• lymphoid tissues
  • Non-activated (immature) DCs are usually located in the peripheral non-lymphoid tissues and they can present self-antigens to T cells, that leads to immune tolerance either through T cell deletion or through the differentiation of regulatory T cells or suppressor T cells. (wikipedia.org)
  • Mature DCs have ability to present antigens in the lymphoid tissues and prime, activate and expand effector immune cells with unique functions and cytokine profiles. (wikipedia.org)
  • Specificity
  • DCs are equipped with molecular sensors and antigen-processing machinery to recognize pathogens, integrate chemical information and guide the specificity, magnitude and polarity of immune responses. (biomedsearch.com)
  • Presentation
  • Most critical step in vaccination is the effective presentation of cancer antigens to T cells and because of DCs are the most efficient antigen presenting cells, they are the promising option for improvement of therapeutic vaccines. (wikipedia.org)
  • Recent studies have shown that increased levels of soluble CD23 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. (wikipedia.org)
  • mice
  • CD11c-eYFP Crb1 wt/wt mice received an i.p injection of LPS (9mg/kg, n=23) or saline (n=18) and retinas were collected 24h later for confocal microscopy and flow cytometry. (arvojournals.org)
  • For functional studies, retinal CD11c-eYFP + cells and microglia (CD45 lo YFP - ) were isolated from CD11c-eYFP Crb1 wt/wt mice (n=20) 24h post-LPS injection by FACS. (arvojournals.org)
  • At 12 days PI, cytospin slides of BALF cells from the two groups of mice were prepared and AM were stained for both C. burnetii and CD11c expression (Figure 8A-representative sample, Figure 8B-negative control). (nih.gov)
  • cells
  • We hypothesised that retinal CD11c-eYFP + cells are a subset of microglia and thus would have a limited capacity to present antigen to naïve T cells. (arvojournals.org)
  • We first tested the ability of retinal CD11c-eYFP + cells to upregulate APC markers following systemic inflammation. (arvojournals.org)
  • Retinal CD11c-eYFP + cells retracted their processes and displayed a stout morphology 24h post-LPS injection. (arvojournals.org)
  • Retinal CD11c-eYFP + cells do not upregulate APC markers following systemic inflammation and are incapable of presenting antigen to naïve CD4 + T cells in vitro . (arvojournals.org)
  • Moreover, retinal CD11c-eYFP + cells are phenotypically and functionally identical to microglia. (arvojournals.org)
  • Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. (biomedsearch.com)
  • A) Twelve days PI with 1×104 NMI, infected cells were identified by the presence of Coxiella (stained red) and CD11c expression (stained green). (nih.gov)
  • Natural killer cells and activated B and T cells also express CD11c (Luk, 1995). (merckmillipore.com)
  • Peripheral blood CD8αα+CD11c+MHC-II+CD3- cells attenuate autoimmune glomerulonephritis in rats. (nih.gov)
  • Our previous studies suggested that glomeruli-infiltrating leukocytes with a phenotype of CD8αα+CD11c+MHC-II+CD3- (GIL CD8αα+ cells) were responsible for recovery through induction of T-cell apoptosis. (nih.gov)
  • Now, we identified peripheral blood CD8αα+CD11c+MHC-II+CD3- cells (PBMC CD8αα+CD3- cells), which shared 9 markers with GIL CD8αα+ cells. (nih.gov)
  • CD11C antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation. (uic.edu)
  • In order to instruct naïve T cells into the required functional profile, DCs must present tumor antigens via MHC class I and II molecules (signal 1), express co-stimulatory ligands (signal 2), and inflammatory mediators (signal 3) such as IL-12 or type I interferons (IFNs) ( 8 , 9 ). (frontiersin.org)
  • Dendritic cells function as antigen-presenting cells. (wikipedia.org)
  • They process antigen material and present it on the surface to other cells of the immune system. (wikipedia.org)
  • Dendritic cells (DCs) are most powerful antigen presenting cells for the induction of antigen specific T cell response and because of this function DCs are the crucial component of vaccination. (wikipedia.org)
  • Myeloid or conventional DCs (cDCs) are derived from myeloid progenitor cells in the bone marrow and are characterized by expression of CD11c. (wikipedia.org)
  • They should prime naive T cells as well as induce transition from chronically activated non-protective CD8+ T cells to healthy CD8+ T cells able to produce cytotoxic T lymphocytes (CTLs), that recognise and eliminate cancer cells in an antigen-specific way and also provide long-lived memory CD8+ T cells that will act to prevent relapse. (wikipedia.org)
  • It is an active cellular immunotherapy, which involves obtaining antigen-presenting autologous dendritic cells from the patient following a leukapheresis procedure. (wikipedia.org)
  • The cells are incubated ex vivo in the presence of a recombinant fusion protein PA2024 containing a prostate antigen, prostate acid phosphatase and GM-CSF, an immune-cell activator. (wikipedia.org)
  • The antigen is then transferred from CD23+ B cells to CD11c+ antigen presenting cells. (wikipedia.org)
  • PGE2 is able to elevate the expression of indoleamine 2,3-dioxygenase in CD11C(+) dendritic cells and promotes the development of functional Treg cells. (wikipedia.org)
  • immune responses
  • This paper reviews recent findings in murine models regarding the antitumoral mechanisms of DC-based vaccination, covering issues related to antigen sources, the use of adjuvants and maturing agents, and the role of DC subsets and their interaction in the initiation of antitumoral immune responses. (frontiersin.org)
  • surface
  • Immunophenotyping helps distinguish B-PLL from similar diseases, one of its key identifiers is the absence in expression of the surface antigens CD10, CD11c, CD25, CD103 and cyclin D1 - an important regulator of cell-cycle progression. (wikipedia.org)
  • cell
  • The islet resident macrophage was first identified in 1979 as an antigen-presenting cell (APC), which expresses major histocompatibility complexes (MHCs). (wikipedia.org)