Monoclonal antibodiesSensitivityReactivitySecondary antibodySpeciesConjugateReactsPolyclonal AntibodyProteinIgG1ProteinsCloneImmunoglobulinDetectsAntigen-antibody interactionEpitope specificityComplementarity determAssaysPeptidesResponsesFine specificitiesSerumAffinityMouse monoclonalRabbitPresence of antibodiesRecognizesELISADetectionResiduesPrimaryACPAPositivityAutoimmune disorderCellsAntigenicHumanSeraSpecificHighAutoantibodiesGenesDilutionHer20.05TitersValidationNotablyBoundMethodsTest
Monoclonal antibodies8
- abstract = 'In this study, polyclonal and monoclonal antibodies to native and denatured chicken ovalbumin (OVA) were produced to compare their dependency on continuous and three-dimensional epitopes. (ku.dk)
- Monoclonal antibodies to native OVA reacted preferentially with three-dimensional epitopes on native OVA and not with denatured OVA. (ku.dk)
- Monoclonal antibodies to denatured OVA showed reactivity to both OVA forms. (ku.dk)
- Two of these monoclonal antibodies, HYB 94-06 and 94-07, showed reactivity to overlapping peptides and their epitopes were identified as flexible structures constituting amino acids 130-135 and 136-141, respectively. (ku.dk)
- Moreover, as differences in monoclonal antibody reactivity was found between the two assays, monoclonal antibodies always should be selected by an assay mimicking the desired use of the final antibodies as closely as possible. (ku.dk)
- In this study, the precise epitopes in GAD-65 of three different mouse monoclonal antibodies (MoAbs) (N-terminal MoAb within amino acid residues 4-17. (nottingham.ac.uk)
- We report in this paper the complete sequence of eight V kappa regions pertaining to eight anti-GAT monoclonal antibodies derived from three strains of mice: BALB/c, DBA/2, and C57BL/6. (rupress.org)
- Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)
Sensitivity14
- In general, sensitivity and specificity exist in a state of balance. (aidsmap.com)
- Increased sensitivity (the ability to correctly identify people who have HIV) usually comes at the expense of reduced specificity (meaning more false positives). (aidsmap.com)
- Likewise, high specificity usually means that the test has lower sensitivity (more false negatives). (aidsmap.com)
- Therefore, healthcare services use a two-part testing procedure: a test with high sensitivity (to detect as many HIV-positive individuals as possible, allowing some false positives but very few false negatives), followed by a confirmatory test with high specificity (to eliminate as many of the false positives as possible). (aidsmap.com)
- Nevertheless, IgG antigliadin antibodies have a high sensitivity not only for patients with coeliac disease but also for those with minimal or no bowel damage where the principal target organ is the cerebellum or peripheral nervous system. (asiatox.org)
- In fact 85% of our patients with neurological disorders associated with gluten sensitivity have an HLA genotype in keeping with coeliac disease compared with 25% of the normal population.8 Unlike antiendomysium or antireticulin antibodies, antigliadin antibodies are antibodies against the extrinsic causal factor for gluten sensitivity. (asiatox.org)
- Antiendomysium antibodies may be more specific for coeliac disease, but no large scale data are available as yet on their specificity or sensitivity in patients with gluten sensitivity where the immunological target organ may be other than the gut. (asiatox.org)
- In addition, the licensed screening tests, which use HTLV-I antigens, vary in their sensitivity to detect antibodies to HTLV-II (4,5). (cdc.gov)
- The high rican trypanosomiasis) depends on case sensitivity and specificity of CATT on filter detection by means of parasitological ex- paper allows a better estimation of sero- amination of blood, lymph or cerebrospinal prevalence and incidence of the disease. (who.int)
- To state, Southern Sudan [10] it is suggested increase the specificity of serological tests that this area is a low-endemic region of hu- and the sensitivity of parasitological tests man African trypanosomiasis. (who.int)
- The use of these of this study was to evaluate the specificity concentration techniques can increase the and efficiency of a combination of different sensitivity of trypanosome detection by serological antibody detection techniques in several orders of magnitude [6]. (who.int)
- The Committee also reviewed preliminary data on a diagnostic assay based on protein-array technology, and agreed that additional studies will be needed to evaluate its robustness, stability, sensitivity and specificity. (who.int)
