ReceptorCD59LigandReceptorsCell adhesionProteinAdhesionAntibodiesGlycoproteinsBlood Group AnTumorRecognitionSurfaceCD15CellsMoleculesSuperfamilyTransmembraneTransductionMoleculeResponsesHumanSignaling pathwayRheumatoid arthritisProliferationProgressionCarbohydrateGeneIsotypeColorectalImmune evasionAutoimmune
Receptor7
- For a regulatory T cell to become activated, the recognition of an antigen located within a major histocompatibility complex (MHC) protein by the TcR, or T cell receptor, is insufficient. (wikipedia.org)
- [ 25 ] In addition to antigen recognition through the T-cell receptor, T-cell activation requires costimulatory signals involving specific molecules on the surface of both T-cells and dendritic cells. (medscape.com)
- CD2 antigen has been characterised as the receptor for sheep erythrocytes. (immune-source.com)
- CD2 antigen also functions as the receptor for the CD58 antigen(LFA-3). (immune-source.com)
- The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. (ox.ac.uk)
- A component of the B-cell antigen receptor that is involved in B-cell antigen receptor heavy chain transport to the PLASMA MEMBRANE. (rush.edu)
- Upon T cell receptor engagement, Kv1.3 polarized toward the synaptic cleft and diffused throughout the F-actin rich distal compartment of the synaptic interface-an effect enhanced by CD2-CD58 corolla formation. (ox.ac.uk)
CD591
- Multiple ligands for CD2 include CD58 (LFA-3), CD59, and CD48. (adipogen.com)
Ligand5
- The natural ligand to CD58, CD2, is most commonly found on the surfaces of both T cells and Natural Killer cells (T/NK cells). (wikipedia.org)
- A case-control study was undertaken to examine the possible association of low responsiveness to the HBV vaccine in a Chinese population with genetic polymorphisms in integrin subunit alpha L, CD58, tumor necrosis factor superfamily member 15, C-C motif chemokine ligand 15, transforming growth factor beta 3, and B-cell lymphoma 6 protein. (nih.gov)
- CD2 is a ligand for CD58 in the human and is involved in adhesion and activation of T cells. (thermofisher.com)
- The major ligand for CD2 is CD58 (also known as LFA-3). (biolegend.com)
- Protection in these models is mediated by Ly49H + NK cells, which upon recognition of m157 viral antigen (Ly49H ligand) proliferate and persist in lymphoid and nonlymphoid organs. (hindawi.com)
Receptors3
- This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation, when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to. (wikipedia.org)
- CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120. (uams.edu)
- Detailed analyses of the structure and interactions of CD2 were the first involving a molecule that has not been directly linked to antigen recognition in the manner of antigen receptors or co-receptors. (ox.ac.uk)
Cell adhesion4
- CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on Antigen Presenting Cells (APCs), particularly macrophages, and other tissue cells. (wikipedia.org)
- During an immune response, the interactions between the CD2 and CD58 glycoproteins allows for the activation and proliferation of both T and Natural Killer cells (T/NK cells), enhancing cell adhesion. (wikipedia.org)
- The structure of CD58 also plays a role in cell adhesion. (wikipedia.org)
- A study found that effective cell adhesion was dependent on the density of CD58. (wikipedia.org)
Protein6
- The CD58 glycoprotein can be found in two different protein isoforms, each on the cell surface. (wikipedia.org)
- Alefacept is a lymphocyte function-associated antigen-3/IgG1 fusion protein that inhibits T-cells by antagonizing CD2, which has been developed and launched by Biogen for the potential treatment of psoriasis. (elsevierpure.com)
- [1] [2] The Kell antigens are peptides found within the Kell protein , a 93- kilodalton transmembrane zinc -dependent endopeptidase which is responsible for cleaving endothelin-3 . (wikidoc.org)
- The Kell glycoprotein links via a single disulfide bond to the XK membrane protein [6] that carries the Kx antigen . (wikidoc.org)
- Absence of the XK protein (such as through genetic deletion or through a single point mutation within the coding region of the XK gene [8] ), leads to marked reduction of the Kell antigens on the red blood cell surface. (wikidoc.org)
