. (uni-wuerzburg.de)
  • TIMER was used to evaluate the connection between candidate antigens and infiltration of antigen-presenting cells. (frontiersin.org)
  • Genetic inactivation of the machinery or re-introduction of ANKRD52 frequent patient mutations dampens the JAK-STAT-interferon-γ signaling and antigen presentation in cancer cells, largely by abolishing miR-155-targeted silencing of suppressor of cytokine signaling 1 (SOCS1). (nature.com)
  • CD274 is expressed on antigen-presenting cells including activated monocytes/macrophages and dendritic cells, as well as, activated T cells, and keratinocytes. (bdbiosciences.com)
  • CD274 is also expressed on placental trophoblasts, myocardial endothelium, cortical thymic epithelial cells, and on most carcinomas. (bdbiosciences.com)
  • Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. (biolegend.com)
  • In turn, clonal expansion of antigen-specific CD8+ T cells and/or CD4+ helper cells is propagated. (wikipedia.org)
  • This reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) - further mediated by a lower regulation of the gene Bcl-2. (wikipedia.org)
  • Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. (biolegend.com)
  • P-Tex cells could aggregate in the antigen-presenting cell niches and activate certain signaling pathways. (elifesciences.org)
  • Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. (novoprolabs.com)
  • Cytosine-phosphate-guanosine-DNA induces CD274 expression in human B cells and suppresses T helper type 2 cytokine production in pollen antigen-stimulated CD4-positive cells. (cams.cn)
  • Normally the immune system reacts to foreign antigens where there is some accumulation in the lymph nodes or spleen which triggers a proliferation of antigen-specific CD8+ T cells. (lucknownewsflash.in)
  • Specific tumor-associated antigens (TAAs) expressed by cancer cells can be identified by the immune system and results in the activation of immune system effectors and the consequent elimination of the cancer cells. (oaepublish.com)
  • Antigen distribution is to be found across many hemopoietic and non-hemopoietic cells. (immunostep.com)
  • CD274 and PD-L2 (CD273) are type I transmembrane glycoproteins that belong to the B7 family and serve as ligands for CD279 (Program Death 1/PD-1). (bdbiosciences.com)
  • PD-L1 (B7-H1, CD274) and PD-L2 (B7-DC, CD273) are ligands of CD279 (PD-1) and are members of the B7 gene family. (biolegend.com)
  • Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). (neobiotechnologies.com)
  • Normally the adaptive immune system reacts to antigens that are associated with immune system activation by exogenous or endogenous danger signals. (wikipedia.org)
  • CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. (biolegend.com)
  • Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. (biolegend.com)
  • 2009) B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. (novoprolabs.com)
  • AP2S1 , P3H4 , and RAC3 were identified as candidate tumor-specific antigens for BLCA. (frontiersin.org)
  • AP2S1 , P3H4 , and RAC3 were identified as candidate tumor-specific antigens, and patients with the BCS2 and BCS1A subtypes were identified as candidate populations for mRNA vaccines. (frontiersin.org)
  • Mediante el bloqueo de la vía PD1/PD-L1 se produce una mejora de la efectividad de las células T en el microambiente del tumor mientras tenga lugar la interacción. (histopat.es)
  • Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. (wikidoc.org)
  • Indeed, both DNA methylation and post-translational histone modifications have been described to regulate immune checkpoint inhibitor expression, tumor-associated antigen presentation or cancer cell editing by the immune system and therefore establishing epigenetic drugs as a potential complement to immunotherapies to improve their efficiency. (oaepublish.com)
  • Integrated analysis revealed enriched biological pathways and unexplored druggable targets (cancer-testis antigens, metabolic enzymes, kinases, and transcription regulators). (bvsalud.org)
  • Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion . (wikidoc.org)
  • CD274 plays an important role in regulating T cell responses. (bdbiosciences.com)
  • Alterations in multiple classes of genes are associated with resistance, including B cell identity (PAX5 and IRF8), immune checkpoints (CD274), and those affecting the microenvironment (TMEM30A). (stanfordhealthcare.org)
  • Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. (histopat.es)
  • Therefore, this study filtered candidate antigens and specific mRNA-suitable populations in BLCA via comprehensive multi-omics analysis. (frontiersin.org)
  • Homo sapiens CD274 molecule (CD274), transcript variant 1, mRNA. (origene.com)
  • Synergistic effects of BTN3A1, SHP2, CD274, and STAT3 gene polymorphisms on the risk of systemic lupus erythematosus: a multifactorial dimensional reduction analysis. (cdc.gov)
  • PD-L1 / B7-H1 / CD274 specific IgG was purified by Cynomolgus PD-L1 / B7-H1 / CD274 affinity chromatography. (novoprolabs.com)
  • Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. (wikipedia.org)
  • A monoclonal antibody that targets programmed death-ligand 1 ( CD274 ANTIGEN ) and is used to treat urothelial carcinoma, the most common type of bladder cancer. (nih.gov)
  • Programed Death-Ligand 1 (PD-L1, also known as B7-H1 or CD274) is a cell surface protein that binds to Programmed Cell Death Protein 1 (PD-1, also known as CD279). (nih.gov)
  • Bavencio (avelumab) is a monoclonal antibody binds to human immunosuppressive ligand programmed death-ligand 1 (PD-L1, CD274) and blocks protein signaling, resulting in immune regulation and antitumor immunity ( PMID: 26014098 ). (jax.org)
  • These are called tumor-specific or tumor-associated antigens (Fig. 1 ). (biomedcentral.com)
  • Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies" doi: 10.1136/jitc-2022-005018. (ancell.com)
  • [1] [2] The Kell antigens are peptides found within the Kell protein , a 93- kilodalton transmembrane zinc -dependent endopeptidase which is responsible for cleaving endothelin-3 . (wikidoc.org)
  • The Kell glycoprotein links via a single disulfide bond to the XK membrane protein [6] that carries the Kx antigen . (wikidoc.org)
  • Absence of the XK protein (such as through genetic deletion or through a single point mutation within the coding region of the XK gene [8] ), leads to marked reduction of the Kell antigens on the red blood cell surface. (wikidoc.org)
  • PD-1 (CD279) is a 288-amino acid type I transmembrane protein predominantly expressed on antigen-experienced memory T cells in peripheral tissues and less commonly on B cells, activated monocytes, dendritic cells (DC), and natural killer (NK) cells. (biomedcentral.com)
  • system_update_altデータシートsystem_update_alt安全性データシート概要商品名:Human CTLA4 / CD152 ELISA Kit製品コード:HUFI00481サイズ:96Tエイリアス:CTLA4, Cytotoxic T Lymphocyte Associated Antigen 4, CD152, CD, CD152 antigen, CD28 (assaygenie.jp)
  • system_update_altデータシートsystem_update_alt安全性データシート概要商品名:Human CD86 / B7-2 ELISA Kit製品コード:HUFI00476サイズ:96Tエイリアス:B7-2, CD86, Activation B7-2 antigen, B70, B7-2 antigen, B-lymphocyte activation antigen B7-2 (assaygenie.jp)
  • CD273), are physiologically expressed respectively by a subset of ALCL is a specific subtype of peripheral T-cell lymphoma (PTCL) cells of the hematopoietic lineage (B cells, T cells and macrophages) in which the different sub-entities, though sharing the presence of and by antigen-presenting cells and epithelial tissues. (anyflip.com)
  • In turn, clonal expansion of antigen-specific CD8+ T cells and/or CD4+ helper cells is propagated. (wikipedia.org)
  • PD-L1 binding to PD-1 also contributes to ligand-induced TCR down-modulation during antigen presentation to naive T cells, by inducing the up-regulation of the E3 ubiquitin ligase CBL-b. (wikipedia.org)
  • The Kell antigen system (also known as Kell-Cellano system ) is a group of antigens on the human red blood cell surface which are important determinants of blood type and are targets for autoimmune or alloimmune diseases which destroy red blood cells. (wikidoc.org)
  • PD-1 is expressed on the surface of antigen-stimulated T cells. (nih.gov)
  • Tumor cells have surface antigens like those present on normal cells. (biomedcentral.com)
  • However, they also manifest additional antigens that are either absent or expressed in minimal quantities on non-neoplastic cells. (biomedcentral.com)
  • In addition to binding to antigen-loaded MHC, T cells require a secondary signal to become activated. (biomedcentral.com)
  • An inhibitory B7 antigen that contains V-type and C2 type immunoglobulin domains. (nih.gov)
  • Normally the adaptive immune system reacts to antigens that are associated with immune system activation by exogenous or endogenous danger signals. (wikipedia.org)
  • CD274 / PD-L1 plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). (arigobio.cn)
  • Ad-CEA is a cancer vaccine expressing carcinoembryonic antigen (CEA), which may result in an improved anti-tumor immune response ( PMID: 15906358 , PMID: 17053815 , PMID: 31192764 ). (jax.org)
  • CV301 is a poxvirus-based vaccine that encodes tumor antigens CEA and MUC-1, and 3 costimulatory molecules including B7.1, ICAM-1, and LFA-3, which may stimulate antitumor immune response ( PMID: 31110074 ). (jax.org)
  • Interaction of T-cell and antigen presenting cell co-stimulatory genes in childhood IgE. (cdc.gov)
  • system_update_altデータシートsystem_update_alt安全性データシート概要商品名:Human HLA-B27 ELISA Kit製品コード:HUFI01652サイズ:96Tエイリアス:HLA-B27, HLA class I histocompatibility antigen, B-27 alpha chain (assaygenie.jp)
  • The XK appears to be required for proper synthesis or presentation of the Kell antigens on the red blood cell surface. (wikidoc.org)
  • Both AIHA and HDN may be severe when caused by anti-Kell antibodies, [10] as they are the most immunogenic antigens after those of the ABO and Rhesus blood group systems . (wikidoc.org)
  • McLeod phenotype (or McLeod syndrome) is an X-linked anomaly of the Kell blood group system in which Kell antigens are poorly detected by laboratory tests. (wikidoc.org)