- Salivary anti-H. pylori antibody positivity showed low sensitivity (36.6%) and high specificity (75.8%) in CLD patients. (who.int)
- Sensitivity and specificity of salivary rently, managing chronically-ill patients tests have indicted that saliva could be with hepatic disease is a challenge for den- useful as a non-invasive technique for de- tal practitioners. (who.int)
Reactivity8
- Antibodies with specificity for native and denatured forms of ovalbumin differ in reactivity between enzyme-linked immunosorbent assays. (ku.dk)
- These antibodies were characterized with respect to reactivity to native and denatured OVA by enzyme-linked immunosorbent assay (ELISA) employing surface-bound OVA and streptavidin-capture ELISA to determine whether effects of different coating influence antibody specificity and with respect to epitope specificity by peptide ELISA, using overlapping peptides, covering the complete OVA sequence. (ku.dk)
- Moreover, comparison of antibody reactivity to N OVA revealed that in the streptavidin-capture ELISA, antibody reactivity was notably reduced compared to ELISA employing surface-bound OVA. (ku.dk)
- To ensure minimal cross-reactivity, the antibody has been pre-adsorbed with serum proteins from the following species. (abcam.com)
- This product shows no reactivity at a dilution of 1:100 when tested against purified Sm, nRNP, La/SS-B, Scl-70, Jo-1, Mitochondrial, or Ribosomal P antigens in an ELISA system designed to detect IgG antibody. (calbiotech.com)
- The reactivity of the antiserum is directed to the Fc subunit of the IgA molecule which expresses strict isotypic (class) specificity. (fishersci.com)
- Changes in mucosal bacteria, and a switch from internal to surface antigen/antibody reactivity of a predominantly IgG1 type, leads to greater opsonisation of the respiratory burst in PMN, providing a mechanism for maintaining the inflammatory state in UC. (bmj.com)
- Anti-cCK13-1 antibody levels correlated with anti-cTNC5 antibody levels, and absorption experiments confirmed this was not due to cross-reactivity. (ox.ac.uk)
Secondary antibody3
- Anti-rabbit IgG (H+L), F(ab') 2 Fragment (Alexa Fluor ® 488 Conjugate) #4412 was used as a secondary antibody. (cellsignal.com)
- Anti-rabbit IgG, HRP-linked Antibody #7074 was used as the secondary antibody. (cellsignal.com)
- After the primary antibody is bound to the target protein, a complex with HRP-linked secondary antibody is formed. (cellsignal.com)
Species7
- Find Dual Specificity Phosphatase 3 Antibodies for a variety of species such as anti-Human Dual Specificity Phosphatase 3, anti-Mouse Dual Specificity Phosphatase 3, anti-Rat Dual Specificity Phosphatase 3. (antibodies-online.com)
- The antibody may cross-react with immunoglobulins from other species. (jacksonimmuno.com)
- See technical information section (min X ... Sr Prot) before selecting an antibody adsorbed against closely related species. (jacksonimmuno.com)
- The antibody has been tested by ELISA and/or solid-phase adsorbed to ensure minimal cross-reaction with human, bovine, horse, rabbit and rat serum proteins, but it may cross-react with immunoglobulins from other species. (jacksonimmuno.com)
- With a collection of over 100,000 primary antibodies and commonly used secondary and tag antibodies, OriGene offers an extensive range of antibodies from various species. (origene.com)
- Find A4GNT Antibodies for a variety of species such as anti-Human A4GNT, anti-Rat A4GNT, anti-Cow A4GNT. (antibodies-online.com)
- Antibodies from UC patients greatly enhanced the respiratory burst in PMN, in response to individual bacterial species. (bmj.com)
Conjugate2
- Find Dual Specificity Phosphatase 3 Antibodies with a specific conjugate such as Biotin, FITC, HRP. (antibodies-online.com)
- Find A4GNT Antibodies with a specific conjugate such as Biotin, FITC, Alexa Fluor 488. (antibodies-online.com)
Reacts4
- This antibody reacts to lysine-acetylated proteins. (sigmaaldrich.com)
- Based on immunoelectrophoresis and/or ELISA, the antibody reacts with the F(ab') 2 /Fab portion of human IgG. (jacksonimmuno.com)
- Based on immunoelectrophoresis and/or ELISA, the antibody reacts with whole molecule mouse IgG. (jacksonimmuno.com)
- The antibody reacts with both free and conjugated fluorescein isothiocyanate (FITC). (anobase.org)
Polyclonal Antibody4
- Western Blot analysis of Jurkat cells and K562 cells using FAK Polyclonal Antibody at dilution of 1:1000. (elabscience.com)