- Alefacept is a chimeric protein combining CD58 immunoglobulin-like domain 1 with human IgG1 Fc. (ox.ac.uk)
Adhesion8
- CD58 binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion and recognition between the T cells and Professional Antigen Presenting Cells, facilitating signal transduction necessary for an immune response. (wikipedia.org)
- More specifically, CD58 is expressed on cell surfaces, allowing for effector-target adhesion sequentially to antigen recognition. (wikipedia.org)
- The interaction between CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. (thermofisher.com)
- Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. (thermofisher.com)
- Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. (thermofisher.com)
- Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58. (ox.ac.uk)
- This study describes quantitative investigations of the impact of single charge mutations on equilibrium binding, kinetics, and the adhesion strength of the CD2-CD58 interaction. (ox.ac.uk)
- Alefacept competitively inhibited cell bilayer adhesion mediated by the CD2-CD58 interaction. (ox.ac.uk)
Antibodies3
- Individuals lacking a specific Kell antigen may develop antibodies against Kell antigens when transfused with blood containing that antigen. (wikidoc.org)
- Both AIHA and HDN may be severe when caused by anti-Kell antibodies, [10] as they are the most immunogenic antigens after those of the ABO and Rhesus blood group systems . (wikidoc.org)
- Antibodies directed towards self-antigens are a hallmark of autoimmune diseases. (nih.gov)
Glycoproteins1
- A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. (childrensmercy.org)
Blood Group An1
- 19. Cellular localization of blood group antigens (including HLA markers) in human bladder urothelium. (nih.gov)
Tumor8
- CD58 plays a role in the regulation of colorectal tumor-initiating cells (CT-ICs). (wikipedia.org)
- Accumulating evidence shows that CD58-expressing tumor cell is implicated in development of various cancers. (biomedcentral.com)
- Elevation of CD58 expression correlated with more satellite foci and vascular invasion, and poorer tumor-free and overall survival in HCC patients. (biomedcentral.com)
- A recent study reported that CD58 was overexpressed in HCC tissues and positively correlated with tumor-infiltrating immune cells [ 18 ]. (biomedcentral.com)
- 3. Expression of HLA-A,B,C antigens on primary and metastatic tumor cell populations of human carcinomas. (nih.gov)
- 5. Frequency of abnormal expression of HLA-A,B,C and HLA-DR molecules, invariant chain, and LFA-3 (CD58) in colorectal carcinoma and its impact on tumor recurrence. (nih.gov)
- 15. Luminal epithelial antigen (LEA.135) expression correlates with tumor progression for transitional carcinoma of the bladder. (nih.gov)
- 16. Tumor-specific upregulation of human leukocyte antigen-G expression in bladder transitional cell carcinoma. (nih.gov)
Recognition3
- CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. (uams.edu)
- The threshold for T cell activation depends on the strength and frequency of the calcium (Ca2+) signaling induced by antigen recognition, and it must be tightly regulated to avoid undesired harm to healthy cells. (ox.ac.uk)
- Elucidating the role of the HLA molecules in antigen recognition, peptide presentation and autoimmunity induction is an important area of focus. (nih.gov)
Surface6
- CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. (thermofisher.com)
- Mouse monoclonal to CD2.This recognizes a 50KDa lymphocyte surface antigen which is expressed on all peripheral blood T lymphocytes,the majority of lymphocytes and malignant cells of T cell origin, including T ALL cells. (immune-source.com)
- Normal B lymphocytes, monocytes or granulocytes do not express surface CD2 antigen, neither do common ALL cells. (immune-source.com)
- The Kell antigen system (also known as Kell-Cellano system ) is a group of antigens on the human red blood cell surface which are important determinants of blood type and are targets for autoimmune or alloimmune diseases which destroy red blood cells. (wikidoc.org)