- Immunohistochemistry of paraffin-embedded Human thyroid cancer using STX11 Polyclonal Antibody at dilution of 1:30. (elabscience.com)
- Western Blot analysis of Mouse lung tissue using STX11 Polyclonal Antibody at dilution of 1:400. (elabscience.com)
- IgA Fc Polyclonal antibody specifically detects IgA Fc in Human samples. (fishersci.com)
Protein12
- The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. (antibodies-online.com)
- An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)
- These tests can detect both HIV antibodies (proteins produced by the immune system in response to a foreign substance) and p24 antigen (a protein contained in HIV's viral core that can be detected sooner than antibodies). (aidsmap.com)
- Furthermore, an explanation for the observed restricted germline gene usage in certain antibody responses against protein epitopes is provided. (lu.se)
- In the in situ method, protein synthesis is carried out on a protein array surface that is pre-coated with a protein-capturing reagent or antibody. (wikipedia.org)
- Once the newly synthesized proteins are released from the ribosome, the tag sequence that is also synthesized at the N- or C-terminus of each nascent protein will be bound by the capture reagent or antibody, thus immobilizing the proteins to form an array. (wikipedia.org)
- Moreover, the resulting protein array is not 'pure' because the proteins are co-localized with their DNA templates and capture antibodies. (wikipedia.org)
- FITC is a commonly used marker for antibodies in immunofluorescent techniques because the conjugation of FITC to proteins is relatively easy and generally does not destroy the biological activity of the labeled protein. (anobase.org)
- We use advanced technologies to generate better antigens and validate the antibodies through multiple applications and protein samples. (origene.com)
- The specificity is further proved by using an independent antibody (anti-DDK antibody in the middle) against the same recombinant overexpressed Her2 protein. (origene.com)
- Anti-citrullinated protein antibody specificities and pulmonary fibrosis in relation to genetic loci in early rheumatoid arthritis. (scilifelab.se)
- Within the past 2 years, investigational peptide- and recombinant protein-based serologic assays that can more easily differentiate the antibodies to HTLV-I and HTLV-II have been developed (8,9). (cdc.gov)
IgG12
- Earlier, human studies had shown that thyroid-stimulating antibodies are predominantly of the immunoglobulin G1 (IgG1) subclass with a narrow specificity to TSHR, and antibodies that block thyroid function could be of any subclass with a brooder specificity. (elsevierpure.com)
- One vial containing 420 mg of trastuzumab, a humanised IgG1 monoclonal antibody produced by mammalian (Chinese hamster ovary) cell suspension culture and purified by chromatography including specific viral inactivation and removal procedures. (who.int)
Proteins6
- Antibodies are heavy (~150 k Da ) proteins of about 10 nm in size, [7] arranged in three globular regions that roughly form a Y shape. (wikipedia.org)
- No antibody was detected against the Fc portion of human IgG or against non-immunoglobulin serum proteins. (jacksonimmuno.com)
- The antibody exhibits inherent minimal cross-reaction to mouse serum proteins and has been tested by ELISA and/or solid-phase adsorbed to ensure minimal cross-reaction with bovine, horse and mouse serum proteins. (jacksonimmuno.com)
- No antibody was detected against non-immunoglobulin serum proteins. (jacksonimmuno.com)
- Newly synthesized proteins which are tagged with GST are then immobilized next to the template DNA by binding to the adjacent polyclonal anti-GST capture antibody that is also pre-coated onto the capture surface. (wikipedia.org)
- Antibodies to FITC are used to identify FITC labeled proteins and as models to study the mechanism of antibody response to a well defined hapten. (anobase.org)
Clone3
- Detect VEGF using this Anti-VEGF Antibody, clone VG1 validated for use in WB. (sigmaaldrich.com)
- Mouse monoclonal clone FL-D6 anti-FITC antibody will react with either free or conjugated FITC. (anobase.org)
- Mouse monoclonal clone FL-D6 anti-FITC antibody may be used for the detection of FITC and as a universal indicator reagent for bridging FITC with other immunochemical reagents. (anobase.org)
Immunoglobulin4
- Antibodies are glycoproteins belonging to the immunoglobulin superfamily . (wikipedia.org)
- The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
- These antibodies can be either immunoglobulin (Ig) M or IgG. (medscape.com)
- AHG is an animal antibody that binds to the F c portion of human immunoglobulin. (medscape.com)
Detects1
- The AHG detects bound RBC antibodies that do not produce direct agglutination (sensitizing antibody). (medscape.com)
Antigen-antibody interaction2
- Fluorochrome labeling provides rapid, accurate localization of antigen-antibody interaction when one of the reactants is part of a cell, tissue or other biological structure. (anobase.org)
- The tubes are then spun for 15 seconds at room temperature to facilitate antigen-antibody interaction. (medscape.com)
Epitope specificity1
- The importance of several of these conserved residues was supported by their presence in a mouse monoclonal antibody with a known structure and the same epitope specificity. (lu.se)
Complementarity determ1
- Five of these loops display a limited diversity in length and sequence while the third complementarity determining region (CDR) of the heavy chain is highly different between antibodies not only with respect to sequence but also with respect to length. (nih.gov)
Assays3
- Polyclonal antibodies to native OVA reacted strongly with native and denatured OVA in both assays, but did not react with the overlapping peptides. (ku.dk)
- Other applications include enzymatic inhibition assays and screenings of antibody specificity. (wikipedia.org)
- A(H7N9) virus-specific antibody responses were assessed by hemagglutination inhibition (HAI) and neutralization (NT) assays. (ox.ac.uk)
Peptides3
- Polyclonal antibodies to denatured OVA reacted strongly with both OVA forms and with several of the overlapping peptides. (ku.dk)
- Although SJL/J sera reacted with peptides to which blocking antibodies bind, they did not show hypothyroidism, suggesting that their sera contained a mixture of blocking and stimulating antibodies that negated the effects of each other. (elsevierpure.com)
- This study was undertaken to elucidate the mechanism by which PD could induce antibodies to citrullinated peptides (ACPAs), by examining the antibody response to a novel citrullinated peptide of cytokeratin 13 (CK-13) identified in gingival crevicular fluid (GCF), and comparing the response to 4 other citrullinated peptides in patients with RA who were well-characterized for PD and smoking. (ox.ac.uk)
Responses9
- Specificity, kinetics and longevity of antibody responses to avian influenza A(H7N9) virus infection in humans. (ox.ac.uk)
- ObjectivesThe long-term dynamics of antibody responses in patients with influenza A(H7N9) virus infection are not well understood.MethodsWe conducted a longitudinal serological follow-up study in patients who were hospitalized with A(H7N9) virus infection, during 2013-2018. (ox.ac.uk)
- A random intercept model was used to fit a curve to HAI antibody responses over time. (ox.ac.uk)
- HAI antibody responses were compared by clinical severity.ResultsOf 67 patients with A(H7N9) virus infection, HAI antibody titers reached 40 on average 11 days after illness onset and peaked at a titer of 290 after three months, and average titers of ≥80 and ≥40 were present until 11 months and 22 months respectively. (ox.ac.uk)
- HAI antibody responses were significantly higher in patients who experienced severe disease, including respiratory failure and acute respiratory distress syndrome, compared with patients who experienced less severe illness.ConclusionsPatients with A(H7N9) virus infection who survived severe disease mounted higher antibody responses that persisted for longer periods compared with those that experienced moderate disease. (ox.ac.uk)
- Therefore, antibody responses in susceptible (BALB/cJ) and resistant (SJL/J) mice were characterized. (elsevierpure.com)
- Systemic antibody responses were measured against total antigens and surface antigens of these organisms in UC and Crohn's disease (CD) patients, together with healthy controls. (bmj.com)
- Distinct differences were observed in some bacterial populations in UC biopsies, which were generally reflected in antibody responses towards these organisms. (bmj.com)
- Association of Distinct Fine Specificities of Anti-Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis. (ox.ac.uk)
Fine specificities2
- The presence of 21 ACPA fine specificities was analysed using a custom-made microarray chip (Thermo Fisher Scientific, Uppsala, Sweden). (scilifelab.se)