- The XK appears to be required for proper synthesis or presentation of the Kell antigens on the red blood cell surface. (wikidoc.org)
- 14. Non-polarized cell surface expression of HLA-A,B,C and HLA-DR antigens in Graves' thyroid follicle cells. (nih.gov)
CD154
- Antigens, CD15" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
- In addition, CD15 antigen is a stage-specific embryonic antigen. (childrensmercy.org)
- This graph shows the total number of publications written about "Antigens, CD15" by people in this website by year, and whether "Antigens, CD15" was a major or minor topic of these publications. (childrensmercy.org)
- Below are the most recent publications written about "Antigens, CD15" by people in Profiles. (childrensmercy.org)
Cells18
- Genomic region containing the single-nucleotide polymorphism rs1335532, associated with high risk of multiple sclerosis, has enhancer properties and can significantly boost the CD58 promoter activity in lymphoblast cells. (wikipedia.org)
- Thus, cells that express CD58 have become a cell of interest in tumorigenesis. (wikipedia.org)
- CD58 is expressed on a variety of different cells, including hematopoietic and nonhematopoietic cells. (wikipedia.org)
- This allows for a high affinity of the extracellular amino-terminal sequence on CD2 to bind with CD58, which has a capacity to bind to CD2 on T cells, on target cells. (wikipedia.org)
- and are able to abrogate the response of memory T-cells to their antigen. (medscape.com)
- This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. (nih.gov)
- Autoimmune hemolytic anemia (AIHA) occurs when the body produces an antibody against a blood group antigen on its own red blood cells. (wikidoc.org)
- Immunohistochemical staining (IHC), and western blotting were used to detect the expression of CD58 in HCC tissues and cells. (biomedcentral.com)
- Transwell assay and sphere formation assay were performed to evaluate the effect of CD58 and sCD58 on metastasis and self-renewal ability of HCC cells. (biomedcentral.com)
- Western blotting, immunofluorescence (IF), TOP/FOP Flash reporter assay, and subcellular fractionation assay were conducted to investigate the molecular regulation between CD58/sCD58 and AKT/GSK-3β/β-catenin axis in HCC cells. (biomedcentral.com)
- Functionally, CD58 promotes the proliferation of HCC cells in vitro and in vivo. (biomedcentral.com)
- Meanwhile, CD58 and sCD58 induce metastasis, self-renewal and pluripotency in HCC cells in vitro. (biomedcentral.com)
- Furthermore, AKT activator SC-79 or inhibitor LY294002 abolished the inhibitory effect of CD58 silencing on the proliferation, metastasis, and stemness of HCC cells. (biomedcentral.com)
- Current methods for preparing dendritic cells (DCs) for cancer vaccine immunotherapy, utilizing antigen-loaded monocyte-derived DCs (MoDCs) that are activated via a complex process, result in DCs that are difficult to maintain in culture, have low growth potential, and require repeated preparations for several rounds of vaccine delivery. (acir.org)
- Aiming to enhance antigen presentation of a desirable target epitope, the team transduced ihv-DC2 cells with a fusion construct encoding pTERT, which consisted of a fragment from human telomerase reverse transcriptase (hTERT) linked to a proteasomal target sequence of IκBα. (acir.org)
- engineered ihv-DC1 cells to express high levels of the NK cell activators MICA and 4-1BBL, in addition to the endogenously expressed CD58, in order to efficiently activate NK cells. (acir.org)
- The first demonstration of antigen-specific recall responses by NK cells was in the setting of hapten-induced contact hypersensitivity, where CXCR6 + liver-derived murine NK cells could mediate antigen-specific contact hypersensitivity independently from B and T cells [ 13 , 14 ]. (hindawi.com)
- Human leukocyte antigen ( HLA ) genes have the strongest influence on autoimmune disease susceptibility and these HLA alleles encode variations in the antigen-binding grooves of the HLA molecules that determine their binding affinity for specific antigens presented to T cells. (nih.gov)
Molecules1
Superfamily1