- CONCLUSION: This study identifies 2 groups of ACPA fine specificities associated with different RA risk factors. (ox.ac.uk)
Serum6
- The specificity is verified by a precipitin line of identity with the CDC-AF reference serum. (calbiotech.com)
- Naturally occurring anti-A and anti-B are the only RBC antibodies in normal human serum or plasma. (medscape.com)
- The antibody screening test performed in a clinical laboratory and/or blood bank is designed to detect the presence of unexpected antibodies, especially alloantibodies in the serum to antigens of the non-ABO blood group system: Duffy, Kell, Kidd, MNS, P, and certain Rh types that are considered clinically significant. (medscape.com)
- It is also used in antenatal screening to detect the presence of antibodies in a pregnant woman's serum that could result in hemolytic disease of the fetus and newborn . (medscape.com)
- Notably, the specificity test showed the half-maximal effective concentration values of the three humanized antibodies were lower than that of positive patient serum . (bvsalud.org)
- ABSTRACT In this study, endoscopy patients with and without chronic liver disease (CLD) were ex- amined and tested for Helicobacter pylori infection by detecting the presence of serum and salivary anti-H. pylori antibody. (who.int)
Affinity2
- Human-murine chimeric autoantibodies with high affinity and specificity for systemic sclerosis. (bvsalud.org)
- In this study, murine-sourced scFv library were screened by phage display technology against human Scl-70, and the scFvs with high affinity were constructed into humanized antibodies for clinical application. (bvsalud.org)
Mouse monoclonal1
- Several of these corresponding residues in the mouse monoclonal antibody are known to interact with the antigen. (lu.se)
Rabbit1
- mTOR (7C10) Rabbit mAb confirms silencing of mTOR expression, while the α-Tubulin (11H10) Rabbit mAb is used to control for loading and specificity of mTOR siRNA. (cellsignal.com)
Presence of antibodies1
- The presence of antibodies to HTLV-I or HTLV-II indicates that a person is infected with the virus. (cdc.gov)
Recognizes2
- The antibody recognizes a unique molecule of the pathogen, called an antigen . (wikipedia.org)
- To understand better the cellular mechanisms of NE and its adrenergic receptors in the LA, we used antibodies directed against dopamine beta-hydroxylase (DβH), the synthetic enzyme for NE, or against two different isoforms of the beta-adrenergic receptors (βARs), one that predominately recognizes neurons (βAR 248) and the other astrocytes (βAR 404), to characterize the microenvironments of DβH and βAR. (frontiersin.org)
ELISA2
- Find Dual Specificity Phosphatase 3 Antibodies validated for a specific application such as WB, ELISA, IHC, IF (cc). (antibodies-online.com)
- Find A4GNT Antibodies validated for a specific application such as WB, ELISA, IHC, IHC (p). (antibodies-online.com)
Detection7
- Utilize our A4GNT antibodies in your research endeavors for dependable A4GNT detection. (antibodies-online.com)
- After immediate spin, the tubes are incubated at 37°C. To promote the detection of warm reactive antibodies, especially of the IgG class, additional enhancement techniques such as low ionic strength saline (LISS) and polyethylene glycol (PEG) are often used. (medscape.com)
- [ 1 , 2 ] PEG, a water-soluble linear polymer, appears to accelerate antibody-RBC binding by steric exclusion of water molecules in the diluents and to promote antibody detection. (medscape.com)
- The climate is hot body detection test based on reaction throughout the year with the rains falling of specific antibodies with the same between March and November. (who.int)
- Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is important to diagnose a current or resolved infection. (lu.se)
- In PCR-confirmed COVID-19 patients (n = 45), the total antibody detection rate is 92% in hospitalized patients and 79% in non-hospitalized patients. (lu.se)
- Our study provides a comprehensive validation of the rapid COVID-19 IgM/IgG serology test, and mapped antibody detection patterns in association with disease progress and hospitalization. (lu.se)
Residues4
- The antigen binding site of an antibody is made up of residues residing in six hypervariable loops of the heavy and light chains. (nih.gov)
- Using CDR shuffling, residues important for the assembly of mucin-1 specific paratopes were defined by random recombination of the complementarity determining regions derived from a set of mucin-1 specific clones, previously selected from an antibody fragment library. (lu.se)
- In conclusion, critical residues important for maintaining a human antigen-specific binding site during the process of in vitro antibody evolution were defined. (lu.se)
- The CS-35 antibody is widely used in the characterization of glycans containing D-arabinofuranose residues, in particular polysaccharides present in the mycobacterial cell wall. (uni-luebeck.de)
Primary4
- The virtual lane view (left) shows the target band (as indicated) at 1:10 and 1:50 dilutions of primary antibody. (cellsignal.com)
- The corresponding electropherogram view (right) plots chemiluminescence by molecular weight along the capillary at 1:10 (blue line) and 1:50 (green line) dilutions of primary antibody. (cellsignal.com)
- 2. According to the recommended primary antibody dilution ratio, use the TBST Buffer containing 5% Skim Milk Powder to dilute the FAK Antibody at , soak the PVDF Membrane in the primary antibody working solution, incubate overnight at 4 ℃, and gently shake. (elabscience.com)
- 2. According to the recommended primary antibody dilution ratio, use the TBST Buffer containing 5% Skim Milk Powder to dilute the STX11 Antibody at , soak the PVDF Membrane in the primary antibody working solution, incubate overnight at 4 ℃, and gently shake. (elabscience.com)
ACPA2
- In unadjusted analyses, 11 ACPA specificities were associated with PF development. (scilifelab.se)
- The development of PF in an inception cohort of RA patients was associated with both presence of certain ACPA and the number of ACPA specificities and risk genes. (scilifelab.se)
Positivity1
- Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies' positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition. (unife.it)
Autoimmune disorder2
- Myasthenia gravis (MG) is a relatively rare acquired, autoimmune disorder caused by an antibody-mediated blockade of neuromuscular transmission resulting in skeletal muscle weakness and rapid muscle fatigue. (medscape.com)
- Myasthenia gravis (MG) is a relatively rare autoimmune disorder in which antibodies form against acetylcholine nicotinic postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)
Cells5
- Together with B and T cells , antibodies comprise the most important part of the adaptive immune system . (wikipedia.org)
- After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells , which secrete soluble antibodies with the same paratope, or memory B cells , which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
- The antibody can also be used to isolate cells that have an FITC-labeled ligand on their surface. (anobase.org)
- The mucosa in ulcerative colitis (UC) is replete with antibody producing plasma B cells and polymorphonuclear leucocytes (PMN). (bmj.com)
- This combination of effector cells requires a crosslinking antigen to evoke an antibody driven PMN inflammatory response via their Fc receptors. (bmj.com)
Antigenic3
- To investigate this matter further we have used an approach employing combinatorial antibody libraries and antigen-specific selection in the search for CDRH3 length and sequence diversity compatible with a given antigen specificity, the major antigenic determinant on the tumour-associated antigen mucin-1. (nih.gov)
- Additionally, high specificity of circulating ASCs after antigenic challenge highlights the diagnostic value of interrogating ASCs as an ideal single-time-point diagnostic immune surrogate for serology during acute infection. (syr.edu)
- The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. (bvsalud.org)
Human3
- human monoclonal antibody (b96.11 huAb) and polyclonal antibodies (SMS patients' sera) were investigated. (nottingham.ac.uk)
- Human monoclonal antibody. (abcam.com)
- Multiple conformation- or misfolded-specific antibodies for human SOD1 were compared. (nature.com)
Sera1
- Test specificity was determined to be 97% on 69 sera/plasma samples collected between 2016-2018. (lu.se)
Specific11
- Find Dual Specificity Phosphatase 3 Antibodies with a specific Host. (antibodies-online.com)
- Collectively, immunization with native OVA preferentially generates highly specific antibodies reacting with three-dimensional epitopes, whereas immunization with denatured OVA generates antibodies occasionally reacting with continuous epitopes. (ku.dk)
- V kappa gene family in (Glu60 Ala30 Tyr10)n (GAT)-specific antibodies that express CGAT (or pGAT) public idiotypic specificities. (rupress.org)