- [ 20 ] Among the many candidates that could represent such a soluble factor, members of the transforming growth factor superfamily (transforming growth factor-β), hepatic growth factors, prostaglandin E2, and IL-10 secreted by MSCs have all been found to suppress T-cell-mediated antigen responses in vitro. (medscape.com)
Transmembrane5
- Despite this, the transmembrane CD58 form can trigger independent signaling without the need for the GPI-anchored isoform. (wikipedia.org)
- Transmembrane CD58 has a structure that consists of six N-linked glycosylation sites in the extracellular domain, a hydrophobic transmembrane domain, and finally a short cytoplasmic domain. (wikipedia.org)
- GPI-anchored CD58 has a similar extracellular domain, but no hydrophobic transmembrane domain or cytoplasmic domain. (wikipedia.org)
- Regardless, the structure of both the GPI-anchor and transmembrane CD58 are crucial in overall function. (wikipedia.org)
- The KEL gene encodes a type II transmembrane glycoprotein [5] that is the highly polymorphic Kell blood group antigen. (wikidoc.org)
Transduction1
- The binding of CD2-CD58 allows for the formation of a co-stimulatory signal, contributing to further regulatory T cell proliferation and regulation of T cell responses via signaling transduction. (wikipedia.org)
Molecule1
- These modified DCs were also transduced with the HLA-A2.1 molecule and made to overexpress the testis antigen MAGEA3, which is present in many cancer types. (acir.org)
Responses1
- Overall, CD58-CD2 interactions are intricate and involved in a variety of immune regulatory responses, including antiviral, inflammation in numerous autoimmune diseases, and immune rejections in organ transplants. (wikipedia.org)
Human3
- Two-parameter flow cytometric analysis of CD58 expression on human peripheral blood leucocytes. (bdbiosciences.com)
- Left Panel) or BD Horizon BUV395 Mouse Anti-Human CD58 antibody (Cat. (bdbiosciences.com)
- 10. Recombinant human interferon gamma exerts an anti-proliferative effect and modulates the expression of human leukocyte antigens A,B,C and DR in human urothelial cell lines. (nih.gov)
Signaling pathway1
- Mechanistically, CD58 activates the AKT/GSK-3β/β-catenin signaling pathway by increasing phosphorylation of AKT or GSK3β signaling, promoting expression of Wnt/β-catenin target proteins and TCF/LEF-mediated transcriptional activity. (biomedcentral.com)
Rheumatoid arthritis1
- Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (ox.ac.uk)
Proliferation1
- CCK-8, colony formation, and xenograft assays were used to detect the function of CD58 on proliferation in vitro and in vivo. (biomedcentral.com)
Progression2
- The present study aimed to reveal the functional significance of CD58 in HCC progression and the underlying mechanisms. (biomedcentral.com)
- Taken together, CD58 promotes HCC progression and metastasis via activating the AKT/GSK-3β/β-catenin pathway, suggesting that CD58 is a novel prognostic biomarker and therapeutic target for HCC. (biomedcentral.com)
Carbohydrate1
- It is estimated that the CD58 structure is made of approximately 44-68% carbohydrate. (wikipedia.org)
Gene1
- Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis. (wikipedia.org)
Isotype1
- Two-parameter contour plots showing the correlated expression of CD58 (or Ig Isotype control staining) versus side-light scatter (SSC-A) signals were derived from gated events with the forward and side-light scatter characteristics of intact leucocyte populations. (bdbiosciences.com)
Colorectal2
- 2. Loss of HLA-A,B,C allele products and lymphocyte function-associated antigen 3 in colorectal neoplasia. (nih.gov)
- 8. Influence of major histocompatibility complex class I and II antigens on survival in colorectal carcinoma. (nih.gov)
Immune evasion2
- Mutations of CD58 have been linked to immune evasion observed in some lymphomas and studies are underway to analyze how its involvement directly affects classical Hodgkin lymphoma (cHL). (wikipedia.org)
- CD58 loss or downregulation resulted in immune evasion by reducing CTLs and NK cell-mediated cytolysis [ 14 ]. (biomedcentral.com)
Autoimmune1
- Kell antigens are important in transfusion medicine , autoimmune hemolytic anemia and hemolytic disease of the newborn (anti-Kell) . (wikidoc.org)