- A large proportion of (Glu60 Ala30 Tyr10)n (GAT)-specific antibodies expresses public idiotypic specificities, termed CGAT (or pGAT), that require the presence of both the heavy and the light chains in order to be expressed. (rupress.org)
- [2] [3] Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. (wikipedia.org)
- Find A4GNT Antibodies with a specific Grade. (antibodies-online.com)
- We have established clear experimental protocols and provide specific guidelines for working, with conformational/misfolded SOD1-specific antibodies. (nature.com)
- In contrast, some TSHR-specific antibodies in BALB/cJ probably represented stimulating antibodies. (elsevierpure.com)
- The aim of this investigation was to compare the principal culturable bacterial populations on the rectal mucosa of UC patients, and to determine whether specific antibodies towards these bacteria can activate infiltrating PMN through opsonisation. (bmj.com)
- The presence of agglutination with the addition of AHG indicates antibody binding to a specific red cell antigen. (medscape.com)
- 1985. Specific bronchoalveolar lavage IgG antibody in hypersensitivity pneumonitis from diphenylmethane diisocyanate. (cdc.gov)
High5
- The high rate of CHB reported in the paper may raise undue concern in counselling women with anti-SSA/Ro antibodies facing pregnancy. (bmj.com)
- 7 It is already well known that CHB more frequently develops in mothers with high titre antibodies. (bmj.com)
- To incrementally advance the field beyond what is already known, it would be important to enrol at the very least only women with high titre antibodies during the pregnancy under study. (bmj.com)
- Addgene: Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity. (addgene.org)
- Moreover, these humanized antibodies showed high specificity for Scl-70 in diagnostic immunoassays for ANA. (bvsalud.org)
Autoantibodies1
- All others are unexpected and can be divided into alloantibodies (an antibody to an antigen that an individual lacks) and autoantibodies (an antibody to an antigen a person has). (medscape.com)
Genes1
- It seems likely, however, that any given strain may not necessarily use all three genes for making anti-GAT antibodies. (rupress.org)
Dilution1
- Western Blot Analysis: A 1:500 dilution of this antibody detected VEGF on 10 µg of NIH/3T3 cell lysate. (sigmaaldrich.com)
Her21
- Specificity validation of anti-Her2 antibody (Cat. (origene.com)
0.051
- Only anti-cCK13-1 and anti-cTNC5 were associated with antibodies to the periodontal pathogen Prevotella intermedia (P = 0.05 and P = 0.001, respectively), but not with antibodies to Porphyromonas gingivalis arginine gingipains. (ox.ac.uk)
Titers1
- There were no significant differences in the titers, relative affinities, or isotypes of antibodies against the TSHR. (elsevierpure.com)
Validation1
- Specificity Validation for OriGene antibody Cat. (origene.com)
Notably1
- Antibody screening is routinely used in conjunction with typing and crossmatch before the administration of blood products, especially RBCs, to avoid transfusion reactions and to prevent notably decreased survival of transfused RBCs. (medscape.com)
Bound1
- The antibody does not react with bound or free TRITC (tetramethylrhodamine isothiocyanate). (anobase.org)
Methods1
- The efficacy of our antibodies is well-established, demonstrated through multiple methods. (antibodies-online.com)
Test8
- The specificity of a test is the percentage of results that will be correctly negative when HIV is not present. (aidsmap.com)
- The specificity of an HIV test is the proportion of people without HIV who will have a negative result. (aidsmap.com)
- In other words, the specificity of a test refers to how accurate the test is when used by HIV-negative people. (aidsmap.com)
- A test with this specificity would give correct results to 99% of HIV-negative people, but 'false positive' results to 1% of them. (aidsmap.com)
- A sub-optimal test, with only 94% specificity, would give a negative result to 94% of people who don't have HIV, but 'false positive' results to 6% of them. (aidsmap.com)
- Elecsys Testosterone is based on a competitive test principle using a monoclonal antibody specifically directed against testosterone. (cdc.gov)
- The antibody screening test, as part of pretransfusion compatibility testing (see Special Considerations ), along with the type and crossmatch, prevents transfusion reactions such as hemolysis from occurring. (medscape.com)
- In this study, we applied a rapid COVID-19 IgM/IgG antibody test and performed serology assessment of antibody response to SARS-CoV-2. (lu.se)